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UniProtKB - Q9VWB0 (TECPR_DROME)

Entry version 152 (02 Dec 2020)
Sequence version 2 (01 Oct 2002)
Previous versions | rss
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Protein

Tectonin beta-propeller repeat-containing protein

Gene

Pex23

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in peroxisome biogenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeroxisome biogenesis
LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tectonin beta-propeller repeat-containing protein
Alternative name(s):
Peroxin-23 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pex23
ORF Names:CG32226
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0052226, Pex23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003370651 – 1350Tectonin beta-propeller repeat-containing proteinAdd BLAST1350

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9VWB0

PRoteomics IDEntifications database

More...PRIDEi		Q9VWB0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0052226, Expressed in oocyte and 37 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9VWB0, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		65492, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q9VWB0, 3 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0074615

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VWB0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati23 – 59TECPR 1Add BLAST37
Repeati233 – 271TECPR 2Add BLAST39
Repeati280 – 320TECPR 3Add BLAST41
Repeati336 – 371TECPR 4Add BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini816 – 955GalectinPROSITE-ProRule annotationAdd BLAST140
Repeati966 – 1000TECPR 5Add BLAST35
Repeati1187 – 1223TECPR 6Add BLAST37
Repeati1232 – 1269TECPR 7Add BLAST38
Repeati1278 – 1322TECPR 8Add BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1114 – 1117Poly-Arg4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TECPR1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3587, Eukaryota
KOG3669, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000047886

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008303_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9VWB0

Identification of Orthologs from Complete Genome Data

More...OMAi		MAWQWDG

Database of Orthologous Groups

More...OrthoDBi		119234at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9VWB0

Family and domain databases

Conserved Domains Database

More...CDDi		cd00070, GLECT, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006624, Beta-propeller_rpt_TECPR
IPR013320, ConA-like_dom_sf
IPR001079, Galectin_CRD
IPR010482, Peroxin
IPR006614, Peroxin/Ferlin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00337, Gal-bind_lectin, 1 hit
PF06462, Hyd_WA, 2 hits
PF06398, Pex24p, 1 hit
PF19193, Tectonin, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00694, DysFC, 2 hits
SM00693, DysFN, 2 hits
SM00908, Gal-bind_lectin, 1 hit
SM00276, GLECT, 1 hit
SM00706, TECPR, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51304, GALECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VWB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSFYLFAAS SEGRVYTLST NSGAWRELPY LGLEFKKICA VPNFLWAIGG 
        60         70         80         90        100
DRQVYVHVHG LDVPIRIREE SYENERWLPI EGFSKTLLPT DRYRYSSADG 
       110        120        130        140        150
SVERGVDKIR LPSMAWQWDG DWHLDLELDG QPLTEDGWMY ALDFPATYSA 
       160        170        180        190        200
KKSWNSYVRR RKWVRYRRYA ALNSWCAVAP LHKDPTQEPF IDVAIGGTCV 
       210        220        230        240        250
PNAPAGTLCV WAITAHGRAM FRTGVSKTAP EGLRWTAVPT PTGSELAQIS 
       260        270        280        290        300
VGPTGLVWAV LHNGRVIVRT GVTRDNLVGD SWLDVKTPVA ASSLRIVHVS 
       310        320        330        340        350
VGTDAVWCVT NDHHAWFRRG VKGEAAGISE DSAIGKGWVE MVGNISMVSV 
       360        370        380        390        400
AANDQVFAIG AADRCLYHRS GVTSADPTGK KWRLIQCPMQ ISRTSSSLSI 
       410        420        430        440        450
VSRKSGGSSS TPGSKHQSFS NLYSKEKEKG VVETCAVIET VLNSSTGSCS 
       460        470        480        490        500
SNGGPPGLLK NERWKLSADS PPTIGSLNLN DRHKQRTAAL RETSHASSAP 
       510        520        530        540        550
AADVVEVVTG KFETQLRNPR AWSPVRSVGS VVGTEAHPES DSTVFESDST 
       560        570        580        590        600
HHGSDVFLGE DDDHTGSQFW TECGILWSCV ASGAVTVDAS NMPNWFNEQT 
       610        620        630        640        650
SDSKVDVNAN WRKDIVNKLQ RRQEKLAKLQ TVAKFEKAVE LSSWVKSADA 
       660        670        680        690        700
RYQRPGGEFE DCIIELEWVS SGSGTDTNSS ENSRSGDSGT FTVLSPDGAA 
       710        720        730        740        750
TKIQFPLSDI TCVQCCSEAG APRIAIHAPH LPVNCSPVKL QFSSDSEMED 
       760        770        780        790        800
WLSHLSSVCS QINTMVGKPA GNAIWITSEL GDVFVFDPAN MKAHQTSEPS 
       810        820        830        840        850
EGYVEKMDVS TCETPYYNTL YNGMPCGTEL EISGCVYDDA DQIRFDLQSH 
       860        870        880        890        900
SAVKVQPHRV EKHRVIALHL NPRFNERTTV LNSMKESEWL DEIRNDKMAF 
       910        920        930        940        950
APGATFSLKI RALQDHYLII VNNAVYTDYK YRIDPESVTR LYVSGRIKLF 
       960        970        980        990       1000
NVLYRCPSLI VSMERMHWRQ MGGHIKRIFN SGVDVVWGIS CDNTGWVYNG 
      1010       1020       1030       1040       1050
GWGGMFLKGL EGSGKINPMI DTHTYYVYEN QRWNPISGFT AKSLPTDRHM 
      1060       1070       1080       1090       1100
WSDATGRQKR SKEHTKLLST HCEWISDWAI DYNIPGGADK EGWQYAIDFP 
      1110       1120       1130       1140       1150
ANYHAHKKLT DCVRRRRWMK RCRLSSSGPW QELSQSKILD AALQVLDEDV 
      1160       1170       1180       1190       1200
DHSCSGERNT AVAAWAIASN GDVLIRHGVC SLNPRGDAWE HITSDQPLVG 
      1210       1220       1230       1240       1250
ISVGPTGQVW TVARNGMVFF RYGISRQNPC GDAWQQVEAP AGVTFKAISV 
      1260       1270       1280       1290       1300
GRAGIWALDN QQRLAVRKEI SRTFPEGSHW QFLPNAANVP PHTDQHCGFR 
      1310       1320       1330       1340       1350
SVSVGSEVWA ISLNGIICRR CGITEENPAG VGWNLGIAGQ WQNVSVEGYM
Length:1,350
Mass (Da):149,486
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC90308E58320BD4B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ACZ54681 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49038.2
BT100319 mRNA Translation: ACZ54681.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_730508.1, NM_168841.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0074846; FBpp0074615; FBgn0052226

Database of genes from NCBI RefSeq genomes

More...GeneIDi		40229

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG32226

UCSC genome browser

More...UCSCi		CG32226-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49038.2
BT100319 mRNA Translation: ACZ54681.1 Different initiation.
RefSeqiNP_730508.1, NM_168841.2

3D structure databases

SMRiQ9VWB0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi65492, 3 interactors
IntActiQ9VWB0, 3 interactors
STRINGi7227.FBpp0074615

Proteomic databases

PaxDbiQ9VWB0
PRIDEiQ9VWB0

Genome annotation databases

EnsemblMetazoaiFBtr0074846; FBpp0074615; FBgn0052226
GeneIDi40229
KEGGidme:Dmel_CG32226
UCSCiCG32226-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		40229
FlyBaseiFBgn0052226, Pex23

Phylogenomic databases

eggNOGiKOG3587, Eukaryota
KOG3669, Eukaryota
GeneTreeiENSGT00510000047886
HOGENOMiCLU_008303_0_0_1
InParanoidiQ9VWB0
OMAiMAWQWDG
OrthoDBi119234at2759
PhylomeDBiQ9VWB0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		40229, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		40229

Protein Ontology

More...PROi		PR:Q9VWB0

Gene expression databases

BgeeiFBgn0052226, Expressed in oocyte and 37 other tissues
GenevisibleiQ9VWB0, DM

Family and domain databases

CDDicd00070, GLECT, 1 hit
InterProiView protein in InterPro
IPR006624, Beta-propeller_rpt_TECPR
IPR013320, ConA-like_dom_sf
IPR001079, Galectin_CRD
IPR010482, Peroxin
IPR006614, Peroxin/Ferlin
PfamiView protein in Pfam
PF00337, Gal-bind_lectin, 1 hit
PF06462, Hyd_WA, 2 hits
PF06398, Pex24p, 1 hit
PF19193, Tectonin, 3 hits
SMARTiView protein in SMART
SM00694, DysFC, 2 hits
SM00693, DysFN, 2 hits
SM00908, Gal-bind_lectin, 1 hit
SM00276, GLECT, 1 hit
SM00706, TECPR, 8 hits
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304, GALECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTECPR_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VWB0
Secondary accession number(s): D0Z772
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2002
Last modified: December 2, 2020
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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