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UniProtKB - Q9VXG4 (ANX11_DROME)
Protein
Annexin B11
Gene
AnxB11
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: FlyBase
- calcium ion binding Source: GO_Central
GO - Biological processi
- response to calcium ion Source: FlyBase
Keywordsi
Ligand | Calcium, Calcium/phospholipid-binding |
Enzyme and pathway databases
SignaLinki | Q9VXG4 |
Names & Taxonomyi
Protein namesi | Recommended name: Annexin B11 |
Gene namesi | Name:AnxB11 ORF Names:CG9968 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0030749, AnxB11 |
VEuPathDBi | VectorBase:FBgn0030749 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067518 | 1 – 511 | Annexin B11Add BLAST | 511 |
Proteomic databases
PaxDbi | Q9VXG4 |
PRIDEi | Q9VXG4 |
Expressioni
Gene expression databases
Bgeei | FBgn0030749, Expressed in arthropod fat body and 34 other tissues |
Genevisiblei | Q9VXG4, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 58952, 8 interactors |
IntActi | Q9VXG4, 3 interactors |
STRINGi | 7227.FBpp0306158 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 204 – 275 | Annexin 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 276 – 347 | Annexin 2PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 359 – 431 | Annexin 3PROSITE-ProRule annotationAdd BLAST | 73 | |
Repeati | 435 – 506 | Annexin 4PROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 76 | DisorderedSequence analysisAdd BLAST | 76 | |
Regioni | 93 – 123 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 138 – 195 | DisorderedSequence analysisAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 35 – 49 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 104 – 118 | Polar residuesSequence analysisAdd BLAST | 15 |
Domaini
A pair of annexin repeats may form one binding site for calcium and phospholipid.By similarity
Sequence similaritiesi
Keywords - Domaini
Annexin, RepeatPhylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000172288 |
HOGENOMi | CLU_025300_6_3_1 |
InParanoidi | Q9VXG4 |
OMAi | GQMGYPP |
PhylomeDBi | Q9VXG4 |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 3 hits PS51897, ANNEXIN_2, 4 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform B (identifier: Q9VXG4-1) [UniParc]FASTAAdd to basket
Also known as: E, G
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYPFGSGMPS HPPTSTNHHE PPRAPFGAGW VPPMQQNSPY PPPSQPHPHS
60 70 80 90 100
QPSSQMHPQQ HQQYPGGAPA PYPPMSAPYP SAAPSYPPYP TSNPYPAQYA
110 120 130 140 150
PPAHNHYQQP SVSNSPYPAD RGYTPAMTAG YDAGYGYGNG QGHGQGHGHG
160 170 180 190 200
QGHGHGHGQG HEYGHGYGQG YGHGQGHGNG QGHAHRSLPA HREGTPTVVP
210 220 230 240 250
AANFDAVKDA HDLRKAMKGF GTDEDALINI ICRRSNEQRQ EIQRQFKTHF
260 270 280 290 300
GKDLIEDIKS ETSGNFEKLL VGLLRPIVDY YCAELNDAMA GLGTDEEVLI
310 320 330 340 350
EILCTLSNME INTIKNQYLR LYGAHLESEL KSETSGNFKR LLTSLCTAAR
360 370 380 390 400
DESGRVDPVA AKNDARELLK AGELRVGTDE SMFNMILCQR NYQQLKLIFQ
410 420 430 440 450
EYEGMTGHSL EKAIKKEFSG DVMEGLIAIY RCVTNKAEYF ASRLHKAMAG
460 470 480 490 500
IGTNDTQLIR VIITRSEIDM TDIKVAFERL YGKSLKSWIK GDTSGHYKHA
510
LYALVGEQRS S
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053656 | 1 – 216 | Missing in isoform D. CuratedAdd BLAST | 216 | |
Alternative sequenceiVSP_053657 | 6 – 194 | Missing in isoform A. 2 PublicationsAdd BLAST | 189 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ276963 mRNA Translation: CAB86189.1 AE014298 Genomic DNA Translation: AAF48609.1 AE014298 Genomic DNA Translation: AAF48610.1 AE014298 Genomic DNA Translation: AGB95456.1 AE014298 Genomic DNA Translation: AGB95457.1 AE014298 Genomic DNA Translation: AGB95458.1 AE014298 Genomic DNA Translation: AGB95459.1 AE014298 Genomic DNA Translation: AGB95460.1 AY058397 mRNA Translation: AAL13626.1 AY122138 mRNA Translation: AAM52650.1 BT125828 mRNA Translation: ADR83713.1 |
RefSeqi | NP_001259614.1, NM_001272685.1 [Q9VXG4-2] NP_001259615.1, NM_001272686.1 [Q9VXG4-3] NP_001259616.1, NM_001272687.1 [Q9VXG4-1] NP_001259617.1, NM_001272688.1 [Q9VXG4-2] NP_001259618.1, NM_001272689.1 [Q9VXG4-1] NP_523370.1, NM_078646.3 [Q9VXG4-2] NP_727978.1, NM_167519.2 [Q9VXG4-1] |
Genome annotation databases
EnsemblMetazoai | FBtr0074302; FBpp0074077; FBgn0030749 [Q9VXG4-2] FBtr0074303; FBpp0074078; FBgn0030749 [Q9VXG4-1] FBtr0334038; FBpp0306154; FBgn0030749 [Q9VXG4-2] FBtr0334039; FBpp0306155; FBgn0030749 [Q9VXG4-3] FBtr0334040; FBpp0306156; FBgn0030749 [Q9VXG4-1] FBtr0334041; FBpp0306157; FBgn0030749 [Q9VXG4-2] FBtr0334042; FBpp0306158; FBgn0030749 [Q9VXG4-1] |
GeneIDi | 32612 |
KEGGi | dme:Dmel_CG9968 |
UCSCi | CG9968-RB, d. melanogaster |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ276963 mRNA Translation: CAB86189.1 AE014298 Genomic DNA Translation: AAF48609.1 AE014298 Genomic DNA Translation: AAF48610.1 AE014298 Genomic DNA Translation: AGB95456.1 AE014298 Genomic DNA Translation: AGB95457.1 AE014298 Genomic DNA Translation: AGB95458.1 AE014298 Genomic DNA Translation: AGB95459.1 AE014298 Genomic DNA Translation: AGB95460.1 AY058397 mRNA Translation: AAL13626.1 AY122138 mRNA Translation: AAM52650.1 BT125828 mRNA Translation: ADR83713.1 |
RefSeqi | NP_001259614.1, NM_001272685.1 [Q9VXG4-2] NP_001259615.1, NM_001272686.1 [Q9VXG4-3] NP_001259616.1, NM_001272687.1 [Q9VXG4-1] NP_001259617.1, NM_001272688.1 [Q9VXG4-2] NP_001259618.1, NM_001272689.1 [Q9VXG4-1] NP_523370.1, NM_078646.3 [Q9VXG4-2] NP_727978.1, NM_167519.2 [Q9VXG4-1] |
3D structure databases
AlphaFoldDBi | Q9VXG4 |
SMRi | Q9VXG4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 58952, 8 interactors |
IntActi | Q9VXG4, 3 interactors |
STRINGi | 7227.FBpp0306158 |
Proteomic databases
PaxDbi | Q9VXG4 |
PRIDEi | Q9VXG4 |
Protocols and materials databases
DNASUi | 32612 |
Genome annotation databases
EnsemblMetazoai | FBtr0074302; FBpp0074077; FBgn0030749 [Q9VXG4-2] FBtr0074303; FBpp0074078; FBgn0030749 [Q9VXG4-1] FBtr0334038; FBpp0306154; FBgn0030749 [Q9VXG4-2] FBtr0334039; FBpp0306155; FBgn0030749 [Q9VXG4-3] FBtr0334040; FBpp0306156; FBgn0030749 [Q9VXG4-1] FBtr0334041; FBpp0306157; FBgn0030749 [Q9VXG4-2] FBtr0334042; FBpp0306158; FBgn0030749 [Q9VXG4-1] |
GeneIDi | 32612 |
KEGGi | dme:Dmel_CG9968 |
UCSCi | CG9968-RB, d. melanogaster |
Organism-specific databases
CTDi | 32612 |
FlyBasei | FBgn0030749, AnxB11 |
VEuPathDBi | VectorBase:FBgn0030749 |
Phylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000172288 |
HOGENOMi | CLU_025300_6_3_1 |
InParanoidi | Q9VXG4 |
OMAi | GQMGYPP |
PhylomeDBi | Q9VXG4 |
Enzyme and pathway databases
SignaLinki | Q9VXG4 |
Miscellaneous databases
BioGRID-ORCSi | 32612, 0 hits in 3 CRISPR screens |
ChiTaRSi | AnxB11, fly |
GenomeRNAii | 32612 |
PROi | PR:Q9VXG4 |
Gene expression databases
Bgeei | FBgn0030749, Expressed in arthropod fat body and 34 other tissues |
Genevisiblei | Q9VXG4, DM |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 3 hits PS51897, ANNEXIN_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ANX11_DROME | |
Accessioni | Q9VXG4Primary (citable) accession number: Q9VXG4 Secondary accession number(s): M9PEV0, M9PHW3, Q9VXG3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 7, 2006 |
Last sequence update: | February 19, 2014 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families