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Protein

Putative alpha-L-fucosidase

Gene

Fuca

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.By similarity

Caution

Lacks the cysteine thought to be important for catalysis. It is replaced by Ala-288.Curated

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

GO - Molecular functioni

  • alpha-L-fucosidase activity Source: UniProtKB
  • fucose binding Source: FlyBase

GO - Biological processi

  • binding of sperm to zona pellucida Source: FlyBase
  • defense response to bacterium Source: FlyBase
  • fucose metabolic process Source: InterPro
  • glycosaminoglycan catabolic process Source: UniProtKB

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51 1994
ReactomeiR-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-6798695 Neutrophil degranulation
R-DME-8957275 Post-translational protein phosphorylation
R-DME-975578 Reactions specific to the complex N-glycan synthesis pathway

Protein family/group databases

CAZyiGH29 Glycoside Hydrolase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Putative alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase
Gene namesi
Name:Fuca
ORF Names:CG6128
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0285958 Fuca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001031826 – 494Putative alpha-L-fucosidaseAdd BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9VTJ4
PRIDEiQ9VTJ4

Expressioni

Gene expression databases

BgeeiFBgn0036169 Expressed in 3 organ(s), highest expression level in larva
GenevisibleiQ9VTJ4 DM

Interactioni

Protein-protein interaction databases

DIPiDIP-19942N
STRINGi7227.FBpp0100046

Structurei

3D structure databases

ProteinModelPortaliQ9VTJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3340 Eukaryota
COG3669 LUCA
GeneTreeiENSGT00440000035378
InParanoidiQ9VTJ4
KOiK01206
OMAiWNWNAID
OrthoDBiEOG091G085V
PhylomeDBiQ9VTJ4

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR016286 FUC_metazoa-typ
IPR031919 Fucosidase_C
IPR000933 Glyco_hydro_29
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10030 PTHR10030, 1 hit
PfamiView protein in Pfam
PF01120 Alpha_L_fucos, 1 hit
PF16757 Fucosidase_C, 1 hit
PIRSFiPIRSF001092 Alpha-L-fucosidase, 1 hit
PRINTSiPR00741 GLHYDRLASE29
SMARTiView protein in SMART
SM00812 Alpha_L_fucos, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VTJ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAISAWMPLL VALIVVWISA AEVDAQVPGP RTRYQPNWAS LDQRPLPQWY
60 70 80 90 100
DDAKVGIFLH YGVYSVPSFG SEWFWTNWKN LRNPEYVQFM QRNYKPDFTY
110 120 130 140 150
QEFASQFTAE LFNATKWALL FKDSGARYVV LTSKHHDGFT LWPSKNSYGW
160 170 180 190 200
NSMDVGPKRD IVKELAAAIR KESDLRFGLY YSLFEWFNPL WTDDKLHLLM
210 220 230 240 250
QQHFVERKVR PEQMELVQQY LPEIIWSDGD WEAPAKYWRS EEFIAWLYND
260 270 280 290 300
SPVRDTVVTN DRWGFGTACM HGDFYNCADR FNPGVLQAHK WENAFTLDRT
310 320 330 340 350
SWGQRFDVSL SDFMTSKEVI KEIITTVSCN GNVLINVGPT KFGTILPIFE
360 370 380 390 400
ERLRDMGRWL KFNGEGIYGS VPWIYQNDTI NGNVWYTRQK EASNGKITIY
410 420 430 440 450
AFVLEYPYDT NELDIYPLGK DINIFRNVML TGIDMGTGGD ILNEQSTEVV
460 470 480 490
MLGMEDTKIK WNADHNRLHI VFPPKNHIDK RGLDYAWTFK ITIT
Length:494
Mass (Da):57,723
Last modified:October 1, 2002 - v2
Checksum:i96E0B3C893E45F56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAO41255.1
AY119638 mRNA Translation: AAM50292.1
RefSeqiNP_001303363.1, NM_001316434.1
NP_648472.1, NM_140215.3
UniGeneiDm.7762

Genome annotation databases

EnsemblMetazoaiFBtr0100588; FBpp0100046; FBgn0285958
FBtr0346860; FBpp0312400; FBgn0285958
GeneIDi3772574
KEGGidme:Dmel_CG6128
UCSCiCG6128-RA d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAO41255.1
AY119638 mRNA Translation: AAM50292.1
RefSeqiNP_001303363.1, NM_001316434.1
NP_648472.1, NM_140215.3
UniGeneiDm.7762

3D structure databases

ProteinModelPortaliQ9VTJ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-19942N
STRINGi7227.FBpp0100046

Protein family/group databases

CAZyiGH29 Glycoside Hydrolase Family 29

Proteomic databases

PaxDbiQ9VTJ4
PRIDEiQ9VTJ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0100588; FBpp0100046; FBgn0285958
FBtr0346860; FBpp0312400; FBgn0285958
GeneIDi3772574
KEGGidme:Dmel_CG6128
UCSCiCG6128-RA d. melanogaster

Organism-specific databases

CTDi3772574
FlyBaseiFBgn0285958 Fuca

Phylogenomic databases

eggNOGiKOG3340 Eukaryota
COG3669 LUCA
GeneTreeiENSGT00440000035378
InParanoidiQ9VTJ4
KOiK01206
OMAiWNWNAID
OrthoDBiEOG091G085V
PhylomeDBiQ9VTJ4

Enzyme and pathway databases

BRENDAi3.2.1.51 1994
ReactomeiR-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-6798695 Neutrophil degranulation
R-DME-8957275 Post-translational protein phosphorylation
R-DME-975578 Reactions specific to the complex N-glycan synthesis pathway

Miscellaneous databases

ChiTaRSiFuca fly
GenomeRNAii3772574
PROiPR:Q9VTJ4

Gene expression databases

BgeeiFBgn0036169 Expressed in 3 organ(s), highest expression level in larva
GenevisibleiQ9VTJ4 DM

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR016286 FUC_metazoa-typ
IPR031919 Fucosidase_C
IPR000933 Glyco_hydro_29
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10030 PTHR10030, 1 hit
PfamiView protein in Pfam
PF01120 Alpha_L_fucos, 1 hit
PF16757 Fucosidase_C, 1 hit
PIRSFiPIRSF001092 Alpha-L-fucosidase, 1 hit
PRINTSiPR00741 GLHYDRLASE29
SMARTiView protein in SMART
SM00812 Alpha_L_fucos, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFUCO_DROME
AccessioniPrimary (citable) accession number: Q9VTJ4
Secondary accession number(s): A4V1U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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