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UniProtKB - Q9VW78 (Q9VW78_DROME)
Protein
Submitted name:
IP13856p
Gene
Ir76b
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- ligand-gated ion channel activity Source: FlyBase
- salty taste receptor activity Source: FlyBase
- signaling receptor activity Source: GO_Central
- sodium channel activity Source: FlyBase
GO - Biological processi
- cellular response to amino acid stimulus Source: FlyBase
- cellular response to salt Source: FlyBase
- detection of chemical stimulus Source: FlyBase
- detection of chemical stimulus involved in sensory perception of smell Source: FlyBase
- response to amino acid Source: FlyBase
- transmission of nerve impulse Source: FlyBase
Keywordsi
Molecular function | ReceptorImported |
Enzyme and pathway databases
Reactomei | R-DME-204005, COPII-mediated vesicle transport R-DME-399710, Activation of AMPA receptors R-DME-438066, Unblocking of NMDA receptors, glutamate binding and activation R-DME-451308, Activation of Ca-permeable Kainate Receptor R-DME-5694530, Cargo concentration in the ER |
Protein family/group databases
TCDBi | 1.A.10.1.17, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
Names & Taxonomyi
Protein namesi | Submitted name: IP13856pImportedSubmitted name: IP13956pImportedSubmitted name: Ionotropic receptor 76bImported |
Gene namesi | Name:Ir76bImported Synonyms:CT22733Imported, Dmel\CG7385Imported, DmelIR76bImported, IR76BImported, IR76bImported, ir76bImported ORF Names:CG7385Imported, Dmel_CG7385Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0036937, Ir76b |
VEuPathDBi | VectorBase:FBgn0036937 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: FlyBase
- receptor complex Source: FlyBase
- sensory dendrite Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 207 – 229 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 277 – 298 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 476 – 497 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_5015100753 | 17 – 636 | Sequence analysisAdd BLAST | 620 |
Interactioni
Protein-protein interaction databases
IntActi | Q9VW78, 3 interactors |
STRINGi | 7227.FBpp0074638 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 209 – 483 | PBPeInterPro annotationAdd BLAST | 275 |
Sequence similaritiesi
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]ARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG1052, Eukaryota |
GeneTreei | ENSGT00930000152474 |
HOGENOMi | CLU_025094_0_0_1 |
OMAi | QEANKWA |
OrthoDBi | 188544at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001320, Iontro_rcpt |
Pfami | View protein in Pfam PF00060, Lig_chan, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VW78-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATGIELLVA AALCVACPPL NDSPPTNLIQ MGENGTLSPV TELPMDVDAS
60 70 80 90 100
EAGFDADAPV ETLETINRKK PKLREMLDWI GGKHLRIATL EDFPLSYTEV
110 120 130 140 150
LENGTRVGHG VSFQIIDFLK KKFNFTYEVV VPQDNIIGSP SDFDRSLIEM
160 170 180 190 200
VNSSTVDLAA AFIPSLSDQR SFVYYSTTTL DEGEWIMVMQ RPRESASGSG
210 220 230 240 250
LLAPFEFWVW ILILVSLLAV GPIIYALIIL RNRLTGDGQQ TPYSLGHCAW
260 270 280 290 300
FVYGALMKQG STLSPIADST RLLFATWWIF ITILTSFYTA NLTAFLTLSK
310 320 330 340 350
FTLPYNTVND ILTKNKHFVS MRGGGVEYAI RTTNESLSML NRMIQNNYAV
360 370 380 390 400
FSDETNDTYN LQNYVEKNGY VFVRDRPAIN IMLYRDYLYR KTVSFSDEKV
410 420 430 440 450
HCPFAMAKEP FLKKKRTFAY PIGSNLSQLF DPELLHLVES GIVKHLSKRN
460 470 480 490 500
LPSAEICPQD LGGTERQLRN GDLMMTYYIM LAGFATALAV FSTELMFRYV
510 520 530 540 550
NSRQEANKWA RHGIGRTPNG QSVAPSRWLR GWRRLNSGHG QLLGASTHGQ
560 570 580 590 600
NVTPPPPYQS IFNGGSHGDP LNRWRRPLAN GNALGNGVLL GGDSEGGVRR
610 620 630
LINGRDYMVF RNPNGQSQLV PVRSPSAALF QYSYTE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF49071.1 BT022767 mRNA Translation: AAY55183.1 BT022775 mRNA Translation: AAY55191.1 HQ600589 mRNA Translation: ADU79033.1 |
RefSeqi | NP_649176.1, NM_140919.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0074869; FBpp0074638; FBgn0036937 |
GeneIDi | 40198 |
KEGGi | dme:Dmel_CG7385 |
UCSCi | CG7385-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF49071.1 BT022767 mRNA Translation: AAY55183.1 BT022775 mRNA Translation: AAY55191.1 HQ600589 mRNA Translation: ADU79033.1 |
RefSeqi | NP_649176.1, NM_140919.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9VW78, 3 interactors |
STRINGi | 7227.FBpp0074638 |
Protein family/group databases
TCDBi | 1.A.10.1.17, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
Protocols and materials databases
DNASUi | 40198 |
Genome annotation databases
EnsemblMetazoai | FBtr0074869; FBpp0074638; FBgn0036937 |
GeneIDi | 40198 |
KEGGi | dme:Dmel_CG7385 |
UCSCi | CG7385-RA, d. melanogaster |
Organism-specific databases
CTDi | 40198 |
FlyBasei | FBgn0036937, Ir76b |
VEuPathDBi | VectorBase:FBgn0036937 |
Phylogenomic databases
eggNOGi | KOG1052, Eukaryota |
GeneTreei | ENSGT00930000152474 |
HOGENOMi | CLU_025094_0_0_1 |
OMAi | QEANKWA |
OrthoDBi | 188544at2759 |
Enzyme and pathway databases
Reactomei | R-DME-204005, COPII-mediated vesicle transport R-DME-399710, Activation of AMPA receptors R-DME-438066, Unblocking of NMDA receptors, glutamate binding and activation R-DME-451308, Activation of Ca-permeable Kainate Receptor R-DME-5694530, Cargo concentration in the ER |
Miscellaneous databases
BioGRID-ORCSi | 40198, 0 hits in 1 CRISPR screen |
GenomeRNAii | 40198 |
Gene expression databases
Bgeei | FBgn0036937, Expressed in neuron and 11 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR001320, Iontro_rcpt |
Pfami | View protein in Pfam PF00060, Lig_chan, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VW78_DROME | |
Accessioni | Q9VW78Primary (citable) accession number: Q9VW78 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | January 19, 2022 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |