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Protein

Annexin B11

Gene

AnxB11

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: FlyBase
  • calcium-dependent phospholipid binding Source: FlyBase
  • calcium ion binding Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-114608 Platelet degranulation
R-DME-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Annexin B11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AnxB11
ORF Names:CG9968
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0030749 AnxB11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000675181 – 511Annexin B11Add BLAST511

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VXG4

PRoteomics IDEntifications database

More...
PRIDEi
Q9VXG4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0030749 Expressed in 21 organ(s), highest expression level in larva

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VXG4 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
58952, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VXG4, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0306158

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9VXG4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VXG4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati208 – 273Annexin 1Add BLAST66
Repeati281 – 345Annexin 2Add BLAST65
Repeati364 – 429Annexin 3Add BLAST66
Repeati439 – 504Annexin 4Add BLAST66

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0819 Eukaryota
ENOG410XPUN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000172288

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VXG4

KEGG Orthology (KO)

More...
KOi
K17095

Identification of Orthologs from Complete Genome Data

More...
OMAi
IGMMTPT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0H6H

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VXG4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.220.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00191 Annexin, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00196 ANNEXIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00335 ANX, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00223 ANNEXIN, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: Q9VXG4-1) [UniParc]FASTAAdd to basket
Also known as: E, G

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYPFGSGMPS HPPTSTNHHE PPRAPFGAGW VPPMQQNSPY PPPSQPHPHS
60 70 80 90 100
QPSSQMHPQQ HQQYPGGAPA PYPPMSAPYP SAAPSYPPYP TSNPYPAQYA
110 120 130 140 150
PPAHNHYQQP SVSNSPYPAD RGYTPAMTAG YDAGYGYGNG QGHGQGHGHG
160 170 180 190 200
QGHGHGHGQG HEYGHGYGQG YGHGQGHGNG QGHAHRSLPA HREGTPTVVP
210 220 230 240 250
AANFDAVKDA HDLRKAMKGF GTDEDALINI ICRRSNEQRQ EIQRQFKTHF
260 270 280 290 300
GKDLIEDIKS ETSGNFEKLL VGLLRPIVDY YCAELNDAMA GLGTDEEVLI
310 320 330 340 350
EILCTLSNME INTIKNQYLR LYGAHLESEL KSETSGNFKR LLTSLCTAAR
360 370 380 390 400
DESGRVDPVA AKNDARELLK AGELRVGTDE SMFNMILCQR NYQQLKLIFQ
410 420 430 440 450
EYEGMTGHSL EKAIKKEFSG DVMEGLIAIY RCVTNKAEYF ASRLHKAMAG
460 470 480 490 500
IGTNDTQLIR VIITRSEIDM TDIKVAFERL YGKSLKSWIK GDTSGHYKHA
510
LYALVGEQRS S
Note: No experimental confirmation available.
Length:511
Mass (Da):56,215
Last modified:February 19, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74712A8F1C54283B
GO
Isoform A (identifier: Q9VXG4-2) [UniParc]FASTAAdd to basket
Also known as: C, F

The sequence of this isoform differs from the canonical sequence as follows:
     6-194: Missing.

Show »
Length:322
Mass (Da):36,289
Checksum:i7CCFCCF7FB9C217D
GO
Isoform D (identifier: Q9VXG4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.

Note: No experimental confirmation available.
Show »
Length:295
Mass (Da):33,375
Checksum:iC227EE6252509AE2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0536561 – 216Missing in isoform D. CuratedAdd BLAST216
Alternative sequenceiVSP_0536576 – 194Missing in isoform A. 2 PublicationsAdd BLAST189

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ276963 mRNA Translation: CAB86189.1
AE014298 Genomic DNA Translation: AAF48609.1
AE014298 Genomic DNA Translation: AAF48610.1
AE014298 Genomic DNA Translation: AGB95456.1
AE014298 Genomic DNA Translation: AGB95457.1
AE014298 Genomic DNA Translation: AGB95458.1
AE014298 Genomic DNA Translation: AGB95459.1
AE014298 Genomic DNA Translation: AGB95460.1
AY058397 mRNA Translation: AAL13626.1
AY122138 mRNA Translation: AAM52650.1
BT125828 mRNA Translation: ADR83713.1

NCBI Reference Sequences

More...
RefSeqi
NP_001259614.1, NM_001272685.1 [Q9VXG4-2]
NP_001259615.1, NM_001272686.1 [Q9VXG4-3]
NP_001259616.1, NM_001272687.1 [Q9VXG4-1]
NP_001259617.1, NM_001272688.1 [Q9VXG4-2]
NP_001259618.1, NM_001272689.1 [Q9VXG4-1]
NP_523370.1, NM_078646.3 [Q9VXG4-2]
NP_727978.1, NM_167519.2 [Q9VXG4-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.12489

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0074302; FBpp0074077; FBgn0030749 [Q9VXG4-2]
FBtr0074303; FBpp0074078; FBgn0030749 [Q9VXG4-1]
FBtr0334038; FBpp0306154; FBgn0030749 [Q9VXG4-2]
FBtr0334039; FBpp0306155; FBgn0030749 [Q9VXG4-3]
FBtr0334040; FBpp0306156; FBgn0030749 [Q9VXG4-1]
FBtr0334041; FBpp0306157; FBgn0030749 [Q9VXG4-2]
FBtr0334042; FBpp0306158; FBgn0030749 [Q9VXG4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32612

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG9968

UCSC genome browser

More...
UCSCi
CG9968-RB d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276963 mRNA Translation: CAB86189.1
AE014298 Genomic DNA Translation: AAF48609.1
AE014298 Genomic DNA Translation: AAF48610.1
AE014298 Genomic DNA Translation: AGB95456.1
AE014298 Genomic DNA Translation: AGB95457.1
AE014298 Genomic DNA Translation: AGB95458.1
AE014298 Genomic DNA Translation: AGB95459.1
AE014298 Genomic DNA Translation: AGB95460.1
AY058397 mRNA Translation: AAL13626.1
AY122138 mRNA Translation: AAM52650.1
BT125828 mRNA Translation: ADR83713.1
RefSeqiNP_001259614.1, NM_001272685.1 [Q9VXG4-2]
NP_001259615.1, NM_001272686.1 [Q9VXG4-3]
NP_001259616.1, NM_001272687.1 [Q9VXG4-1]
NP_001259617.1, NM_001272688.1 [Q9VXG4-2]
NP_001259618.1, NM_001272689.1 [Q9VXG4-1]
NP_523370.1, NM_078646.3 [Q9VXG4-2]
NP_727978.1, NM_167519.2 [Q9VXG4-1]
UniGeneiDm.12489

3D structure databases

ProteinModelPortaliQ9VXG4
SMRiQ9VXG4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58952, 8 interactors
IntActiQ9VXG4, 2 interactors
STRINGi7227.FBpp0306158

Proteomic databases

PaxDbiQ9VXG4
PRIDEiQ9VXG4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074302; FBpp0074077; FBgn0030749 [Q9VXG4-2]
FBtr0074303; FBpp0074078; FBgn0030749 [Q9VXG4-1]
FBtr0334038; FBpp0306154; FBgn0030749 [Q9VXG4-2]
FBtr0334039; FBpp0306155; FBgn0030749 [Q9VXG4-3]
FBtr0334040; FBpp0306156; FBgn0030749 [Q9VXG4-1]
FBtr0334041; FBpp0306157; FBgn0030749 [Q9VXG4-2]
FBtr0334042; FBpp0306158; FBgn0030749 [Q9VXG4-1]
GeneIDi32612
KEGGidme:Dmel_CG9968
UCSCiCG9968-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32612
FlyBaseiFBgn0030749 AnxB11

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00940000172288
InParanoidiQ9VXG4
KOiK17095
OMAiIGMMTPT
OrthoDBiEOG091G0H6H
PhylomeDBiQ9VXG4

Enzyme and pathway databases

ReactomeiR-DME-114608 Platelet degranulation
R-DME-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AnxB11 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32612

Protein Ontology

More...
PROi
PR:Q9VXG4

Gene expression databases

BgeeiFBgn0030749 Expressed in 21 organ(s), highest expression level in larva
GenevisibleiQ9VXG4 DM

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANX11_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VXG4
Secondary accession number(s): M9PEV0, M9PHW3, Q9VXG3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 19, 2014
Last modified: December 5, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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