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Protein
Submitted name:

ATP7, isoform B

Gene

ATP7

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi23PROSITE-ProRule annotation1
Metal bindingi26PROSITE-ProRule annotation1
Metal bindingi104PROSITE-ProRule annotation1
Metal bindingi107PROSITE-ProRule annotation1
Metal bindingi219PROSITE-ProRule annotation1
Metal bindingi222PROSITE-ProRule annotation1
Metal bindingi295PROSITE-ProRule annotation1
Metal bindingi298PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • copper-exporting ATPase activity Source: GO_Central
  • copper ion binding Source: FlyBase
  • copper ion transmembrane transporter activity Source: FlyBase
  • copper-transporting ATPase activity Source: GO_Central
  • nucleotide binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMetal-bindingPROSITE-ProRule annotation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.3.4 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-936837 Ion transport by P-type ATPases

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.3.5.37 the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP7, isoform BImported
Submitted name:
ATP7, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP7Imported
Synonyms:DmATP7Imported, dmATP7Imported, Dmel\CG1886Imported, lincRNA.S9122Imported
ORF Names:CG1886Imported, Dmel_CG1886Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0030343 ATP7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei375 – 395HelicalUniRule annotationAdd BLAST21
Transmembranei417 – 436HelicalUniRule annotationAdd BLAST20
Transmembranei448 – 474HelicalUniRule annotationAdd BLAST27
Transmembranei480 – 500HelicalUniRule annotationAdd BLAST21
Transmembranei640 – 665HelicalUniRule annotationAdd BLAST26
Transmembranei685 – 709HelicalUniRule annotationAdd BLAST25
Transmembranei1093 – 1114HelicalUniRule annotationAdd BLAST22
Transmembranei1120 – 1143HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0030343 Expressed in 26 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0271765

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 79HMAInterPro annotationAdd BLAST67
Domaini94 – 160HMAInterPro annotationAdd BLAST67
Domaini209 – 275HMAInterPro annotationAdd BLAST67
Domaini285 – 351HMAInterPro annotationAdd BLAST67

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0207 Eukaryota
COG2217 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155749

KEGG Orthology (KO)

More...
KOi
K17686

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTGYEAR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G022E

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00371 HMA, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00403 HMA, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55008 SSF55008, 4 hits
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
TIGR00003 TIGR00003, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 3 hits
PS50846 HMA_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VYT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSDERVEAT MSTVRLPIVG MTCQSCVRNI TEHIGQKSGI LGVRVILEEN
60 70 80 90 100
AGYFDYDPRQ TDPARIASDI DDMGFECSYP GDAADPPETP ASAWTNIRVV
110 120 130 140 150
GMTCQSCVRN IEGNIGTKPG IHSIEVQLAA KNARVQYDPA QYDPAQIAEL
160 170 180 190 200
IDDMGFEASV QEPRSPSQSP SPAPASSPKK RATPTPPPPS YAQNGSAVAI
210 220 230 240 250
PVEQELLTKC FLHIRGMTCA SCVAAIEKHC KKIYGLDSIL VALLAAKAEV
260 270 280 290 300
KFNANVVTAE NIAKSITELG FPTELIDEPD NGEAEVELEI MGMTCASCVN
310 320 330 340 350
KIESHVLKIR GVTTASVTLL TKRGKFRYIT EETGPRSICE AIEALGFEAK
360 370 380 390 400
LMTGRDKMAH NYLEHKEEIR KWRNAFLVSL IFGGPCMVAM IYFMLEMSDK
410 420 430 440 450
GHANMCCLVP GLSMENLVMF LLSTPVQFFG GFHFYVQSYR AIKHGTTNMD
460 470 480 490 500
VLISMVTTIS YVYSVAVVIA AVLLEQNSSP LTFFDTPPML LIFISLGRWL
510 520 530 540 550
EHIAKGKTSE ALSKLLSLKA ADALLVEISP DFDIISEKVI SVDYVQRGDI
560 570 580 590 600
LKVIPGAKVP VDGKVLYGHS SCDESLITGE SMPVAKRKGS VVIGGSINQN
610 620 630 640 650
GVLLVEATHT GENTTLAQIV RLVEEAQTSK APIQQLADRI AGYFVPFVVV
660 670 680 690 700
VSSITLIAWI IIGFSNPNLV PVAMEHKMHM DQNTIIVSYA FKCALSVLAI
710 720 730 740 750
ACPCALGLAT PTAVMVATGT GAINGVLVKG ATALENAHKV KTVVFDKTGT
760 770 780 790 800
ITHGTPMTSK VTLFVTAQVC SLARALTIVG AAEQNSEHPI ASAIVHFAKD
810 820 830 840 850
MLNVGATPQA GSFGKSSHFQ AVPGCGIRVT VSNYEQTLRQ ACNADRIINY
860 870 880 890 900
ENLHRTHPQG SVPVDNGASI EHLLPQRSVR KSMELNNQQL LSDLVLEPEE
910 920 930 940 950
ELLTDQKIID SPEILVLIGN REWMERNAIE VPLEISDCMT HEERKGHTAV
960 970 980 990 1000
LCALNGQLVC MFAVSDMVKP EAHLAVYTLK RMGIDVVLLT GDNKNTAASI
1010 1020 1030 1040 1050
AREVGIRTVY AEVLPSHKVA KIQRIQANGI RVAMVGDGVN DSPALAQADV
1060 1070 1080 1090 1100
GITIAAGTDV AAEASDIVLM RNDLLDVVAC LDLSRCTVRR IRYNFFFASM
1110 1120 1130 1140 1150
YNLLGIPLAS GLFAPYGFTL LPWMASVAMA ASSVSVVCSS LLLKMYRKPT
1160 1170 1180 1190 1200
AKTLRTAEYE AQLAAERASG SEDELDKLSL HRGLDDLPEK GRMPFKRSST
1210 1220 1230 1240 1250
SLISRIFMHD YGNITSPDAK YGEGLLDPEE QYDGRTKIVR SRFHANDSTE

LQKL
Length:1,254
Mass (Da):136,082
Last modified:March 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15EC83DDA66EA403
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48104.3
AE014298 Genomic DNA Translation: AGB95309.1

NCBI Reference Sequences

More...
RefSeqi
NP_001259466.1, NM_001272537.2
NP_572756.3, NM_132528.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.18759

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0273257; FBpp0271765; FBgn0030343
FBtr0334454; FBpp0306530; FBgn0030343

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32142

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1886

UCSC genome browser

More...
UCSCi
CG1886-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48104.3
AE014298 Genomic DNA Translation: AGB95309.1
RefSeqiNP_001259466.1, NM_001272537.2
NP_572756.3, NM_132528.3
UniGeneiDm.18759

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7227.FBpp0271765

Protein family/group databases

TCDBi3.A.3.5.37 the p-type atpase (p-atpase) superfamily

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0273257; FBpp0271765; FBgn0030343
FBtr0334454; FBpp0306530; FBgn0030343
GeneIDi32142
KEGGidme:Dmel_CG1886
UCSCiCG1886-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32142
FlyBaseiFBgn0030343 ATP7

Phylogenomic databases

eggNOGiKOG0207 Eukaryota
COG2217 LUCA
GeneTreeiENSGT00940000155749
KOiK17686
OMAiKTGYEAR
OrthoDBiEOG091G022E

Enzyme and pathway databases

BRENDAi3.6.3.4 1994
ReactomeiR-DME-936837 Ion transport by P-type ATPases

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32142

Protein Ontology

More...
PROi
PR:Q9VYT4

Gene expression databases

BgeeiFBgn0030343 Expressed in 26 organ(s), highest expression level in testis

Family and domain databases

CDDicd00371 HMA, 4 hits
Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 4 hits
SUPFAMiSSF55008 SSF55008, 4 hits
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
TIGR00003 TIGR00003, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 3 hits
PS50846 HMA_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VYT4_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VYT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 3, 2009
Last modified: December 5, 2018
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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