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UniProtKB - Q9VWX8 (Q9VWX8_DROME)

Entry version 182 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

FI18190p1

Gene

Frq2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi73Calcium 1Combined sources1
Metal bindingi75Calcium 1Combined sources1
Metal bindingi77Calcium 1Combined sources1
Metal bindingi79Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi84Calcium 1Combined sources1
Metal bindingi109Calcium 2Combined sources1
Metal bindingi111Calcium 2Combined sources1
Metal bindingi113Calcium 2Combined sources1
Metal bindingi115Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi120Calcium 2Combined sources1
Metal bindingi156Calcium 3Combined sources1
Metal bindingi158Calcium 3Combined sources1
Metal bindingi160Calcium 3Combined sources1
Metal bindingi162Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi167Calcium 3Combined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi73 – 84PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 120PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi156 – 167PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumPROSITE-ProRule annotationARBA annotation, Metal-bindingCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FI18190p1Imported
Submitted name:
Frequenin 2, isoform AImported
Submitted name:
Frequenin 2, isoform BImported
Submitted name:
Frequenin 2, isoform CImported
Submitted name:
Frequenin 2, isoform DImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Frq2Imported
Synonyms:Dmel\CG5907Imported, dNCS-1Imported, FrqImported, frqImported, frq2Imported, Frq2-RAImported
ORF Names:CG5907Imported, Dmel_CG5907Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0083228, Frq2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295984

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q9VWX8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0083228, Expressed in central nervous system and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9VWX8, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9VWX8, 2 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0305513

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9VWX8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VWX8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 95EF-handInterPro annotationAdd BLAST36
Domaini96 – 131EF-handInterPro annotationAdd BLAST36
Domaini143 – 178EF-handInterPro annotationAdd BLAST36

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0044, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000166508

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_072366_1_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		NMDRDKD

Database of Orthologous Groups

More...OrthoDBi		1369072at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00051, EFh, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR028846, Recoverin

The PANTHER Classification System

More...PANTHERi		PTHR23055, PTHR23055, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00036, EF-hand_1, 1 hit
PF13499, EF-hand_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 3 hits
PS50222, EF_HAND_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VWX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKKNSKLKQ DTIDRLTTDT YFTEKEIRQW HKGFLKDCPN GLLTEQGFIK 
        60         70         80         90        100
IYKQFFPDGD PSKFASLVFR VFDENNDGAI EFEEFIRALS ITSRGNLDEK 
       110        120        130        140        150
LHWAFRLYDV DNDGYITREE MYNIVDAIYQ MVGQQPQTED ENTPQKRVDK 
       160        170        180 
IFDQMDKNHD DRLTLEEFRE GSKADPRIVQ ALSLGGD
Length:187
Mass (Da):21,875
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF12AADF07BB8249D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48809.1
AE014298 Genomic DNA Translation: AAS65399.1
AE014298 Genomic DNA Translation: AAS65400.1
BT133347 mRNA Translation: AFF57512.1
AE014298 Genomic DNA Translation: AGB95517.1

NCBI Reference Sequences

More...RefSeqi		NP_001259675.1, NM_001272746.1
NP_525093.1, NM_080354.4
NP_996501.1, NM_206778.3
NP_996502.1, NM_206779.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0074546; FBpp0074320; FBgn0083228
FBtr0301627; FBpp0089317; FBgn0083228
FBtr0301628; FBpp0089318; FBgn0083228
FBtr0333321; FBpp0305513; FBgn0083228

Database of genes from NCBI RefSeq genomes

More...GeneIDi		32799

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG5907

UCSC genome browser

More...UCSCi		CG5907-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48809.1
AE014298 Genomic DNA Translation: AAS65399.1
AE014298 Genomic DNA Translation: AAS65400.1
BT133347 mRNA Translation: AFF57512.1
AE014298 Genomic DNA Translation: AGB95517.1
RefSeqiNP_001259675.1, NM_001272746.1
NP_525093.1, NM_080354.4
NP_996501.1, NM_206778.3
NP_996502.1, NM_206779.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BY4X-ray2.30A/B1-187[»]
4BY5X-ray2.22A/B/C/D1-187[»]
5AANX-ray1.60A1-187[»]
5FYXX-ray1.80A1-187[»]
5G08X-ray1.52A1-187[»]
6EPAX-ray1.82A1-187[»]
SMRiQ9VWX8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ9VWX8, 2 interactors
STRINGi7227.FBpp0305513

Chemistry databases

BindingDBiQ9VWX8
ChEMBLiCHEMBL4295984

Proteomic databases

PRIDEiQ9VWX8

Genome annotation databases

EnsemblMetazoaiFBtr0074546; FBpp0074320; FBgn0083228
FBtr0301627; FBpp0089317; FBgn0083228
FBtr0301628; FBpp0089318; FBgn0083228
FBtr0333321; FBpp0305513; FBgn0083228
GeneIDi32799
KEGGidme:Dmel_CG5907
UCSCiCG5907-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		32799
FlyBaseiFBgn0083228, Frq2

Phylogenomic databases

eggNOGiKOG0044, Eukaryota
GeneTreeiENSGT00940000166508
HOGENOMiCLU_072366_1_0_1
OMAiNMDRDKD
OrthoDBi1369072at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		32799, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		32799

Gene expression databases

BgeeiFBgn0083228, Expressed in central nervous system and 21 other tissues
ExpressionAtlasiQ9VWX8, baseline and differential

Family and domain databases

CDDicd00051, EFh, 2 hits
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR028846, Recoverin
PANTHERiPTHR23055, PTHR23055, 1 hit
PfamiView protein in Pfam
PF00036, EF-hand_1, 1 hit
PF13499, EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 3 hits
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 3 hits
PS50222, EF_HAND_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VWX8_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VWX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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