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UniProtKB - Q9VT51 (INSL2_DROME)
Protein
Probable insulin-like peptide 2
Gene
Ilp2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.
1 PublicationMiscellaneous
Of the insulin-like peptides, Ilp2 is the closest homolog of human insulin.
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: InterPro
- insulin receptor binding Source: UniProtKB
- receptor ligand activity Source: FlyBase
GO - Biological processi
- carbohydrate utilization Source: FlyBase
- cellular response to glucose stimulus Source: FlyBase
- determination of adult lifespan Source: FlyBase
- female mating behavior Source: FlyBase
- germ-line stem-cell niche homeostasis Source: FlyBase
- glucose homeostasis Source: FlyBase
- insulin receptor signaling pathway Source: FlyBase
- larval feeding behavior Source: FlyBase
- locomotor rhythm Source: FlyBase
- negative regulation of entry into reproductive diapause Source: FlyBase
- negative regulation of feeding behavior Source: FlyBase
- negative regulation of glycogen catabolic process Source: FlyBase
- positive regulation of cell growth Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of cell size Source: FlyBase
- positive regulation of multicellular organism growth Source: FlyBase
- positive regulation of organ growth Source: FlyBase
- regulation of cell size Source: FlyBase
- regulation of growth rate Source: FlyBase
- regulation of multicellular organism growth Source: UniProtKB
- regulation of organ growth Source: UniProtKB
- response to amino acid starvation Source: FlyBase
- response to food Source: FlyBase
- sleep Source: FlyBase
- triglyceride homeostasis Source: FlyBase
Keywordsi
Molecular function | Growth factor |
Biological process | Growth regulation |
Enzyme and pathway databases
Reactomei | R-DME-110478, Insulin signaling pathway |
SignaLinki | Q9VT51 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable insulin-like peptide 2Short name: dILP2 Alternative name(s): Insulin-related peptide 2 Cleaved into the following 2 chains: |
Gene namesi | Name:Ilp2 Synonyms:IRP ORF Names:CG8167 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0036046, Ilp2 |
VEuPathDBi | VectorBase:FBgn0036046 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: FlyBase
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000016189 | 27 – 137 | Probable insulin-like peptide 2Add BLAST | 111 | |
PeptideiPRO_0000016190 | 27 – 50 | Probable insulin-like peptide 2 B chainSequence analysisAdd BLAST | 24 | |
PropeptideiPRO_0000016191 | 53 – 104 | Connecting peptideSequence analysisAdd BLAST | 52 | |
PeptideiPRO_0000016192 | 108 – 137 | Probable insulin-like peptide 2 A chainSequence analysisAdd BLAST | 30 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 119 | Interchain (between B and A chains)By similarity | ||
Disulfide bondi | 41 ↔ 132 | Interchain (between B and A chains)By similarity | ||
Disulfide bondi | 118 ↔ 123 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondProteomic databases
PaxDbi | Q9VT51 |
Expressioni
Tissue specificityi
Broadly expressed at a low level in the embryonic mesoderm, beginning at stage 12. Expressed at a high level in the embryonic anterior midgut, with expression diminishing at late stage 16. Expressed at a low level in larval imaginal disks. Expressed at a high level in larval salivary glands and in seven cells of each larval brain hemisphere that may correspond to neurosecretory cells.1 Publication
Developmental stagei
Expressed in the embryo and larva.1 Publication
Gene expression databases
Bgeei | FBgn0036046, Expressed in head and 22 other tissues |
ExpressionAtlasi | Q9VT51, baseline and differential |
Genevisiblei | Q9VT51, DM |
Interactioni
Subunit structurei
Heterodimer of a B chain and an A chain linked by two disulfide bonds.
By similarityGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: InterPro
- insulin receptor binding Source: UniProtKB
- receptor ligand activity Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 64538, 13 interactors |
STRINGi | 7227.FBpp0076058 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the insulin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502T6SN, Eukaryota |
HOGENOMi | CLU_125164_0_1_1 |
InParanoidi | Q9VT51 |
OMAi | CKEFNSV |
OrthoDBi | 1644517at2759 |
PhylomeDBi | Q9VT51 |
Family and domain databases
InterProi | View protein in InterPro IPR016179, Insulin-like IPR036438, Insulin-like_sf IPR040228, Insulin-relat-peptide_inver IPR022353, Insulin_CS IPR022352, Insulin_family |
PANTHERi | PTHR13647, PTHR13647, 1 hit |
Pfami | View protein in Pfam PF00049, Insulin, 1 hit |
PRINTSi | PR00276, INSULINFAMLY |
SMARTi | View protein in SMART SM00078, IlGF, 1 hit |
SUPFAMi | SSF56994, SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262, INSULIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9VT51-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKPLSFISM VAVILLASST VKLAQGTLCS EKLNEVLSMV CEEYNPVIPH
60 70 80 90 100
KRAMPGADSD LDALNPLQFV QEFEEEDNSI SEPLRSALFP GSYLGGVLNS
110 120 130
LAEVRRRTRQ RQGIVERCCK KSCDMKALRE YCSVVRN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ291726 mRNA Translation: CAC17605.1 AE014296 Genomic DNA Translation: AAF50204.1 AY069095 mRNA Translation: AAL39240.1 |
RefSeqi | NP_524012.1, NM_079288.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0076329; FBpp0076058; FBgn0036046 |
GeneIDi | 39150 |
KEGGi | dme:Dmel_CG8167 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ291726 mRNA Translation: CAC17605.1 AE014296 Genomic DNA Translation: AAF50204.1 AY069095 mRNA Translation: AAL39240.1 |
RefSeqi | NP_524012.1, NM_079288.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 64538, 13 interactors |
STRINGi | 7227.FBpp0076058 |
Proteomic databases
PaxDbi | Q9VT51 |
Protocols and materials databases
DNASUi | 39150 |
Genome annotation databases
EnsemblMetazoai | FBtr0076329; FBpp0076058; FBgn0036046 |
GeneIDi | 39150 |
KEGGi | dme:Dmel_CG8167 |
Organism-specific databases
CTDi | 39150 |
FlyBasei | FBgn0036046, Ilp2 |
VEuPathDBi | VectorBase:FBgn0036046 |
Phylogenomic databases
eggNOGi | ENOG502T6SN, Eukaryota |
HOGENOMi | CLU_125164_0_1_1 |
InParanoidi | Q9VT51 |
OMAi | CKEFNSV |
OrthoDBi | 1644517at2759 |
PhylomeDBi | Q9VT51 |
Enzyme and pathway databases
Reactomei | R-DME-110478, Insulin signaling pathway |
SignaLinki | Q9VT51 |
Miscellaneous databases
BioGRID-ORCSi | 39150, 0 hits in 1 CRISPR screen |
GenomeRNAii | 39150 |
PROi | PR:Q9VT51 |
Gene expression databases
Bgeei | FBgn0036046, Expressed in head and 22 other tissues |
ExpressionAtlasi | Q9VT51, baseline and differential |
Genevisiblei | Q9VT51, DM |
Family and domain databases
InterProi | View protein in InterPro IPR016179, Insulin-like IPR036438, Insulin-like_sf IPR040228, Insulin-relat-peptide_inver IPR022353, Insulin_CS IPR022352, Insulin_family |
PANTHERi | PTHR13647, PTHR13647, 1 hit |
Pfami | View protein in Pfam PF00049, Insulin, 1 hit |
PRINTSi | PR00276, INSULINFAMLY |
SMARTi | View protein in SMART SM00078, IlGF, 1 hit |
SUPFAMi | SSF56994, SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262, INSULIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | INSL2_DROME | |
Accessioni | Q9VT51Primary (citable) accession number: Q9VT51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | September 29, 2021 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families