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Entry version 151 (02 Jun 2021)
Sequence version 2 (01 Oct 2002)
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Protein

Rho GTPase-activating protein 190

Gene

RhoGAPp190

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein (GAP) for RhoA/Rho1 that plays an essential role in the stability of dorsal branches of mushroom body (MB) neurons. The MB neurons are the center for olfactory learning and memory. Acts by converting RhoA/Rho1 to an inactive GDP-bound state, leading to repress the RhoA/Rho1-Drok-MRLC signaling pathway thereby maintaining axon branch stability.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Negatively regulated by integrin, bsk and Src/Src64B.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: FlyBase
  • GTPase activity Source: InterPro
  • GTP binding Source: InterPro
  • semaphorin receptor binding Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, GTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-194840, Rho GTPase cycle
R-DME-350407, RHO1 GTPase cycle
R-DME-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 190
Alternative name(s):
Rho GTPase-activating protein of 190 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CG32555
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0026375, RhoGAPp190

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003728561 – 1561Rho GTPase-activating protein 190Add BLAST1561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei973Phosphoserine1 Publication1
Modified residuei975Phosphoserine1 Publication1
Modified residuei985Phosphoserine1 Publication1
Modified residuei988Phosphoserine1 Publication1
Modified residuei996Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VX32

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0026375, Expressed in brain and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VX32, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VX32, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
59069, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VX32, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305817

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VX32

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini252 – 320FF 1Add BLAST69
Domaini365 – 419FF 2Add BLAST55
Domaini426 – 480FF 3Add BLAST55
Domaini482 – 547FF 4Add BLAST66
Domaini592 – 765pG1 pseudoGTPasePROSITE-ProRule annotationAdd BLAST174
Domaini766 – 926pG2 pseudoGTPasePROSITE-ProRule annotationAdd BLAST161
Domaini1349 – 1552Rho-GAPPROSITE-ProRule annotationAdd BLAST204

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1054 – 1074DisorderedSequence analysisAdd BLAST21

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4271, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VX32

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VX32

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.440, 2 hits
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002713, FF_domain
IPR036517, FF_domain_sf
IPR027417, P-loop_NTPase
IPR039007, pG1
IPR008936, Rho_GTPase_activation_prot
IPR032835, RhoGAP-FF1
IPR000198, RhoGAP_dom
IPR039006, RhoGAP_pG2
IPR001806, Small_GTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00071, Ras, 1 hit
PF00620, RhoGAP, 1 hit
PF16512, RhoGAP-FF1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51676, FF, 4 hits
PS51852, PG1, 1 hit
PS51853, PG2, 1 hit
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9VX32-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRQFNISVIG LSGTEKDRGQ VGVGKSCLCN RFMRPMADDY FIDHISVLSQ
60 70 80 90 100
SDFSGRIVNN DHFLYWGDVR KTTEEGVEYQ FNIIEQTEFM DDSTFQAFKV
110 120 130 140 150
GKMDPYSKRC TATKVFSAEK LMYICKNQLG IEKEYEQKVM PDGRLSIDGF
160 170 180 190 200
VVVFDVSPVP NRSVEKQVEF VQNVIATILK NKKPLVLVTT KNDDAYELYV
210 220 230 240 250
REAEKISQRK DYKSTVQLIE TSAHESINID LAFLLLAQMI DKVKNRVKII
260 270 280 290 300
SYQESAKSRK ELLDTRSEAV TRLIRNQITD YHVLWSQGSK MLSQYREWNE
310 320 330 340 350
FLNIFGHEAG QKLFRRHMKK LRDDHLNKKL HQYLDKFALA LEYLLPDIGA
360 370 380 390 400
LNISDDDAWE CARNYLQNHI EFEQYFFECP QASWTELVDM DEAEDEARIP
410 420 430 440 450
FDVLETSEAE TVFRNYLNSV QQDKKKIGWK QQFKMLLEES GFVTPGKQLS
460 470 480 490 500
EVRVLFMGRE CFEALSEHDC QQIYDIHQDD IIEKSKQNFV ELLLEHAQYF
510 520 530 540 550
LQFKNVDNIT QEDVRQITDV IQEDSRYKML DRLDQERRLM LVQHLRFIHC
560 570 580 590 600
PIRDHCPFFY NCVDSLIEEV LSDKSASNHK TPSGGGWKSS GSGSDRTLNL
610 620 630 640 650
LIVGSEHLAS DLLNDIRICT GSKGEYIYEN QTYYLNYRIA NGDMEAFKAI
660 670 680 690 700
DVYSSGLICV YSNQQSFETL KDNLERTLLC NLELEDKFEN LPIVLVYQPQ
710 720 730 740 750
DLKENEVEYL RNEGMRLSEM LHCDFIDHTQ NHQKYVYDIL NIVILSLKLT
760 770 780 790 800
EMKSYEPYPS NHTDLRILCC IFCGDQYDIE NIVQPLVEES TLVKANEHSI
810 820 830 840 850
IVDVFIGDAK RRVEFILSSY HGTSQYRDEL IHGYIYFYST KRRSSLANLS
860 870 880 890 900
ILAAQNANIP LQIIAVTESG GVNAFFNSDI CQFLITEGNA VADRFKGSFM
910 920 930 940 950
TFSADQYVKF AFYNPFLKTA WDNKYEVENL HVEESITLDS GEGTLENSVN
960 970 980 990 1000
QMPRPPPRHE SYMLSNTLGT DGSGSENYEM APTRSLNSLN EERDISLDEI
1010 1020 1030 1040 1050
YDDNEKPKHL HQKWLEDKSD GRRNMNKNLI WNNFSGSTHA YTTGRRHIDS
1060 1070 1080 1090 1100
NLNKIRPKGP SQTLKVGEAP SRNCPAMSSS TFTLPTQQPG KLNMKNFQLV
1110 1120 1130 1140 1150
SDAVAKMNFT GSGSGSGSGS GSGSTGLGLG LGSGSGCMGD SFLEPVDKDG
1160 1170 1180 1190 1200
KRYDHAQLDG EDEDSEELAE YEQIYENEDC TESDSCASST ERRVRQQNAY
1210 1220 1230 1240 1250
YKASKKPVAA KKQKKKKVAI PVQTPRVPPF GSYVSPPEIP LHYQRMAVGG
1260 1270 1280 1290 1300
SGPEKPEPCV PEFMKSDKSP EYSMVPELAG AGIFGAENLP EYNMNQAKCL
1310 1320 1330 1340 1350
KDFEKLEKRR IKEETARQRK LQEKEKEQEK KLKRKLKQNA KGLVESAEAQ
1360 1370 1380 1390 1400
FGKLMITSEQ GEIPIFLNKC VEFIEKEGLD SEGIYRVPGS RAHVDMLFQR
1410 1420 1430 1440 1450
FEEDTNTEID ALDIPVNAVA TALKDFFSKR LPPLFSKDII KELEEIAGSR
1460 1470 1480 1490 1500
GVGNSKLNVE VKTDRSCRLI ALKSLLQKLP PINFAILKYI FQHFVHVSDN
1510 1520 1530 1540 1550
SKLNSMDSKN LAICWWPTLI PIDFTDMGHF EQLRPYLEDI VQTMIDQFPY
1560
LFCGKDAFVM V
Length:1,561
Mass (Da):178,772
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E28A17B6AF9E308
GO
Isoform 2 (identifier: Q9VX32-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1253-1254: PE → PGEKK

Show »
Length:1,564
Mass (Da):179,086
Checksum:i0830E9C6503FD327
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PHG0M9PHG0_DROME
Rho GTPase activating protein p190,...
RhoGAPp190 8267, BcDNA:GH17919, BcDNA:GM05133, CG8240, CG8267
1,564Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PHV3M9PHV3_DROME
Rho GTPase activating protein p190,...
RhoGAPp190 8267, BcDNA:GH17919, BcDNA:GM05133, CG8240, CG8267
1,621Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PHY4M9PHY4_DROME
Rho GTPase activating protein p190,...
RhoGAPp190 8267, BcDNA:GH17919, BcDNA:GM05133, CG8240, CG8267
1,579Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PJQ3M9PJQ3_DROME
Rho GTPase activating protein p190,...
RhoGAPp190 8267, BcDNA:GH17919, BcDNA:GM05133, CG8240, CG8267
1,398Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti356D → G in AAM51993 (PubMed:12537569).Curated1
Sequence conflicti505N → Y in AAM51993 (PubMed:12537569).Curated1
Sequence conflicti580K → E in AAM51993 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0372111253 – 1254PE → PGEKK in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF387518 mRNA Translation: AAL01872.1
AE014298 Genomic DNA Translation: AAF48748.2
AE014298 Genomic DNA Translation: AAF48749.2
AE014298 Genomic DNA Translation: AAN09591.1
AY121666 mRNA Translation: AAM51993.1

NCBI Reference Sequences

More...
RefSeqi
NP_001259656.1, NM_001272727.1 [Q9VX32-2]
NP_573231.2, NM_133003.3 [Q9VX32-1]
NP_728089.1, NM_167572.2 [Q9VX32-1]
NP_728090.1, NM_167573.2 [Q9VX32-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0074481; FBpp0074255; FBgn0026375 [Q9VX32-1]
FBtr0074482; FBpp0074256; FBgn0026375 [Q9VX32-1]
FBtr0074483; FBpp0074257; FBgn0026375 [Q9VX32-1]
FBtr0333659; FBpp0305815; FBgn0026375 [Q9VX32-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32743

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG32555

UCSC genome browser

More...
UCSCi
CG32555-RA, d. melanogaster [Q9VX32-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387518 mRNA Translation: AAL01872.1
AE014298 Genomic DNA Translation: AAF48748.2
AE014298 Genomic DNA Translation: AAF48749.2
AE014298 Genomic DNA Translation: AAN09591.1
AY121666 mRNA Translation: AAM51993.1
RefSeqiNP_001259656.1, NM_001272727.1 [Q9VX32-2]
NP_573231.2, NM_133003.3 [Q9VX32-1]
NP_728089.1, NM_167572.2 [Q9VX32-1]
NP_728090.1, NM_167573.2 [Q9VX32-1]

3D structure databases

SMRiQ9VX32
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi59069, 14 interactors
IntActiQ9VX32, 1 interactor
STRINGi7227.FBpp0305817

PTM databases

iPTMnetiQ9VX32

Genome annotation databases

EnsemblMetazoaiFBtr0074481; FBpp0074255; FBgn0026375 [Q9VX32-1]
FBtr0074482; FBpp0074256; FBgn0026375 [Q9VX32-1]
FBtr0074483; FBpp0074257; FBgn0026375 [Q9VX32-1]
FBtr0333659; FBpp0305815; FBgn0026375 [Q9VX32-2]
GeneIDi32743
KEGGidme:Dmel_CG32555
UCSCiCG32555-RA, d. melanogaster [Q9VX32-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32743
FlyBaseiFBgn0026375, RhoGAPp190

Phylogenomic databases

eggNOGiKOG4271, Eukaryota
InParanoidiQ9VX32
PhylomeDBiQ9VX32

Enzyme and pathway databases

ReactomeiR-DME-194840, Rho GTPase cycle
R-DME-350407, RHO1 GTPase cycle
R-DME-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
32743, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32743

Protein Ontology

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PROi
PR:Q9VX32

Gene expression databases

BgeeiFBgn0026375, Expressed in brain and 39 other tissues
ExpressionAtlasiQ9VX32, baseline and differential
GenevisibleiQ9VX32, DM

Family and domain databases

Gene3Di1.10.10.440, 2 hits
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR002713, FF_domain
IPR036517, FF_domain_sf
IPR027417, P-loop_NTPase
IPR039007, pG1
IPR008936, Rho_GTPase_activation_prot
IPR032835, RhoGAP-FF1
IPR000198, RhoGAP_dom
IPR039006, RhoGAP_pG2
IPR001806, Small_GTPase
PfamiView protein in Pfam
PF00071, Ras, 1 hit
PF00620, RhoGAP, 1 hit
PF16512, RhoGAP-FF1, 1 hit
SMARTiView protein in SMART
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51676, FF, 4 hits
PS51852, PG1, 1 hit
PS51853, PG2, 1 hit
PS50238, RHOGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRG190_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VX32
Secondary accession number(s): Q8MRC6, Q95VZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 1, 2002
Last modified: June 2, 2021
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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