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Entry version 154 (19 Jan 2022)
Sequence version 2 (01 Mar 2001)
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Protein
Submitted name:

BcDNA.LD24702

Gene

spd-2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
BcDNA.LD24702Imported
Submitted name:
Spindle defective 2Imported (EC:3.6.1.13Imported, EC:3.6.1.5Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:spd-2Imported
Synonyms:anon-73BaImported, BcDNA.LD24702Imported, BcDNA:LD24702Imported, CEP192Imported, Cep192Imported, CG17286-PAImported, D-SPD2Imported, D-Spd2Imported, Dmel\CG17286Imported, DSPD-2Imported, DSpd-2Imported, Dspd-2Imported, DSpd2Imported, Dspd2Imported, dSpd2Imported, SPD-2Imported, Spd-2Imported, SPD2Imported, Spd2Imported, spd2Imported
ORF Names:CG17286Imported, Dmel_CG17286Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0027500, spd-2

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
VectorBase:FBgn0027500

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0027500, Expressed in embryo and 31 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9VV79, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0075122

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni308 – 349DisorderedSequence analysisAdd BLAST42
Regioni373 – 392DisorderedSequence analysisAdd BLAST20
Regioni424 – 455DisorderedSequence analysisAdd BLAST32
Regioni480 – 566DisorderedSequence analysisAdd BLAST87
Regioni604 – 672DisorderedSequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi425 – 441Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi512 – 527Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi532 – 546Polar residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RT76, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017405

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008758_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
MDQNSLG

Database of Orthologous Groups

More...
OrthoDBi
105660at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039989, NUDT9

The PANTHER Classification System

More...
PANTHERi
PTHR13030, PTHR13030, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VV79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSSSGSQGN GSFMDQNSLG ILNMDNLKVF GDLSSFSKSG RRSGTGRDSP
60 70 80 90 100
AVHERLREER LRALETLEKP RPSRSSQAKS TALQMRLSTN ISELVTDDTI
110 120 130 140 150
DLNSSSSFAL VTPATKGTNI SFEPAEITGR STLCQAGKQR RREKPSLSVA
160 170 180 190 200
EILKSSFVEK ARLLERKLQD ASQAEASYHL SRGSSSSLSD SFNCSRSLPR
210 220 230 240 250
TADMSELSLN GGGGFSFGSA SLAAEGQDES FAPAELMQSK LVLGEISWAQ
260 270 280 290 300
EFTAMPTATL STQALKKIAA PTSEIETSVS NSVLAGDPDF SLGNYFQTRS
310 320 330 340 350
ENIWNIVSNS SPNRSRTNQP LLEPESNVTL DSVGEKTPQP DNKTYTKTDA
360 370 380 390 400
ITGSNLGRNL MRKMQQDRIE TALKSRNGLA AKETKRPPSS SEILSLSAID
410 420 430 440 450
KALRDIDLNS DTSTVEVVNH LWEHGRGNNY DDGENKENQS SNSHAERTSC
460 470 480 490 500
GSNKLTDTMS FTDSVLNSTD FRHLQQSISR KPLSPLADHP QITISRADTD
510 520 530 540 550
PVETEAEADI DEWPSTPVKE PSRRVRRTKI SPRAASPSSS DGVRPLTCTE
560 570 580 590 600
DENDEEDEDK TPVNKKRVSI ATMGLIPRKA SSLSSTRLDG CDVAVASSTE
610 620 630 640 650
RDFGISPNLA KNLSPLSSPR SCLSSPLLDS TTSSDRRQLM SGAARKANSS
660 670 680 690 700
PAGSEASSTS GFTASGRRGL GTSSVAVPRS ISRCSNSSEF SHRDGKLLPL
710 720 730 740 750
KVTHTTLCWG STKLRTDVRK SMQVKNTADK RLVIRLGIQG PGFQLVGTDS
760 770 780 790 800
STITLQAMEC RSVVINFCPT VCGAAIGALS FYAPPGAHNS NQPGLEIPLY
810 820 830 840 850
GYGGSASITI NGLLKGPVGA SFLTIGDVCE LSAGPLSANL KFHNKGPLTA
860 870 880 890 900
FVGISVDSTV LMKLRLSEAF EVRPSRLILP PNSERCVQIL FRPNREDLKN
910 920 930 940 950
ILKKTAQVLT LANMRIFCGD EPNRQRMRSL VQRMSSRQRE KLTSPMLDSI
960 970 980 990 1000
WGEFPDEQPV RNIGQLNEPP EFILDLVTVV RIIDVALTLN RDFDESSESS
1010 1020 1030 1040 1050
LMFLPEADET VLFRTICVAN SPTPTQSHLL EPVDELLEAD TTTLTPVEQN
1060 1070 1080 1090 1100
WCVQPGLLEF GVGCSPLATL SVTNSFCSRQ LIEVTCNVPD LVRISPSECY
1110 1120 1130 1140
VSPDGGHAEI DVRLLRSPRQ DLLEREPLIV VSMENERISV PISFKF
Length:1,146
Mass (Da):124,542
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB0427DA17FA0AC6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF145687 mRNA Translation: AAD38662.1
AE014296 Genomic DNA Translation: AAF49440.2

NCBI Reference Sequences

More...
RefSeqi
NP_648906.1, NM_140649.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0075363; FBpp0075122; FBgn0027500

Database of genes from NCBI RefSeq genomes

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GeneIDi
39850

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17286

UCSC genome browser

More...
UCSCi
CG17286-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145687 mRNA Translation: AAD38662.1
AE014296 Genomic DNA Translation: AAF49440.2
RefSeqiNP_648906.1, NM_140649.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9VV79, 3 interactors
STRINGi7227.FBpp0075122

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
39850

Genome annotation databases

EnsemblMetazoaiFBtr0075363; FBpp0075122; FBgn0027500
GeneIDi39850
KEGGidme:Dmel_CG17286
UCSCiCG17286-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39850
FlyBaseiFBgn0027500, spd-2
VEuPathDBiVectorBase:FBgn0027500

Phylogenomic databases

eggNOGiENOG502RT76, Eukaryota
GeneTreeiENSGT00390000017405
HOGENOMiCLU_008758_0_0_1
OMAiMDQNSLG
OrthoDBi105660at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
39850, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39850

Gene expression databases

BgeeiFBgn0027500, Expressed in embryo and 31 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR039989, NUDT9
PANTHERiPTHR13030, PTHR13030, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VV79_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VV79
Secondary accession number(s): Q9Y0Y9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: January 19, 2022
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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