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UniProtKB - Q9VYD1 (C1716_DROME)

Entry version 162 (07 Apr 2021)
Sequence version 2 (31 Oct 2006)
Previous versions | rss
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Protein

Probable histone-lysine N-methyltransferase CG1716

Gene

Set2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi17 – 29A.T hook 1Add BLAST13
DNA bindingi197 – 209A.T hook 2Add BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9VYD1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable histone-lysine N-methyltransferase CG1716 (EC:2.1.1.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Set2
ORF Names:CG1716
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0030486, Set2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595231 – 2313Probable histone-lysine N-methyltransferase CG1716Add BLAST2313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei404Phosphothreonine1 Publication1
Modified residuei786Phosphoserine1 Publication1
Modified residuei788Phosphoserine1 Publication1
Modified residuei2130Phosphoserine1 Publication1
Modified residuei2131Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9VYD1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9VYD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0030486, Expressed in oocyte and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9VYD1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9VYD1, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		58681, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q9VYD1, 1 interactor

STRING: functional protein association networks

More...STRINGi		7227.FBpp0073610

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1307 – 1360AWSPROSITE-ProRule annotationAdd BLAST54
Domaini1362 – 1479SETPROSITE-ProRule annotationAdd BLAST118
Domaini1486 – 1502Post-SETPROSITE-ProRule annotationAdd BLAST17
Domaini1963 – 1996WWPROSITE-ProRule annotationAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi326 – 672Glu-richAdd BLAST347
Compositional biasi675 – 898Lys-richAdd BLAST224
Compositional biasi983 – 1008Ser-richAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4442, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000172873

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000516_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9VYD1

Family and domain databases

Conserved Domains Database

More...CDDi		cd19172, SET_SETD2, 1 hit
cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1740.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017956, AT_hook_DNA-bd_motif
IPR006560, AWS_dom
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR044437, SETD2/Set2_SET
IPR013257, SRI
IPR038190, SRI_sf
IPR001202, WW_dom
IPR036020, WW_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17907, AWS, 1 hit
PF00856, SET, 1 hit
PF08236, SRI, 1 hit
PF00397, WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00384, AT_hook, 2 hits
SM00570, AWS, 1 hit
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SM00456, WW, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51045, SSF51045, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51215, AWS, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VYD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEESGPPSNP SPVASRGRGR GRPPKVALSA LGNTPPHINP SLKHADAEAS 
        60         70         80         90        100
PTAPEDQDSG QSECRRSSRK KIIKFDVRDL LNKNRKAHKI QIEARIDSNP 
       110        120        130        140        150
STGHSQSGTT AASTSMSTAT ASAASASSAA TVSRLFSMFE MSHQSLPPPP 
       160        170        180        190        200
PPPTALEIFA KPRPTQSLIV AQVTSEPSAV GGAHPVQTMA GLPPVTPRKR 
       210        220        230        240        250
GRPRKSQLAD AAIIPTVIVP SCSDSDTNST STTTSNMSSD SGELPGFPIQ 
       260        270        280        290        300
KPKSKLRVSL KRLKLGGRLE SSDSGNSPSS SSPEVEPPAL QDENAMDERP 
       310        320        330        340        350
KQEQNLSRMV DAEENSDSDS QIIFIEIETE SPKGEEEQEE GRPVEVEPQD 
       360        370        380        390        400
LIDIDMELAK QEPTPDPEED LDEIMVEVLS GPPSLWSADD EAEEEEDATV 
       410        420        430        440        450
QRATPPGKEP AADSCSSAPR RSRRSAPLSG SSRQGKTLEE TFAEIAAESS 
       460        470        480        490        500
KQILEAEESQ DQEEQHILID LIEDTLKSDN IAASLNKDIF EPKVETKATC 
       510        520        530        540        550
GEVVPRPEMV TEDVYITEGI AATLEKSAVV TKPTTEMIAE TKLSDEVVIE 
       560        570        580        590        600
PPLKDESDPK QTEVELPESK PAVNIPKSER ILSAEVETTS SPLVPPECCT 
       610        620        630        640        650
LESVSGPVLL ETSLSTEEKS NENVETTPLK TEAAKEDSPP AAPEEEASNS 
       660        670        680        690        700
SEEPNFLLED YESNQEQVAE DEMMKCNNQK GQKQTPLPEM KEPEKPVAET 
       710        720        730        740        750
VSKKEKAMEN PARSSPAIVD KKVRAGEMEK KVVKSTKGTV PEKKMDSKKS 
       760        770        780        790        800
CAAVTPAKQK ESGKSAKEAI LKKETEKEKS SAKLDSSSPN TLDKKGKDTA 
       810        820        830        840        850
QWSPQLQTLP KSSTKPPQES APSVISKTTS NQPAPKEEQH AAKKGLSDNS 
       860        870        880        890        900
PPSVLKAKEK AVSGFVECDA MFKAMDLANA QLRLDEKNKK KLKKVPTKVE 
       910        920        930        940        950
APPKVEPPTA VPVPGQKKSL SGKTSLRRNT VYEDSPNLER NSSPSSDSAQ 
       960        970        980        990       1000
ANTSAGKLKP SKVKKKINPR RSTICEAAKD LRSSSSSSTP TREVAASSPV 
      1010       1020       1030       1040       1050
STSSDSSSKR NGSKRTTSDL DGGSKLDQRR YTICEDRQPE TAIPVPLTKR 
      1060       1070       1080       1090       1100
RFSMHPKASA NPLHDTLLQT AGKKRGRKEG KESLSRQNSL DSSSSASQGA 
      1110       1120       1130       1140       1150
PKKKALKSAE ILSAALLETE SSESTSSGSK MSRWDVQTSP ELEAANPFGD 
      1160       1170       1180       1190       1200
IAKFIEDGVN LLKRDKVDED QRKEGQDEVK READPEEDEF AQRVANMETP 
      1210       1220       1230       1240       1250
ATTPTPSPTQ SNPEDSASTT TVLKELETGG GVRRSHRIKQ KPQGPRASQG 
      1260       1270       1280       1290       1300
RGVASVALAP ISMDEQLAEL ANIEAINEQF LRSEGLNTFQ LLKENFYRCA 
      1310       1320       1330       1340       1350
RQVSQENAEM QCDCFLTGDE EAQGHLSCGA GCINRMLMIE CGPLCSNGAR 
      1360       1370       1380       1390       1400
CTNKRFQQHQ CWPCRVFRTE KKGCGITAEL LIPPGEFIME YVGEVIDSEE 
      1410       1420       1430       1440       1450
FERRQHLYSK DRNRHYYFMA LRGEAVIDAT SKGNISRYIN HSCDPNAETQ 
      1460       1470       1480       1490       1500
KWTVNGELRI GFFSVKPIQP GEEITFDYQY LRYGRDAQRC YCEAANCRGW 
      1510       1520       1530       1540       1550
IGGEPDSDEG EQLDEESDSD AEMDEEELEA EPEEGQPRKS AKAKAKSKLK 
      1560       1570       1580       1590       1600
AKLPLATGRK RKEQTKPKDR EYKAGRWLKP SATGSSSSAE KPPKKPKVNK 
      1610       1620       1630       1640       1650
FQAMLEDPDV VEELSLLRRG GLKNQQDTLR FSRCLVRAKL LKTRLALLRV 
      1660       1670       1680       1690       1700
LTHGELPCRR LFLDYHGLRL LHAWISENGN DDQLREALLD TLESLPIPNR 
      1710       1720       1730       1740       1750
TMLSDSRVYQ SVQLWSNSLE QQLAVVPQEK QAALHKRMVA LLQKWQALPE 
      1760       1770       1780       1790       1800
IFRIPKRERI EQMKEHEREA DRQQKHVHAS TALEDQRERE SSNDRFRQDR 
      1810       1820       1830       1840       1850
FRRDTTSSRI GKPIRMSGNN TICTITTQQK GSNGAPDGMT RNDNRRRSDI 
      1860       1870       1880       1890       1900
GPPSEQRRTL SKELRRSLFE RKVALDEAER RVCTEDRLEH ELRCEFFGAD 
      1910       1920       1930       1940       1950
INTDPKQLPF YQKTDTNEWF NSDDVPVPAP PRTELLTKAL LSPDIDVGQG 
      1960       1970       1980       1990       2000
ATDVEYKLPP GVDPLPPAWN WQVTSDGDIY YYNLRERISQ WEPPSPEQRL 
      2010       2020       2030       2040       2050
QTLLEENTTQ QPLHELQIDP AVLENELIQV DTDYVGSLSA KSLAQYIEAK 
      2060       2070       2080       2090       2100
VRERRDLRRS KLVSIRLISP RRDEDRLYNQ LESRKYKENK EKIRRRKELY 
      2110       2120       2130       2140       2150
RRRKIEVLPD AVDEIPVPGK ALPIQPYLFS SDEEETKVAA IEQPAAEEEQ 
      2160       2170       2180       2190       2200
DSLNMAPSTS HAAMAALGKA VAQPTGLGTV GKRKLPMPPS VTVKKHRQEQ 
      2210       2220       2230       2240       2250
RSKKVKSSQS PLTATSAREA HEKFRFEISG HVANFLRPYR KESCTLGRIT 
      2260       2270       2280       2290       2300
SDEDYKFLVN RLSYHITTKE MRYCEVSGNP LSCTESVKHK SYDFINQYMR 
      2310 
QKGPVYKKPA END
Length:2,313
Mass (Da):256,791
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i811F133520284E2F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JJN9E1JJN9_DROME
SET domain containing 2, isoform B
Set2 dHypb, Dmel\CG1716, dSet2, Hypb, SET2
2,313Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF48273 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAK84931 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti490F → S in AAK84931 (PubMed:12537569).Curated1
Sequence conflicti500C → R in AAK84931 (PubMed:12537569).Curated1
Sequence conflicti509M → L in AAK84931 (PubMed:12537569).Curated1
Sequence conflicti700T → A in AAK84931 (PubMed:12537569).Curated1
Sequence conflicti710N → K in AAK84931 (PubMed:12537569).Curated1
Sequence conflicti737K → R in AAK84931 (PubMed:12537569).Curated1
Sequence conflicti2148E → A in AAK84931 (PubMed:12537569).Curated1
Sequence conflicti2179T → S in AAK84931 (PubMed:12537569).Curated1
Sequence conflicti2202S → N in AAK84931 (PubMed:12537569).Curated1
Sequence conflicti2215T → S in AAK84931 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48273.2 Sequence problems.
BT025042 mRNA Translation: ABE73213.1
AY050232 mRNA Translation: AAK84931.1 Frameshift.

NCBI Reference Sequences

More...RefSeqi		NP_001162740.1, NM_001169269.2
NP_572888.2, NM_132660.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0301559; FBpp0290774; FBgn0030486

Database of genes from NCBI RefSeq genomes

More...GeneIDi		32301

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1716

UCSC genome browser

More...UCSCi		CG1716-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48273.2 Sequence problems.
BT025042 mRNA Translation: ABE73213.1
AY050232 mRNA Translation: AAK84931.1 Frameshift.
RefSeqiNP_001162740.1, NM_001169269.2
NP_572888.2, NM_132660.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi58681, 4 interactors
IntActiQ9VYD1, 1 interactor
STRINGi7227.FBpp0073610

PTM databases

iPTMnetiQ9VYD1

Proteomic databases

PaxDbiQ9VYD1

Genome annotation databases

EnsemblMetazoaiFBtr0301559; FBpp0290774; FBgn0030486
GeneIDi32301
KEGGidme:Dmel_CG1716
UCSCiCG1716-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		32301
FlyBaseiFBgn0030486, Set2

Phylogenomic databases

eggNOGiKOG4442, Eukaryota
GeneTreeiENSGT00940000172873
HOGENOMiCLU_000516_0_0_1
InParanoidiQ9VYD1

Enzyme and pathway databases

ReactomeiR-DME-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
SignaLinkiQ9VYD1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		32301, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		32301

Protein Ontology

More...PROi		PR:Q9VYD1

Gene expression databases

BgeeiFBgn0030486, Expressed in oocyte and 40 other tissues
ExpressionAtlasiQ9VYD1, baseline and differential
GenevisibleiQ9VYD1, DM

Family and domain databases

CDDicd19172, SET_SETD2, 1 hit
cd00201, WW, 1 hit
Gene3Di1.10.1740.100, 1 hit
InterProiView protein in InterPro
IPR017956, AT_hook_DNA-bd_motif
IPR006560, AWS_dom
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR044437, SETD2/Set2_SET
IPR013257, SRI
IPR038190, SRI_sf
IPR001202, WW_dom
IPR036020, WW_dom_sf
PfamiView protein in Pfam
PF17907, AWS, 1 hit
PF00856, SET, 1 hit
PF08236, SRI, 1 hit
PF00397, WW, 1 hit
SMARTiView protein in SMART
SM00384, AT_hook, 2 hits
SM00570, AWS, 1 hit
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SM00456, WW, 1 hit
SUPFAMiSSF51045, SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51215, AWS, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC1716_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VYD1
Secondary accession number(s): Q1RL18, Q961S6, Q9VYD0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 7, 2021
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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