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Entry version 155 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

Nuclear RNA export factor 2

Gene

nxf2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the export of mRNA from the nucleus to the cytoplasm (PubMed:11780633).

In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31570835, PubMed:31384064).

On recruitment to a target transcript, interacts with single stranded RNA, thereby anchoring the complex via the nascent target transcript to chromatin and allowing Panx to recruit silencing effectors to establishing repressive heterochromatin at transposon loci (PubMed:31368590, PubMed:31570835, PubMed:31384064).

Does not affect piRNA biogenesis (PubMed:31384064).

The interaction with Panx stabilizes the nuclear protein complex (PubMed:31384064).

Does not bind nucleoporins, but regulates sbr/Nxf1 binding to nucleoporins and, indirectly, transposon exports (PubMed:31570835, PubMed:31384064).

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear RNA export factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nxf2
ORF Names:CG4118
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0036640, nxf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Results in sterility where fewer eggs are laid and none reach larval stage (PubMed:31219034, PubMed:31384064). Increases transposon expression (PubMed:31219034, PubMed:31384064). RNAi-mediated knockdown in the germline does not affect ovary morphology but results in severe fertility defects where eggs are laied but do not hatch (PubMed:31368590). RNAi-mediated knockdown in the germline increases transposon expression and impairs Panx localization in nurse cells by reducing its stability (PubMed:31219034, PubMed:31570835, PubMed:31368590, PubMed:31384064).4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi210R → A: Abolishes RNA-binding; when associated with 236-A--A-240. 1 Publication1
Mutagenesisi236 – 240KSAER → ASAEA: Abolishes RNA-binding; when associated with A-210. 1 Publication5
Mutagenesisi751 – 754IANE → GGAA: Retains localization to the nucleus and interaction with Panx but reduces interaction with Nxt1. Increases transposon expression after loss of gene. 1 Publication4
Mutagenesisi754 – 756ERL → AGA: Retains localization to the nucleus and interaction with Panx but reduces interaction with Nxt1. Increases transposon expression after loss of gene. 1 Publication3
Mutagenesisi755 – 758RLHI → AGVK: Retains localization to the nucleus and interaction with Panx. Increases transposon expression after loss of gene. 1 Publication4
Mutagenesisi755R → G: Retains localization to the nucleus and interaction with Panx. Reduces transposon expression after loss of gene. 1 Publication1
Mutagenesisi811 – 814IVEE → KRGG: Reduces binding to Panx, increases cytoplasmic localization and increases transposon expression after loss of gene. 1 Publication4
Mutagenesisi823L → A: Reduces binding to Panx. 1 Publication1
Mutagenesisi826 – 827FI → AA: Reduces binding to Panx. 1 Publication2
Mutagenesisi835 – 836IP → NA: Reduces binding to Panx, increases cytoplasmic localization and increases transposon expression after loss of gene. 1 Publication2
Mutagenesisi837D → A: Reduces binding to Panx. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205391 – 841Nuclear RNA export factor 2Add BLAST841

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VV73

PRoteomics IDEntifications database

More...
PRIDEi
Q9VV73

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in female gonads (at protein level) (PubMed:31219034, PubMed:31570835, PubMed:31368590, PubMed:31384064). Expressed ubiquitously (PubMed:11780633).5 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout embryonic development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0036640, Expressed in embryo and 41 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VV73, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VV73, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

In the ovaries, part of a complex composed of at least Panx, nxf2, piwi and Nxt1 (PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064). The complex is knowns as Panx-induced cotranscriptional silencing (PICTS) complex, Panx-nxf2-dependent TAP/p15 silencing (Pandas complex), SFiNX (silencing factor interacting nuclear export variant) or piwi-Panx-nxf2-p15 (PPNP) complex (PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064).

Interacts (via TAP-C domain) with Panx (via NIR region); the interaction is direct (PubMed:31570835, PubMed:31219034, PubMed:31368590).

Interacts (via NTF2 domain) with Nxt1; the interaction is direct and prevents Nxt1 binding to nucleoporins (PubMed:31368590).

Interacts with sbr/Nxf1 (PubMed:31570835).

4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
65146, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VV73, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088483

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1841
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VV73

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati200 – 221LRR 1Add BLAST22
Repeati224 – 245LRR 2Add BLAST22
Repeati249 – 270LRR 3Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini325 – 408RRMAdd BLAST84
Repeati475 – 496LRR 4Add BLAST22
Repeati500 – 521LRR 5Add BLAST22
Repeati524 – 545LRR 6Add BLAST22
Domaini585 – 758NTF2PROSITE-ProRule annotationAdd BLAST174
Domaini788 – 841TAP-C4 PublicationsAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 285RNA-binding unit probably involved in Piwi-dependent recruitment and single-stranded RNA-PPNP complex formation3 PublicationsAdd BLAST285
Regioni286 – 553Necessary for silencing function1 PublicationAdd BLAST268

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RNA-binding domain is a non-canonical RNP-type domain.
The TAP-C domain (also known as UBA domain) mediates the interaction with Panx.4 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NXF family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3763, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016827_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VV73

Identification of Orthologs from Complete Genome Data

More...
OMAi
YPCYYKY

Database of Orthologous Groups

More...
OrthoDBi
231208at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VV73

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR032710, NTF2-like_dom_sf
IPR018222, Nuclear_transport_factor_2_euk
IPR030217, NXF_fam
IPR005637, TAP_C_dom
IPR009060, UBA-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10662, PTHR10662, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03943, TAP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00804, TAP_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934, SSF46934, 1 hit
SSF54427, SSF54427, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 5 hits
PS50177, NTF2_DOMAIN, 1 hit
PS51281, TAP_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VV73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNQMRVLDF GDGSVPIQLD YPDSKIFSKC SSYGDRVPGT HWNEITVHHK
60 70 80 90 100
GRLEYSPNPE QIILDALYQA IDGADFFPVF YQRGKNMDTM LVRNCKAAID
110 120 130 140 150
KLFKQRLSIN LKGGASIPIS IQLGVAQYQR HQITPTFHIA RVVTRLMKQL
160 170 180 190 200
IQRDGVDGLL NLDNFGSHPE FKNLVVSLGN PSILMNVCQV IHNDDNERFR
210 220 230 240 250
LNGFILSNNR IRDIRPLTLL ANVDYALLDL RGNKIKSAER LCRALEQFRA
260 270 280 290 300
RELLLENNPI VKISNFPANI KSLESNFELV DGKPFNMLHK IFSPLDVEID
310 320 330 340 350
LEVDGARIDT NNMWKLPEFE NSQHWHAFMI PDPSHEFNQE VFFDFFFIRL
360 370 380 390 400
DPTLSNFYPC YYKYINTEHV FLVRNCFDQI AHLVNNCNLE MTIPTGDRIF
410 420 430 440 450
RYYLRMNVST VKQHHVDPEE CIQKAVSQCY VAQNRMLNLE RFHSRECLKD
460 470 480 490 500
VMVSLSSPKI LTYVLSVASR KFMTTCSEIR LCHNKVLVLD GAHVLGMMGC
510 520 530 540 550
LRAVDLSHNW VQDLSSIHSL GNLPLKSLVL HGNKLCRNYR LPSEYVRAVK
560 570 580 590 600
EVFPQLTTLD GVDLQTNPGQ SLQKNFLCDT GAYELVGAFL ENYLREFEND
610 620 630 640 650
EFRHNLYKYY SENSIFTLTC NYNVVQNHQT PKILQRLSKY NRHARNLRNK
660 670 680 690 700
DYSKASDGVF FGCTYIVEIL LQLPRVTHDF HSLQTDVMHY NGKGAVIYVA
710 720 730 740 750
GLLRDEPPST RNGHGSKTDI GGVLLGFSRQ FVVTFDEANL GLGKRARRLK
760 770 780 790 800
IANERLHITN PSKTAIRNAF SVNFPDPSER QAEEDSLDVK DHKLLLFQEV
810 820 830 840
TGLISTWVTS IVEEADWDFE RALKLFIQKN ADHEIPDLAF A
Length:841
Mass (Da):96,635
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i581CE6B0C57FF098
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PI81M9PI81_DROME
Nuclear RNA export factor 2, isofor...
nxf2 Dmel\CG4118, NXF2, Nxf2, CG4118, Dmel_CG4118
825Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ312282 mRNA Translation: CAC41644.1
AE014296 Genomic DNA Translation: AAF49448.3
AY075582 mRNA Translation: AAL68387.1

NCBI Reference Sequences

More...
RefSeqi
NP_524111.3, NM_079387.6
NP_730179.2, NM_168674.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089478; FBpp0088483; FBgn0036640
FBtr0089479; FBpp0088484; FBgn0036640

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39843

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4118

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312282 mRNA Translation: CAC41644.1
AE014296 Genomic DNA Translation: AAF49448.3
AY075582 mRNA Translation: AAL68387.1
RefSeqiNP_524111.3, NM_079387.6
NP_730179.2, NM_168674.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6IEWX-ray1.50A789-841[»]
6MRKX-ray2.80A/B573-777[»]
6OPFX-ray2.00A/B/D/F781-841[»]
SMRiQ9VV73
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi65146, 17 interactors
IntActiQ9VV73, 1 interactor
STRINGi7227.FBpp0088483

Proteomic databases

PaxDbiQ9VV73
PRIDEiQ9VV73

Genome annotation databases

EnsemblMetazoaiFBtr0089478; FBpp0088483; FBgn0036640
FBtr0089479; FBpp0088484; FBgn0036640
GeneIDi39843
KEGGidme:Dmel_CG4118

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56001
FlyBaseiFBgn0036640, nxf2

Phylogenomic databases

eggNOGiKOG3763, Eukaryota
GeneTreeiENSGT00390000007539
HOGENOMiCLU_016827_0_0_1
InParanoidiQ9VV73
OMAiYPCYYKY
OrthoDBi231208at2759
PhylomeDBiQ9VV73

Enzyme and pathway databases

ReactomeiR-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
39843, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39843

Protein Ontology

More...
PROi
PR:Q9VV73

Gene expression databases

BgeeiFBgn0036640, Expressed in embryo and 41 other tissues
ExpressionAtlasiQ9VV73, baseline and differential
GenevisibleiQ9VV73, DM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR032710, NTF2-like_dom_sf
IPR018222, Nuclear_transport_factor_2_euk
IPR030217, NXF_fam
IPR005637, TAP_C_dom
IPR009060, UBA-like_sf
PANTHERiPTHR10662, PTHR10662, 3 hits
PfamiView protein in Pfam
PF03943, TAP_C, 1 hit
SMARTiView protein in SMART
SM00804, TAP_C, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
SSF54427, SSF54427, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 5 hits
PS50177, NTF2_DOMAIN, 1 hit
PS51281, TAP_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNXF2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VV73
Secondary accession number(s): Q0E8E0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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