UniProtKB - Q9VT51 (INSL2_DROME)
Protein
Probable insulin-like peptide 2
Gene
Ilp2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.1 Publication
Miscellaneous
Of the insulin-like peptides, Ilp2 is the closest homolog of human insulin.
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: InterPro
- insulin receptor binding Source: UniProtKB
- receptor ligand activity Source: FlyBase
GO - Biological processi
- carbohydrate utilization Source: FlyBase
- cell surface receptor signaling pathway Source: Reactome
- cellular response to glucose stimulus Source: FlyBase
- determination of adult lifespan Source: FlyBase
- female mating behavior Source: FlyBase
- germ-line stem-cell niche homeostasis Source: FlyBase
- glucose homeostasis Source: FlyBase
- insulin receptor signaling pathway Source: FlyBase
- larval feeding behavior Source: FlyBase
- locomotor rhythm Source: FlyBase
- negative regulation of entry into reproductive diapause Source: FlyBase
- negative regulation of feeding behavior Source: FlyBase
- negative regulation of glycogen catabolic process Source: FlyBase
- phosphatidylinositol phosphorylation Source: Reactome
- positive regulation of cell growth Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of cell size Source: FlyBase
- positive regulation of multicellular organism growth Source: FlyBase
- positive regulation of organ growth Source: FlyBase
- regulation of cell size Source: FlyBase
- regulation of growth rate Source: FlyBase
- regulation of multicellular organism growth Source: UniProtKB
- regulation of organ growth Source: UniProtKB
- response to amino acid starvation Source: FlyBase
- response to food Source: FlyBase
- sleep Source: FlyBase
- triglyceride homeostasis Source: FlyBase
Keywordsi
Molecular function | Growth factor |
Biological process | Growth regulation |
Enzyme and pathway databases
Reactomei | R-DME-110478 Insulin signaling pathway |
SignaLinki | Q9VT51 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable insulin-like peptide 2Short name: dILP2 Alternative name(s): Insulin-related peptide 2 Cleaved into the following 2 chains: |
Gene namesi | Name:Ilp2 Synonyms:IRP ORF Names:CG8167 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0036046 Ilp2 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: FlyBase
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000016189 | 27 – 137 | Probable insulin-like peptide 2Add BLAST | 111 | |
PeptideiPRO_0000016190 | 27 – 50 | Probable insulin-like peptide 2 B chainSequence analysisAdd BLAST | 24 | |
PropeptideiPRO_0000016191 | 53 – 104 | Connecting peptideSequence analysisAdd BLAST | 52 | |
PeptideiPRO_0000016192 | 108 – 137 | Probable insulin-like peptide 2 A chainSequence analysisAdd BLAST | 30 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 119 | Interchain (between B and A chains)By similarity | ||
Disulfide bondi | 41 ↔ 132 | Interchain (between B and A chains)By similarity | ||
Disulfide bondi | 118 ↔ 123 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondProteomic databases
PaxDbi | Q9VT51 |
PRIDEi | Q9VT51 |
Expressioni
Tissue specificityi
Broadly expressed at a low level in the embryonic mesoderm, beginning at stage 12. Expressed at a high level in the embryonic anterior midgut, with expression diminishing at late stage 16. Expressed at a low level in larval imaginal disks. Expressed at a high level in larval salivary glands and in seven cells of each larval brain hemisphere that may correspond to neurosecretory cells.1 Publication
Developmental stagei
Expressed in the embryo and larva.1 Publication
Gene expression databases
Bgeei | FBgn0036046 Expressed in 14 organ(s), highest expression level in head |
ExpressionAtlasi | Q9VT51 baseline and differential |
Genevisiblei | Q9VT51 DM |
Interactioni
Subunit structurei
Heterodimer of a B chain and an A chain linked by two disulfide bonds.
By similarityGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: InterPro
- insulin receptor binding Source: UniProtKB
- receptor ligand activity Source: FlyBase
Protein-protein interaction databases
BioGridi | 64538, 13 interactors |
STRINGi | 7227.FBpp0076058 |
Family & Domainsi
Sequence similaritiesi
Belongs to the insulin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410KAYT Eukaryota ENOG411141Q LUCA |
InParanoidi | Q9VT51 |
KOi | K04526 |
OMAi | EGIVDRC |
OrthoDBi | 1644517at2759 |
PhylomeDBi | Q9VT51 |
Family and domain databases
InterProi | View protein in InterPro IPR016179 Insulin-like IPR036438 Insulin-like_sf IPR040228 Insulin-relat-peptide_inver IPR022353 Insulin_CS IPR022352 Insulin_family |
PANTHERi | PTHR13647 PTHR13647, 1 hit |
Pfami | View protein in Pfam PF00049 Insulin, 1 hit |
PRINTSi | PR00276 INSULINFAMLY |
SMARTi | View protein in SMART SM00078 IlGF, 1 hit |
SUPFAMi | SSF56994 SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262 INSULIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9VT51-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKPLSFISM VAVILLASST VKLAQGTLCS EKLNEVLSMV CEEYNPVIPH
60 70 80 90 100
KRAMPGADSD LDALNPLQFV QEFEEEDNSI SEPLRSALFP GSYLGGVLNS
110 120 130
LAEVRRRTRQ RQGIVERCCK KSCDMKALRE YCSVVRN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ291726 mRNA Translation: CAC17605.1 AE014296 Genomic DNA Translation: AAF50204.1 AY069095 mRNA Translation: AAL39240.1 |
RefSeqi | NP_524012.1, NM_079288.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0076329; FBpp0076058; FBgn0036046 |
GeneIDi | 39150 |
KEGGi | dme:Dmel_CG8167 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ291726 mRNA Translation: CAC17605.1 AE014296 Genomic DNA Translation: AAF50204.1 AY069095 mRNA Translation: AAL39240.1 |
RefSeqi | NP_524012.1, NM_079288.3 |
3D structure databases
SMRi | Q9VT51 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 64538, 13 interactors |
STRINGi | 7227.FBpp0076058 |
Proteomic databases
PaxDbi | Q9VT51 |
PRIDEi | Q9VT51 |
Genome annotation databases
EnsemblMetazoai | FBtr0076329; FBpp0076058; FBgn0036046 |
GeneIDi | 39150 |
KEGGi | dme:Dmel_CG8167 |
Organism-specific databases
CTDi | 39150 |
FlyBasei | FBgn0036046 Ilp2 |
Phylogenomic databases
eggNOGi | ENOG410KAYT Eukaryota ENOG411141Q LUCA |
InParanoidi | Q9VT51 |
KOi | K04526 |
OMAi | EGIVDRC |
OrthoDBi | 1644517at2759 |
PhylomeDBi | Q9VT51 |
Enzyme and pathway databases
Reactomei | R-DME-110478 Insulin signaling pathway |
SignaLinki | Q9VT51 |
Miscellaneous databases
GenomeRNAii | 39150 |
PROi | PR:Q9VT51 |
Gene expression databases
Bgeei | FBgn0036046 Expressed in 14 organ(s), highest expression level in head |
ExpressionAtlasi | Q9VT51 baseline and differential |
Genevisiblei | Q9VT51 DM |
Family and domain databases
InterProi | View protein in InterPro IPR016179 Insulin-like IPR036438 Insulin-like_sf IPR040228 Insulin-relat-peptide_inver IPR022353 Insulin_CS IPR022352 Insulin_family |
PANTHERi | PTHR13647 PTHR13647, 1 hit |
Pfami | View protein in Pfam PF00049 Insulin, 1 hit |
PRINTSi | PR00276 INSULINFAMLY |
SMARTi | View protein in SMART SM00078 IlGF, 1 hit |
SUPFAMi | SSF56994 SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262 INSULIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INSL2_DROME | |
Accessioni | Q9VT51Primary (citable) accession number: Q9VT51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | October 16, 2019 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Drosophila
Drosophila: entries, gene names and cross-references to FlyBase