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Entry version 166 (08 May 2019)
Sequence version 3 (14 May 2014)
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Protein

Fat-like cadherin-related tumor suppressor homolog

Gene

kug

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells (PubMed:19906848, PubMed:23369713). Required for proper egg chamber shape and elongation of the egg chamber during oogenesis (PubMed:19906848, PubMed:23369713). Required for the correct planar polarization of Rab10 within the basal follicle cell epithelium and is therefore indirectly involved in the Rab10-dependent remodeling of the basal membrane during egg chamber elongation (PubMed:23369713).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fat-like cadherin-related tumor suppressor homolog
Alternative name(s):
Protein kugelei
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kug
Synonyms:fat2
ORF Names:CG7749
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261574 kug

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini39 – 4285ExtracellularSequence analysisAdd BLAST4247
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4286 – 4306HelicalSequence analysisAdd BLAST21
Topological domaini4307 – 4699CytoplasmicSequence analysisAdd BLAST393

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defects in actin filament orientation correlate with a failure of egg chambers to elongate during oogenesis (PubMed:19906848). In follicle cells, Rab10 protein polarizes normally along the apical-basal axis, but is mislocalized within the epithelial plane (PubMed:23369713). Epithelia migration is impaired and the structure of the basal membrane is disrupted (PubMed:23369713).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000401639 – 4699Fat-like cadherin-related tumor suppressor homologAdd BLAST4661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi782N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi846N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi926N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1442N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1476N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1514N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3807 ↔ 3819Sequence analysis
Disulfide bondi3814 ↔ 3851Sequence analysis
Disulfide bondi3853 ↔ 3862Sequence analysis
Disulfide bondi3869 ↔ 3880Sequence analysis
Disulfide bondi3874 ↔ 3891Sequence analysis
Disulfide bondi3893 ↔ 3902Sequence analysis
Disulfide bondi4071 ↔ 4105By similarity
Disulfide bondi4117 ↔ 4128Sequence analysis
Disulfide bondi4122 ↔ 4138Sequence analysis
Disulfide bondi4140 ↔ 4149Sequence analysis
Disulfide bondi4156 ↔ 4167Sequence analysis
Disulfide bondi4161 ↔ 4177Sequence analysis
Disulfide bondi4179 ↔ 4188Sequence analysis
Disulfide bondi4194 ↔ 4205By similarity
Disulfide bondi4199 ↔ 4214By similarity
Disulfide bondi4216 ↔ 4224By similarity
Disulfide bondi4231 ↔ 4242Sequence analysis
Disulfide bondi4236 ↔ 4251Sequence analysis
Disulfide bondi4253 ↔ 4262Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VW71

PRoteomics IDEntifications database

More...
PRIDEi
Q9VW71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Localizes where basal actin filaments terminate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261574 Expressed in 30 organ(s), highest expression level in eye disc (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VW71 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VW71 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
65458, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-24050N

Protein interaction database and analysis system

More...
IntActi
Q9VW71, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0304968

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VW71

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 183Cadherin 1PROSITE-ProRule annotationAdd BLAST121
Domaini184 – 291Cadherin 2PROSITE-ProRule annotationAdd BLAST108
Domaini288 – 400Cadherin 3PROSITE-ProRule annotationAdd BLAST113
Domaini401 – 507Cadherin 4PROSITE-ProRule annotationAdd BLAST107
Domaini508 – 613Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini614 – 716Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini773 – 877Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini878 – 980Cadherin 8PROSITE-ProRule annotationAdd BLAST103
Domaini981 – 1088Cadherin 9PROSITE-ProRule annotationAdd BLAST108
Domaini1089 – 1198Cadherin 10PROSITE-ProRule annotationAdd BLAST110
Domaini1194 – 1299Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1300 – 1405Cadherin 12PROSITE-ProRule annotationAdd BLAST106
Domaini1408 – 1506Cadherin 13PROSITE-ProRule annotationAdd BLAST99
Domaini1507 – 1612Cadherin 14PROSITE-ProRule annotationAdd BLAST106
Domaini1613 – 1717Cadherin 15PROSITE-ProRule annotationAdd BLAST105
Domaini1718 – 1815Cadherin 16PROSITE-ProRule annotationAdd BLAST98
Domaini1816 – 1932Cadherin 17PROSITE-ProRule annotationAdd BLAST117
Domaini1933 – 2033Cadherin 18PROSITE-ProRule annotationAdd BLAST101
Domaini2034 – 2140Cadherin 19PROSITE-ProRule annotationAdd BLAST107
Domaini2141 – 2241Cadherin 20PROSITE-ProRule annotationAdd BLAST101
Domaini2242 – 2341Cadherin 21PROSITE-ProRule annotationAdd BLAST100
Domaini2342 – 2449Cadherin 22PROSITE-ProRule annotationAdd BLAST108
Domaini2450 – 2551Cadherin 23PROSITE-ProRule annotationAdd BLAST102
Domaini2552 – 2654Cadherin 24PROSITE-ProRule annotationAdd BLAST103
Domaini2655 – 2763Cadherin 25PROSITE-ProRule annotationAdd BLAST109
Domaini2764 – 2860Cadherin 26PROSITE-ProRule annotationAdd BLAST97
Domaini2861 – 2967Cadherin 27PROSITE-ProRule annotationAdd BLAST107
Domaini2968 – 3072Cadherin 28PROSITE-ProRule annotationAdd BLAST105
Domaini3068 – 3169Cadherin 29PROSITE-ProRule annotationAdd BLAST102
Domaini3170 – 3273Cadherin 30PROSITE-ProRule annotationAdd BLAST104
Domaini3274 – 3378Cadherin 31PROSITE-ProRule annotationAdd BLAST105
Domaini3379 – 3483Cadherin 32PROSITE-ProRule annotationAdd BLAST105
Domaini3484 – 3588Cadherin 33PROSITE-ProRule annotationAdd BLAST105
Domaini3589 – 3696Cadherin 34PROSITE-ProRule annotationAdd BLAST108
Domaini3865 – 3903EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini3921 – 4105Laminin G-likePROSITE-ProRule annotationAdd BLAST185
Domaini4113 – 4150EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini4152 – 4189EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini4190 – 4225EGF-like 4PROSITE-ProRule annotationAdd BLAST36
Domaini4227 – 4263EGF-like 5PROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219 Eukaryota
ENOG410XPEI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166124

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VW71

KEGG Orthology (KO)

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KOi
K16506

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVFFGGH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 26 hits
PF02210 Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 34 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SM00282 LamG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 34 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 18 hits
PS50268 CADHERIN_2, 34 hits
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 1 hit
PS50025 LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform D (identifier: Q9VW71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFTMKIKKYV TPVKRKAFTI LQWISLLCSL WLIPTVQSKA DEKHTATLEY
60 70 80 90 100
RLENQLQDLY RFSHSVYNVT IPENSLGKTY AKGVLHERLA GLRVGLNAEV
110 120 130 140 150
KYRIISGDKE KLFKAEEKLV GDFAFLAIRT RTNNVVLNRE KTEEYVIRVK
160 170 180 190 200
AHVHLHDRNV SSYETEANIH IKVLDRNDLS PLFYPTQYTV VIPEDTPKYQ
210 220 230 240 250
SILKVTADDA DLGINGEIYY SLLMDSEYFA IHPTTGEITL LQQLQYAENS
260 270 280 290 300
HFELTVVAYD RGSWVNHQNH QASKTKVSIS VKQVNFYAPE IFTKTFSSVT
310 320 330 340 350
PTSNPLIYGI VRVNDKDTGI NGNIGRLEIV DGNPDGTFLL KAAETKDEYY
360 370 380 390 400
IELNQFAHLN QQHFIYNLTL LAEDLGTPRR FAYKSVPIQI KPESKNIPIF
410 420 430 440 450
TQEIYEVSIP ETAPINMPVI RLKVSDPDLG KNALVYLEIV GGNEGDEFRI
460 470 480 490 500
NPDSGMLYTA KQLDAEKKSS YTLTVSAIDQ ANVGSRKQSS AKVKISVQDM
510 520 530 540 550
NDNDPIFENV NKVISINENN LAGSFVVKLT AKDRDSGENS YISYSIANLN
560 570 580 590 600
AVPFEIDHFS GIVKTTSLLD FETMKRNYEL IIRASDWGLP YRRQTEIKLS
610 620 630 640 650
IVVKDINDNR PQFERVNCYG KVTKSAPMGT EVFVTSAIDF DAGDIISYRL
660 670 680 690 700
SDGNEDGCFN LDPTSGSLSI SCDLKKTTLT NRILKVSATD GTHFSDDLII
710 720 730 740 750
NVHLMPEDLG GDSSILHGFG SFECRETGVA RRLAETLSLA EKNNVKSASP
760 770 780 790 800
SVFSDLSLTP SRYGQNVHRP EFVNFPQELS INESVQLGET VAWIEAKDRD
810 820 830 840 850
LGYNGKLVFA ISDGDYDSVF RIDPDRGELQ IIGYLDRERQ NEYVLNITVY
860 870 880 890 900
DLGNPTKSTS KMLPITILDV NDNRPVIQKT LATFRLTESA RIGTVVHCLH
910 920 930 940 950
ATDADSGINA QVTYALSVEC SDFTVNATTG CLRLNKPLDR EKQDNYALHI
960 970 980 990 1000
TAKDGGSPVL SSEALVYVLV DDVNDNAPVF GVQEYIFKVR EDLPRGTVLA
1010 1020 1030 1040 1050
VIEAVDEDIG PNAEIQFSLK EETQDEELFR IDKHTGAIRT QGYLDYENKQ
1060 1070 1080 1090 1100
VHNLIVSAID GGDPSLTSDM SIVIMIIDVN ENRFAPEFDD FVYEGKVKEN
1110 1120 1130 1140 1150
KPKGTFVMNV TARDMDTVDL NSKITYSITG GDGLGIFAVN DQGSITSLSQ
1160 1170 1180 1190 1200
LDAETKNFYW LTLCAQDCAI VPLSNCVEVY IQVENENDNI PLTDKPVYYV
1210 1220 1230 1240 1250
NVTEASVENV EIITLKAFDP DIDPTQTITY NIVSGNLVGY FEIDSKTGVI
1260 1270 1280 1290 1300
KTTERKLDRE NQAEHILEVA ISDNGSPVLS STSRIVVSVL DINDNSPEFD
1310 1320 1330 1340 1350
QRVYKVQVPS SATVNQSIFQ VHAIDSDSGE NGRITYSIKS GKGKNKFRID
1360 1370 1380 1390 1400
SQRGHIHIAK PLDSDNEFEI HIKAEDNGIP KKSQTARVNI VVVPVNPNSQ
1410 1420 1430 1440 1450
NAPLIVRKTS ENVVDLTEND KPGFLVTQIL AVDDDNDQLW YNISNGNDDN
1460 1470 1480 1490 1500
TFYIGQDNGN ILLSKYLDYE TQQSYNLTIS VTDGTFTAFT NLLVQVIDIN
1510 1520 1530 1540 1550
DNPPQFAKDV YHVNISENIE EESVIMQLHA TDRDEDKKLF YHLHATQDPS
1560 1570 1580 1590 1600
SLALFRIDSI SGNVIVTQRL DFEKTAQHIL IVFVKDQGAP GKRNYAKIIV
1610 1620 1630 1640 1650
NVHDHNDHHP EFTAKIIQSK VPESAAIGSK LAEVRAIDRD SGHNAEIQYS
1660 1670 1680 1690 1700
IITGNVGSVF EIDPTFGIIT LAGNLNINKI QEYMLQVKAV DLGNPPLSSQ
1710 1720 1730 1740 1750
IPVHIIVTMS ENDPPKFPTN NIAIEIFENL PIGTFVTQVT ARSSSSIFFN
1760 1770 1780 1790 1800
IISGNINESF RINPSTGVIV INGNIDYESI KVFNLTVKGT NMAAESSCQN
1810 1820 1830 1840 1850
IIIHILDAND NIPYFVQNEY VGALPESAAI GSYVLKVHDS SKDHLTLQVK
1860 1870 1880 1890 1900
DADVGVNGMV EYHIVDDLAK NFFKIDSTTG AIELLRQLDY ETNAGYTFDV
1910 1920 1930 1940 1950
TVSDMGKPKL HSTTTAHVTI RVINVNDCPP VFNERELNVT LFLPTFENVF
1960 1970 1980 1990 2000
VRQVSAKDAD NDTLRFDIVD GNTNECFQIE KYTGIITTRN FEILNNENDR
2010 2020 2030 2040 2050
DYALHVRASD GIFSAILIVK IKVLSAIDSN FAFQRESYRF SAFENNTKVA
2060 2070 2080 2090 2100
TIGLVNVIGN TLDENVEYRI LNPTQLFDIG ISSGALKTTG VIFDREVKDL
2110 2120 2130 2140 2150
YRLFVEAKSM LYDGMNSNVR RAVTSIDISV LDVNDNCPLF VNMPYYATVS
2160 2170 2180 2190 2200
IDDPKGTIIM QVKAIDLDSA ENGEVRYELK KGNGELFKLD RKSGELSIKQ
2210 2220 2230 2240 2250
HVEGHNRNYE LTVAAYDGAI TPCSSEAPLQ VKVIDRSMPV FEKQFYTVSV
2260 2270 2280 2290 2300
KEDVEMYSAL SVSIEAESPL GRSLIYTISS ESQSFEIDYN TGSIFVVNEL
2310 2320 2330 2340 2350
DYEKISSHDV SIRATDSLSG VYAEVVLSVS IMDVNDCYPE IESDIYNLTI
2360 2370 2380 2390 2400
PENASFGTQI LKINATDNDS GANAKLSYYI ESINGQNNSE LFYIDVTDGN
2410 2420 2430 2440 2450
LYLKTPLDYE QIKYHHIVVN VKDHGSPSLS SRSNVFITVK DLNDNAPCFV
2460 2470 2480 2490 2500
EPSYFTKVSV AAVRGQFVAL PKAYDKDISD TDSLEYKIVY GNELQTYSID
2510 2520 2530 2540 2550
KLTGVISLQN MLNFTDKSST VLNISVSDGV HTAYARLKIS LLPENVYSPL
2560 2570 2580 2590 2600
FDQSTYEAQV PENLLHGHNI ITVKASDGDF GTYANLYYEI VSEEMKKIFL
2610 2620 2630 2640 2650
IDQTTGVITS KVTFDREKKD EYVVLLKVSD GGGKFGFASL KVIVVDVNDN
2660 2670 2680 2690 2700
VPYFLLKEYK MVVSTTVEAN QTILTVKAKD DDIVDNGSVH FQIVQKSNDK
2710 2720 2730 2740 2750
AVKDVIEINE KTGDIVFKSK AESYGVNSYQ FFVRASDRGE PQFHSEVPVS
2760 2770 2780 2790 2800
IEIIETDANI PTFEKSSVLL KIIESTPPGT VLTKLHMIGN YTFKFSIAAD
2810 2820 2830 2840 2850
QDHFMISDSG ELILQQTLDR EQQESHNLIV VAETSTVPVF FAYADVLIDV
2860 2870 2880 2890 2900
RDENDNYPKF DNTFYSASVA ENSEKVISLV KVSATDADTG PNGDIRYYLE
2910 2920 2930 2940 2950
SDTENIQNIF DIDIYSGWIT LLTSLDREVQ SEYNFKVIAA DNGHPKHDAK
2960 2970 2980 2990 3000
VPVTIKIVDY NDNAPVFKLP IEGLSVFENA LPGTVLINLL LIDPDIEKQE
3010 3020 3030 3040 3050
MDFFIVSGDK QAQFQIGKSG ELFIAKPLDR EQLMFYNLSI IATDGKFTAK
3060 3070 3080 3090 3100
ANVEIDVKDI NDNTPYCLKP RYHISTNESI SIGTTLVEVK AIDFDFQSKL
3110 3120 3130 3140 3150
RFYLSGKGAD DFSIGKESGI LKVASALDRE TTPKYKLVAH VQDGKDFTQE
3160 3170 3180 3190 3200
CFSEIIITVN DINDNMPIFS MAQYRVSVPE DAQLNTLITK VHAMDKDFGV
3210 3220 3230 3240 3250
NRQIKYSLMG ENHDYFKISK STGIIRLHKS LDRETISLFN LTVKAEDCGV
3260 3270 3280 3290 3300
PKLHSIATVA VNILDINDNP PEFSMRQYSC KILENATHGT EVCKVYATSI
3310 3320 3330 3340 3350
DIGVNADIHY FIMSGNEQGK FKMDSTTGDL VLNATLDYEM SKFYFLTIQA
3360 3370 3380 3390 3400
IDGGTPPLSN NAYVNISILD INDNSPTFLQ NLYRINVNED IFVGSKILDV
3410 3420 3430 3440 3450
KATDEDSDVN GLVTYNIERG DNIGQFSIDP KNGTISVSRP LDRETISHYT
3460 3470 3480 3490 3500
LEIQACDQGD PQRCNSVPIN INILDTNDNA PIFSSSNYSV VLQENRLLGY
3510 3520 3530 3540 3550
VFLTFKISDA DETPNTTPYT FDIRSGNEGG LFRLEQDGSL RTASRFNHNL
3560 3570 3580 3590 3600
QDEFVIQVRV FDNGTPPLYS DAWVVVKIIE ESQYPPIVTP LEVTINSFED
3610 3620 3630 3640 3650
DFSGAFIGKV HASDQDKYDE LNFSLVSGPD DMYQSSKLFN ISNNTGKIYA
3660 3670 3680 3690 3700
ISNLDIGLYK LNVSVSDGKF HVFSIVKINV ELVTNDMLKE SVVIRFRRIS
3710 3720 3730 3740 3750
ASEFLLSHRK TFMRSIRNIM RCRQKDVILI TLQSDYQKAS QHAVGNRRAR
3760 3770 3780 3790 3800
SIDSDLNVVF AVRKQQIIPD SDEFFTSDEI RQTLIDKKNE IENETNLVVE
3810 3820 3830 3840 3850
DVLPSTCQSN KNDCVHGECK QILQILKNNV TTTFTDVISF AAPSYIPVNT
3860 3870 3880 3890 3900
CVCRPGFDGK HCKETVNACS TDPCSPQRIC MPSGSALGYQ CVCPKGFSGT
3910 3920 3930 3940 3950
YCERKSSKCS NESCDMGLFT AVSFGGKSYA HYKINKVKAK FTLENGFSYS
3960 3970 3980 3990 4000
LQIRTVQQTG TLLYASGKVD YNILEIINGA VQYRFDLGSG EGVISVSSIN
4010 4020 4030 4040 4050
ISDGEWHQIS LERSLNSAKV MVDNKHVSHG SAPGVNGILN IQSNDIFVGA
4060 4070 4080 4090 4100
EVRPHPSIIG YEDIQRGFIG CMANIKIAKE SLPLYISGGS TIAALKRFTN
4110 4120 4130 4140 4150
VEFKCDPSNV LVRLGICGSQ PCANSGICKE LDTDVFECAC QPRYSGKHCE
4160 4170 4180 4190 4200
IDLDPCSSGP CLFGGRCDYH GPNNYSCTCP IHLSGKRCEY GKFCTPNPCK
4210 4220 4230 4240 4250
NGGICEEGDG ISHCMCRGYT GPTCEIDVDE CENQPCGNGA TCINEPGSFR
4260 4270 4280 4290 4300
CICPSYLTGA SCGDPLYSNS ISTKLKNFSI EHISGIISGV AVVLVIISCV
4310 4320 4330 4340 4350
LCCVVLKRSS SSKRRNRLEK DKNKSSYKEA NLNSLVDKDN YCKPNVKLSN
4360 4370 4380 4390 4400
LEVNQRPISY TAVPNDNLVL SNRNFVNNLD ILRSYGSAGD ELENVPFEYQ
4410 4420 4430 4440 4450
KVNRNKQHVN INSCHSTDAD NAYKQEWCEQ MHLRTFSENK LNNELKRDFG
4460 4470 4480 4490 4500
PSVSRFSTGK LIQVEMPNVC HSSSANFVDY SALANGQYHW DCSDWVRKSH
4510 4520 4530 4540 4550
NPLPDITEVP GAEIADSSSL HSNDSNESKS KKAFFVHRED GDVDPTRDIA
4560 4570 4580 4590 4600
ALNEDIGSEY LDSEAESCLE PFMLPRSSNQ PLSRLSSFNN IENEDYKSNT
4610 4620 4630 4640 4650
VPLPSKVSHS CKVYLRHPDS YLPTMHFPSE TDGESSMTEG PISRMEIKTR
4660 4670 4680 4690
RTISENSEEA YLFPCTVGEI GSNSNISVRL CEIEDSELEE FLPQQQTNN
Note: No experimental confirmation available.
Length:4,699
Mass (Da):523,781
Last modified:May 14, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1798A54345758C36
GO
Isoform C (identifier: Q9VW71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4601-4611: VPLPSKVSHSC → G

Note: No experimental confirmation available.
Show »
Length:4,689
Mass (Da):522,703
Checksum:i4C6F87D76F334666
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JCN4X2JCN4_DROME
Kugelei, isoform E
kug Cad76E, CT23445, DCad76E, Dmel\CG7749, fat2
4,689Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL28503 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAM50035 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAM50035 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3946G → E in AAL28503 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0544504601 – 4611VPLPSKVSHSC → G in isoform C. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49078.3
AE014296 Genomic DNA Translation: AAZ66056.2
AY060955 mRNA Translation: AAL28503.1 Different initiation.
AY118666 mRNA Translation: AAM50035.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_001027138.2, NM_001031967.2 [Q9VW71-1]
NP_001287126.1, NM_001300197.1 [Q9VW71-2]
NP_649171.3, NM_140914.3 [Q9VW71-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0332721; FBpp0304967; FBgn0261574 [Q9VW71-2]
FBtr0332722; FBpp0304968; FBgn0261574 [Q9VW71-1]
FBtr0346077; FBpp0311915; FBgn0261574 [Q9VW71-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40191

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7749

UCSC genome browser

More...
UCSCi
CG7749-RA d. melanogaster [Q9VW71-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49078.3
AE014296 Genomic DNA Translation: AAZ66056.2
AY060955 mRNA Translation: AAL28503.1 Different initiation.
AY118666 mRNA Translation: AAM50035.1 Sequence problems.
RefSeqiNP_001027138.2, NM_001031967.2 [Q9VW71-1]
NP_001287126.1, NM_001300197.1 [Q9VW71-2]
NP_649171.3, NM_140914.3 [Q9VW71-2]

3D structure databases

SMRiQ9VW71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65458, 4 interactors
DIPiDIP-24050N
IntActiQ9VW71, 7 interactors
STRINGi7227.FBpp0304968

Proteomic databases

PaxDbiQ9VW71
PRIDEiQ9VW71

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0332721; FBpp0304967; FBgn0261574 [Q9VW71-2]
FBtr0332722; FBpp0304968; FBgn0261574 [Q9VW71-1]
FBtr0346077; FBpp0311915; FBgn0261574 [Q9VW71-2]
GeneIDi40191
KEGGidme:Dmel_CG7749
UCSCiCG7749-RA d. melanogaster [Q9VW71-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
40191
FlyBaseiFBgn0261574 kug

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA
GeneTreeiENSGT00940000166124
InParanoidiQ9VW71
KOiK16506
OMAiHVFFGGH

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40191

Protein Ontology

More...
PROi
PR:Q9VW71

Gene expression databases

BgeeiFBgn0261574 Expressed in 30 organ(s), highest expression level in eye disc (Drosophila)
ExpressionAtlasiQ9VW71 baseline and differential
GenevisibleiQ9VW71 DM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00028 Cadherin, 26 hits
PF02210 Laminin_G_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 34 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SM00282 LamG, 1 hit
SUPFAMiSSF49313 SSF49313, 34 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 18 hits
PS50268 CADHERIN_2, 34 hits
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 1 hit
PS50025 LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAT2_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VW71
Secondary accession number(s): A4V252, Q95S51
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 14, 2014
Last modified: May 8, 2019
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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