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UniProtKB - Q9VXV3 (Q9VXV3_DROME)
Protein
Submitted name:
Shattered
Gene
shtd
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- molecular adaptor activity Source: GO_Central
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: FlyBase
- compound eye development Source: FlyBase
- metaphase/anaphase transition of mitotic cell cycle Source: GO_Central
- mitotic cell cycle Source: FlyBase
- protein K11-linked ubiquitination Source: GO_Central
Enzyme and pathway databases
Reactomei | R-DME-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174154, APC/C:Cdc20 mediated degradation of Securin R-DME-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176408, Regulation of APC/C activators between G1/S and early anaphase R-DME-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176412, Phosphorylation of the APC/C R-DME-179409, APC-Cdc20 mediated degradation of Nek2A R-DME-2467813, Separation of Sister Chromatids R-DME-2559582, Senescence-Associated Secretory Phenotype (SASP) R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6 R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Submitted name: ShatteredImported |
Gene namesi | Name:shtdImported Synonyms:APC1Imported, Apc1Imported, Dmel\CG9198Imported, SHTDImported, ShtdImported ORF Names:CG9198Imported, Dmel_CG9198Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0004391, shtd |
VEuPathDBi | VectorBase:FBgn0004391 |
Expressioni
Gene expression databases
Bgeei | FBgn0004391, Expressed in cleaving embryo and 36 other tissues |
ExpressionAtlasi | Q9VXV3, baseline and differential |
Genevisiblei | Q9VXV3, DM |
Interactioni
Protein-protein interaction databases
IntActi | Q9VXV3, 14 interactors |
STRINGi | 7227.FBpp0073893 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1815 – 1923 | APC1_CInterPro annotationAdd BLAST | 109 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 556 – 583 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 749 – 774 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 1065 – 1086 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 749 – 770 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the APC1 family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG1858, Eukaryota |
GeneTreei | ENSGT00390000016757 |
HOGENOMi | CLU_001202_1_0_1 |
InParanoidi | Q9VXV3 |
OMAi | MQPPDSR |
OrthoDBi | 738153at2759 |
PhylomeDBi | Q9VXV3 |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
InterProi | View protein in InterPro IPR024990, Apc1 IPR041221, APC1_C IPR011989, ARM-like |
PANTHERi | PTHR12827, PTHR12827, 1 hit |
Pfami | View protein in Pfam PF12859, ANAPC1, 1 hit PF18122, APC1_C, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VXV3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIAVAEPPLE FVPRGRQTSA EHPGPHDQPM ARHQLPTTEH LLLQRLQNVN
60 70 80 90 100
ISSAGEDCPS GGQESWTVRE LYDDYEASEE RAALRRKLTE RTKRCGLQAT
110 120 130 140 150
SLPNRLLNPP LVRRVEPMCD YMVNNEEELY VNRNTVVWTQ GVNDDDDTDN
160 170 180 190 200
GVYRRMCFTT DTPVRFACFL NRSFVRGRLA QLKAAVHPDD DHLTAICVMD
210 220 230 240 250
QDALRVYCSN GEDFLANLDF PVSQLWQTKY GLLLEKDSSN ALISHMSIPM
260 270 280 290 300
PRLFSMSHPL HEACPVVLKT ATGSTGYMTE PEYTVVFTTE ESDLVMLYDA
310 320 330 340 350
KFFKHFVARL RKVTPEEINY VSQQMELGQT LMGPRSMAGN SFSSTKQTGA
360 370 380 390 400
TPKATNLSFA ARNINTTTTG MGNQFGLSQS QSFSGVLGQS NRASLGTPLS
410 420 430 440 450
QLQSSISQQS MSVKDMRKLT HVKPAKPIEP ELCMEHIWTE NIYGTQREFC
460 470 480 490 500
EMATRAFIHT DLVGQTFLCY LLARSCRLQL VRLTGYGRGE VQLSTHASTL
510 520 530 540 550
AAKDAVGLKR MHMIAVLDPS GSLLLYTGTV LISKVHITPF LAPTSIPTPL
560 570 580 590 600
VTPMTAAPSP SASPAPSHVK TPMAAAGPAS GIPSGSSSFV EVRRSSLLPT
610 620 630 640 650
KAPGDVAAFE EELHMLSPIQ PQPVSYTQRQ AHNVCKSLRD PAGNRLTLVY
660 670 680 690 700
ATGRMLRIAL PFLNDTRLLT RCVATLRQVL SPTQFLDFVI RWYSDRNPPG
710 720 730 740 750
SRNYSIEQEW LLFRSTLLAL MGLTAAPDVD AGENYARCAT PPLHTQFGGG
760 770 780 790 800
ATATESSDGS SCSSNSTLGG QDEPKKRRIY NDCDDFTDDD WEFLLLQTTL
810 820 830 840 850
APCGADGHSY SVNIGALLFR MIPAIFFSLH LLYEDLKLDA DFYGALPYLA
860 870 880 890 900
TFLHQLAIDM QLESYVLHYI LDFPELSNRT GKLSLLGAEH GAMMLHQELL
910 920 930 940 950
RVPAPSVFAQ LEHIIVGEEE VMPYTFLECV NERSRILLQL VSLVTHGHER
960 970 980 990 1000
LNYWWQLLEI PGAVQANFTR RSKRNITADA PRSHQMLQLL LAMRLTRRDI
1010 1020 1030 1040 1050
ERFPAAVHLI VAEALEEARL SPPMGCSMAT YELILRPELA AHAQLPFLET
1060 1070 1080 1090 1100
STGQPHCGRV YKEDSLSARC PPTGGSETDS PAQLRRDDMD NMDTKLLRLR
1110 1120 1130 1140 1150
FPDDMRVDEV RRLLNSSEPV VIEVQQAPGT SDHEFIEEQE KQLFALCSRT
1160 1170 1180 1190 1200
MTLPVGRGMF TLRTMLPRPS ESLTMPKLCL LGKEPLKGTT IEMQQIEFPA
1210 1220 1230 1240 1250
NMQMWPSFHN GVATGLKISP QAQDIDSNWI VYNKPKTHSH NALEHAGFLM
1260 1270 1280 1290 1300
ALGLNGHLKT LSFMSVYKYL VKCDEMTNVG LLLGISAAHR GTMDTKTTKL
1310 1320 1330 1340 1350
LSVHLEALLP ATAMELDIPQ STQVAAIMGV GLLYQGSAKR HIAEVLLQEI
1360 1370 1380 1390 1400
GRPPGPEMEN SIERESYAMT AGLSLGLVTL GQGESPAGLR DLQLPDTLHY
1410 1420 1430 1440 1450
YMVGGVKRPI GGSQKEKYRL ASFQVREGDT VNIDVTAPGA TLALGLMFFN
1460 1470 1480 1490 1500
SGNAAIAEWM QPPDSRYLLD MVRPDFLLLR TISRGLILWQ DVRPDNAWFQ
1510 1520 1530 1540 1550
AQFPRALRAH LKLPFYENEY APEDYDVDYE AISQAYCNIM AGAAFCIGLK
1560 1570 1580 1590 1600
YAGTENLVAF ATLRSVIKDF LRFPSRPMGE CAGRTTVESC LMVLLISISL
1610 1620 1630 1640 1650
VFAGSGNCEI LRIIRFLRSR VGPQYPHITY GSHMAIHMSL GLLFLGAGRF
1660 1670 1680 1690 1700
TISQTPESIA ALVCAFFPKF PIHSNDNRYH LQALRHLYVL AVEPRLFLPR
1710 1720 1730 1740 1750
DIDTNKLCLA NISVLEVGAT ELRRLPIAPC ILPVLSTLQQ VVVDDENYWP
1760 1770 1780 1790 1800
VCFERSRNWD QLEKALEMSA PIDIKKRTGC LSHLEDPDRL KSMLAQTLTM
1810 1820 1830 1840 1850
EQSICWQIDM NDLQQFASER MVKQFLSRCL DTKGTDLSPP ELMKRHQVML
1860 1870 1880 1890 1900
LFYNAVVKDR MHFLPVYLTL YDHVTKSMPN NIDVWQMKLI DAYLSRSQES
1910 1920 1930 1940 1950
EHPLISVELI QMMQELFKQE MEDSTRELCL PLREFLSRRR LDPSYVTTVS
1960 1970 1980 1990 2000
GPDLQRAFCV INYYNLLPNM LNGVDLSTGT VNYMRLLYEF RRLNLGAHTI
2010 2020 2030
FGLMKILQSL ATEVVTLDEA ALLAYTMGDQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF48455.1 |
RefSeqi | NP_573025.2, NM_132797.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0074077; FBpp0073893; FBgn0004391 |
GeneIDi | 32473 |
KEGGi | dme:Dmel_CG9198 |
UCSCi | CG9198-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF48455.1 |
RefSeqi | NP_573025.2, NM_132797.3 |
3D structure databases
AlphaFoldDBi | Q9VXV3 |
SMRi | Q9VXV3 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9VXV3, 14 interactors |
STRINGi | 7227.FBpp0073893 |
Proteomic databases
PaxDbi | Q9VXV3 |
Protocols and materials databases
DNASUi | 32473 |
Genome annotation databases
EnsemblMetazoai | FBtr0074077; FBpp0073893; FBgn0004391 |
GeneIDi | 32473 |
KEGGi | dme:Dmel_CG9198 |
UCSCi | CG9198-RA, d. melanogaster |
Organism-specific databases
CTDi | 32473 |
FlyBasei | FBgn0004391, shtd |
VEuPathDBi | VectorBase:FBgn0004391 |
Phylogenomic databases
eggNOGi | KOG1858, Eukaryota |
GeneTreei | ENSGT00390000016757 |
HOGENOMi | CLU_001202_1_0_1 |
InParanoidi | Q9VXV3 |
OMAi | MQPPDSR |
OrthoDBi | 738153at2759 |
PhylomeDBi | Q9VXV3 |
Enzyme and pathway databases
Reactomei | R-DME-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174154, APC/C:Cdc20 mediated degradation of Securin R-DME-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176408, Regulation of APC/C activators between G1/S and early anaphase R-DME-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176412, Phosphorylation of the APC/C R-DME-179409, APC-Cdc20 mediated degradation of Nek2A R-DME-2467813, Separation of Sister Chromatids R-DME-2559582, Senescence-Associated Secretory Phenotype (SASP) R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6 R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 32473, 1 hit in 1 CRISPR screen |
ChiTaRSi | shtd, fly |
GenomeRNAii | 32473 |
Gene expression databases
Bgeei | FBgn0004391, Expressed in cleaving embryo and 36 other tissues |
ExpressionAtlasi | Q9VXV3, baseline and differential |
Genevisiblei | Q9VXV3, DM |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
InterProi | View protein in InterPro IPR024990, Apc1 IPR041221, APC1_C IPR011989, ARM-like |
PANTHERi | PTHR12827, PTHR12827, 1 hit |
Pfami | View protein in Pfam PF12859, ANAPC1, 1 hit PF18122, APC1_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VXV3_DROME | |
Accessioni | Q9VXV3Primary (citable) accession number: Q9VXV3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |