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Entry version 152 (02 Dec 2020)
Sequence version 2 (01 Oct 2002)
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Protein

Tectonin beta-propeller repeat-containing protein

Gene

Pex23

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in peroxisome biogenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeroxisome biogenesis
LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tectonin beta-propeller repeat-containing protein
Alternative name(s):
Peroxin-23 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pex23
ORF Names:CG32226
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0052226, Pex23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003370651 – 1350Tectonin beta-propeller repeat-containing proteinAdd BLAST1350

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VWB0

PRoteomics IDEntifications database

More...
PRIDEi
Q9VWB0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0052226, Expressed in oocyte and 37 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VWB0, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
65492, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VWB0, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0074615

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VWB0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati23 – 59TECPR 1Add BLAST37
Repeati233 – 271TECPR 2Add BLAST39
Repeati280 – 320TECPR 3Add BLAST41
Repeati336 – 371TECPR 4Add BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini816 – 955GalectinPROSITE-ProRule annotationAdd BLAST140
Repeati966 – 1000TECPR 5Add BLAST35
Repeati1187 – 1223TECPR 6Add BLAST37
Repeati1232 – 1269TECPR 7Add BLAST38
Repeati1278 – 1322TECPR 8Add BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1114 – 1117Poly-Arg4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TECPR1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3587, Eukaryota
KOG3669, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047886

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008303_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VWB0

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAWQWDG

Database of Orthologous Groups

More...
OrthoDBi
119234at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VWB0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00070, GLECT, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006624, Beta-propeller_rpt_TECPR
IPR013320, ConA-like_dom_sf
IPR001079, Galectin_CRD
IPR010482, Peroxin
IPR006614, Peroxin/Ferlin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00337, Gal-bind_lectin, 1 hit
PF06462, Hyd_WA, 2 hits
PF06398, Pex24p, 1 hit
PF19193, Tectonin, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00694, DysFC, 2 hits
SM00693, DysFN, 2 hits
SM00908, Gal-bind_lectin, 1 hit
SM00276, GLECT, 1 hit
SM00706, TECPR, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51304, GALECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VWB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSFYLFAAS SEGRVYTLST NSGAWRELPY LGLEFKKICA VPNFLWAIGG
60 70 80 90 100
DRQVYVHVHG LDVPIRIREE SYENERWLPI EGFSKTLLPT DRYRYSSADG
110 120 130 140 150
SVERGVDKIR LPSMAWQWDG DWHLDLELDG QPLTEDGWMY ALDFPATYSA
160 170 180 190 200
KKSWNSYVRR RKWVRYRRYA ALNSWCAVAP LHKDPTQEPF IDVAIGGTCV
210 220 230 240 250
PNAPAGTLCV WAITAHGRAM FRTGVSKTAP EGLRWTAVPT PTGSELAQIS
260 270 280 290 300
VGPTGLVWAV LHNGRVIVRT GVTRDNLVGD SWLDVKTPVA ASSLRIVHVS
310 320 330 340 350
VGTDAVWCVT NDHHAWFRRG VKGEAAGISE DSAIGKGWVE MVGNISMVSV
360 370 380 390 400
AANDQVFAIG AADRCLYHRS GVTSADPTGK KWRLIQCPMQ ISRTSSSLSI
410 420 430 440 450
VSRKSGGSSS TPGSKHQSFS NLYSKEKEKG VVETCAVIET VLNSSTGSCS
460 470 480 490 500
SNGGPPGLLK NERWKLSADS PPTIGSLNLN DRHKQRTAAL RETSHASSAP
510 520 530 540 550
AADVVEVVTG KFETQLRNPR AWSPVRSVGS VVGTEAHPES DSTVFESDST
560 570 580 590 600
HHGSDVFLGE DDDHTGSQFW TECGILWSCV ASGAVTVDAS NMPNWFNEQT
610 620 630 640 650
SDSKVDVNAN WRKDIVNKLQ RRQEKLAKLQ TVAKFEKAVE LSSWVKSADA
660 670 680 690 700
RYQRPGGEFE DCIIELEWVS SGSGTDTNSS ENSRSGDSGT FTVLSPDGAA
710 720 730 740 750
TKIQFPLSDI TCVQCCSEAG APRIAIHAPH LPVNCSPVKL QFSSDSEMED
760 770 780 790 800
WLSHLSSVCS QINTMVGKPA GNAIWITSEL GDVFVFDPAN MKAHQTSEPS
810 820 830 840 850
EGYVEKMDVS TCETPYYNTL YNGMPCGTEL EISGCVYDDA DQIRFDLQSH
860 870 880 890 900
SAVKVQPHRV EKHRVIALHL NPRFNERTTV LNSMKESEWL DEIRNDKMAF
910 920 930 940 950
APGATFSLKI RALQDHYLII VNNAVYTDYK YRIDPESVTR LYVSGRIKLF
960 970 980 990 1000
NVLYRCPSLI VSMERMHWRQ MGGHIKRIFN SGVDVVWGIS CDNTGWVYNG
1010 1020 1030 1040 1050
GWGGMFLKGL EGSGKINPMI DTHTYYVYEN QRWNPISGFT AKSLPTDRHM
1060 1070 1080 1090 1100
WSDATGRQKR SKEHTKLLST HCEWISDWAI DYNIPGGADK EGWQYAIDFP
1110 1120 1130 1140 1150
ANYHAHKKLT DCVRRRRWMK RCRLSSSGPW QELSQSKILD AALQVLDEDV
1160 1170 1180 1190 1200
DHSCSGERNT AVAAWAIASN GDVLIRHGVC SLNPRGDAWE HITSDQPLVG
1210 1220 1230 1240 1250
ISVGPTGQVW TVARNGMVFF RYGISRQNPC GDAWQQVEAP AGVTFKAISV
1260 1270 1280 1290 1300
GRAGIWALDN QQRLAVRKEI SRTFPEGSHW QFLPNAANVP PHTDQHCGFR
1310 1320 1330 1340 1350
SVSVGSEVWA ISLNGIICRR CGITEENPAG VGWNLGIAGQ WQNVSVEGYM
Length:1,350
Mass (Da):149,486
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC90308E58320BD4B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ACZ54681 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49038.2
BT100319 mRNA Translation: ACZ54681.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_730508.1, NM_168841.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0074846; FBpp0074615; FBgn0052226

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40229

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG32226

UCSC genome browser

More...
UCSCi
CG32226-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49038.2
BT100319 mRNA Translation: ACZ54681.1 Different initiation.
RefSeqiNP_730508.1, NM_168841.2

3D structure databases

SMRiQ9VWB0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi65492, 3 interactors
IntActiQ9VWB0, 3 interactors
STRINGi7227.FBpp0074615

Proteomic databases

PaxDbiQ9VWB0
PRIDEiQ9VWB0

Genome annotation databases

EnsemblMetazoaiFBtr0074846; FBpp0074615; FBgn0052226
GeneIDi40229
KEGGidme:Dmel_CG32226
UCSCiCG32226-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
40229
FlyBaseiFBgn0052226, Pex23

Phylogenomic databases

eggNOGiKOG3587, Eukaryota
KOG3669, Eukaryota
GeneTreeiENSGT00510000047886
HOGENOMiCLU_008303_0_0_1
InParanoidiQ9VWB0
OMAiMAWQWDG
OrthoDBi119234at2759
PhylomeDBiQ9VWB0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
40229, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40229

Protein Ontology

More...
PROi
PR:Q9VWB0

Gene expression databases

BgeeiFBgn0052226, Expressed in oocyte and 37 other tissues
GenevisibleiQ9VWB0, DM

Family and domain databases

CDDicd00070, GLECT, 1 hit
InterProiView protein in InterPro
IPR006624, Beta-propeller_rpt_TECPR
IPR013320, ConA-like_dom_sf
IPR001079, Galectin_CRD
IPR010482, Peroxin
IPR006614, Peroxin/Ferlin
PfamiView protein in Pfam
PF00337, Gal-bind_lectin, 1 hit
PF06462, Hyd_WA, 2 hits
PF06398, Pex24p, 1 hit
PF19193, Tectonin, 3 hits
SMARTiView protein in SMART
SM00694, DysFC, 2 hits
SM00693, DysFN, 2 hits
SM00908, Gal-bind_lectin, 1 hit
SM00276, GLECT, 1 hit
SM00706, TECPR, 8 hits
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304, GALECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTECPR_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VWB0
Secondary accession number(s): D0Z772
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2002
Last modified: December 2, 2020
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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