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UniProtKB - Q9VXY0 (CP4S3_DROME)
Protein
Probable cytochrome P450 4s3
Gene
Cyp4s3
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
By similarityCofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 307 | Heme; covalent, via 1 linkBy similarity | 1 | |
Metal bindingi | 436 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-DME-193144, Estrogen biosynthesis R-DME-211976, Endogenous sterols |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp4s3 ORF Names:CG9081 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0030615, Cyp4s3 |
VEuPathDBi | VectorBase:FBgn0030615 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Peripheral membrane protein Curated
- Microsome membrane Curated; Peripheral membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051848 | 1 – 495 | Probable cytochrome P450 4s3Add BLAST | 495 |
Proteomic databases
PaxDbi | Q9VXY0 |
Expressioni
Gene expression databases
Bgeei | FBgn0030615, Expressed in arthropod fat body and 19 other tissues |
ExpressionAtlasi | Q9VXY0, baseline and differential |
Genevisiblei | Q9VXY0, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 58799, 1 interactor |
DIPi | DIP-19604N |
IntActi | Q9VXY0, 2 interactors |
STRINGi | 7227.FBpp0073845 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000166362 |
HOGENOMi | CLU_001570_5_1_1 |
InParanoidi | Q9VXY0 |
OMAi | SVFRIWF |
OrthoDBi | 1247045at2759 |
PhylomeDBi | Q9VXY0 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VXY0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTLALVAFV LWAAFLRYLP KILNFLRLQR FAKTLPGPTI GELIANVKKG
60 70 80 90 100
EILNWLKELR EKHGPVFRIW FGKDLMVMFT DPEDIKQLLG NNQLLTKSRN
110 120 130 140 150
YELLEPWLGK GLLTNGGESW HRRRKLLTPG FHFRILSEFK EPMEENCRIL
160 170 180 190 200
VRRLRTKANG ESFDIYPYIT LFALDAICET AMGIKKHAQL QSDSEYVQAV
210 220 230 240 250
QSICRVMHKQ SFSFWQRLNV FFKHTKPGKE REAALKVLHD ETNRVIRLRR
260 270 280 290 300
EQLIQERNEW KPEAEQDDVG AKRRLAFLDM LLLTQMEGGA ELSDTDIREE
310 320 330 340 350
VDTFMFEGHD TTSSAIAFAL SLLSKNPDVQ QRAFEEASEL EGREKESMPY
360 370 380 390 400
LEAVIKETLR IYPSVPFFSR KVLEDLEVGK LTVPKGASIS CLIYMLHRDP
410 420 430 440 450
KNFPDPERFD PDRFLVNEKQ MHPFAFAAFS AGPRNCIGQK FAMLELKTSL
460 470 480 490
AMLLRSYRFL PDKDHQPKPL AELVTKSGNG IRLRILPRDE NGTTA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF48426.1 |
RefSeqi | NP_573003.2, NM_132775.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0074028; FBpp0073845; FBgn0030615 |
GeneIDi | 32444 |
KEGGi | dme:Dmel_CG9081 |
UCSCi | CG9081-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF48426.1 |
RefSeqi | NP_573003.2, NM_132775.3 |
3D structure databases
AlphaFoldDBi | Q9VXY0 |
SMRi | Q9VXY0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 58799, 1 interactor |
DIPi | DIP-19604N |
IntActi | Q9VXY0, 2 interactors |
STRINGi | 7227.FBpp0073845 |
Proteomic databases
PaxDbi | Q9VXY0 |
Protocols and materials databases
DNASUi | 32444 |
Genome annotation databases
EnsemblMetazoai | FBtr0074028; FBpp0073845; FBgn0030615 |
GeneIDi | 32444 |
KEGGi | dme:Dmel_CG9081 |
UCSCi | CG9081-RA, d. melanogaster |
Organism-specific databases
CTDi | 32444 |
FlyBasei | FBgn0030615, Cyp4s3 |
VEuPathDBi | VectorBase:FBgn0030615 |
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000166362 |
HOGENOMi | CLU_001570_5_1_1 |
InParanoidi | Q9VXY0 |
OMAi | SVFRIWF |
OrthoDBi | 1247045at2759 |
PhylomeDBi | Q9VXY0 |
Enzyme and pathway databases
Reactomei | R-DME-193144, Estrogen biosynthesis R-DME-211976, Endogenous sterols |
Miscellaneous databases
BioGRID-ORCSi | 32444, 0 hits in 3 CRISPR screens |
GenomeRNAii | 32444 |
PROi | PR:Q9VXY0 |
Gene expression databases
Bgeei | FBgn0030615, Expressed in arthropod fat body and 19 other tissues |
ExpressionAtlasi | Q9VXY0, baseline and differential |
Genevisiblei | Q9VXY0, DM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP4S3_DROME | |
Accessioni | Q9VXY0Primary (citable) accession number: Q9VXY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families