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Protein

26S proteasome non-ATPase regulatory subunit 2

Gene

Rpn1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.UniRule annotation

GO - Molecular functioni

  • enzyme regulator activity Source: UniProtKB-UniRule
  • zinc ion binding Source: FlyBase

GO - Biological processi

  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase
  • regulation of protein catabolic process Source: InterPro

Enzyme and pathway databases

BRENDAi3.4.25.1 1994
ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209406 Degradation of NF-kappa-B inhibitor, CACT
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-216167 Nuclear CI is degraded
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-432395 Degradation of TIM
R-DME-432524 Degradation of PER
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-538848 Degradation of CLK
R-DME-538864 Degradation of CRY
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-6798695 Neutrophil degranulation
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 2UniRule annotation
Gene namesi
Name:Rpn1Imported
Synonyms:BcDNA:LD21723Imported, Dmel\CG7762Imported, p97Imported, RPN1Imported, S2Imported
ORF Names:CG7762Imported, Dmel_CG7762Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0028695 Rpn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ProteasomeUniRule annotationImported

PTM / Processingi

Proteomic databases

PRIDEiQ9VW54

Expressioni

Gene expression databases

BgeeiFBgn0028695

Interactioni

Subunit structurei

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).UniRule annotation

Protein-protein interaction databases

IntActiQ9VW54, 12 interactors
STRINGi7227.FBpp0074662

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili634 – 655Sequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the proteasome subunit S2 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2005 Eukaryota
COG5110 LUCA
GeneTreeiENSGT00550000074983
KOiK03028
OMAiMVDICAY
OrthoDBiEOG091G04TC

Family and domain databases

InterProiView protein in InterPro
IPR016643 26S_Psome_Rpn1
IPR016024 ARM-type_fold
IPR002015 Proteasome/cyclosome_rpt
PANTHERiPTHR10943:SF1 PTHR10943:SF1, 1 hit
PfamiView protein in Pfam
PF01851 PC_rep, 3 hits
PIRSFiPIRSF015965 26S_Psome_Rpn1, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

Q9VW54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGETKLEKK PLKPAASEGD AKDPKAKKDE KKDGKDKEQQ PELSDEDQQL
60 70 80 90 100
QEELELLVQH LQEPDAKLYQ PTLESMAKLI RASTTSMTSV PKPLKFMRPH
110 120 130 140 150
YETMKTVYKH MPNEQARQLC ADIISVLSMT MGSGKDCLAY RFLCDRKQRI
160 170 180 190 200
GDWGHEYVRH LSGEISAHYH DTTGDFRVQL IELVKQIIPY NMEHNAEADA
210 220 230 240 250
CDLLIEIDHL HLLSDFVDES AYPRVCLYLQ SCYPYVPDPD NTIILETALQ
260 270 280 290 300
LSRKFNQYTQ AMRLALMLND MDKIGEIFKE PKEPAMQKQL AFMLARQQIC
310 320 330 340 350
LELDELVPDY DDLMEIMSNA NLNKHFLNLA RELDIMEPKT PEDIYKSHLD
360 370 380 390 400
NSRSRFASIQ VDSAKQNLAA SFVNGFVNAG FGVDKLLSED GNKWLYKNKE
410 420 430 440 450
HGMLSATASL GLILLWDVDG GLTMIDKYLY STDDNIKSGA LLACGIVNCG
460 470 480 490 500
IRNEVDPAHA LLSDYIDNQN SCMRVGAILG LGIAYAGSNR SIVIDTLKTV
510 520 530 540 550
FSFGSNNKSS ASVEILGITA LSLGLISVGS CNSEITEILL QTIMGLTKAD
560 570 580 590 600
LKDTYTRFLF LGLGLLYLGR QKSTEAVMMT LEVLEEPYRS MATTMVDICA
610 620 630 640 650
YAGTGNVLKI QQLLHICSDH YETSSADDEK EKSKKDKGKD KEKEKEKEKE
660 670 680 690 700
KEREKDLSAT QSIAVLGIAL IAMGEDIGAE MAYRSFGNLL RYCEPAIRRA
710 720 730 740 750
VPLALGLISA SNPKLNIIDT LSKFSHDSDA EVAHNAIFAM GLVGAGTNNA
760 770 780 790 800
RLASMLRQLA QYHSKDPSNL FMVRIAQSLT HLGKGTLSLS PYHSDRQLMN
810 820 830 840 850
PMAVAGLMAT LVSLLDVKNL ILNRSHYLLY TLVPAMQARM LITFDEELNQ
860 870 880 890 900
LQVPVRVGIA IDVVGQAGKP KTITGFQTHT TPVLLAIGER AELATDEYLA
910
LTPVMEGFVI LKKNPNFVK
Length:919
Mass (Da):102,278
Last modified:March 1, 2001 - v2
Checksum:i8CCBF33D2664C7D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132182 mRNA Translation: AAD34770.1
AF145304 mRNA Translation: AAF08385.1
AE014296 Genomic DNA Translation: AAF49095.2
RefSeqiNP_649158.1, NM_140901.3
UniGeneiDm.3192

Genome annotation databases

EnsemblMetazoaiFBtr0074893; FBpp0074662; FBgn0028695
GeneIDi40174
KEGGidme:Dmel_CG7762
UCSCiCG7762-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VW54_DROME
AccessioniPrimary (citable) accession number: Q9VW54
Secondary accession number(s): Q9XZ26
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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