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Protein

Phospholipid-transporting ATPase

Gene

Dmel\CG4301

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • magnesium ion binding Source: UniProtKB-UniRule
  • phospholipid-translocating ATPase activity Source: FlyBase

GO - Biological processi

  • phospholipid translocation Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation
R-DME-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
Name:Dmel\CG4301Imported
Synonyms:DmCG4301Imported
ORF Names:CG4301Imported, Dmel_CG4301Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030747 CG4301

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei99 – 117HelicalUniRule annotationAdd BLAST19
Transmembranei314 – 336HelicalUniRule annotationAdd BLAST23
Transmembranei367 – 386HelicalUniRule annotationAdd BLAST20
Transmembranei1099 – 1119HelicalUniRule annotationAdd BLAST21
Transmembranei1131 – 1151HelicalUniRule annotationAdd BLAST21
Transmembranei1179 – 1206HelicalUniRule annotationAdd BLAST28
Transmembranei1212 – 1236HelicalUniRule annotationAdd BLAST25
Transmembranei1248 – 1270HelicalUniRule annotationAdd BLAST23
Transmembranei1290 – 1309HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9VXG6
PRIDEiQ9VXG6

Expressioni

Gene expression databases

BgeeiFBgn0030747
ExpressionAtlasiQ9VXG6 baseline and differential
GenevisibleiQ9VXG6 DM

Interactioni

Protein-protein interaction databases

IntActiQ9VXG6, 1 interactor
STRINGi7227.FBpp0074048

Structurei

3D structure databases

ProteinModelPortaliQ9VXG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 122PhoLip_ATPase_NInterPro annotationAdd BLAST53
Domaini1068 – 1317PhoLip_ATPase_CInterPro annotationAdd BLAST250

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ITKC Eukaryota
ENOG410XSS0 LUCA
GeneTreeiENSGT00910000144008
InParanoidiQ9VXG6
OMAiRCSPTHV
OrthoDBiEOG091G00LI
PhylomeDBiQ9VXG6

Family and domain databases

Gene3Di3.40.1110.10, 2 hits
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VXG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFFGHDHLS GFRRIDRLGA HRQTPWADQE SFHLKDAFLW NWHKGSRVST
60 70 80 90 100
INDWLQIQIG GPQDIKKKRP KGQNRIKSTK YTLITFLPQN LLEQFRRIAN
110 120 130 140 150
FYFLVMTIIS LLIDSPVSPM TSLLPLVFVI AVTAAKQGYE DILRYRTDNV
160 170 180 190 200
VNSSPVTVIR DGKEAIIKSQ DVIPGELIVV ERDCDVPCDL VLLRSTDPHG
210 220 230 240 250
KCFITTANLD GESNLKTLMV PRDLPTVDLP EMHKLGIIEC ESPTTDLYSF
260 270 280 290 300
NGKIELKGGE GRVLPLSTEN VLLRGSRVKN TECVIGCAVY TGMISKLQLN
310 320 330 340 350
SRLTRNKNAS SETYINRFLI VILVALIAIV TLLYFLKRYN ELFVIPKLTY
360 370 380 390 400
LGDATDSYSV KQFLQDYLSF LILFNYLIPI SLYVTIELQR VIGSWFMEWD
410 420 430 440 450
LELYENETDQ PCVVNTSNLN EELGQINILF SDKTGTLTKN EMNFQQCSIN
460 470 480 490 500
GNKFLFKKTR LEDEETKALL DINKFSANQR VFFQALSICH TVQVASGSLE
510 520 530 540 550
QADAGTAKRE PVTAIKSGPP EMYSISDITE ESHNASQQSE LNVGHTIDNS
560 570 580 590 600
VSAHPNGVNS TIISSDVNPL LVSDDGYGVE RRKRPVVIKR SPNFARSNRM
610 620 630 640 650
NNGAASDLNI NQTDPNTVTN GVEPTTNFRP ISLQFRRSTS EKDLQQSWEA
660 670 680 690 700
PSGQAPGHRR AHSYGAPNAY LTNPVTASTP PAGVLFRSPS TTSRESYAAP
710 720 730 740 750
TFTRQPTILV RAESQRRKNE IRDFIFTLDY QASSPDEKAL VEACANLGMV
760 770 780 790 800
YTGDDDETLR VRIVPPHMDY KRPFAKPREE TFQRLHVLEF TSDRKRMSVI
810 820 830 840 850
VRDTDGKKWI YTKGAESYVF PLCANSSAEL VTKTDAHISD FARLGLRTLA
860 870 880 890 900
IARRLISEEE YQDFLVELAQ ANSSLENRKQ LSEECYAKIE SNLDLLGATA
910 920 930 940 950
VEDALQDDVA DTLVSLQAAG IKIWVLTGDK VETALNIALS CGHIPPDAKK
960 970 980 990 1000
YFIMECKNRE EMLLHLNALD REIIFGIGQE CALLIDGKSL GVALAEASSE
1010 1020 1030 1040 1050
FRDVAVKCTA VLCCRLSPLQ KSEVVSLIKS SNENYNTASI GDGANDVSMI
1060 1070 1080 1090 1100
QEAHVGIGIM GREGRQAARC ADFAFAKFCM LKRLLLVHGH YHSVRLSLLV
1110 1120 1130 1140 1150
LYFFYKNIVF MGIMFLFQFH TLFSSSSVYD SLFLTLYNVI YTSLPILFIA
1160 1170 1180 1190 1200
ISEKPYTEEK LMRTPQLYKK NTDNKQLHWP YFLMWVLFAI YHSVIIFYFA
1210 1220 1230 1240 1250
FCFFYYNNVL LNYGQTVAFS CFGTLLMWTV VVVVNLKLWL ESMYLSFWYI
1260 1270 1280 1290 1300
FTIIISILGF VVTTVIYNVI NLDYDTDIYW AYNNLLASLP VWLWIIVTCV
1310 1320 1330 1340
ACLVPDYTIR MLQRALNIKS FSIFPGKQRK LKMREKFEST YL
Length:1,342
Mass (Da):152,046
Last modified:October 1, 2002 - v2
Checksum:i4D2F454F11C02217
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48606.2
RefSeqiNP_573125.1, NM_132897.3

Genome annotation databases

EnsemblMetazoaiFBtr0074272; FBpp0074048; FBgn0030747
GeneIDi32610
UCSCiCG4301-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VXG6_DROME
AccessioniPrimary (citable) accession number: Q9VXG6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: July 18, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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