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UniProtKB - Q9VW23 (Q9VW23_DROME)

Entry version 131 (07 Oct 2020)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Male sterile (3) 76Cc

Gene

ms(3)76Cc

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • spermatid differentiation Source: FlyBase
Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Male sterile (3) 76CcImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ms(3)76CcImported
Synonyms:Dmel\CG9392Imported
ORF Names:CG9392Imported, Dmel_CG9392Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0036895, ms(3)76Cc

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9VW23

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0036895, Expressed in testis and 18 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9VW23, differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9VW23, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9VW23, 2 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0074716

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VW23

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni622 – 906DisorderedSequence analysisAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi664 – 678PolyampholyteSequence analysisAdd BLAST15
Compositional biasi679 – 719PolarSequence analysisAdd BLAST41
Compositional biasi749 – 768PolarSequence analysisAdd BLAST20
Compositional biasi769 – 783PolyampholyteSequence analysisAdd BLAST15
Compositional biasi801 – 821PolyampholyteSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RTMS, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00540000073643

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_300962_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9VW23

Identification of Orthologs from Complete Genome Data

More...OMAi		CYGVELC

Database of Orthologous Groups

More...OrthoDBi		444180at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9VW23

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VW23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPISQHDLAR FASAPGSCPR ISMSNSSNTY LSYSDLDLGS KFCGGGSLRT 
        60         70         80         90        100
EPSCDHWKFC EKVPNRSDVE ADSLGCPVGL VCSNATVNNP CGCSPKQQEA 
       110        120        130        140        150
NVLNFATYLK AFALIYVLPE TDWTAEKIDM LLEEGTDLFR ASSDVNQGHD 
       160        170        180        190        200
DPDEHKLLEP EIYTNEEKRI KRNFNLEGHT FTLALEPRYL GVGSKPLDQQ 
       210        220        230        240        250
PPHIIKNLGT ILQSFFKSSR YCLLLTRVGH LLIWRRRRVF FVLDVKGRAK 
       260        270        280        290        300
DDLATVKDNG VAMLVCLKSI DNVVHLASNL SGISPRDEFS IRELVVVRLE 
       310        320        330        340        350
TPDGRIYMRD TSHRSIEFKV VNKSYAYLKG TLHLSLNKDD PVRNRSSLMV 
       360        370        380        390        400
AVGSVLASKI DHPANWDTNM LDRLISYGVE LCRSCWSDCL RDRRPIDLDT 
       410        420        430        440        450
FPTQLRMGQF VLELKLIPNV RTGHWRCGVR IIGTDFEAHV SQALKELGNV 
       460        470        480        490        500
VFQINNQMYA IWLKDGFYYL VDPYRHTIVG THVAEDKAEG AKWATVRMFR 
       510        520        530        540        550
DQLTMLSVFH QLLKESNRQS AYYVHVVRIR NLAECPEGYA LLPMPDGKDS 
       560        570        580        590        600
CEVKSLNETI FFNEQQCVRV CNKSLAEISD YEEDVVSLLT DKSDIDHFQV 
       610        620        630        640        650
LDEQQNGGAE CEFCEEEFRT EPLKRRPKGK NTNSKSRVGL SKREQDIKDT 
       660        670        680        690        700
SGKMLPTASR TPNDKDSPRL DKKSRSANRQ AGGRSSSTKS PGLTKSRENT 
       710        720        730        740        750
SNRIAKRSVL PSKQTELGTH FPPSKAPVKT TPNVAPPSGR IVRSTIKTRE 
       760        770        780        790        800
VGGRSSNRSQ NNTLGRSRSR EEPFPERITT KKMQFKRQAG GMCSRDPLST 
       810        820        830        840        850
SPERCKPREG SSPDRTIKKI VKSSRQTGGT VCSPPPDVSS LRYRSKEDVT 
       860        870        880        890        900
PGKIMIKSEN TKDSGSPIKS HLRSKSRNRS PGKFSPRGTP SRKMAPKVDD 
       910        920        930        940        950
SKGANPALDL SITKEAIRTQ VANKEASDRK GVIASKGVML LRKVNMKTDT 
       960        970        980        990       1000
AIEPSKKEAT QTHILQQSVD KSKSLGVAPL AAAHLNTPAA SNFVNELDQK 
      1010       1020       1030       1040       1050
EKPPYPKMNV RNAEQSIEHP KNCCCRDAEE DSMEGIGSRM PVKFPGFSRA 
      1060       1070       1080       1090       1100
PHLLAVAGSE SGTVESLNRV LSSAFKVANR VLTMTPWGNY VVFRHHPTNR 
      1110       1120       1130       1140       1150
SAATWFYVFD GCTCDIDRFR HLDLSTGTAG LIAFRKQSEV VCHIIDSREE 
      1160       1170 
KALKMLRSGM EDPPHKRIQR LLAR
Length:1,174
Mass (Da):131,389
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D1C9F0D6910F417
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49130.1

NCBI Reference Sequences

More...RefSeqi		NP_649136.1, NM_140879.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0074948; FBpp0074716; FBgn0036895

Database of genes from NCBI RefSeq genomes

More...GeneIDi		40142

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG9392

UCSC genome browser

More...UCSCi		CG9392-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49130.1
RefSeqiNP_649136.1, NM_140879.2

3D structure databases

SMRiQ9VW23
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9VW23, 2 interactors
STRINGi7227.FBpp0074716

Proteomic databases

PaxDbiQ9VW23

Genome annotation databases

EnsemblMetazoaiFBtr0074948; FBpp0074716; FBgn0036895
GeneIDi40142
KEGGidme:Dmel_CG9392
UCSCiCG9392-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		40142
FlyBaseiFBgn0036895, ms(3)76Cc

Phylogenomic databases

eggNOGiENOG502RTMS, Eukaryota
GeneTreeiENSGT00540000073643
HOGENOMiCLU_300962_0_0_1
InParanoidiQ9VW23
OMAiCYGVELC
OrthoDBi444180at2759
PhylomeDBiQ9VW23

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		40142, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		40142

Gene expression databases

BgeeiFBgn0036895, Expressed in testis and 18 other tissues
ExpressionAtlasiQ9VW23, differential
GenevisibleiQ9VW23, DM

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VW23_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VW23
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 7, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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