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Entry version 171 (07 Apr 2021)
Sequence version 3 (01 Oct 2002)
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Protein
Submitted name:

LD37257p

Gene

RAF2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LD37257pImported
Submitted name:
RING-associated factor 2, isoform AImported
Submitted name:
RING-associated factor 2, isoform BImported
Submitted name:
RING-associated factor 2, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAF2Imported
Synonyms:CG4689Imported, Dmel\CG4877Imported, dRAF2Imported, Raf2Imported
ORF Names:CG4877Imported, Dmel_CG4877Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0036624, RAF2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VV52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0036624, Expressed in embryo and 37 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VV52, 9 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0075144

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VV52

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1078 – 1115MYND-typeInterPro annotationAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 81DisorderedSequence analysisAdd BLAST81
Regioni141 – 239DisorderedSequence analysisAdd BLAST99
Regioni275 – 351DisorderedSequence analysisAdd BLAST77
Regioni365 – 387DisorderedSequence analysisAdd BLAST23
Regioni451 – 731DisorderedSequence analysisAdd BLAST281
Regioni930 – 965DisorderedSequence analysisAdd BLAST36
Regioni989 – 1071DisorderedSequence analysisAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili777 – 797Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15PolarSequence analysisAdd BLAST15
Compositional biasi62 – 77PolyampholyteSequence analysisAdd BLAST16
Compositional biasi154 – 180PolarSequence analysisAdd BLAST27
Compositional biasi300 – 315PolyampholyteSequence analysisAdd BLAST16
Compositional biasi316 – 330PolarSequence analysisAdd BLAST15
Compositional biasi369 – 387PolarSequence analysisAdd BLAST19
Compositional biasi454 – 474Pro-richSequence analysisAdd BLAST21
Compositional biasi505 – 591Pro-richSequence analysisAdd BLAST87
Compositional biasi614 – 656Pro-richSequence analysisAdd BLAST43
Compositional biasi657 – 687PolarSequence analysisAdd BLAST31
Compositional biasi702 – 731PolarSequence analysisAdd BLAST30
Compositional biasi930 – 952PolyampholyteSequence analysisAdd BLAST23
Compositional biasi989 – 1031PolarSequence analysisAdd BLAST43
Compositional biasi1039 – 1059BasicSequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S4AG, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_307624_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNLYFKR

Database of Orthologous Groups

More...
OrthoDBi
681384at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024119, TF_DEAF-1
IPR002893, Znf_MYND

The PANTHER Classification System

More...
PANTHERi
PTHR10237, PTHR10237, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01753, zf-MYND, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VV52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNEIYDSSN SQLSSDEYSH EEEEYDALMD AAVSKQRPQK TKSKGSESEK
60 70 80 90 100
PGNGAPESAA ATEKNEKPDD DAVPPSTRSE TIRRIRQLQL QRGRLPNLYF
110 120 130 140 150
KRRSIRWLRP NKMDYNSYFD GLKDLLPKRK LKHLVRFHDR QRRTYDSRSI
160 170 180 190 200
SRSRSHSRSL SRSCSRSRSR SYSRSRSGSG SPELICLDDT ENEDSPEKPE
210 220 230 240 250
QEPARVTPIK ENKPTLPAPP QLNYELPERK KANPLGNNEN GASILDEFLV
260 270 280 290 300
KKDPQEPVFD YGKLSACREL EQALKDRSRD APNEAESLVV DATLKRRRSV
310 320 330 340 350
TPPASEEKRN NEVEDDNIIG FSTVQQQKPM EAAPPLNLRM PTTPSTNPLQ
360 370 380 390 400
RQQAFKLSTP YTLAPPTAAK QADTYSLNTP PPTATQMQIS YPNEKLSNNM
410 420 430 440 450
KANATFSIQQ TALSQVAASY AAAPQVAALA QRAPSQVAPL QQAPVQQMHF
460 470 480 490 500
PRSVPPQQLP PPQQRAPPQQ LATAPFAPPR HLAQHRPSPQ QLAPSQQLAP
510 520 530 540 550
PHQLAPPHQL APPQQRAPPQ QLAPPHQLAP PHQLAPPQQR APPQQLAPPQ
560 570 580 590 600
QLAPPQQLAP PQQLAPPQQL APPQQRAPPQ QRAPPQQLAP PQQRAPTQHM
610 620 630 640 650
APPQHMAPPQ QLAPTQQLAP PPQQLAPRPQ QLAPPPQQLA PPPQQLAPPP
660 670 680 690 700
QQPDSSRPAS VQPLTPQRHA SPHQLAQSQQ VHQSPSQLHP VPVAAPNFAV
710 720 730 740 750
PQQPQPRRSE TVSTQTQGLG SPAASSSTTR QKSFVDLNNS DANFHYRVKE
760 770 780 790 800
LFDELNSTMI DKINSVPPDE DSLKKERERI VADLAALDKL MAQKEDEYNR
810 820 830 840 850
LLYLSCIKKE LHERMERKER LIRIKDLLPI LINKCGTKEL SEVKAMLEEE
860 870 880 890 900
IDSPMASKHS LSAIEKLLNY AELNQNIIQL LRGSLGLNKR APSVSPANFE
910 920 930 940 950
DDQMLFRRDS LPVSHLSMRD QHYESRNAVN DHLLDSNPDR DPPAKRPKLI
960 970 980 990 1000
HSQDSNQDMA SSSTHLSANL SETLRKIRAW KNYSHFSNVS MEDNNSDNES
1010 1020 1030 1040 1050
QIEPLFNSSP MASRRQLANR QSYQEQHSAN INDHENVQKR HKSHKRKSHK
1060 1070 1080 1090 1100
HKSHKHRSSH KSQAESSATI NGNTGRQCHE CKLYGATFMC SNCQNQWYCS
1110
RECQLSDWDT HHRTCGI
Length:1,117
Mass (Da):125,491
Last modified:October 1, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C1C6CB5C523D09D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49469.2
AE014296 Genomic DNA Translation: AAF49470.3
BT021383 mRNA Translation: AAX33531.1
AE014296 Genomic DNA Translation: AGB94636.1

NCBI Reference Sequences

More...
RefSeqi
NP_001261943.1, NM_001275014.1
NP_648889.2, NM_140632.3
NP_730163.1, NM_168664.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0075386; FBpp0075144; FBgn0036624
FBtr0075387; FBpp0075145; FBgn0036624
FBtr0333596; FBpp0305773; FBgn0036624

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39821

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4877

UCSC genome browser

More...
UCSCi
CG4877-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49469.2
AE014296 Genomic DNA Translation: AAF49470.3
BT021383 mRNA Translation: AAX33531.1
AE014296 Genomic DNA Translation: AGB94636.1
RefSeqiNP_001261943.1, NM_001275014.1
NP_648889.2, NM_140632.3
NP_730163.1, NM_168664.2

3D structure databases

SMRiQ9VV52
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9VV52, 9 interactors
STRINGi7227.FBpp0075144

Proteomic databases

PRIDEiQ9VV52

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
39821

Genome annotation databases

EnsemblMetazoaiFBtr0075386; FBpp0075144; FBgn0036624
FBtr0075387; FBpp0075145; FBgn0036624
FBtr0333596; FBpp0305773; FBgn0036624
GeneIDi39821
KEGGidme:Dmel_CG4877
UCSCiCG4877-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39821
FlyBaseiFBgn0036624, RAF2

Phylogenomic databases

eggNOGiENOG502S4AG, Eukaryota
HOGENOMiCLU_307624_0_0_1
OMAiPNLYFKR
OrthoDBi681384at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
39821, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39821

Gene expression databases

BgeeiFBgn0036624, Expressed in embryo and 37 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR024119, TF_DEAF-1
IPR002893, Znf_MYND
PANTHERiPTHR10237, PTHR10237, 1 hit
PfamiView protein in Pfam
PF01753, zf-MYND, 1 hit
PROSITEiView protein in PROSITE
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VV52_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VV52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: April 7, 2021
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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