Mirror, isoform A

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo."
    Bilioni A., Craig G., Hill C., McNeill H.
    Proc Natl Acad Sci U S A 102:14671-14676(2005) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo."
    Bilioni A., Craig G., Hill C., McNeill H.
    Proc Natl Acad Sci U S A 102:14671-14676(2005) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• compound eye morphogenesis Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Patterning the peripheral retina of the fly: decoding a gradient."
    Tomlinson A.
    Dev Cell 5:799-809(2003) [PubMed] [Europe PMC] [Abstract]
• dorsal appendage formation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Capicua regulates follicle cell fate in the Drosophila ovary through repression of mirror."
    Atkey M.R., Lachance J.F., Walczak M., Rebello T., Nilson L.A.
    Development 133:2115-2123(2006) [PubMed] [Europe PMC] [Abstract]
  • "Graded Egfr activity patterns the Drosophila eggshell independently of autocrine feedback."
    Boisclair Lachance J.F., Fregoso Lomas M., Eleiche A., Bouchard Kerr P., Nilson L.A.
    Development 136:2893-2902(2009) [PubMed] [Europe PMC] [Abstract]
  • "Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror."
    Peters N.C., Thayer N.H., Kerr S.A., Tompa M., Berg C.A.
    Dev Biol 378:154-169(2013) [PubMed] [Europe PMC] [Abstract]
• embryonic development via the syncytial blastoderm Source: FlyBaseInferred from mutant phenotypeⁱ
  • "mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye."
    McNeill H., Yang C.H., Brodsky M., Ungos J., Simon M.A.
    Genes Dev 11:1073-1082(1997) [PubMed] [Europe PMC] [Abstract]
• equator specification Source: FlyBaseInferred from mutant phenotypeⁱ
  • "mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye."
    McNeill H., Yang C.H., Brodsky M., Ungos J., Simon M.A.
    Genes Dev 11:1073-1082(1997) [PubMed] [Europe PMC] [Abstract]
• imaginal disc-derived wing morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "white+ transgene insertions presenting a dorsal/ventral pattern define a single cluster of homeobox genes that is silenced by the polycomb-group proteins in Drosophila melanogaster."
    Netter S., Fauvarque M.O., Diez del Corral R., Dura J.M., Coen D.
    Genetics 149:257-275(1998) [PubMed] [Europe PMC] [Abstract]
• negative regulation of growth Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Homeodomain Iroquois Proteins Control Cell Cycle Progression and Regulate the Size of Developmental Fields."
    Barrios N., Gonzalez-Perez E., Hernandez R., Campuzano S.
    PLoS Genet 11:e1005463-e1005463(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: FlyBaseInferred from direct assayⁱ
  • "Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo."
    Bilioni A., Craig G., Hill C., McNeill H.
    Proc Natl Acad Sci U S A 102:14671-14676(2005) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• peripheral nervous system development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "white+ transgene insertions presenting a dorsal/ventral pattern define a single cluster of homeobox genes that is silenced by the polycomb-group proteins in Drosophila melanogaster."
    Netter S., Fauvarque M.O., Diez del Corral R., Dura J.M., Coen D.
    Genetics 149:257-275(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: FlyBase <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye."
    McNeill H., Yang C.H., Brodsky M., Ungos J., Simon M.A.
    Genes Dev 11:1073-1082(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sensory neuron axon guidance Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Convergent local identity and topographic projection of sensory neurons."
    Karim M.R., Moore A.W.
    J Neurosci 31:17017-17027(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein homodimerization activity Source: FlyBaseInferred from physical interactionⁱ
  • "Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo."
    Bilioni A., Craig G., Hill C., McNeill H.
    Proc Natl Acad Sci U S A 102:14671-14676(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MTVHSNETGI CLVMNAVSTH LATSSPNTPP TNAPQSPPST LPTLACPAAQ 
        60         70         80         90        100
PLSAPGIAGP GHSGMVTSTV PPGARSTSPC GPSAGLPALS LVGAPPPGPH 
       110        120        130        140        150
SSAPGGAPAP GAGNPPNRCC DTGRTIYTDP VSGQTICSCQ YDMLNYQRLA 
       160        170        180        190        200
AAGGVPLGVY PEGMSAYLSG IAADQPPFYA NPAGIDLKEN LVAGASPWPY 
       210        220        230        240        250
PSMYHPYDAA FAGYPFNSYG MDLNGARRKN ATRETTSTLK AWLNEHKKNP 
       260        270        280        290        300
YPTKGEKIML AIITKMTLTQ VSTWFANARR RLKKENKMTW EPRNRVDDDD 
       310        320        330        340        350
ANIDDDDDKN TEDNDLLDAK DSGVGSTDDK DRSGRLGDMM TDRPGESNNS 
       360        370        380        390        400
EWSESRPGSP NGSPDLYDRP GSMPPGAHPL FHPAALHHHF RPPAGSPPDI 
       410        420        430        440        450
AAYHHHQQQL LQQHQQAQQN SLQTAVGGTA KPRIWSLADM ASKDSKDSSS 
       460        470        480        490        500
GAKDNHPELP PAHPGFYGHP GQQPSPGKIL SPLAARIPNY SPYVRPDLYR 
       510        520        530        540        550
GFYGPAAAHL GAPTQEFLEH QRTFGASLAA HNGPLGMNPL LWKAAVSGAA 
       560        570        580        590        600
NGHHFAPLSL TTSGGSSGGQ QVAPPPVASP SASSSSSSMG CDVVHIPTSS 
       610        620        630        640 
GQSAAQHMMG PISSNSTASS SSSHSGKISP GVNVTSLSAK P          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ