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UniProtKB - Q9VW87 (SSK_DROME)
Protein
Protein snakeskin
Gene
Ssk
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Required for assembly of smooth septate junctions (sSJs), together with mesh and Tsp2A (PubMed:22854041, PubMed:26848177).
May be important for barrier function of the midgut epithelium.
1 PublicationGO - Biological processi
- anterior midgut development Source: FlyBase
- intestinal epithelial cell development Source: FlyBase
- septate junction assembly Source: FlyBase
Names & Taxonomyi
Protein namesi | Recommended name: Protein snakeskinCurated |
Gene namesi | Name:SskImported ORF Names:CG6981Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0036945, Ssk |
VEuPathDBi | VectorBase:FBgn0036945 |
Subcellular locationi
Plasma membrane
- Apicolateral cell membrane 3 Publications; Multi-pass membrane protein Sequence analysis
Other locations
- septate junction 3 Publications
Note: Specific to smooth septate junctions.1 Publication
Plasma Membrane
- apicolateral plasma membrane Source: FlyBase
- integral component of plasma membrane Source: FlyBase
Other locations
- smooth septate junction Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 6 | Cytoplasmic1 Publication | 5 | |
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 28 – 53 | Extracellular1 PublicationAdd BLAST | 26 | |
Transmembranei | 54 – 74 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 75 – 88 | Cytoplasmic1 PublicationAdd BLAST | 14 | |
Transmembranei | 89 – 109 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 110 – 128 | Extracellular1 PublicationAdd BLAST | 19 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 150 – 162 | Cytoplasmic1 PublicationAdd BLAST | 13 |
Keywords - Cellular componenti
Cell junction, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000437457 | 1 – 162 | Protein snakeskinAdd BLAST | 162 |
Proteomic databases
PaxDbi | Q9VW87 |
PRIDEi | Q9VW87 |
PTM databases
SwissPalmi | Q9VW87 |
Expressioni
Developmental stagei
Detected from embryonic stage 12 onwards in midgut and Malpighian tubules (at protein level) (PubMed:22328496, PubMed:22854041, PubMed:26848177). Also detected in the outer epithelial layer of the proventriculus in first instar larvae (at protein level) (PubMed:22854041).3 Publications
Gene expression databases
Bgeei | FBgn0036945, Expressed in digestive system element and 36 other tissues |
ExpressionAtlasi | Q9VW87, baseline and differential |
Interactioni
Subunit structurei
Protein-protein interaction databases
IntActi | Q9VW87, 11 interactors |
STRINGi | 7227.FBpp0074589 |
Structurei
3D structure databases
AlphaFoldDBi | Q9VW87 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZZJ, Eukaryota |
HOGENOMi | CLU_130085_0_0_1 |
InParanoidi | Q9VW87 |
OMAi | HYWHGYQ |
OrthoDBi | 1368396at2759 |
PhylomeDBi | Q9VW87 |
Family and domain databases
InterProi | View protein in InterPro IPR038976, Ssk |
PANTHERi | PTHR36692, PTHR36692, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VW87-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSVETVGSI FIKALKLIIN LVIIFLYRWG DGGEFLGIGG TWNLNEEKSA
60 70 80 90 100
DAEIVASGVM VGFLIYTGCH TIAFAFGTTK HKGELCDTIM NVVGCIMWIA
110 120 130 140 150
VGGVALHYWK GYMSDEGFLY VNSERQVGIA MGSLCVIEGA LYLLDTVLAC
160
IHYSKGDTDY TQ
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | T → A in ADE60669 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF49062.1 AE014296 Genomic DNA Translation: AAG22313.1 AY052037 mRNA Translation: AAK93461.1 BT122195 mRNA Translation: ADE60669.1 Sequence problems. |
RefSeqi | NP_649184.1, NM_140927.5 NP_730487.1, NM_168831.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0074820; FBpp0074589; FBgn0036945 FBtr0074821; FBpp0074590; FBgn0036945 |
GeneIDi | 40207 |
KEGGi | dme:Dmel_CG6981 |
UCSCi | CG6981-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF49062.1 AE014296 Genomic DNA Translation: AAG22313.1 AY052037 mRNA Translation: AAK93461.1 BT122195 mRNA Translation: ADE60669.1 Sequence problems. |
RefSeqi | NP_649184.1, NM_140927.5 NP_730487.1, NM_168831.3 |
3D structure databases
AlphaFoldDBi | Q9VW87 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9VW87, 11 interactors |
STRINGi | 7227.FBpp0074589 |
PTM databases
SwissPalmi | Q9VW87 |
Proteomic databases
PaxDbi | Q9VW87 |
PRIDEi | Q9VW87 |
Protocols and materials databases
DNASUi | 40207 |
Genome annotation databases
EnsemblMetazoai | FBtr0074820; FBpp0074589; FBgn0036945 FBtr0074821; FBpp0074590; FBgn0036945 |
GeneIDi | 40207 |
KEGGi | dme:Dmel_CG6981 |
UCSCi | CG6981-RA, d. melanogaster |
Organism-specific databases
CTDi | 40207 |
FlyBasei | FBgn0036945, Ssk |
VEuPathDBi | VectorBase:FBgn0036945 |
Phylogenomic databases
eggNOGi | ENOG502RZZJ, Eukaryota |
HOGENOMi | CLU_130085_0_0_1 |
InParanoidi | Q9VW87 |
OMAi | HYWHGYQ |
OrthoDBi | 1368396at2759 |
PhylomeDBi | Q9VW87 |
Miscellaneous databases
BioGRID-ORCSi | 40207, 0 hits in 1 CRISPR screen |
ChiTaRSi | Ssk, fly |
GenomeRNAii | 40207 |
PROi | PR:Q9VW87 |
Gene expression databases
Bgeei | FBgn0036945, Expressed in digestive system element and 36 other tissues |
ExpressionAtlasi | Q9VW87, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR038976, Ssk |
PANTHERi | PTHR36692, PTHR36692, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SSK_DROME | |
Accessioni | Q9VW87Primary (citable) accession number: Q9VW87 Secondary accession number(s): D5A7R8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 5, 2016 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase