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Entry version 143 (11 Dec 2019)
Sequence version 3 (03 Mar 2009)
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Protein

Formin-like protein

Gene

Frl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with Cdc42, involved in establishment of planar cell polarity in the developing compound eye by contributing to ommatidial rotation. Together with DAAM and Cdc42, has a role in neuronal development of mushroom bodies.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: InterPro
  • axon extension Source: FlyBase
  • mushroom body development Source: FlyBase
  • ommatidial rotation Source: FlyBase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5663220 RHO GTPases Activate Formins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Formin-like proteinCurated
Alternative name(s):
Formin related in leukocytes1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Frl1 PublicationImported
ORF Names:CG32138Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0267795 Frl

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Lethal; shows planar cell polarity defects with abnormal ommatidial orientation. RNAi-mediated knockdown in the eye results in planar cell polarity defects with ommatidia showing defective rotation.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi373 – 1183Missing : Loss of autoinhibition mediated by self-association results in severe eye defects including loss of R-cells. 1 PublicationAdd BLAST811
Mutagenesisi683 – 1131Missing : Loss of autoinhibition mediated by self-association results in rotation defects in the adult eye. 1 PublicationAdd BLAST449

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003726481 – 1183Formin-like proteinAdd BLAST1183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei225Phosphoserine1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VUC6

PRoteomics IDEntifications database

More...
PRIDEi
Q9VUC6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VUC6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0267795 Expressed in 27 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VUC6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VUC6 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates.

Interacts (via GBD/FH3 domain) with Cdc42; the interaction is stronger with the GTP bound form of Cdc42.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
64899, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VUC6, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0075517

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VUC6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 559GBD/FH3PROSITE-ProRule annotationAdd BLAST484
Domaini687 – 1088FH2PROSITE-ProRule annotationAdd BLAST402
Domaini1136 – 1169DADPROSITE-ProRule annotationAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 38His-richAdd BLAST17
Compositional biasi606 – 681Pro-richAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the formin homology family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1923 Eukaryota
ENOG410Y3DT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169082

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VUC6

Identification of Orthologs from Complete Genome Data

More...
OMAi
MMPGFSP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VUC6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.2220, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR014767 DAD_dom
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR010472 FH3_dom
IPR014768 GBD/FH3_dom
IPR010473 GTPase-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06367 Drf_FH3, 1 hit
PF06371 Drf_GBD, 2 hits
PF02181 FH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01139 Drf_FH3, 1 hit
SM01140 Drf_GBD, 1 hit
SM00498 FH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51231 DAD, 1 hit
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q9VUC6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAVKSRTIT SADVDADEQL QHPHSHAHHH SMRNGHQHNG SISSGTLQKQ
60 70 80 90 100
DLRYDIGCSS QYQHVRQPSL RSRSQQPMPT TDELDRRFAK VLASMDLPPD
110 120 130 140 150
KAKLLRNYDD EKKWDMICDQ EMVQAKDPPS HYLSKLRTYL DPKASRSHRL
160 170 180 190 200
YLFYFLCQKR KMVGESTSTQ VLRDLEISLR TNHIEWVKEF LDDTNQGLDA
210 220 230 240 250
LVDYLSFRLQ MMRHEQRLQG VLCASEERLN LTNGGDGGEI VMGNSSSVSP
260 270 280 290 300
GGGGGLLSHG NSTGHGLANG TLDSRQQHTM SYGFLRPTIA DALDSPSLKR
310 320 330 340 350
RSRHIAKLNM GAATDDIHVS IMCLRAIMNN KYGFNMVIQH REAINCIALS
360 370 380 390 400
LIHKSLRTKA LVLELLAAIC LVKGGHEIIL GSFDNFKDVC QEKRRFQTLM
410 420 430 440 450
EYFMNFEAFN IDFMVACMQF MNIVVHSVED MNYRVHLQYE FTALGLDKYL
460 470 480 490 500
ERIRLTESEE LKVQISAYLD NVFDVAALME DSETKTSALE RVQELEDQLE
510 520 530 540 550
REIDRNSEFL YKYAELESES LTLKTEREQL AMIRQKLEEE LTVMQRMLQH
560 570 580 590 600
NEQELKKRDT LLHTKNMELQ TLSRSLPRSA SSGDGSLANG GLMAGSTSGA
610 620 630 640 650
ASLTLPPPPP PMPASPTASS AAPPPPPPPA PPAPPPPPGF SPLGSPSGSL
660 670 680 690 700
ASTAPSPPHA PPMLSSFQPP PPPVAGFMPA PDGAMTIKRK VPTKYKLPTL
710 720 730 740 750
NWIALKPNQV RGTIFNELDD EKIFKQIDFN EFEERFKIGI GGALRNGSNG
760 770 780 790 800
TEVDGSLQSS KRFKRPDNVS LLEHTRLRNI AISRRKLGMP IDDVIAAIHS
810 820 830 840 850
LDLKKLSLEN VELLQKMVPT DAEVKSYKEY IIERKDQQLL TEEDKFMLQL
860 870 880 890 900
SRVERISSKL AIMNYMGNFV DSVHLISPQV QSIAGASTSL KQSRKFKAVL
910 920 930 940 950
EIVLAFGNYL NSNKRGPAYG FKLQSLDTLI DTKSTDKRSS LLHYIVATIR
960 970 980 990 1000
AKFPELLNFE SELYGTDKAA SVALENVVAD VQELEKGMDL VRKEAELRVK
1010 1020 1030 1040 1050
GAQTHILRDF LNNSEDKLKK IKSDLRHAQE AFKECVEYFG DSSRNADAAA
1060 1070 1080 1090 1100
FFALIVRFTR AFKQHDQENE QRLRLEKAAA LAASKKENDQ VLMRNKVNQK
1110 1120 1130 1140 1150
KQQLPSNGAL SLQEAVINEL KSKAHSVREK KLLQQDEVYN GALEDILLGL
1160 1170 1180
KSEPYRRADA VRRSQRRRID NNRLSRTLEE MDC
Length:1,183
Mass (Da):133,159
Last modified:March 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52347E7178704576
GO
Isoform B (identifier: Q9VUC6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-158: Missing.
     1104-1113: Missing.

Show »
Length:1,164
Mass (Da):130,986
Checksum:iC2A9C0F373DA668F
GO
Isoform C (identifier: Q9VUC6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-158: Missing.

Show »
Length:1,174
Mass (Da):131,967
Checksum:i9D935C5639C50A4A
GO
Isoform DImported (identifier: Q9VUC6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-158: Missing.
     1104-1122: LPSNGALSLQEAVINELKS → QIHCLLDFANQQQKQLAQS
     1123-1183: Missing.

Show »
Length:1,113
Mass (Da):124,975
Checksum:i16CC01107A6714B7
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO39658 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25S → P in AAO39658 (Ref. 3) Curated1
Sequence conflicti246 – 248SSV → TSF in AAO39658 (Ref. 3) Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037173150 – 158Missing in isoform B, isoform C and isoform D. 1 Publication9
Alternative sequenceiVSP_0596911104 – 1122LPSNG…NELKS → QIHCLLDFANQQQKQLAQS in isoform D. CuratedAdd BLAST19
Alternative sequenceiVSP_0371751104 – 1113Missing in isoform B. Curated10
Alternative sequenceiVSP_0596921123 – 1183Missing in isoform D. CuratedAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49761.3
AE014296 Genomic DNA Translation: AAF49762.3
AE014296 Genomic DNA Translation: ACL83303.1
AE014296 Genomic DNA Translation: AGB94517.1
BT003654 mRNA Translation: AAO39658.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001137948.1, NM_001144476.3 [Q9VUC6-3]
NP_001261824.1, NM_001274895.2 [Q9VUC6-4]
NP_729954.2, NM_168575.4 [Q9VUC6-1]
NP_729955.2, NM_168576.4 [Q9VUC6-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0075775; FBpp0075517; FBgn0267795 [Q9VUC6-1]
FBtr0075776; FBpp0075518; FBgn0267795 [Q9VUC6-2]
FBtr0114573; FBpp0113065; FBgn0267795 [Q9VUC6-3]
FBtr0334053; FBpp0306179; FBgn0267795 [Q9VUC6-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39561

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG32138

UCSC genome browser

More...
UCSCi
CG32138-RA d. melanogaster [Q9VUC6-1]
CG32138-RB d. melanogaster
CG32138-RC d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49761.3
AE014296 Genomic DNA Translation: AAF49762.3
AE014296 Genomic DNA Translation: ACL83303.1
AE014296 Genomic DNA Translation: AGB94517.1
BT003654 mRNA Translation: AAO39658.1 Different initiation.
RefSeqiNP_001137948.1, NM_001144476.3 [Q9VUC6-3]
NP_001261824.1, NM_001274895.2 [Q9VUC6-4]
NP_729954.2, NM_168575.4 [Q9VUC6-1]
NP_729955.2, NM_168576.4 [Q9VUC6-2]

3D structure databases

SMRiQ9VUC6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi64899, 30 interactors
IntActiQ9VUC6, 5 interactors
STRINGi7227.FBpp0075517

PTM databases

iPTMnetiQ9VUC6

Proteomic databases

PaxDbiQ9VUC6
PRIDEiQ9VUC6

Genome annotation databases

EnsemblMetazoaiFBtr0075775; FBpp0075517; FBgn0267795 [Q9VUC6-1]
FBtr0075776; FBpp0075518; FBgn0267795 [Q9VUC6-2]
FBtr0114573; FBpp0113065; FBgn0267795 [Q9VUC6-3]
FBtr0334053; FBpp0306179; FBgn0267795 [Q9VUC6-4]
GeneIDi39561
KEGGidme:Dmel_CG32138
UCSCiCG32138-RA d. melanogaster [Q9VUC6-1]
CG32138-RB d. melanogaster
CG32138-RC d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
103936
FlyBaseiFBgn0267795 Frl

Phylogenomic databases

eggNOGiKOG1923 Eukaryota
ENOG410Y3DT LUCA
GeneTreeiENSGT00940000169082
InParanoidiQ9VUC6
OMAiMMPGFSP
PhylomeDBiQ9VUC6

Enzyme and pathway databases

ReactomeiR-DME-5663220 RHO GTPases Activate Formins

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39561

Protein Ontology

More...
PROi
PR:Q9VUC6

Gene expression databases

BgeeiFBgn0267795 Expressed in 27 organ(s), highest expression level in testis
ExpressionAtlasiQ9VUC6 baseline and differential
GenevisibleiQ9VUC6 DM

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR014767 DAD_dom
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR010472 FH3_dom
IPR014768 GBD/FH3_dom
IPR010473 GTPase-bd
PfamiView protein in Pfam
PF06367 Drf_FH3, 1 hit
PF06371 Drf_GBD, 2 hits
PF02181 FH2, 1 hit
SMARTiView protein in SMART
SM01139 Drf_FH3, 1 hit
SM01140 Drf_GBD, 1 hit
SM00498 FH2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51231 DAD, 1 hit
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRL_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VUC6
Secondary accession number(s): B7Z050
, M9PCF8, Q86NT2, Q9VUC5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: March 3, 2009
Last modified: December 11, 2019
This is version 143 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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