Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 154 (13 Feb 2019)
Sequence version 2 (01 Oct 2002)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

E3 ubiquitin-protein ligase Nedd-4

Gene

Nedd4

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation.3 Publications

Caution

According to some authors (PubMed:12165468) it is involved in axon guidance by promoting ubiquitination of comm and subsequent endocytosis of the comm/robo complex. However, according to others (PubMed:15657595), it is not the case.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei974Glycyl thioester intermediate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • myosin binding Source: FlyBase
  • Notch binding Source: UniProtKB
  • protein domain specific binding Source: FlyBase
  • ubiquitin protein ligase activity Source: FlyBase
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Transferase
Biological processNotch signaling pathway, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1169408 ISG15 antiviral mechanism
R-DME-1253288 Downregulation of ERBB4 signaling
R-DME-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-DME-8948747 Regulation of PTEN localization
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9VVI3

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase Nedd-4 (EC:2.3.2.26By similarity)
Short name:
DNedd4
Alternative name(s):
HECT-type E3 ubiquitin transferase NEDD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nedd4
ORF Names:CG7555
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0259174 Nedd4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi974C → A: Abolishes activity; no effect on interaction with comm. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001203221 – 1007E3 ubiquitin-protein ligase Nedd-4Add BLAST1007

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VVI3

PRoteomics IDEntifications database

More...
PRIDEi
Q9VVI3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0259174 Expressed in 33 organ(s), highest expression level in egg chamber

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VVI3 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VVI3 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via WW2 domain) with comm (via PY-motifs) (PubMed:12165468, PubMed:16531238). Interacts with N (PubMed:15620649).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
commQ241393EBI-498113,EBI-118294

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
65246, 15 interactors

Database of interacting proteins

More...
DIPi
DIP-29040N

Protein interaction database and analysis system

More...
IntActi
Q9VVI3, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0289746

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11007
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EZ5NMR-W526-566[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9VVI3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VVI3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9VVI3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 159C2PROSITE-ProRule annotationAdd BLAST103
Domaini246 – 279WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini529 – 562WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini580 – 613WW 3PROSITE-ProRule annotationAdd BLAST34
Domaini672 – 1006HECTPROSITE-ProRule annotationAdd BLAST335

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi434 – 482Gln-richAdd BLAST49

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0940 Eukaryota
COG5021 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168483

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VVI3

KEGG Orthology (KO)

More...
KOi
K10591

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VVI3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078 HECTc, 1 hit
cd00201 WW, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR024928 E3_ub_ligase_SMURF1
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 1 hit
PF00632 HECT, 1 hit
PF00397 WW, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001569 E3_ub_ligase_SMURF1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00360 C2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit
SM00119 HECTc, 1 hit
SM00456 WW, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51045 SSF51045, 3 hits
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS50237 HECT, 1 hit
PS01159 WW_DOMAIN_1, 3 hits
PS50020 WW_DOMAIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9VVI3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSARSSGLVA AAALPVPSSS SSVAGGDVPR PPPRRRAASV AGQQQTRQEF
60 70 80 90 100
GNGYTPRRSL AAVNDSGDSC HLRIVVLTGQ SLAKKDIFGA SDPYVRIDLN
110 120 130 140 150
TINGDINIDS VLTKTKKKTL NPTWNEEFIF RVKPSEHKLV FQVFDENRLT
160 170 180 190 200
RDDFLGMVEL TLVNLPTEQE GRTIGEQSYT LRPRRSVGAK SRIKGTLRIY
210 220 230 240 250
HAFIRETREQ SEPSSGNSDG EWEHVEATNA GETSAQPHPF PTGGHDALPA
260 270 280 290 300
GWEERQDANG RTYYVNHTAR TTQWDRPTVL NSHSSQSTDD QLASDFQRRF
310 320 330 340 350
HISVDDTESG RSADSISHNS IEDNNNAAGL AYTPKTAATS SAPPNTPTNN
360 370 380 390 400
NGILAQIAMQ YRAEEDQDPT VDHTSFVYNS LRHPVAHRQP EISATSLQND
410 420 430 440 450
LRPVREAPGV PDIAITNPFT RRAAGNMAGG AGWQQERRRQ QMQLHIQQHQ
460 470 480 490 500
QRQQQQQQNR ILLDVDHRQQ EPQHRGQRHQ QQHRPSNEDT DHTDSHNPSD
510 520 530 540 550
ISAPSTRRNS EEDNAAVPPM EQNTGGEEEP LPPRWSMQVA PNGRTFFIDH
560 570 580 590 600
ASRRTTWIDP RNGRASPMPN QTRRVEDDLG PLPEGWEERV HTDGRVFYID
610 620 630 640 650
HNTRTTQWED PRLSNPNIAG QAVPYSRDYK QKYEYFKSHI RKPTNVPNKF
660 670 680 690 700
EIRIRRTSIL EDSYRIISSV TKTDLLKTKL WVEFEGETGL DYGGLAREWF
710 720 730 740 750
YLLSKEMFNP YYGLFEYSAM DNYTLQINNG SGLCNEEHLS YFKFIGRIAG
760 770 780 790 800
MAVYHGKLLD AFFIRPFYKM MLQKPIDLKD MESVDTEYYN SLMWIKENDP
810 820 830 840 850
RILELTFCLD EDVFGQKSQH ELKPGGANID VTNENKDEYI KLVIEWRFVA
860 870 880 890 900
RVKEQMSSFL DGFGSIIPLN LIKIFDEHEL ELLMCGIQNI DVKDWRENTL
910 920 930 940 950
YKGDYHMNHI IIQWFWRAVL SFSNEMRSRL LQFVTGTSRV PMNGFKELYG
960 970 980 990 1000
SNGPQMFTIE KWGTPNNFPR AHTCFNRLDL PPYEGYLQLK DKLIKAIEGS

QGFAGVD
Length:1,007
Mass (Da):114,875
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC5994BD19543760
GO
Isoform 2 (identifier: Q9VVI3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     39-63: SVAGQQQTRQEFGNGYTPRRSLAAV → MAESTTTSPSVTSEDGQIHGCNNSD
     375-387: Missing.

Note: No experimental confirmation available.
Show »
Length:956
Mass (Da):109,544
Checksum:iD42D3130C86B5F5A
GO
Isoform 3 (identifier: Q9VVI3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-486: Missing.

Note: No experimental confirmation available.
Show »
Length:834
Mass (Da):95,303
Checksum:iCD0B385C93C95B00
GO
Isoform 4 (identifier: Q9VVI3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     39-63: SVAGQQQTRQEFGNGYTPRRSLAAV → MAESTTTSPSVTSEDGQIHGCNNSD
     314-486: Missing.

Note: No experimental confirmation available.
Show »
Length:796
Mass (Da):91,480
Checksum:iB94B1A42F4213939
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IQR5Q8IQR5_DROME
E3 ubiquitin-protein ligase
Nedd4 ACN62428.1, CG32184, CG7555, Dmel\CG42279, DNedd4
931Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z067B7Z067_DROME
Nedd4, isoform I
Nedd4 ACN62428.1, CG32184, CG7555, Dmel\CG42279, DNedd4
983Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z068B7Z068_DROME
Nedd4, isoform H
Nedd4 ACN62428.1, CG32184, CG7555, Dmel\CG42279, DNedd4
994Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PFY9M9PFY9_DROME
Nedd4, isoform M
Nedd4 ACN62428.1, CG32184, CG7555, Dmel\CG42279, DNedd4
999Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PFK2M9PFK2_DROME
Nedd4, isoform L
Nedd4 ACN62428.1, CG32184, CG7555, Dmel\CG42279, DNedd4
1,005Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL13848 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti185 – 188RSVG → S in AAS64973 (PubMed:10731132).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0154401 – 38Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_01544139 – 63SVAGQ…SLAAV → MAESTTTSPSVTSEDGQIHG CNNSD in isoform 2 and isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_015442314 – 486Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_015443375 – 387Missing in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ278468 mRNA Translation: CAC42101.1
AE014296 Genomic DNA Translation: AAF49328.2
AE014296 Genomic DNA Translation: AAS64973.1
AE014296 Genomic DNA Translation: AAN11694.1
AE014296 Genomic DNA Translation: AAN11695.1
AY061595 mRNA Translation: AAL29143.1
AY058619 mRNA Translation: AAL13848.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_648993.1, NM_140736.3 [Q9VVI3-1]
NP_730282.1, NM_168736.4 [Q9VVI3-3]
NP_730283.1, NM_168737.2 [Q9VVI3-2]
NP_996116.1, NM_206394.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.988

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0299645; FBpp0288920; FBgn0259174 [Q9VVI3-2]
FBtr0300519; FBpp0289746; FBgn0259174 [Q9VVI3-1]
FBtr0300520; FBpp0289747; FBgn0259174 [Q9VVI3-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39958

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG42279

UCSC genome browser

More...
UCSCi
CG42279-RC d. melanogaster [Q9VVI3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278468 mRNA Translation: CAC42101.1
AE014296 Genomic DNA Translation: AAF49328.2
AE014296 Genomic DNA Translation: AAS64973.1
AE014296 Genomic DNA Translation: AAN11694.1
AE014296 Genomic DNA Translation: AAN11695.1
AY061595 mRNA Translation: AAL29143.1
AY058619 mRNA Translation: AAL13848.1 Different initiation.
RefSeqiNP_648993.1, NM_140736.3 [Q9VVI3-1]
NP_730282.1, NM_168736.4 [Q9VVI3-3]
NP_730283.1, NM_168737.2 [Q9VVI3-2]
NP_996116.1, NM_206394.2
UniGeneiDm.988

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EZ5NMR-W526-566[»]
ProteinModelPortaliQ9VVI3
SMRiQ9VVI3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65246, 15 interactors
DIPiDIP-29040N
IntActiQ9VVI3, 7 interactors
STRINGi7227.FBpp0289746

Proteomic databases

PaxDbiQ9VVI3
PRIDEiQ9VVI3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0299645; FBpp0288920; FBgn0259174 [Q9VVI3-2]
FBtr0300519; FBpp0289746; FBgn0259174 [Q9VVI3-1]
FBtr0300520; FBpp0289747; FBgn0259174 [Q9VVI3-3]
GeneIDi39958
KEGGidme:Dmel_CG42279
UCSCiCG42279-RC d. melanogaster [Q9VVI3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4734
FlyBaseiFBgn0259174 Nedd4

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00940000168483
InParanoidiQ9VVI3
KOiK10591
PhylomeDBiQ9VVI3

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-DME-1169408 ISG15 antiviral mechanism
R-DME-1253288 Downregulation of ERBB4 signaling
R-DME-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-DME-8948747 Regulation of PTEN localization
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ9VVI3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nedd4 fly
EvolutionaryTraceiQ9VVI3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39958

Protein Ontology

More...
PROi
PR:Q9VVI3

Gene expression databases

BgeeiFBgn0259174 Expressed in 33 organ(s), highest expression level in egg chamber
ExpressionAtlasiQ9VVI3 differential
GenevisibleiQ9VVI3 DM

Family and domain databases

CDDicd00078 HECTc, 1 hit
cd00201 WW, 3 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR024928 E3_ub_ligase_SMURF1
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00632 HECT, 1 hit
PF00397 WW, 3 hits
PIRSFiPIRSF001569 E3_ub_ligase_SMURF1, 1 hit
PRINTSiPR00360 C2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00119 HECTc, 1 hit
SM00456 WW, 3 hits
SUPFAMiSSF51045 SSF51045, 3 hits
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50237 HECT, 1 hit
PS01159 WW_DOMAIN_1, 3 hits
PS50020 WW_DOMAIN_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEDD4_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VVI3
Secondary accession number(s): Q7KUR2
, Q8IQR6, Q95R64, Q95TQ0, Q95ZF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: February 13, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again