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Entry version 168 (02 Jun 2021)
Sequence version 4 (04 Dec 2007)
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Protein

Nuclear pore complex protein Nup153

Gene

Nup153

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (PubMed:17682050).

Functions as a scaffolding element in the nuclear phase of the NPC (PubMed:17682050).

Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner (PubMed:17682050).

Required for nuclear import of Mad (PubMed:20547758).

Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment (PubMed:20174442).

Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome (PubMed:20174442).

Associates with extended chromosomal regions that alternate between domains of high density binding with those of low occupancy (PubMed:20174442).

Preferentially binds to NARs of the male X chromosome (PubMed:20174442).

In males, together with Mtor, required for the localization of the male-specific lethal (MSL) histone acetyltransferase complex to the X chromosome and therefore for the transcription of dosage compensation genes (PubMed:16543150).

May play a role in double strand break DNA repair (PubMed:26502056).

5 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds at least 4 zinc ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi909Zinc 1By similarity1
Metal bindingi912Zinc 1By similarity1
Metal bindingi923Zinc 1By similarity1
Metal bindingi926Zinc 1By similarity1
Metal bindingi970Zinc 2By similarity1
Metal bindingi973Zinc 2By similarity1
Metal bindingi984Zinc 2By similarity1
Metal bindingi987Zinc 2By similarity1
Metal bindingi1015Zinc 3By similarity1
Metal bindingi1018Zinc 3By similarity1
Metal bindingi1029Zinc 3By similarity1
Metal bindingi1032Zinc 3By similarity1
Metal bindingi1074Zinc 4By similarity1
Metal bindingi1077Zinc 4By similarity1
Metal bindingi1088Zinc 4By similarity1
Metal bindingi1091Zinc 4By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri903 – 932RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri962 – 993RanBP2-type 2PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri1009 – 1038RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri1067 – 1097RanBP2-type 4PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri1126 – 1155RanBP2-type 5PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri1237 – 1266RanBP2-type 6PROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processDNA damage, mRNA transport, Protein transport, Transcription, Transcription regulation, Translocation, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-159227, Transport of the SLBP independent Mature mRNA
R-DME-159230, Transport of the SLBP Dependant Mature mRNA
R-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453, Regulation of HSF1-mediated heat shock response
R-DME-4551638, SUMOylation of chromatin organization proteins
R-DME-4615885, SUMOylation of DNA replication proteins
R-DME-5578749, Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup153
Alternative name(s):
153 kDa nucleoporin
Nucleoporin Nup153
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nup153
ORF Names:CG4453
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0061200, Nup153

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Membrane, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004221421 – 1883Nuclear pore complex protein Nup153Add BLAST1883

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VXE6

PRoteomics IDEntifications database

More...
PRIDEi
Q9VXE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adult male accessory glands (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in syncytial embryos.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0061200, Expressed in embryo and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VXE6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VXE6, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the nuclear pore complex (NPC) (PubMed:17682050). Associates with male-specific lethal (MSL) histone acetyltransferase complex (PubMed:16543150).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58967, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VXE6, 11 interactors

Molecular INTeraction database

More...
MINTi
Q9VXE6

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0112385

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VXE6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1287 – 12881Curated2
Repeati1315 – 13162Curated2
Repeati1317 – 13183Curated2
Repeati1340 – 13414Curated2
Repeati1353 – 13545Curated2
Repeati1415 – 14166Curated2
Repeati1469 – 14707Curated2
Repeati1511 – 15128Curated2
Repeati1528 – 15299Curated2
Repeati1548 – 154910Curated2
Repeati1586 – 158711Curated2
Repeati1599 – 160012Curated2
Repeati1613 – 161413Curated2
Repeati1647 – 164814Curated2
Repeati1653 – 165415Curated2
Repeati1672 – 167316Curated2
Repeati1694 – 169517Curated2
Repeati1724 – 172518Curated2
Repeati1737 – 173819Curated2
Repeati1748 – 174920Curated2
Repeati1768 – 176921Curated2
Repeati1785 – 178622Curated2

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 57DisorderedSequence analysisAdd BLAST57
Regioni70 – 116DisorderedSequence analysisAdd BLAST47
Regioni176 – 227DisorderedSequence analysisAdd BLAST52
Regioni400 – 439DisorderedSequence analysisAdd BLAST40
Regioni498 – 518DisorderedSequence analysisAdd BLAST21
Regioni580 – 604DisorderedSequence analysisAdd BLAST25
Regioni627 – 657DisorderedSequence analysisAdd BLAST31
Regioni694 – 769DisorderedSequence analysisAdd BLAST76
Regioni791 – 812DisorderedSequence analysisAdd BLAST22
Regioni1173 – 1197DisorderedSequence analysisAdd BLAST25
Regioni1287 – 178622 X 2 AA repeats of F-GCuratedAdd BLAST500
Regioni1301 – 1331DisorderedSequence analysisAdd BLAST31
Regioni1449 – 1473DisorderedSequence analysisAdd BLAST25
Regioni1597 – 1616DisorderedSequence analysisAdd BLAST20
Regioni1855 – 1883DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 27Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi28 – 43Acidic residuesSequence analysisAdd BLAST16
Compositional biasi70 – 102Polar residuesSequence analysisAdd BLAST33
Compositional biasi182 – 210Acidic residuesSequence analysisAdd BLAST29
Compositional biasi417 – 431Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi583 – 604Polar residuesSequence analysisAdd BLAST22
Compositional biasi633 – 657Polar residuesSequence analysisAdd BLAST25
Compositional biasi697 – 711Polar residuesSequence analysisAdd BLAST15
Compositional biasi745 – 759Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1301 – 1325Polar residuesSequence analysisAdd BLAST25
Compositional biasi1855 – 1871Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NUP153 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri903 – 932RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri962 – 993RanBP2-type 2PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri1009 – 1038RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri1067 – 1097RanBP2-type 4PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri1126 – 1155RanBP2-type 5PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri1237 – 1266RanBP2-type 6PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4719, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153253

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002102_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VXE6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026054, Nucleoporin
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23193, PTHR23193, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00641, zf-RanBP, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00547, ZnF_RBZ, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF90209, SSF90209, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01358, ZF_RANBP2_1, 6 hits
PS50199, ZF_RANBP2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VXE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDAQEQRES SQAELAKKHP LTPLKELPEE SEEEEEEEDE SSAGALRESD
60 70 80 90 100
SNNSIMGKMK MRVSSILPAS LSGWFSPSSK DGNDALSSPA NLRQSQPRQS
110 120 130 140 150
NGRLTTKRKR GRRRIMLAEV DADAADDLDD GSDAKGLNYE EVALADNIAE
160 170 180 190 200
HDLAAEDEQT RRSEYNVFLL RKRAGAVAAA GGDEDEAEED ELEEDDEDGD
210 220 230 240 250
EEDDDEEQEN LQQSAAVQTK RRRLELETPV NLPNMRRLPL LSSTPAAPLA
260 270 280 290 300
AATSSSSSQM YKGVSHIAPH RRNHLNLYGS QRQREPAYNF FTGNEAAEGS
310 320 330 340 350
TGDLPHSIRR SLNIPFGGSS TATSYNNSLS SLPNHKRPSL IGKQTHRRDL
360 370 380 390 400
TMDETGTGPA MSSEEHLNHL LRISRTNNNT SNNNNNNNNN NNVIETKTRR
410 420 430 440 450
SELSAAAGGC GDSQSESDMN EYHDNGEGHD GLRPSHYNSN SNLEFYGNLQ
460 470 480 490 500
SSKSIFNRSN TAAQQSHRNS TWSLNSLTQR RRFNASIYGS TSALSDSRLL
510 520 530 540 550
SGSASNSGSA SASSSPFYQG RTTFGGNSGN NRLFSRSNLS SSAASSMLGL
560 570 580 590 600
NSAGSSPAHQ LHASMTGGIG YGMKAVDMRP SDSGSLAETS VGQGGSKKPG
610 620 630 640 650
TGLSNTTMRI LNLLESYSTP LIDAKRMGSS IKEHQSSRQQ RQGTPATPYL
660 670 680 690 700
RSTSASRNVS VPNHINELAE LRSNKLLVPT MQQLLERRRL HRVTQNSRDV
710 720 730 740 750
VHSQNVRAGG ENNQEKPKPT APYVAPIDQS ANHTQHTNKM RSRLSHQTRN
760 770 780 790 800
KETRTAEEEA PPPLDLPQIS FPDMASAPKF DLIIKPTVPV VSKPSTTDPI
810 820 830 840 850
QSSKSSNTNL STTNSKQMPN FLANPQPAAP IVNFAANGNV SAISKPSKRT
860 870 880 890 900
FTFSEPTPLS NFQENCIPKP KINRKYTFSA PAPLDDLRIT NKQSQPTING
910 920 930 940 950
TPSSKEWECD TCMVRNKPEI NKCVACETAK PVASAAPVQA PLPPSTAAID
960 970 980 990 1000
TQSFVGFGDR FKKSTTAWEC DACMLSNKAE ASKCIACETP RKTVAPKVNN
1010 1020 1030 1040 1050
FSPLITNAKS NEWECSVCLV RNKVEVSKCV ACESAKPGAT MALPATSNIA
1060 1070 1080 1090 1100
VATPSIITDG FGDRFKKSAT AWECDACMLS NKAEASKCIA CETPRKSSTP
1110 1120 1130 1140 1150
IANSSYPSIN NNLPAGSGFD ISFTRKANMW ECQTCLVMNK SSDEECIACQ
1160 1170 1180 1190 1200
TPNSQARNSN SESALISSIS SSSASFSGSL SRPSSRSSSG STSTCGSVCS
1210 1220 1230 1240 1250
GSIVSISSTT ESAKALSAKK VPPKPDAGFQ QLVAAQKTST WECEACLAKN
1260 1270 1280 1290 1300
DMSRKTCICC EQMMPEAFNP AATTANSAAS SVPKFRFGFS HVKEVVKPSV
1310 1320 1330 1340 1350
ETTTTPAPTS AQFSFGFGQS NQGKDVADSK KTEAPKTFMF GVSKVEEPKT
1360 1370 1380 1390 1400
VSFGTGIKET TATSSTEATA PTPAAAAPAP VQFVFKAPTT ATTASSLTTT
1410 1420 1430 1440 1450
ISTTSNAPAL GGFSFGAPSS SSTVSSSTTS TSANPAAVKP MFSWSGAGSA
1460 1470 1480 1490 1500
VSSTSSSQQP VAKAPTLGFG VSSSTVTTTT TSTKVFAFTP ASGLDPAAAT
1510 1520 1530 1540 1550
SAPAAGAGFS FGSQSKPATT QNTGTFFFGQ PTAVAPATPT NPSVSSIFGA
1560 1570 1580 1590 1600
PATSTTASTS VSATTSTSTA NAIASSFAPT STPQLFGNWG EKKTDLTTFG
1610 1620 1630 1640 1650
ASSGSGTTTT PSFGWSSNGD AAKSNSAAVG SAAVPSSSAS TMATPIFGSS
1660 1670 1680 1690 1700
SMFGPSSSSN NTTSTSTTSL PFGSAATTAA TTPAGGNAAL TGLFGNVGNS
1710 1720 1730 1740 1750
LAGVGAPVAT TPAATAAAPL TNIFGNPTPV AAAAPVFGSG STIPSAGFGA
1760 1770 1780 1790 1800
PAAAAPLAAP ALPGAFNFGG ATAATPAASS APFVFGSSTN EPLAKPSFNF
1810 1820 1830 1840 1850
TGSAASSTAP APAFNFTANT AATNNPSGGD STPNANALFQ FSATSTAPAN
1860 1870 1880
IFAFNPPAAG NSAQSSQTAR RKIRAPVRRL PPR
Length:1,883
Mass (Da):196,585
Last modified:December 4, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46CC3237B37E2454
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8JV18A8JV18_DROME
Nucleoporin 153kD, isoform D
Nup153 Dmel\CG4453, dmNup153, dNup153, Nup 153, NUP153
1,929Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48628.4
AE014298 Genomic DNA Translation: ACL82938.1
BT025178 mRNA Translation: ABE98144.1

NCBI Reference Sequences

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RefSeqi
NP_001138206.1, NM_001144734.2
NP_573136.3, NM_132908.5

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0074284; FBpp0074059; FBgn0061200
FBtr0299587; FBpp0288862; FBgn0061200

Database of genes from NCBI RefSeq genomes

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GeneIDi
32630

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG4453

UCSC genome browser

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UCSCi
CG4453-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48628.4
AE014298 Genomic DNA Translation: ACL82938.1
BT025178 mRNA Translation: ABE98144.1
RefSeqiNP_001138206.1, NM_001144734.2
NP_573136.3, NM_132908.5

3D structure databases

SMRiQ9VXE6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi58967, 19 interactors
IntActiQ9VXE6, 11 interactors
MINTiQ9VXE6
STRINGi7227.FBpp0112385

Proteomic databases

PaxDbiQ9VXE6
PRIDEiQ9VXE6

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
32630

Genome annotation databases

EnsemblMetazoaiFBtr0074284; FBpp0074059; FBgn0061200
FBtr0299587; FBpp0288862; FBgn0061200
GeneIDi32630
KEGGidme:Dmel_CG4453
UCSCiCG4453-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9972
FlyBaseiFBgn0061200, Nup153

Phylogenomic databases

eggNOGiKOG4719, Eukaryota
GeneTreeiENSGT00940000153253
HOGENOMiCLU_002102_0_0_1
InParanoidiQ9VXE6

Enzyme and pathway databases

ReactomeiR-DME-159227, Transport of the SLBP independent Mature mRNA
R-DME-159230, Transport of the SLBP Dependant Mature mRNA
R-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453, Regulation of HSF1-mediated heat shock response
R-DME-4551638, SUMOylation of chromatin organization proteins
R-DME-4615885, SUMOylation of DNA replication proteins
R-DME-5578749, Transcriptional regulation by small RNAs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
32630, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32630

Protein Ontology

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PROi
PR:Q9VXE6

Gene expression databases

BgeeiFBgn0061200, Expressed in embryo and 40 other tissues
ExpressionAtlasiQ9VXE6, baseline and differential
GenevisibleiQ9VXE6, DM

Family and domain databases

InterProiView protein in InterPro
IPR026054, Nucleoporin
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
PANTHERiPTHR23193, PTHR23193, 3 hits
PfamiView protein in Pfam
PF00641, zf-RanBP, 5 hits
SMARTiView protein in SMART
SM00547, ZnF_RBZ, 6 hits
SUPFAMiSSF90209, SSF90209, 6 hits
PROSITEiView protein in PROSITE
PS01358, ZF_RANBP2_1, 6 hits
PS50199, ZF_RANBP2_2, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU153_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VXE6
Secondary accession number(s): Q1LZ48
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: December 4, 2007
Last modified: June 2, 2021
This is version 168 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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