UniProtKB - Q9VWB0 (TECPR_DROME)
Protein
Tectonin beta-propeller repeat-containing protein
Gene
Pex23
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Involved in peroxisome biogenesis.1 Publication
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- phosphatidylinositol-3-phosphate binding Source: GO_Central
GO - Biological processi
- peroxisome organization Source: UniProtKB-KW
Keywordsi
Biological process | Peroxisome biogenesis |
Ligand | Lectin |
Names & Taxonomyi
Protein namesi | Recommended name: Tectonin beta-propeller repeat-containing proteinAlternative name(s): Peroxin-23 protein |
Gene namesi | Name:Pex23 ORF Names:CG32226 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0052226, Pex23 |
Subcellular locationi
Lysosome
- lysosomal membrane Source: GO_Central
Other locations
- autophagosome membrane Source: GO_Central
- integral component of membrane Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337065 | 1 – 1350 | Tectonin beta-propeller repeat-containing proteinAdd BLAST | 1350 |
Proteomic databases
PaxDbi | Q9VWB0 |
PRIDEi | Q9VWB0 |
Expressioni
Gene expression databases
Bgeei | FBgn0052226, Expressed in oocyte and 37 other tissues |
Genevisiblei | Q9VWB0, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 65492, 3 interactors |
IntActi | Q9VWB0, 3 interactors |
STRINGi | 7227.FBpp0074615 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 23 – 59 | TECPR 1Add BLAST | 37 | |
Repeati | 233 – 271 | TECPR 2Add BLAST | 39 | |
Repeati | 280 – 320 | TECPR 3Add BLAST | 41 | |
Repeati | 336 – 371 | TECPR 4Add BLAST | 36 | |
Domaini | 816 – 955 | GalectinPROSITE-ProRule annotationAdd BLAST | 140 | |
Repeati | 966 – 1000 | TECPR 5Add BLAST | 35 | |
Repeati | 1187 – 1223 | TECPR 6Add BLAST | 37 | |
Repeati | 1232 – 1269 | TECPR 7Add BLAST | 38 | |
Repeati | 1278 – 1322 | TECPR 8Add BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1114 – 1117 | Poly-Arg | 4 |
Sequence similaritiesi
Belongs to the TECPR1 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3587, Eukaryota KOG3669, Eukaryota |
GeneTreei | ENSGT00510000047886 |
HOGENOMi | CLU_008303_0_0_1 |
InParanoidi | Q9VWB0 |
OMAi | MAWQWDG |
OrthoDBi | 119234at2759 |
PhylomeDBi | Q9VWB0 |
Family and domain databases
CDDi | cd00070, GLECT, 1 hit |
InterProi | View protein in InterPro IPR006624, Beta-propeller_rpt_TECPR IPR013320, ConA-like_dom_sf IPR001079, Galectin_CRD IPR010482, Peroxin IPR006614, Peroxin/Ferlin |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 1 hit PF06462, Hyd_WA, 2 hits PF06398, Pex24p, 1 hit PF19193, Tectonin, 3 hits |
SMARTi | View protein in SMART SM00694, DysFC, 2 hits SM00693, DysFN, 2 hits SM00908, Gal-bind_lectin, 1 hit SM00276, GLECT, 1 hit SM00706, TECPR, 8 hits |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VWB0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSFYLFAAS SEGRVYTLST NSGAWRELPY LGLEFKKICA VPNFLWAIGG
60 70 80 90 100
DRQVYVHVHG LDVPIRIREE SYENERWLPI EGFSKTLLPT DRYRYSSADG
110 120 130 140 150
SVERGVDKIR LPSMAWQWDG DWHLDLELDG QPLTEDGWMY ALDFPATYSA
160 170 180 190 200
KKSWNSYVRR RKWVRYRRYA ALNSWCAVAP LHKDPTQEPF IDVAIGGTCV
210 220 230 240 250
PNAPAGTLCV WAITAHGRAM FRTGVSKTAP EGLRWTAVPT PTGSELAQIS
260 270 280 290 300
VGPTGLVWAV LHNGRVIVRT GVTRDNLVGD SWLDVKTPVA ASSLRIVHVS
310 320 330 340 350
VGTDAVWCVT NDHHAWFRRG VKGEAAGISE DSAIGKGWVE MVGNISMVSV
360 370 380 390 400
AANDQVFAIG AADRCLYHRS GVTSADPTGK KWRLIQCPMQ ISRTSSSLSI
410 420 430 440 450
VSRKSGGSSS TPGSKHQSFS NLYSKEKEKG VVETCAVIET VLNSSTGSCS
460 470 480 490 500
SNGGPPGLLK NERWKLSADS PPTIGSLNLN DRHKQRTAAL RETSHASSAP
510 520 530 540 550
AADVVEVVTG KFETQLRNPR AWSPVRSVGS VVGTEAHPES DSTVFESDST
560 570 580 590 600
HHGSDVFLGE DDDHTGSQFW TECGILWSCV ASGAVTVDAS NMPNWFNEQT
610 620 630 640 650
SDSKVDVNAN WRKDIVNKLQ RRQEKLAKLQ TVAKFEKAVE LSSWVKSADA
660 670 680 690 700
RYQRPGGEFE DCIIELEWVS SGSGTDTNSS ENSRSGDSGT FTVLSPDGAA
710 720 730 740 750
TKIQFPLSDI TCVQCCSEAG APRIAIHAPH LPVNCSPVKL QFSSDSEMED
760 770 780 790 800
WLSHLSSVCS QINTMVGKPA GNAIWITSEL GDVFVFDPAN MKAHQTSEPS
810 820 830 840 850
EGYVEKMDVS TCETPYYNTL YNGMPCGTEL EISGCVYDDA DQIRFDLQSH
860 870 880 890 900
SAVKVQPHRV EKHRVIALHL NPRFNERTTV LNSMKESEWL DEIRNDKMAF
910 920 930 940 950
APGATFSLKI RALQDHYLII VNNAVYTDYK YRIDPESVTR LYVSGRIKLF
960 970 980 990 1000
NVLYRCPSLI VSMERMHWRQ MGGHIKRIFN SGVDVVWGIS CDNTGWVYNG
1010 1020 1030 1040 1050
GWGGMFLKGL EGSGKINPMI DTHTYYVYEN QRWNPISGFT AKSLPTDRHM
1060 1070 1080 1090 1100
WSDATGRQKR SKEHTKLLST HCEWISDWAI DYNIPGGADK EGWQYAIDFP
1110 1120 1130 1140 1150
ANYHAHKKLT DCVRRRRWMK RCRLSSSGPW QELSQSKILD AALQVLDEDV
1160 1170 1180 1190 1200
DHSCSGERNT AVAAWAIASN GDVLIRHGVC SLNPRGDAWE HITSDQPLVG
1210 1220 1230 1240 1250
ISVGPTGQVW TVARNGMVFF RYGISRQNPC GDAWQQVEAP AGVTFKAISV
1260 1270 1280 1290 1300
GRAGIWALDN QQRLAVRKEI SRTFPEGSHW QFLPNAANVP PHTDQHCGFR
1310 1320 1330 1340 1350
SVSVGSEVWA ISLNGIICRR CGITEENPAG VGWNLGIAGQ WQNVSVEGYM
Sequence cautioni
The sequence ACZ54681 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF49038.2 BT100319 mRNA Translation: ACZ54681.1 Different initiation. |
RefSeqi | NP_730508.1, NM_168841.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0074846; FBpp0074615; FBgn0052226 |
GeneIDi | 40229 |
KEGGi | dme:Dmel_CG32226 |
UCSCi | CG32226-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF49038.2 BT100319 mRNA Translation: ACZ54681.1 Different initiation. |
RefSeqi | NP_730508.1, NM_168841.2 |
3D structure databases
SMRi | Q9VWB0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 65492, 3 interactors |
IntActi | Q9VWB0, 3 interactors |
STRINGi | 7227.FBpp0074615 |
Proteomic databases
PaxDbi | Q9VWB0 |
PRIDEi | Q9VWB0 |
Genome annotation databases
EnsemblMetazoai | FBtr0074846; FBpp0074615; FBgn0052226 |
GeneIDi | 40229 |
KEGGi | dme:Dmel_CG32226 |
UCSCi | CG32226-RA, d. melanogaster |
Organism-specific databases
CTDi | 40229 |
FlyBasei | FBgn0052226, Pex23 |
Phylogenomic databases
eggNOGi | KOG3587, Eukaryota KOG3669, Eukaryota |
GeneTreei | ENSGT00510000047886 |
HOGENOMi | CLU_008303_0_0_1 |
InParanoidi | Q9VWB0 |
OMAi | MAWQWDG |
OrthoDBi | 119234at2759 |
PhylomeDBi | Q9VWB0 |
Miscellaneous databases
BioGRID-ORCSi | 40229, 0 hits in 1 CRISPR screen |
GenomeRNAii | 40229 |
PROi | PR:Q9VWB0 |
Gene expression databases
Bgeei | FBgn0052226, Expressed in oocyte and 37 other tissues |
Genevisiblei | Q9VWB0, DM |
Family and domain databases
CDDi | cd00070, GLECT, 1 hit |
InterProi | View protein in InterPro IPR006624, Beta-propeller_rpt_TECPR IPR013320, ConA-like_dom_sf IPR001079, Galectin_CRD IPR010482, Peroxin IPR006614, Peroxin/Ferlin |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 1 hit PF06462, Hyd_WA, 2 hits PF06398, Pex24p, 1 hit PF19193, Tectonin, 3 hits |
SMARTi | View protein in SMART SM00694, DysFC, 2 hits SM00693, DysFN, 2 hits SM00908, Gal-bind_lectin, 1 hit SM00276, GLECT, 1 hit SM00706, TECPR, 8 hits |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TECPR_DROME | |
Accessioni | Q9VWB0Primary (citable) accession number: Q9VWB0 Secondary accession number(s): D0Z772 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families