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Protein

Zinc finger MYND domain-containing protein 10 homolog

Gene

Zmynd10

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in axonemal structure organization and motility. May be involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri412 – 448MYND-typePROSITE-ProRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

  • axoneme assembly Source: FlyBase
  • flagellated sperm motility Source: UniProtKB
  • motile cilium assembly Source: UniProtKB
  • outer dynein arm assembly Source: UniProtKB
  • proprioception Source: FlyBase
  • sensory perception of sound Source: FlyBase

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYND domain-containing protein 10 homolog
Gene namesi
Name:Zmynd10Imported
ORF Names:CG11253Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0266709 Zmynd10

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Sensory defects and loss of the axonemal dynein arms. Flies display defective proprioception as a result of malfunctioning Ch neurons caused by inner and outer dynein arms (IDA and ODA, respectively) defects. Males sterility due to immotile sperm.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi14V → G: Partially rescues sterility when transfected in a homozygous mutant fly. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004248181 – 451Zinc finger MYND domain-containing protein 10 homologAdd BLAST451

Proteomic databases

PaxDbiQ9VU41
PRIDEiQ9VU41

Expressioni

Tissue specificityi

Specifically expressed in cells with flagella and motile cilia: chordotonal sensory neurons and sperm.1 Publication

Developmental stagei

During embryogenesis expression is restricted to developing Ch neurons and absent from other ciliated sensory neurons. In the pupal antenna, expressed exclusively in the Ch neurons of Johnston's organ.

Inductioni

Expression is dependent on the transcription factors that regulate motile cilia such as Rfx and Fd3F.1 Publication

Gene expression databases

BgeeiFBgn0266709 Expressed in 12 organ(s), highest expression level in testis
GenevisibleiQ9VU41 DM

Interactioni

Protein-protein interaction databases

BioGridi64827, 4 interactors
IntActiQ9VU41, 2 interactors
STRINGi7227.FBpp0075628

Structurei

3D structure databases

ProteinModelPortaliQ9VU41
SMRiQ9VU41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZMYND10 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri412 – 448MYND-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIFT Eukaryota
ENOG410Z083 LUCA
GeneTreeiENSGT00390000010195
InParanoidiQ9VU41
OMAiIYKIGLR
PhylomeDBiQ9VU41

Family and domain databases

InterProiView protein in InterPro
IPR017333 UCP037948_Znf-MYND
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF01753 zf-MYND, 1 hit
PIRSFiPIRSF037948 UCP037948_Znf_MYND10, 1 hit
PROSITEiView protein in PROSITE
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VU41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNFVHPEEM YLFVESIRPF EVREVGSPKW LEVHEMILGL SQQAALELSQ
60 70 80 90 100
NREEEVKEFL ISRDKLRVLI HEAYCVTLWK TRVLPHLLEI DPNPQATFLI
110 120 130 140 150
YTVLYHEAAL VALLDVCLYH PSGCETLQES VLDLIDYCAQ AISQVIGLVS
160 170 180 190 200
MGYHENETKL DVDEAVLTEL ERQKRDFIYK IGLRCISVLN YIADNVTLFH
210 220 230 240 250
LSAARRLLVT HDIPWLMADV LSFRPWQRKT SKGIQKFIDE KWTNVDDVTK
260 270 280 290 300
IVKPEAQAWF CVRQLLLNPQ IMENYAFNEA RCKQLHKLLG LMHEPLLDQL
310 320 330 340 350
PPLIELKVFL SRLTLSGNTA KTQPLLLEDI PQIQEELLKD VEENGGFYQI
360 370 380 390 400
AQDQDSVFLS KNKENICALA TRLSKAYGTD LLCELEQNMD DLKMGEAKDA
410 420 430 440 450
GAGGDGDTDH TCATCQAKAK KKCACCKKVH YCSRDCQLKD WPQHKLVCLK

T
Length:451
Mass (Da):51,634
Last modified:May 1, 2000 - v1
Checksum:iF69EC560494BB623
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116V → M in AAM29314 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49850.1
AY113309 mRNA Translation: AAM29314.1
BT044380 mRNA Translation: ACH92445.1
RefSeqiNP_648625.1, NM_140368.2
UniGeneiDm.31194

Genome annotation databases

EnsemblMetazoaiFBtr0075894; FBpp0075628; FBgn0266709
GeneIDi39481
KEGGidme:Dmel_CG11253
UCSCiCG11253-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiZMY10_DROME
AccessioniPrimary (citable) accession number: Q9VU41
Secondary accession number(s): Q8MZ82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 11, 2013
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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