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Entry version 130 (11 Dec 2019)
Sequence version 2 (01 Oct 2002)
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Protein

Mediator of RNA polymerase II transcription subunit 12

Gene

kto

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for leg and eye development and macrochaete specification or differentiation.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 12
Alternative name(s):
Mediator complex subunit 12
Mediator complex subunit Kohtalo
dTRAP230
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kto
Synonyms:Med12, Trap230
ORF Names:CG8491
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001324 kto

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003129631 – 2531Mediator of RNA polymerase II transcription subunit 12Add BLAST2531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei745Phosphothreonine1 Publication1
Modified residuei748Phosphoserine1 Publication1
Modified residuei781Phosphoserine1 Publication1
Modified residuei806Phosphoserine1 Publication1
Modified residuei1356Phosphoserine1 Publication1
Modified residuei1360Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VW47

PRoteomics IDEntifications database

More...
PRIDEi
Q9VW47

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VW47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0001324 Expressed in 27 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VW47 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VW47 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Cdk8 module of the Mediator complex, composed of CycC, Cdk8, kto and skd.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P250082EBI-139710,EBI-195485

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
69311, 14 interactors

Database of interacting proteins

More...
DIPi
DIP-29990N

Protein interaction database and analysis system

More...
IntActi
Q9VW47, 9 interactors

Molecular INTeraction database

More...
MINTi
Q9VW47

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0074653

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VW47

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1943 – 2527Gln-richAdd BLAST585

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 12 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3598 Eukaryota
ENOG410XP2V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000037505

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VW47

KEGG Orthology (KO)

More...
KOi
K15162

Identification of Orthologs from Complete Genome Data

More...
OMAi
VWLDTVA

Database of Orthologous Groups

More...
OrthoDBi
20034at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VW47

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019035 Mediator_Med12
IPR021990 Mediator_Med12_LCEWAV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09497 Med12, 1 hit
PF12145 Med12-LCEWAV, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01281 Med12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VW47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSMLQEKRP LKRTRLGPPD IYPQDAKQRE DELTPTNVKH GFTTTPPLSD
60 70 80 90 100
EFGTAHNSNV NASKVSAFFS GVLAKKEELM TLPDTGRKKQ QINCKDNFWP
110 120 130 140 150
VSPRRKCTVD AWFKDLAGNK PLLSLAKRAP SFNKKEEIFI TLCENQVNMQ
160 170 180 190 200
RATWFIKLSA AYTLSFTESK NKKRSIYDPA AEWTGNMIKF MKELLPKLQE
210 220 230 240 250
YYQQNHDKSS SNGTTSGSLT AAGNGPASNG STGTSSINSV TGSSASTNVI
260 270 280 290 300
PVPSMASPLP PIHSPANGQQ AAPGGGVNAG SVMPTTGSLG GVVGGPGSSV
310 320 330 340 350
VGGAAGAGAA VPPGSTISGI GSQFEDSRNA LKYWKYCHQL SKYMYEESLL
360 370 380 390 400
DRQEFLNWIL DLLDKMRTQA SFDEPLKKLV LSFALQYMHD FVQSERLCRK
410 420 430 440 450
MAYIVSKKLA QLLNTVVEQQ TIKELDEPKL QQDPYELALQ EQMSCPHHRD
460 470 480 490 500
IVLYLSTILQ IITIECPTAL VWSGIAAHRA PSSLLGSPLD HLPLAPSVLP
510 520 530 540 550
MPTRCPRTNH EIRRQLRAAE SDIVLRTQHA EQRWFAAKWL SAGKNQYTSV
560 570 580 590 600
LATLDHLDTH CFDRMEHNNS IDTLYAQIFP SPTVSRRREE DQVEPRPPYE
610 620 630 640 650
PKQDKDTVRI LCEWAVSGQR WGEHRAMVVA ILLDKRQIDV TSTPADQQSS
660 670 680 690 700
DKDDKDSLAS GAGLIDGLPV FQHVLMHFLD HDAPVLDEHV SSPQQRTEFT
710 720 730 740 750
NLVQLFSALI RHDVFSHNAY MHTLISRGDL LLESVLVIKS GTTATKTSPP
760 770 780 790 800
PPAPPPTTTH GFDDDGFGGG LDFKHNEFDD SNVDDDLDKL VQNIKEKGQQ
810 820 830 840 850
HEAPDSPKIG PPGDGETNPG GSISRHYVYT KHFPIPQDDP SMSSYSSESN
860 870 880 890 900
QRYILLFGVG KERDEKKHAV KKMSKEIGKL FTKKFSIDVA AAGHVKKHSR
910 920 930 940 950
NEFNFEATTS KCQQMAYFDQ HVVTAQCAAN VLEQLNGFAL GNNNYLPVQE
960 970 980 990 1000
HVAFLFDLME LALNIYSLLE LCDSLLKELP EVEHQLQLKK SNLVRSYTTS
1010 1020 1030 1040 1050
LALYIVSILR RYHSCLLLSP EQTLSVFEGV CRTIRHVSNP SECTSAERCI
1060 1070 1080 1090 1100
IAYLSDLHES CVLLQGKEQS TEYYQQLQCI KRFKDIFNTP EQLDLPPQGY
1110 1120 1130 1140 1150
NPLLLQELFM APRRGGKLDP HWLGTLHESP ANVYSFVSNA LIAVCRETDN
1160 1170 1180 1190 1200
ERLNDVALAC AELTASCNVL SEEWIYALQS LCSGSKSPRY PHLGGQVDIG
1210 1220 1230 1240 1250
QLKTHNALAV FVCILVARHC FSLADFVSKF ALPTLARSVS AGGAELSVDA
1260 1270 1280 1290 1300
EAGARLTCHL VLKLFKTLEI PQPGMYSVST SPNPLHAVGN DFSIRLSCDR
1310 1320 1330 1340 1350
HLLVGAHKTI PIAAVLAVLK AILIVVDNAA LKTPLASGSG TSSGGLGGAF
1360 1370 1380 1390 1400
GSGKRSGFNT PVHPGSTPKS NEQRPADLSQ ILGTSDLQLG SSLTSEPEAL
1410 1420 1430 1440 1450
QQPSVGGMEQ ISLLEFAQAV LKQICAQEHV LERCLKNAEQ LCDMIIDEML
1460 1470 1480 1490 1500
TAKQAQRVLH MICYPEPEFN IISELDQRSM IVRILENLGQ WTLRISWLDL
1510 1520 1530 1540 1550
QLMYRQSLSN NAELNVWLDT VARAAIDVFH MEEVVLPGAV KATHKPKPST
1560 1570 1580 1590 1600
WLVAPLIAKL TPAVQGRILR VAGQVLESMN YFSKVSKSDC NSSGSGDERE
1610 1620 1630 1640 1650
KSNSCHSSNS YGLGGVPARN KKMPLDYQPF LGLILTCLKG QDEYKENLLV
1660 1670 1680 1690 1700
SLYAQLSQCL QSFAELDTIG GIDEPQAREE ILDALQLRFS LVGGMFEAIQ
1710 1720 1730 1740 1750
KNSTPTTDWA ILLAQLVCQG VVDLSCNREL FTTVVDMLAT LVHSTLVSDD
1760 1770 1780 1790 1800
ERHYMNLMKK LKKEIGEKNN ASIRVIRQLL PLYKQPTEVI ACEHSGMDTK
1810 1820 1830 1840 1850
GNKICDIDKK QLRISDKQRI SVWDILEGHK NPAPLSWVWF GAVKLERKPL
1860 1870 1880 1890 1900
TYEEAHRNLK YHTHSLVKPS SYYYEPLPLP PEDIEPVPEK ICIKDEMKAD
1910 1920 1930 1940 1950
TPSSVDQSPS AVVGGTGRGR GKGTTTRKRK PKNPKTPPVV NTQQQQPQLA
1960 1970 1980 1990 2000
QQPQQPQNVQ QQQLQQQQQQ QQHMQQQHMQ QQQMQPNQMG QMPMNMPMNM
2010 2020 2030 2040 2050
QQFAPNPNNM MQQNAMLQQQ QQQQMQQMGN NPMQQQLNVG GGNGQPNPQM
2060 2070 2080 2090 2100
NFMQQGPGGG GAGPQGMPGQ QQQWHNAPQQ QQPPQPYHNQ YAPHQQNMQS
2110 2120 2130 2140 2150
NRIERPPLNA NSKQALSQML RQRQPFQQQA QQGPGGGFNP MQQQPQASQQ
2160 2170 2180 2190 2200
QPGPQQQMNP NQMRQQQMNP QQNPQSVAAF NAMQQQPQQN AQQQQMNPNQ
2210 2220 2230 2240 2250
QQQQQFMRGG NMRPGMAPNQ MNQMNMGGQG MSQNPMMQQQ IPQNMVGMVN
2260 2270 2280 2290 2300
PNANQMMQSG GAQGGNGVGV GVGVGVGGAG NNPNMGMGGM PQQGMIQQQP
2310 2320 2330 2340 2350
QQQPQQQVQF QNFQNQYQQQ QQQGMQQQGG GAGVGVGVGM APNQQQQQQA
2360 2370 2380 2390 2400
NMMGNFNPQM QQGNRNNPDF MAAAAVAQQQ QQQQQQQRVV PGGMMAGNRN
2410 2420 2430 2440 2450
QYMNQAPNVT MSTMMGPGPG GVVGQVPPYA RQQSAGGGKP GVLNTQQQFQ
2460 2470 2480 2490 2500
QQQQQQQQLR HQMMQLQGMG GGAGGGMGAG PQQGGGAVGG GAGGGMVPQQ
2510 2520 2530
QSMNQQQTPN LVAQLQRQNM MGQQQYQPPP Y
Length:2,531
Mass (Da):279,499
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68B0CD469E83A9F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NDW3M9NDW3_DROME
FI21288p1
kto Brm @ Kto, Dmel\CG8491, dTRAP230, dTrap230, KTO
534Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM52769 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF324426 mRNA Translation: AAG48328.1
AE014296 Genomic DNA Translation: AAF49103.2
AY122257 mRNA Translation: AAM52769.1 Frameshift.

NCBI Reference Sequences

More...
RefSeqi
NP_524786.1, NM_080047.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0074884; FBpp0074653; FBgn0001324

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
44830

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8491

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF324426 mRNA Translation: AAG48328.1
AE014296 Genomic DNA Translation: AAF49103.2
AY122257 mRNA Translation: AAM52769.1 Frameshift.
RefSeqiNP_524786.1, NM_080047.2

3D structure databases

SMRiQ9VW47
ModBaseiSearch...

Protein-protein interaction databases

BioGridi69311, 14 interactors
DIPiDIP-29990N
IntActiQ9VW47, 9 interactors
MINTiQ9VW47
STRINGi7227.FBpp0074653

PTM databases

iPTMnetiQ9VW47

Proteomic databases

PaxDbiQ9VW47
PRIDEiQ9VW47

Genome annotation databases

EnsemblMetazoaiFBtr0074884; FBpp0074653; FBgn0001324
GeneIDi44830
KEGGidme:Dmel_CG8491

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
44830
FlyBaseiFBgn0001324 kto

Phylogenomic databases

eggNOGiKOG3598 Eukaryota
ENOG410XP2V LUCA
GeneTreeiENSGT00440000037505
InParanoidiQ9VW47
KOiK15162
OMAiVWLDTVA
OrthoDBi20034at2759
PhylomeDBiQ9VW47

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
kto fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
44830

Protein Ontology

More...
PROi
PR:Q9VW47

Gene expression databases

BgeeiFBgn0001324 Expressed in 27 organ(s), highest expression level in embryo
ExpressionAtlasiQ9VW47 baseline and differential
GenevisibleiQ9VW47 DM

Family and domain databases

InterProiView protein in InterPro
IPR019035 Mediator_Med12
IPR021990 Mediator_Med12_LCEWAV
PfamiView protein in Pfam
PF09497 Med12, 1 hit
PF12145 Med12-LCEWAV, 1 hit
SMARTiView protein in SMART
SM01281 Med12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED12_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VW47
Secondary accession number(s): Q8MQW4, Q9GPH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: December 11, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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