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UniProtKB - Q9VYD5 (Q9VYD5_DROME)

Entry version 172 (19 Jan 2022)
Sequence version 2 (01 Oct 2002)
Previous versions | rss
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Protein

Branched-chain-amino-acid aminotransferase

Gene

Dmel\CG1673

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphateUniRule annotationARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminotransferaseUniRule annotationARBA annotation, Transferase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotationARBA annotation
LigandPyridoxal phosphateUniRule annotationARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-70895, Branched-chain amino acid catabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Branched-chain-amino-acid aminotransferaseUniRule annotation (EC:2.6.1.42UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dmel\CG1673Imported
Synonyms:cg1673Imported
ORF Names:CG1673Imported, Dmel_CG1673Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0030482, CG1673

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0030482

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0030482, Expressed in mouthpart (Drosophila) and 36 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9VYD5, 1 interactor

STRING: functional protein association networks

More...STRINGi		7227.FBpp0073608

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0975, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009532

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_031922_0_3_1

Identification of Orthologs from Complete Genome Data

More...OMAi		LTEVFAC

Database of Orthologous Groups

More...OrthoDBi		853728at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd01557, BCAT_beta_family, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.10.10, 1 hit
3.30.470.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001544, Aminotrans_IV
IPR018300, Aminotrans_IV_CS
IPR036038, Aminotransferase-like
IPR005786, B_amino_transII
IPR043132, BCAT-like_C
IPR043131, BCAT-like_N
IPR033939, BCAT_family

The PANTHER Classification System

More...PANTHERi		PTHR11825, PTHR11825, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01063, Aminotran_4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56752, SSF56752, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01123, ilvE_II, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00770, AA_TRANSFER_CLASS_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VYD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTKMAINAK DIFRNQHRLI RFLEQSIRLC SNQSLKAAQA AQLQQKSSAD 
        60         70         80         90        100
FEITASLDAQ YTSAPEPIKH DKNLGHQFRA SQISVRLAAP EQLQPKPDND 
       110        120        130        140        150
EELGFGRLFT DHMLKIYYHK SLGGWQRPEI TPLENLVMHP AAKVLHYAVE 
       160        170        180        190        200
LFEGMKAYRG VDGKIRIFRP DMNMNRMNLA AQRSGLPTFE GKEFVQCLSR 
       210        220        230        240        250
LLSIDSEWVP HTDTASLYIR PTLIGIDPTL GVASSDSALL YTILSPVGSY 
       260        270        280        290        300
FKTGSSGAVS LLADPSYVRA WPGGVGNRKM GSNYAPTINV QKEAAAKGLQ 
       310        320        330        340        350
QVLWLYGEDH QLTEVGTMNI FMFFVNDQGE QELVTPPLSG LILPGITRDS 
       360        370        380        390        400
ILRMTRQWGK FKVSEANITM PMVCELLNQG RLLELFGAGT ACVVSPVNRI 
       410        420        430        440 
SYLGQDLYIP TMEQEKPVHE LIRETLTDIQ YGRVDHPWAV VID
Length:443
Mass (Da):49,537
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EB838FC994EE349
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48268.2
BT004848 mRNA Translation: AAO45204.1

NCBI Reference Sequences

More...RefSeqi		NP_572884.1, NM_132656.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0073777; FBpp0073608; FBgn0030482

Database of genes from NCBI RefSeq genomes

More...GeneIDi		32297

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1673

UCSC genome browser

More...UCSCi		CG1673-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48268.2
BT004848 mRNA Translation: AAO45204.1
RefSeqiNP_572884.1, NM_132656.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9VYD5, 1 interactor
STRINGi7227.FBpp0073608

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		32297

Genome annotation databases

EnsemblMetazoaiFBtr0073777; FBpp0073608; FBgn0030482
GeneIDi32297
KEGGidme:Dmel_CG1673
UCSCiCG1673-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0030482, CG1673
VEuPathDBiVectorBase:FBgn0030482

Phylogenomic databases

eggNOGiKOG0975, Eukaryota
GeneTreeiENSGT00390000009532
HOGENOMiCLU_031922_0_3_1
OMAiLTEVFAC
OrthoDBi853728at2759

Enzyme and pathway databases

ReactomeiR-DME-70895, Branched-chain amino acid catabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		32297, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		32297

Gene expression databases

BgeeiFBgn0030482, Expressed in mouthpart (Drosophila) and 36 other tissues

Family and domain databases

CDDicd01557, BCAT_beta_family, 1 hit
Gene3Di3.20.10.10, 1 hit
3.30.470.10, 1 hit
InterProiView protein in InterPro
IPR001544, Aminotrans_IV
IPR018300, Aminotrans_IV_CS
IPR036038, Aminotransferase-like
IPR005786, B_amino_transII
IPR043132, BCAT-like_C
IPR043131, BCAT-like_N
IPR033939, BCAT_family
PANTHERiPTHR11825, PTHR11825, 1 hit
PfamiView protein in Pfam
PF01063, Aminotran_4, 1 hit
SUPFAMiSSF56752, SSF56752, 1 hit
TIGRFAMsiTIGR01123, ilvE_II, 1 hit
PROSITEiView protein in PROSITE
PS00770, AA_TRANSFER_CLASS_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VYD5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VYD5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: January 19, 2022
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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