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Protein

Actin-related protein 2/3 complex subunit 3

Gene

Arpc3B

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.UniRule annotation

GO - Molecular functioni

  • actin binding Source: FlyBase
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

  • Arp2/3 complex-mediated actin nucleation Source: FlyBase

Keywordsi

Molecular functionActin-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-5663213 RHO GTPases Activate WASPs and WAVEs
R-DME-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 3UniRule annotation
Alternative name(s):
Arp2/3 complex 21 kDa subunitUniRule annotation
Gene namesi
Name:Arpc3BImported
Synonyms:Arpc3Imported, Arpc3bImported, BcDNA:SD24339Imported, Dmel\CG8936Imported, P21-ARCImported
ORF Names:CG8936Imported, Dmel_CG8936Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0065032 Arpc3B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Expressioni

Gene expression databases

BgeeiFBgn0065032

Interactioni

Subunit structurei

Component of the Arp2/3 complex.UniRule annotation

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

STRINGi7227.FBpp0074184

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC3 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3155 Eukaryota
ENOG4111FTG LUCA
GeneTreeiENSGT00390000018018
OrthoDBiEOG091G0OUM

Family and domain databases

Gene3Di1.10.1760.10, 1 hit
InterProiView protein in InterPro
IPR007204 ARPC3
IPR036753 ARPC3_sf
PANTHERiPTHR12391 PTHR12391, 1 hit
PfamiView protein in Pfam
PF04062 P21-Arc, 1 hit
PIRSFiPIRSF016315 ARP2/3_P21-Arc, 1 hit
SUPFAMiSSF69060 SSF69060, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VX82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAFHSEIED FQASVGNMAL LPLRTQVRGP APTVDIPNDI IDESLYFWKS
60 70 80 90 100
NIFFRTYEVK SEVDRVLIYI TLYITECLKR LARCTSKSQG QQELYTLAIS
110 120 130 140 150
RFDIPGDAGF PLNGIYTKPE DPELMRQYFL QLRQETGNRL LEKVFDTPDG
160 170
KPSKWWICFA KKKFMEKSLS GPGM
Length:174
Mass (Da):20,085
Last modified:May 1, 2000 - v1
Checksum:iB5E61F8A565035F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48696.1
AY119268 mRNA Translation: AAM51128.1
RefSeqiNP_573193.1, NM_132965.2
UniGeneiDm.19161

Genome annotation databases

EnsemblMetazoaiFBtr0074410; FBpp0074184; FBgn0065032
GeneIDi32696
UCSCiCG8936-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VX82_DROME
AccessioniPrimary (citable) accession number: Q9VX82
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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