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Entry version 169 (07 Oct 2020)
Sequence version 2 (01 Oct 2002)
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Protein
Submitted name:

Neural conserved at 73EF, isoform A

Gene

Nc73EF

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

thiamine diphosphateARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseImportedARBA annotation
LigandThiamine pyrophosphateARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Neural conserved at 73EF, isoform AImported (EC:1.2.4.2Imported)
Submitted name:
Neural conserved at 73EF, isoform BImported
Submitted name:
Neural conserved at 73EF, isoform CImported
Submitted name:
Neural conserved at 73EF, isoform GImported
Submitted name:
SD10782pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nc73EFImported
Synonyms:141810_atImported, anon-WO0118547.329Imported, Dmel\CG11661Imported, DOGDHImported, dOgdhImported, E1Imported, Nc73eFImported
ORF Names:CG11661Imported, Dmel_CG11661Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010352, Nc73EF

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VVC5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010352, Expressed in tagma (Drosophila) and 51 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VVC5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini644 – 857Transket_pyrInterPro annotationAdd BLAST214

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.ARBA annotation

Keywords - Domaini

Transit peptideARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183125

Identification of Orthologs from Complete Genome Data

More...
OMAi
RDSYCRT

Database of Orthologous Groups

More...
OrthoDBi
134699at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11610, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032106, 2-oxogl_dehyd_N
IPR011603, 2oxoglutarate_DH_E1
IPR001017, DH_E1
IPR031717, KGD_C
IPR042179, KGD_C_sf
IPR029061, THDP-binding
IPR005475, Transketolase-like_Pyr-bd

The PANTHER Classification System

More...
PANTHERi
PTHR23152, PTHR23152, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16078, 2-oxogl_dehyd_N, 1 hit
PF00676, E1_dh, 1 hit
PF16870, OxoGdeHyase_C, 1 hit
PF02779, Transket_pyr, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000157, Oxoglu_dh_E1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00861, Transket_pyr, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52518, SSF52518, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00239, 2oxo_dh_E1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9VVC5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHRAHTAFSL ALSPMAHKNF ATWLLKSSSS QQMAKVTAAA AVRTYNSAAA
60 70 80 90 100
EPFANGSTAS YVEEMYNAWL RDPTSVHTSW DAYFRSNSYV SPPNLAPVQA
110 120 130 140 150
NTLPLTAFNF GGAVAGAAPD SKTIDDHLAV QAIIRSYQIR GHNIAHLDPL
160 170 180 190 200
EINTPELPGN SSTKSIYANF SFGEQDMDRQ FKLPSTTFIG GDEASLPLKE
210 220 230 240 250
ILNRLENVYC NKIGVEFMFI NSLEQCNWIR KRFETPGVLN FSPEEKRLIL
260 270 280 290 300
ARLTRATGFE AFLAKKYSSE KRFGLEGCEI MIPALKEIID VSTELGVESV
310 320 330 340 350
IMGMPHRGRL NTLANVCRKP LNQIFTQFAG LEAADDGSGD VKYHLGTYIE
360 370 380 390 400
RLNRVTNKNI RLAVVANPSH LEAVDPVVQG KTRAEQFYRG DQEGKKVMSI
410 420 430 440 450
LIHGDAAFCG QGVVYETMHL SDLPDYTTHG TIHVVANNQI GFTTDPRFSR
460 470 480 490 500
SSPYCTDVAR VVNAPIFHVN ADDPEAVMHV CKVAAEWRAT FHKDCVIDLV
510 520 530 540 550
GYRRNGHNEI DEPMFTQPLM YQKIRKHKNC LDLYADKLIA EGTVTAEEVK
560 570 580 590 600
SVAAKYENIC EEAFALAKTE THVKYKDWLD SPWSGFFEGK DPLKVAPTGV
610 620 630 640 650
KEETLIHIGN RFSSPPPNAA EFVIHKGLLR VLAARKAMVD EKVADWALGE
660 670 680 690 700
AMAFGSLLKE GIHVRLSGQD VERGTFSHRH HVLHHQLVDK ATYNSLQHMY
710 720 730 740 750
PDQAPYSVSN SSLSEYAVLG FEHGYSMTNP NALVLWEAQF GDFSNTAQSI
760 770 780 790 800
IDQFISSGQS KWVRQSGLVM LLPHGMEGMG PEHSSCRVER FLQMSSDDPD
810 820 830 840 850
YFPPESDEFG VRQLHDINWI VANCSTPANY YHILRRQIAL PFRKPLILCT
860 870 880 890 900
PKSLLRHPEA KSPFSEMSEG SEFQRIIPDN GPAGQNPSNV KKVVFCSGRV
910 920 930 940 950
YYDLTKTRRE KQLEGEIAIV RVEQISPFPF DLVKEQANLY KNAELVWAQE
960 970 980 990 1000
EHKNQGSWTY VQPRFLTALN HSRDVSYVGR ACGASTATGS KAQHIRELNA

LLNDAIST
Length:1,008
Mass (Da):112,586
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA833C1AE5B367958
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8JNU6A8JNU6_DROME
Neural conserved at 73EF, isoform I
Nc73EF 141810_at, anon-WO0118547.329, Dmel\CG11661, DOGDH, dOgdh
1,105Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IQQ0Q8IQQ0_DROME
Neural conserved at 73EF, isoform F
Nc73EF 141810_at, anon-WO0118547.329, Dmel\CG11661, DOGDH, dOgdh
1,017Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49388.2
AE014296 Genomic DNA Translation: AAF49389.2
AE014296 Genomic DNA Translation: AAN11722.1
AE014296 Genomic DNA Translation: AAO41240.1
BT003743 mRNA Translation: AAO41404.1

NCBI Reference Sequences

More...
RefSeqi
NP_730223.1, NM_168701.5
NP_730224.1, NM_168702.2
NP_730225.1, NM_168703.5
NP_788519.1, NM_176341.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0075263; FBpp0075023; FBgn0010352
FBtr0075264; FBpp0075024; FBgn0010352
FBtr0075266; FBpp0075026; FBgn0010352
FBtr0075268; FBpp0075028; FBgn0010352

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39899

UCSC genome browser

More...
UCSCi
CG11661-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49388.2
AE014296 Genomic DNA Translation: AAF49389.2
AE014296 Genomic DNA Translation: AAN11722.1
AE014296 Genomic DNA Translation: AAO41240.1
BT003743 mRNA Translation: AAO41404.1
RefSeqiNP_730223.1, NM_168701.5
NP_730224.1, NM_168702.2
NP_730225.1, NM_168703.5
NP_788519.1, NM_176341.3

3D structure databases

SMRiQ9VVC5
ModBaseiSearch...

Proteomic databases

PRIDEiQ9VVC5

Genome annotation databases

EnsemblMetazoaiFBtr0075263; FBpp0075023; FBgn0010352
FBtr0075264; FBpp0075024; FBgn0010352
FBtr0075266; FBpp0075026; FBgn0010352
FBtr0075268; FBpp0075028; FBgn0010352
GeneIDi39899
UCSCiCG11661-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39899
FlyBaseiFBgn0010352, Nc73EF

Phylogenomic databases

GeneTreeiENSGT00950000183125
OMAiRDSYCRT
OrthoDBi134699at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
39899, 0 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nc73EF, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39899

Gene expression databases

BgeeiFBgn0010352, Expressed in tagma (Drosophila) and 51 other tissues

Family and domain databases

Gene3Di3.40.50.11610, 1 hit
InterProiView protein in InterPro
IPR032106, 2-oxogl_dehyd_N
IPR011603, 2oxoglutarate_DH_E1
IPR001017, DH_E1
IPR031717, KGD_C
IPR042179, KGD_C_sf
IPR029061, THDP-binding
IPR005475, Transketolase-like_Pyr-bd
PANTHERiPTHR23152, PTHR23152, 1 hit
PfamiView protein in Pfam
PF16078, 2-oxogl_dehyd_N, 1 hit
PF00676, E1_dh, 1 hit
PF16870, OxoGdeHyase_C, 1 hit
PF02779, Transket_pyr, 1 hit
PIRSFiPIRSF000157, Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861, Transket_pyr, 1 hit
SUPFAMiSSF52518, SSF52518, 2 hits
TIGRFAMsiTIGR00239, 2oxo_dh_E1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VVC5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VVC5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: October 7, 2020
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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