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UniProtKB - Q9VWX8 (Q9VWX8_DROME)
Protein
Submitted name:
FI18190p1
Gene
Frq2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 73 | Calcium 1Combined sources | 1 | |
Metal bindingi | 75 | Calcium 1Combined sources | 1 | |
Metal bindingi | 77 | Calcium 1Combined sources | 1 | |
Metal bindingi | 79 | Calcium 1; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 84 | Calcium 1Combined sources | 1 | |
Metal bindingi | 109 | Calcium 2Combined sources | 1 | |
Metal bindingi | 111 | Calcium 2Combined sources | 1 | |
Metal bindingi | 113 | Calcium 2Combined sources | 1 | |
Metal bindingi | 115 | Calcium 2; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 120 | Calcium 2Combined sources | 1 | |
Metal bindingi | 156 | Calcium 3Combined sources | 1 | |
Metal bindingi | 158 | Calcium 3Combined sources | 1 | |
Metal bindingi | 160 | Calcium 3Combined sources | 1 | |
Metal bindingi | 162 | Calcium 3; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 167 | Calcium 3Combined sources | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- calcium sensitive guanylate cyclase activator activity Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: FlyBase
- neuromuscular junction development Source: FlyBase
- neurotransmitter secretion Source: FlyBase
- regulation of neurotransmitter secretion Source: FlyBase
- vesicle-mediated transport Source: FlyBase
Keywordsi
Ligand | CalciumCombined sources, Metal-bindingCombined sources |
Names & Taxonomyi
Protein namesi | Submitted name: FI18190p1ImportedSubmitted name: Frequenin 2, isoform AImportedSubmitted name: Frequenin 2, isoform BImportedSubmitted name: Frequenin 2, isoform CImportedSubmitted name: Frequenin 2, isoform DImported |
Gene namesi | Name:Frq2Imported Synonyms:Dmel\CG5907Imported, dNCS-1Imported, FrqImported, frqImported, frq2Imported, Frq2-RAImported ORF Names:CG5907Imported, Dmel_CG5907Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0083228, Frq2 |
VEuPathDBi | VectorBase:FBgn0083228 |
Expressioni
Gene expression databases
Bgeei | FBgn0083228, Expressed in central nervous system and 21 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | Q9VWX8, 2 interactors |
STRINGi | 7227.FBpp0305513 |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 95 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 96 – 131 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 143 – 178 | EF-handInterPro annotationAdd BLAST | 36 |
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
eggNOGi | KOG0044, Eukaryota |
GeneTreei | ENSGT00940000166508 |
HOGENOMi | CLU_072366_1_0_1 |
OMAi | EYVFNVF |
OrthoDBi | 1369072at2759 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 3 hits |
i Sequence
Sequence statusi: Complete.
Q9VWX8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKKNSKLKQ DTIDRLTTDT YFTEKEIRQW HKGFLKDCPN GLLTEQGFIK
60 70 80 90 100
IYKQFFPDGD PSKFASLVFR VFDENNDGAI EFEEFIRALS ITSRGNLDEK
110 120 130 140 150
LHWAFRLYDV DNDGYITREE MYNIVDAIYQ MVGQQPQTED ENTPQKRVDK
160 170 180
IFDQMDKNHD DRLTLEEFRE GSKADPRIVQ ALSLGGD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF48809.1 AE014298 Genomic DNA Translation: AAS65399.1 AE014298 Genomic DNA Translation: AAS65400.1 BT133347 mRNA Translation: AFF57512.1 AE014298 Genomic DNA Translation: AGB95517.1 |
RefSeqi | NP_001259675.1, NM_001272746.1 NP_525093.1, NM_080354.4 NP_996501.1, NM_206778.3 NP_996502.1, NM_206779.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0074546; FBpp0074320; FBgn0083228 FBtr0301627; FBpp0089317; FBgn0083228 FBtr0301628; FBpp0089318; FBgn0083228 FBtr0333321; FBpp0305513; FBgn0083228 |
GeneIDi | 32799 |
KEGGi | dme:Dmel_CG5907 |
UCSCi | CG5907-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF48809.1 AE014298 Genomic DNA Translation: AAS65399.1 AE014298 Genomic DNA Translation: AAS65400.1 BT133347 mRNA Translation: AFF57512.1 AE014298 Genomic DNA Translation: AGB95517.1 |
RefSeqi | NP_001259675.1, NM_001272746.1 NP_525093.1, NM_080354.4 NP_996501.1, NM_206778.3 NP_996502.1, NM_206779.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4BY4 | X-ray | 2.30 | A/B | 1-187 | [»] | |
4BY5 | X-ray | 2.22 | A/B/C/D | 1-187 | [»] | |
5AAN | X-ray | 1.60 | A | 1-187 | [»] | |
5FYX | X-ray | 1.80 | A | 1-187 | [»] | |
5G08 | X-ray | 1.52 | A | 1-187 | [»] | |
6EPA | X-ray | 1.82 | A | 1-187 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | Q9VWX8, 2 interactors |
STRINGi | 7227.FBpp0305513 |
Chemistry databases
ChEMBLi | CHEMBL4295984 |
Genome annotation databases
EnsemblMetazoai | FBtr0074546; FBpp0074320; FBgn0083228 FBtr0301627; FBpp0089317; FBgn0083228 FBtr0301628; FBpp0089318; FBgn0083228 FBtr0333321; FBpp0305513; FBgn0083228 |
GeneIDi | 32799 |
KEGGi | dme:Dmel_CG5907 |
UCSCi | CG5907-RA, d. melanogaster |
Organism-specific databases
CTDi | 32799 |
FlyBasei | FBgn0083228, Frq2 |
VEuPathDBi | VectorBase:FBgn0083228 |
Phylogenomic databases
eggNOGi | KOG0044, Eukaryota |
GeneTreei | ENSGT00940000166508 |
HOGENOMi | CLU_072366_1_0_1 |
OMAi | EYVFNVF |
OrthoDBi | 1369072at2759 |
Miscellaneous databases
BioGRID-ORCSi | 32799, 0 hits in 1 CRISPR screen |
GenomeRNAii | 32799 |
Gene expression databases
Bgeei | FBgn0083228, Expressed in central nervous system and 21 other tissues |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VWX8_DROME | |
Accessioni | Q9VWX8Primary (citable) accession number: Q9VWX8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |