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Entry version 162 (02 Jun 2021)
Sequence version 2 (01 Oct 2002)
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Protein
Submitted name:

FI03615p

Gene

rictor

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein serine/threonine kinase activator activity Source: FlyBase

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1257604, PIP3 activates AKT signaling
R-DME-389357, CD28 dependent PI3K/Akt signaling
R-DME-5218920, VEGFR2 mediated vascular permeability

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FI03615pImported
Submitted name:
Rapamycin-insensitive companion of Tor, isoform AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rictorImported
Synonyms:8002Imported, Dmel\CG8002Imported, dRicImported, dRICTORImported, dRictorImported, RICTORImported, RictorImported, rictor-RAImported
ORF Names:CG8002Imported, Dmel_CG8002Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0031006, rictor

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031006, Expressed in female gonad and 36 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0074458

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 440RICTOR_NInterPro annotationAdd BLAST381
Domaini580 – 800RICTOR_MInterPro annotationAdd BLAST221
Domaini976 – 1050RICTOR_VInterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1436 – 1467DisorderedSequence analysisAdd BLAST32
Regioni1695 – 1753DisorderedSequence analysisAdd BLAST59
Regioni1784 – 1806DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1695 – 1715Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RICTOR family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3694, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002096

Database of Orthologous Groups

More...
OrthoDBi
128601at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR028268, Pianissimo_fam
IPR028267, Pianissimo_N
IPR029453, Rictor_IV
IPR029451, RICTOR_M
IPR029452, RICTOR_V

The PANTHER Classification System

More...
PANTHERi
PTHR13298, PTHR13298, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14663, RasGEF_N_2, 1 hit
PF14666, RICTOR_M, 1 hit
PF14664, RICTOR_N, 1 hit
PF14668, RICTOR_V, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01307, RICTOR_M, 1 hit
SM01308, RICTOR_N, 1 hit
SM01310, RICTOR_V, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9VWJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQHSSWRF GKRSKLQLRI KVSQDPEDFY RLDPQRSAAE NAFEIYSMLC
60 70 80 90 100
LEETRDTKRL FLLNALASLC LGARKGSHHS NIRFTTEELL YCLSASLVHT
110 120 130 140 150
FTQVRAAALR TIRYAISTPN DIKTFNALQL QHLLCRSIDL MLKNDDERVQ
160 170 180 190 200
ALKLVRKMLA IAPEDISPAV VRCLVSLADS GIEENDNLLR ACLATLAEFA
210 220 230 240 250
VLNPALLIVC GGVTSITRNV LECHNPRIAE SLCGVLLYLL EWPQTRNICG
260 270 280 290 300
VRLDCLAAPY CDFTYRQSIV DKNKDARELR YTSCRLALLS VLRSWTGTLE
310 320 330 340 350
FCDPSKPSGL KAIVDALYLN QIEVRKAILD LLYELLTLPQ PTWTDDYAVA
360 370 380 390 400
LQAVDPSDFQ DTWLLSNGFV SAEGRSILPT LAARAPSVVE QHLALMLYCF
410 420 430 440 450
LETGLLNALV EVVVSSDQFV SVQATVLIGK ILQLMHTHLP PDICCTSPAL
460 470 480 490 500
PTLVSHATLG NQQANAAVAA LQNYQKLLRQ RPASRSLFLD SIIQGGALIQ
510 520 530 540 550
TRLFRRHLNV QEQAGPVLQL QETAEAAAFA VPPVTQFRGT LDRSRLDSVS
560 570 580 590 600
SSDESNSQAS TSSRSSFRLK RKFLPQALYD NFRAFNRLLT DSRVLSQADA
610 620 630 640 650
HLWDWDVITT ILKSNLIRKL DYTQGKFLKR LVDFYKPRNN RFSHQDLVPG
660 670 680 690 700
QRLPTYVSAG LDLIDVLLSS NELECMRFIT DYFSDISQQL AAVTTSNRAH
710 720 730 740 750
DCLFSPQHMN NTMCQQYFLY IGRMCRTVKG IEVLKNTTVF EYLINLVRVT
760 770 780 790 800
DHVCYVKLIV SGLNYSYEKL PRQVLEKALT SAKTRGRLYS TQFMAVLLRA
810 820 830 840 850
RLPHFEVWGI PLIINQTRDS DRSVGLAAMD VLEEACHDKY YLEEIVSRWP
860 870 880 890 900
NLTHRGDAGR LLMARYYSLP RGLNSTMARI EDEIRYWRNG YNKRYVLLVE
910 920 930 940 950
ADTHSSLTLH IRNEDGYYSR RNCNQRPQTV PPNVAPHLYG QMAQTGQGMT
960 970 980 990 1000
ALRKHGDLPQ LLELLRRAKC TDDAECLELK AAIWALAHAS THSNGIEYFV
1010 1020 1030 1040 1050
ELNARLYEKL IVLVTKCEVY SVRATCFSAL GLIAGTQAGA NILFKLNWLS
1060 1070 1080 1090 1100
VRHDKNTMWP VHQPEDWMSS QYTPVRHYYE DVPADNMTMM DDYIERFYET
1110 1120 1130 1140 1150
GSDFWHMLAD QTDASGGGGG VAGTVVGMHP IVQDPNATIT TTDSVRTTTD
1160 1170 1180 1190 1200
DVHPRMLVGV AAKSKTLPEG SNLRQGKHQR SLSESKTTDV ISLLGSGVGT
1210 1220 1230 1240 1250
MSGAVLYPTP YQHRIRYNSC TDSNTSGVSS CESVTGRTAA AYAAAANELQ
1260 1270 1280 1290 1300
QFPLSPIPSM SNLLESDELF RRNQLATSML PSTLSPMAMK GYVQLRSLRK
1310 1320 1330 1340 1350
HSRPVFSESS AEFYDFAEIL DTPEVQMRKL DWTHSHRRLK VRSLDRQLSD
1360 1370 1380 1390 1400
VYRRLSADEL NVLLPTLNAP KFLPPNDLKG PCYAGICLPK NVLDLFPTRN
1410 1420 1430 1440 1450
LSRTYVSRDI QDQDIVGINL LNTMLRPQCL NDSLTNEGGD ESSVISSLSD
1460 1470 1480 1490 1500
VSSASRRQTR QLQQGAKHSR SLCLHCARSP RQQRNDSGSH SNGGGGASLA
1510 1520 1530 1540 1550
PCELYSSAAA ALVAAGIQAG PVLAKKSGSS AQGASAALGA DISFHSPESM
1560 1570 1580 1590 1600
LSEDSLPDRL TASILYNVQR LANPVSAKQS KMALLELKQK HPHAFQDICL
1610 1620 1630 1640 1650
YSEACKTIGR SSYRMIARRF LQELFLDLNF DSFYVEPQLI IGARKFSAEE
1660 1670 1680 1690 1700
KAEATAPTAM QAMPFKQTIL KPKPAAQLAS VYETSWENLL MDQSPRINKS
1710 1720 1730 1740 1750
SPADQPANAQ TKAKARNQLH IDDTESSLSS TDGENDSGED VCDGSGAGTQ
1760 1770 1780 1790 1800
ASSVTTAHTA LPTGNSNRSS IGTCTASQLV PGAATSNSAG AGTSASDNAS
1810 1820 1830 1840 1850
TSLKNENRQF TRGRFYTLEL DLSCTKNKFP IKNRSQRTPT PPPIESLIES
1860 1870 1880 1890 1900
KPTVQTDVNT SALPIMQRTG GSNDSSSALR YSTVTKSLSA SMARPVGSLY
1910 1920 1930
CEKRLQSSKS EAVLDEVAKA RRASGGVGLT TVRDNS
Length:1,936
Mass (Da):214,503
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49789D604233D1DA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JL73X2JL73_DROME
Rapamycin-insensitive companion of ...
rictor 8002, Dmel\CG8002, dRic, dRICTOR, dRictor
1,916Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JFR5X2JFR5_DROME
Rapamycin-insensitive companion of ...
rictor 8002, Dmel\CG8002, dRic, dRICTOR, dRictor
1,924Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48942.2
BT057984 mRNA Translation: ACM16694.1

NCBI Reference Sequences

More...
RefSeqi
NP_573371.1, NM_133143.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0074689; FBpp0074458; FBgn0031006

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32919

UCSC genome browser

More...
UCSCi
CG8002-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48942.2
BT057984 mRNA Translation: ACM16694.1
RefSeqiNP_573371.1, NM_133143.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0074458

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
32919

Genome annotation databases

EnsemblMetazoaiFBtr0074689; FBpp0074458; FBgn0031006
GeneIDi32919
UCSCiCG8002-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
253260
FlyBaseiFBgn0031006, rictor

Phylogenomic databases

eggNOGiKOG3694, Eukaryota
GeneTreeiENSGT00390000002096
OrthoDBi128601at2759

Enzyme and pathway databases

ReactomeiR-DME-1257604, PIP3 activates AKT signaling
R-DME-389357, CD28 dependent PI3K/Akt signaling
R-DME-5218920, VEGFR2 mediated vascular permeability

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
32919, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32919

Gene expression databases

BgeeiFBgn0031006, Expressed in female gonad and 36 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR028268, Pianissimo_fam
IPR028267, Pianissimo_N
IPR029453, Rictor_IV
IPR029451, RICTOR_M
IPR029452, RICTOR_V
PANTHERiPTHR13298, PTHR13298, 1 hit
PfamiView protein in Pfam
PF14663, RasGEF_N_2, 1 hit
PF14666, RICTOR_M, 1 hit
PF14664, RICTOR_N, 1 hit
PF14668, RICTOR_V, 1 hit
SMARTiView protein in SMART
SM01307, RICTOR_M, 1 hit
SM01308, RICTOR_N, 1 hit
SM01310, RICTOR_V, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VWJ6_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VWJ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: June 2, 2021
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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