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UniProtKB - Q9VXK6 (IF5_DROME)
Protein
Eukaryotic translation initiation factor 5
Gene
eIF5
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 28 – 35 | GTPSequence analysis | 8 |
GO - Molecular functioni
- eukaryotic initiation factor eIF2 binding Source: GO_Central
- GDP-dissociation inhibitor activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
- translation initiation factor activity Source: FlyBase
GO - Biological processi
- formation of cytoplasmic translation initiation complex Source: GO_Central
- formation of translation preinitiation complex Source: GO_Central
- translational initiation Source: FlyBase
Keywordsi
Molecular function | Initiation factor |
Biological process | Protein biosynthesis |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DME-72702, Ribosomal scanning and start codon recognition |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 5Short name: eIF-5 |
Gene namesi | Name:eIF5 ORF Names:CG9177 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0030719, eIF5 |
VEuPathDBi | VectorBase:FBgn0030719 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212520 | 1 – 464 | Eukaryotic translation initiation factor 5Add BLAST | 464 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | Phosphoserine1 Publication | 1 | |
Modified residuei | 412 | Phosphoserine1 Publication | 1 | |
Modified residuei | 413 | Phosphoserine1 Publication | 1 | |
Modified residuei | 415 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9VXK6 |
PRIDEi | Q9VXK6 |
PTM databases
iPTMneti | Q9VXK6 |
Expressioni
Gene expression databases
Bgeei | FBgn0030719, Expressed in central nervous system and 52 other tissues |
Genevisiblei | Q9VXK6, DM |
Interactioni
GO - Molecular functioni
- eukaryotic initiation factor eIF2 binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 58910, 7 interactors |
DIPi | DIP-21354N |
IntActi | Q9VXK6, 1 interactor |
STRINGi | 7227.FBpp0073947 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 254 – 415 | W2PROSITE-ProRule annotationAdd BLAST | 162 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 145 – 203 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 409 – 464 | DisorderedSequence analysisAdd BLAST | 56 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 145 – 160 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 173 – 203 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 411 – 427 | Acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the eIF-2-beta/eIF-5 family.Curated
Phylogenomic databases
eggNOGi | KOG2767, Eukaryota |
GeneTreei | ENSGT00390000016478 |
HOGENOMi | CLU_026663_1_0_1 |
InParanoidi | Q9VXK6 |
OMAi | YRYKMEK |
PhylomeDBi | Q9VXK6 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR045196, IF2/IF5 IPR002735, Transl_init_fac_IF2/IF5_dom IPR016189, Transl_init_fac_IF2/IF5_N IPR016190, Transl_init_fac_IF2/IF5_Zn-bd IPR003307, W2_domain |
PANTHERi | PTHR23001, PTHR23001, 1 hit |
Pfami | View protein in Pfam PF01873, eIF-5_eIF-2B, 1 hit PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00653, eIF2B_5, 1 hit SM00515, eIF5C, 1 hit |
SUPFAMi | SSF100966, SSF100966, 1 hit SSF48371, SSF48371, 1 hit SSF75689, SSF75689, 1 hit |
PROSITEi | View protein in PROSITE PS51363, W2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VXK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATVNVNRSV TDIFYRYKMP RLQAKVEGKG NGIKTVLVNM AEVARAIGRP
60 70 80 90 100
ATYPTKYFGC ELGAQTLFDH KNERFVVNGS HDVNKLQDLL DGFIRKFVLC
110 120 130 140 150
PECDNPETNL TVSAKNQTIS QSCKACGFHG LLKVNHKVNT FIVKNPPSLN
160 170 180 190 200
PAAQGSSLTE GKRSRKQKQK NDNADGSMTN NSLANNSGGE SDGGNGTNQA
210 220 230 240 250
SQTEAEISAA IPEKTAKDDD DEGWSVDVSK EAIRARLQDL TDGAKGMTIS
260 270 280 290 300
DDYDKTEKER IDIFYELVKD KRDKKQLDDV QTHKELVIEA ERLDIINKAP
310 320 330 340 350
LVLAELLFTE NIIKDVQKNR PLLLRFTLNN PKAQRYLIGG VEQTVELHKG
360 370 380 390 400
ILMSKVAGIF KLFYDLDILD EAVILEWAQK VSKRHVSKNI AAEIHEKAMP
410 420 430 440 450
FVLWLKNAEE ESSESEEEED DESEEDNYVS SAGQRGGQRV VQRGIPRAVA
460
GDEDDEDDVN IDDI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF48553.1 AE014298 Genomic DNA Translation: AAS65378.1 AE014298 Genomic DNA Translation: AAS65379.1 AE014298 Genomic DNA Translation: AAS65380.1 AE014298 Genomic DNA Translation: AAS65381.1 AE014298 Genomic DNA Translation: AAS65382.1 AY060843 mRNA Translation: AAL28391.1 |
RefSeqi | NP_573098.1, NM_132870.4 NP_727922.1, NM_167477.2 NP_996477.1, NM_206754.2 NP_996478.1, NM_206755.2 NP_996479.1, NM_206756.2 NP_996480.1, NM_206757.2 NP_996481.1, NM_206758.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0074144; FBpp0073947; FBgn0030719 FBtr0074145; FBpp0073948; FBgn0030719 FBtr0074146; FBpp0089136; FBgn0030719 FBtr0074147; FBpp0089137; FBgn0030719 FBtr0074148; FBpp0089138; FBgn0030719 FBtr0074149; FBpp0089139; FBgn0030719 FBtr0074150; FBpp0089140; FBgn0030719 |
GeneIDi | 32566 |
KEGGi | dme:Dmel_CG9177 |
UCSCi | CG9177-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF48553.1 AE014298 Genomic DNA Translation: AAS65378.1 AE014298 Genomic DNA Translation: AAS65379.1 AE014298 Genomic DNA Translation: AAS65380.1 AE014298 Genomic DNA Translation: AAS65381.1 AE014298 Genomic DNA Translation: AAS65382.1 AY060843 mRNA Translation: AAL28391.1 |
RefSeqi | NP_573098.1, NM_132870.4 NP_727922.1, NM_167477.2 NP_996477.1, NM_206754.2 NP_996478.1, NM_206755.2 NP_996479.1, NM_206756.2 NP_996480.1, NM_206757.2 NP_996481.1, NM_206758.2 |
3D structure databases
AlphaFoldDBi | Q9VXK6 |
SMRi | Q9VXK6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 58910, 7 interactors |
DIPi | DIP-21354N |
IntActi | Q9VXK6, 1 interactor |
STRINGi | 7227.FBpp0073947 |
PTM databases
iPTMneti | Q9VXK6 |
Proteomic databases
PaxDbi | Q9VXK6 |
PRIDEi | Q9VXK6 |
Genome annotation databases
EnsemblMetazoai | FBtr0074144; FBpp0073947; FBgn0030719 FBtr0074145; FBpp0073948; FBgn0030719 FBtr0074146; FBpp0089136; FBgn0030719 FBtr0074147; FBpp0089137; FBgn0030719 FBtr0074148; FBpp0089138; FBgn0030719 FBtr0074149; FBpp0089139; FBgn0030719 FBtr0074150; FBpp0089140; FBgn0030719 |
GeneIDi | 32566 |
KEGGi | dme:Dmel_CG9177 |
UCSCi | CG9177-RA, d. melanogaster |
Organism-specific databases
CTDi | 1983 |
FlyBasei | FBgn0030719, eIF5 |
VEuPathDBi | VectorBase:FBgn0030719 |
Phylogenomic databases
eggNOGi | KOG2767, Eukaryota |
GeneTreei | ENSGT00390000016478 |
HOGENOMi | CLU_026663_1_0_1 |
InParanoidi | Q9VXK6 |
OMAi | YRYKMEK |
PhylomeDBi | Q9VXK6 |
Enzyme and pathway databases
Reactomei | R-DME-72702, Ribosomal scanning and start codon recognition |
Miscellaneous databases
BioGRID-ORCSi | 32566, 0 hits in 1 CRISPR screen |
ChiTaRSi | eIF5, fly |
GenomeRNAii | 32566 |
PROi | PR:Q9VXK6 |
Gene expression databases
Bgeei | FBgn0030719, Expressed in central nervous system and 52 other tissues |
Genevisiblei | Q9VXK6, DM |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR045196, IF2/IF5 IPR002735, Transl_init_fac_IF2/IF5_dom IPR016189, Transl_init_fac_IF2/IF5_N IPR016190, Transl_init_fac_IF2/IF5_Zn-bd IPR003307, W2_domain |
PANTHERi | PTHR23001, PTHR23001, 1 hit |
Pfami | View protein in Pfam PF01873, eIF-5_eIF-2B, 1 hit PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00653, eIF2B_5, 1 hit SM00515, eIF5C, 1 hit |
SUPFAMi | SSF100966, SSF100966, 1 hit SSF48371, SSF48371, 1 hit SSF75689, SSF75689, 1 hit |
PROSITEi | View protein in PROSITE PS51363, W2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IF5_DROME | |
Accessioni | Q9VXK6Primary (citable) accession number: Q9VXK6 Secondary accession number(s): A4V4K0, Q0KHS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Translation initiation factors
List of translation initiation factor entries - Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families