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Entry version 156 (29 Sep 2021)
Sequence version 1 (01 May 2000)
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Protein

Peptidoglycan-recognition protein SA

Gene

PGRP-SA

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE (PubMed:11106397, PubMed:16399077, PubMed:15448690).

Has no activity against Gram-negative bacteria and fungi (PubMed:11742401).

Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition (PubMed:11742401, PubMed:15448690).

May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway (PubMed:14684822, PubMed:14722090, PubMed:11742401).

Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) and lysine-type PGN (Lys-type PGN) (PubMed:15361936).

Has some L,D-carboxypeptidase activity for DAP-type PGN, which are specific to prokaryotes, but not for Lys-type PGN (PubMed:15361936).

6 Publications

Caution

Although suggested, the interaction with GNBP1 has not been experimentally demonstrated.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=21.4 µM for GlcNAc-MurNAc(anhydro)-L-Ala-gamma-D-Glu-meso-DAP-D-Ala1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei182Interacts with peptidoglycanCurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease
Biological processImmunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6798695, Neutrophil degranulation
R-DME-6803157, Antimicrobial peptides

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidoglycan-recognition protein SA (EC:3.4.17.131 Publication)
Alternative name(s):
Protein semmelweis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PGRP-SA
Synonyms:seml
ORF Names:CG11709
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0030310, PGRP-SA

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0030310

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi37C → A: Does not affect activation of Toll pathway. 1 Publication1
Mutagenesisi68H → A: Abolishes L,D-carboxypeptidase activity on DAP-type PGN. 1 Publication1
Mutagenesisi70 – 71VT → AA: Strongly reduces PGN-binding and activation of Toll pathway. 1 Publication2
Mutagenesisi74C → A: Abolishes activation of Toll pathway. 1 Publication1
Mutagenesisi80C → Y in seml; induces susceptibility to Gram-positive bacterial infection. 1 Publication1
Mutagenesisi90 – 91YH → AA: Strongly reduces PGN-binding and activation of Toll pathway. 1 Publication2
Mutagenesisi96 – 98DFN → AAA: Strongly reduces PGN-binding and activation of Toll pathway. 1 Publication3
Mutagenesisi101S → A: Increases PGN-binding and activation of Toll pathway. 1 Publication1
Mutagenesisi126Y → A: Strongly reduces PGN-binding and activation of Toll pathway. 1 Publication1
Mutagenesisi180I → A: Strongly reduces PGN-binding. 1 Publication1
Mutagenesisi182T → Y: Abolishes PGN-binding and activation of Toll pathway. 1 Publication1
Mutagenesisi184S → A or C: Abolishes PGN-binding and activation of Toll pathway. Abolishes L,D-carboxypeptidase activity on DAP-type PGN. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 261 PublicationAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002390627 – 203Peptidoglycan-recognition protein SAAdd BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 160
Disulfide bondi74 ↔ 80

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VYX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In larvae, it is expressed in fat body. Also expressed in uninduced hemocytes and mbn-2 cells.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Strongly up-regulated by PGN from B.subtilis. Regulated by both imd/Relish and Toll pathways.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0030310, Expressed in arthropod fat body and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VYX7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VYX7, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58509, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-60775N

Protein interaction database and analysis system

More...
IntActi
Q9VYX7, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0073358

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1203
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VYX7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9VYX7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 186N-acetylmuramoyl-L-alanine amidaseSequence analysisAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni87 – 90Peptidoglycan bindingCurated4
Regioni97 – 102Peptidoglycan bindingCurated6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S2KY, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037559_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VYX7

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFVVIHH

Database of Orthologous Groups

More...
OrthoDBi
1110472at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VYX7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06583, PGRP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.80.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036505, Amidase/PGRP_sf
IPR002502, Amidase_domain
IPR017331, Peptidoglycan_recognition
IPR015510, PGRP
IPR006619, PGRP_domain_met/bac

The PANTHER Classification System

More...
PANTHERi
PTHR11022, PTHR11022, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01510, Amidase_2, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037945, PGRPs, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00644, Ami_2, 1 hit
SM00701, PGRP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55846, SSF55846, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VYX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPVRFGSPW IMAIGLVLLL LAFVSAGKSR QRSPANCPTI KLKRQWGGKP
60 70 80 90 100
SLGLHYQVRP IRYVVIHHTV TGECSGLLKC AEILQNMQAY HQNELDFNDI
110 120 130 140 150
SYNFLIGNDG IVYEGTGWGL RGAHTYGYNA IGTGIAFIGN FVDKLPSDAA
160 170 180 190 200
LQAAKDLLAC GVQQGELSED YALIAGSQVI STQSPGLTLY NEIQEWPHWL

SNP
Length:203
Mass (Da):22,260
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD200A6EA79C66731
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JEI8X2JEI8_DROME
Peptidoglycan-recognition protein
PGRP-SA BcDNA:AT30827, Dm PGRP-SA, Dmel\CG11709, pgrp-sa, SA
203Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF207540 Genomic DNA Translation: AAG23734.1
AF207541 mRNA Translation: AAG23735.1
AJ556551 Genomic DNA Translation: CAD89116.1
AJ556552 Genomic DNA Translation: CAD89117.1
AJ556553 Genomic DNA Translation: CAD89118.1
AJ556554 Genomic DNA Translation: CAD89119.1
AJ556555 Genomic DNA Translation: CAD89120.1
AJ556556 Genomic DNA Translation: CAD89121.1
AJ556557 Genomic DNA Translation: CAD89122.1
AJ556558 Genomic DNA Translation: CAD89123.1
AJ556559 Genomic DNA Translation: CAD89124.1
AJ556560 Genomic DNA Translation: CAD89125.1
AJ556561 Genomic DNA Translation: CAD89126.1
AE014298 Genomic DNA Translation: AAF48056.1
AY075293 mRNA Translation: AAL68160.1

NCBI Reference Sequences

More...
RefSeqi
NP_001285128.1, NM_001298199.1
NP_572727.1, NM_132499.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0073509; FBpp0073358; FBgn0030310
FBtr0340296; FBpp0309257; FBgn0030310

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32099

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG11709

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207540 Genomic DNA Translation: AAG23734.1
AF207541 mRNA Translation: AAG23735.1
AJ556551 Genomic DNA Translation: CAD89116.1
AJ556552 Genomic DNA Translation: CAD89117.1
AJ556553 Genomic DNA Translation: CAD89118.1
AJ556554 Genomic DNA Translation: CAD89119.1
AJ556555 Genomic DNA Translation: CAD89120.1
AJ556556 Genomic DNA Translation: CAD89121.1
AJ556557 Genomic DNA Translation: CAD89122.1
AJ556558 Genomic DNA Translation: CAD89123.1
AJ556559 Genomic DNA Translation: CAD89124.1
AJ556560 Genomic DNA Translation: CAD89125.1
AJ556561 Genomic DNA Translation: CAD89126.1
AE014298 Genomic DNA Translation: AAF48056.1
AY075293 mRNA Translation: AAL68160.1
RefSeqiNP_001285128.1, NM_001298199.1
NP_572727.1, NM_132499.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S2JX-ray2.20A/B1-203[»]
1SXRX-ray1.56A/B27-203[»]
SMRiQ9VYX7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi58509, 2 interactors
DIPiDIP-60775N
IntActiQ9VYX7, 7 interactors
STRINGi7227.FBpp0073358

Proteomic databases

PaxDbiQ9VYX7

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
32099

Genome annotation databases

EnsemblMetazoaiFBtr0073509; FBpp0073358; FBgn0030310
FBtr0340296; FBpp0309257; FBgn0030310
GeneIDi32099
KEGGidme:Dmel_CG11709

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32099
FlyBaseiFBgn0030310, PGRP-SA
VEuPathDBiVectorBase:FBgn0030310

Phylogenomic databases

eggNOGiENOG502S2KY, Eukaryota
HOGENOMiCLU_037559_3_0_1
InParanoidiQ9VYX7
OMAiRFVVIHH
OrthoDBi1110472at2759
PhylomeDBiQ9VYX7

Enzyme and pathway databases

ReactomeiR-DME-6798695, Neutrophil degranulation
R-DME-6803157, Antimicrobial peptides

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
32099, 0 hits in 3 CRISPR screens
EvolutionaryTraceiQ9VYX7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32099

Protein Ontology

More...
PROi
PR:Q9VYX7

Gene expression databases

BgeeiFBgn0030310, Expressed in arthropod fat body and 34 other tissues
ExpressionAtlasiQ9VYX7, baseline and differential
GenevisibleiQ9VYX7, DM

Family and domain databases

CDDicd06583, PGRP, 1 hit
Gene3Di3.40.80.10, 1 hit
InterProiView protein in InterPro
IPR036505, Amidase/PGRP_sf
IPR002502, Amidase_domain
IPR017331, Peptidoglycan_recognition
IPR015510, PGRP
IPR006619, PGRP_domain_met/bac
PANTHERiPTHR11022, PTHR11022, 1 hit
PfamiView protein in Pfam
PF01510, Amidase_2, 1 hit
PIRSFiPIRSF037945, PGRPs, 1 hit
SMARTiView protein in SMART
SM00644, Ami_2, 1 hit
SM00701, PGRP, 1 hit
SUPFAMiSSF55846, SSF55846, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGPSA_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VYX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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