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Protein

Protein furry

Gene

fry

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Trc/fry signaling pathway plays a key role in maintaining the integrity of polarized cell extensions (arista) during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching. Fry positively regulates trc kinase activity.2 Publications

GO - Biological processi

  • actin filament reorganization Source: GO_Central
  • antennal morphogenesis Source: FlyBase
  • chaeta morphogenesis Source: FlyBase
  • dendrite self-avoidance Source: FlyBase
  • imaginal disc-derived wing hair organization Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • non-sensory hair organization Source: FlyBase
  • oocyte morphogenesis Source: FlyBase
  • positive regulation of protein kinase activity Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of dendrite development Source: UniProtKB
  • regulation of dendrite morphogenesis Source: FlyBase
  • rhabdomere development Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein furry
Gene namesi
Name:fryImported
ORF Names:CG32045
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0016081 fry

Subcellular locationi

Pathology & Biotechi

Disruption phenotypei

Flies exhibit branched arista laterals, branched bristles and a strong multiple hair cell phenotype that consists of clusters of epidermal hairs and branched hairs. Dendrites of fry and trc mutants display excessive terminal branching. Branched laterals in mutant pupae arista are due to the splitting of individual laterals during elongation and abnormally shaped actin bundles.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829391 – 3479Protein furryAdd BLAST3479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei129Phosphoserine1 Publication1
Modified residuei1838Phosphoserine1 Publication1
Modified residuei1841Phosphoserine1 Publication1
Modified residuei2357Phosphoserine1 Publication1
Modified residuei2842Phosphothreonine1 Publication1
Modified residuei2845Phosphoserine1 Publication1
Modified residuei2851Phosphoserine1 Publication1
Modified residuei2853Phosphoserine1 Publication1
Modified residuei2999Phosphoserine1 Publication1
Modified residuei3001Phosphoserine1 Publication1
Modified residuei3004Phosphothreonine1 Publication1
Modified residuei3018Phosphoserine1 Publication1
Modified residuei3019Phosphoserine1 Publication1
Modified residuei3025Phosphoserine1 Publication1
Modified residuei3027Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VT28
PRIDEiQ9VT28

PTM databases

iPTMnetiQ9VT28

Expressioni

Tissue specificityi

Co-expressed with trc in all da neurons in third instar wild-type larvae; axons and dendritic branches.1 Publication

Developmental stagei

Expression is very low in embryonic and early larval stages, increases to be high from third larval instar to adults.1 Publication

Gene expression databases

BgeeiFBgn0016081
ExpressionAtlasiQ9VT28 baseline and differential
GenevisibleiQ9VT28 DM

Interactioni

Protein-protein interaction databases

BioGridi64513, 18 interactors
IntActiQ9VT28, 20 interactors
STRINGi7227.FBpp0297352

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi174 – 202Gln-richSequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the furry protein family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1825 Eukaryota
ENOG410XSZS LUCA
GeneTreeiENSGT00610000086058
InParanoidiQ9VT28
OrthoDBiEOG091G003A
PhylomeDBiQ9VT28

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR025614 Cell_morpho_N
IPR025481 Cell_Morphogen_C
IPR029473 MOR2-PAG1_mid
PfamiView protein in Pfam
PF14225 MOR2-PAG1_C, 1 hit
PF14228 MOR2-PAG1_mid, 5 hits
PF14222 MOR2-PAG1_N, 1 hit
SUPFAMiSSF48371 SSF48371, 12 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B1 Publication (identifier: Q9VT28-1) [UniParc]FASTAAdd to basket
Also known as: Long1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQLELQDDL FGLEAGVAGT NQNPNEQHLS DPAASPSTSS PANNNATAGA
60 70 80 90 100
ATTSTATVIT AVGGAGGGVA AAGVGVVTPT KSPQRNAFQE DAYQANLAGG
110 120 130 140 150
DSVDNIESAQ LDGGNPSGGS PGQRHSINSA EYTSTPKTTR SGPNGSTTAS
160 170 180 190 200
GTTSPINYQL PGDDYPYGIE YESQQLLYQQ QQQQQQQQSQ QQQQQQQQQQ
210 220 230 240 250
QQLPVGDVEQ SSAVTYQSLP VSRQSYASPP ALIIPQRQSL LPWGAHSRSS
260 270 280 290 300
IINVLPSYTQ AEMHALAARV ASVETSAPRP GEIVMRNLFS DFTAQAEKKI
310 320 330 340 350
ELVMLESADK NLSKLLQRGE DQQFDQLLSA LGSVAEHCLP SLLHTLLAWH
360 370 380 390 400
RRQLSDMEIK NDLKKPAPSG SSSQAATNKP TVDLDFQLQR REAAVEFIFC
410 420 430 440 450
LALIEILKQL PYHPGHEDLV RSIENLAFKH FKYKDGLQNN PNALNIHMIA
460 470 480 490 500
DLYAEVIGVL AQSRFASVRK RFMSELKELR GKEVSPTTTQ SIISLLMGMK
510 520 530 540 550
FFRVKMVPIE EFEASFQFMH ECGQYFLEVK DKDIKHALAG LFVEILVPVA
560 570 580 590 600
AAVKNEVNVP CVKNFVELLY VQTLDASTKS KHRLALFPLV TCLLCVSQKT
610 620 630 640 650
FFLTNWHYFL AMCLSNLKNR DAKMSRVALE SLFRLLWVYM IRIKCESNSA
660 670 680 690 700
THSRLQSIVN SLFPKGSKGV VPRDTPLNIF VKIIQFIAQE RLDFAMREIV
710 720 730 740 750
YDLLCVGRSI KLILNPERMS IGLRAFLVVA DSLQQKAGEP PMPRTVPVLP
760 770 780 790 800
SGNTLRVKKT FNKMYVLLTD DTARSIGMST YFPHVRRVFV DILRALDVHY
810 820 830 840 850
GRPLMMTNTQ NQNKEPDEML SGERKPRIDL FRTCVAAVPR LIPDTMTPHE
860 870 880 890 900
LVDMLSRLSV HMDEELRILT HQSLTTLVID FPDWRQDVVH GYTQFLVRDV
910 920 930 940 950
TDTYPQLLEN CTRILFTFLN IWRCATNVNG NNTTSAPSGA TNVVNTSQAK
960 970 980 990 1000
MTTATTTTTV VQATVVQVTS APAKDTASSQ LSKQQHLNTA SSAASSITTS
1010 1020 1030 1040 1050
SGMSSITQHT VLNMASDVGK KNEIPLATTL HFVEGFALVL LCNYRTYLRK
1060 1070 1080 1090 1100
LAALILKEVK NLMRALGIPE TEPPLIDVMD RCVPGIIEKC LPQLPQTEKT
1110 1120 1130 1140 1150
AILNANCIDL QWIAERSSGV WLAGLTDDNS KSSTSTLNLS QSSSTPNASA
1160 1170 1180 1190 1200
TAASSPQLPF DPWATCLFGL LERQNVLQQC PSAVAQAWPI CFTRLNALYS
1210 1220 1230 1240 1250
VIDPTPVSDN RASLLRSSAP TKKVPTESQK DSYLRLWRNQ VACAMRLVPQ
1260 1270 1280 1290 1300
IPSVAVRCAS PDLSLSSSPD SLNADRSDKS AMGSASPQAL YKLVVPLLRC
1310 1320 1330 1340 1350
EVVDVRDAAV NALGLINHDA LKDLMEELVV YIREAVDCKQ ENMRRRRRRD
1360 1370 1380 1390 1400
ALRLQVVRVL EKIAENGTFG VSTCVLERDT MSLHPTFVLY ISGAMGYLTS
1410 1420 1430 1440 1450
ETDKDNLSIR EVKAHFCNFI RKMIKNFPLE ACATLLSRVL KRNLFNLFAA
1460 1470 1480 1490 1500
WCGSFSKPLG YTMQSDHTLE EEKLQFSALQ AMSALLCCGQ IFNPSYLQDD
1510 1520 1530 1540 1550
SIIYKWLDML LTSKNEKIYQ LARDTVVLLL ESNPDIGQLL EWVIDRCYTS
1560 1570 1580 1590 1600
TPREADACFL ALASIFSAKE YPCDHYTSVI TVTLLMTGCP RVEVHATALQ
1610 1620 1630 1640 1650
LLQILDKRFF GSVVGTLHSD SDKEDDKVGT LDVLLSSAYC RSQRFLSKQL
1660 1670 1680 1690 1700
AQLRPELTMS IFSEITHRFQ SAREDVRALL LQCLLPWLQN MELVATSVPP
1710 1720 1730 1740 1750
ATPLSYIMYF PDSGTRGRRE GTGSTEATEM ILNNLFYITA KFSDAHPRDI
1760 1770 1780 1790 1800
EELWGTLCQF WPNNLKVILR YLVIMSGMAP TELLPYAKRV ALYLVRSCPD
1810 1820 1830 1840 1850
RLLDELMAEL QTVETLNCLI ERTETPPFYR LTSMRKASSH SADGQAAGGI
1860 1870 1880 1890 1900
NDSRIQDLAV EKGTIHTKRH SGEDPMKIGT CKSDSGIRAY TQAAAAAAAA
1910 1920 1930 1940 1950
AVTPGSSGNR PPRGADKIRA ASGPSILPRP EDILINDPEL RQEENVELRG
1960 1970 1980 1990 2000
TSDAAPNGHP HPLPMPEYGG YFAPLTEFLP DVSLPISGFH RCNVAVMLLT
2010 2020 2030 2040 2050
DIVVDGIPGI DWTLHLPLML HILFLGLDHT RIIVREHCKQ LCVNLLIVLA
2060 2070 2080 2090 2100
EHNDHLTVAR ILLNSETSKL DLGLTVPALP VIDNNFTELH QQFDSYLLHV
2110 2120 2130 2140 2150
SPQAAAYALQ HNLSSSTIIA AHHQNLSQTP QSQQQTGSQN GQTTTPPGLT
2160 2170 2180 2190 2200
ATPAALQINP NNSENSEVPL IHPDEHAPPQ PGPSMPIAHV IKSLLKFLAQ
2210 2220 2230 2240 2250
DTCQPLWNYE DITAKVWAVK SAEQLSCFLK HMVKVFADSY PQARIAERWA
2260 2270 2280 2290 2300
QTALQLGLSC SSRHYAGRCL QIFRALNVPI NSRMLSDILS RLVETVAEQG
2310 2320 2330 2340 2350
EDMQGYVTEL LLTLEAAVDS LDSDFRPLDV MKDIFKSTPN LNNKDGGPNS
2360 2370 2380 2390 2400
ILPGKKSPSG MTPQSSNYSI PSHGRSTSYS VSYCGRKANN SPCDKQVELR
2410 2420 2430 2440 2450
NRSSGIDLER SVVCKFGVGG GGAGSALSRS RSAQSLKMLG DTATQDDKMT
2460 2470 2480 2490 2500
ILAQLFWLSV SLLESDYEHE FMLALRLLTR VLHRLPLDRP DARDKVEKLQ
2510 2520 2530 2540 2550
QQLKWTAYPG VHALLLKGCT HSATYEPTIT LLSQFAPLLT LPVCDPTQSC
2560 2570 2580 2590 2600
AFPMNVIALL PYMLLHYEDA NEICIRSAEN IAQVSTELGA KLENLGTVMT
2610 2620 2630 2640 2650
LYSRKTFCKE SFQWTKCVVK YLHDTYAHMG LHMVAFLIEV LEKGPQQVQV
2660 2670 2680 2690 2700
PVLNVIHCML HYVDLSAPQA QSINADLLRA IGKYLDTAYW KDSLKILKLI
2710 2720 2730 2740 2750
VTRSSSLQVV PPSDGSSAGL SFSFYGAYPD SDMFCKKELA GRTMEFTFDV
2760 2770 2780 2790 2800
SQTPLIGRRI LLKTEEPVAG GAVSTTGSSS LNSTLTNATT VTVAPSAAQQ
2810 2820 2830 2840 2850
QTNVQMQQQR ANTNVAALAA AAAAQHQQQQ HAIGAGSSVV GTPNSPRRSA
2860 2870 2880 2890 2900
SLSPADTVPL SGWKRPWMSQ CRVRECLVNL LTTCGQRVGL PKSPSVIFSQ
2910 2920 2930 2940 2950
SSDLMERQSS AASSTEETSG PQGDLSSGSR RDDGQPDFTV FKDFDFLEYE
2960 2970 2980 2990 3000
DSIAGESTDN FNWGVRRHQL FEGDEDRLNC GSGIGGSIKG GHSSAFEDSF
3010 3020 3030 3040 3050
SDKTPILSKR KRQIADDSSD EEAESESPLD EDHRQSFLKS GYSAVPPTSL
3060 3070 3080 3090 3100
SLRERRRRNS VSRSDTSGSS AGDLGDLTPC NASPHLPGII RFSAAIHDEA
3110 3120 3130 3140 3150
EENWRRQVQA LLVNQPSAHT SELLQQLYRL IKELTFKTVN ISKEAKKFFT
3160 3170 3180 3190 3200
GIGSQLGNRI SLFTDLLSSR ADPPQVWCSE LQATSPKLFE TLRFNVLEVQ
3210 3220 3230 3240 3250
EHLETFFDRK DQVLECLDAV KTSCKLSLFN EADVAASGLE LPSTSSIVYM
3260 3270 3280 3290 3300
PFDPASTEVV LDLGRSLYKL MFQLLLLIES NHKISSNVVN HFRMNEDMHD
3310 3320 3330 3340 3350
ISDLYALVRD ALVRYISEAE LDCLESSTST EGEHTPTPSP GLPMTPEEFE
3360 3370 3380 3390 3400
AVLTEHIDLQ RWPSAIAHVR QYRRISTLNA SGYQNVTIFS YNSADNRQKW
3410 3420 3430 3440 3450
DEISVILNAY AHGIMKDRTE AFIVSKSDSE VFEIYAILSE NLYQVSSALT
3460 3470
NMEISMKSYS AGSASGNSHR SEQDIVTNL
Length:3,479
Mass (Da):384,352
Last modified:October 1, 2002 - v2
Checksum:i281389C02117A0CF
GO
Isoform D1 Publication (identifier: Q9VT28-2) [UniParc]FASTAAdd to basket
Also known as: Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1624-1629: EDDKVG → GMRFSY
     1630-3479: Missing.

Show »
Length:1,629
Mass (Da):180,448
Checksum:i8447BDC5C3BF75D2
GO

Sequence cautioni

The sequence AAL40005 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170E → V in AAG41424 (PubMed:11526084).Curated1
Sequence conflicti170E → V in AAK37558 (PubMed:11526084).Curated1
Sequence conflicti1876M → I in AAG41424 (PubMed:11526084).Curated1
Sequence conflicti1933I → L in AAG41424 (PubMed:11526084).Curated1
Sequence conflicti2530T → I in AAG41424 (PubMed:11526084).Curated1
Sequence conflicti3375I → V in AAL40005 (PubMed:12537569).Curated1
Sequence conflicti3403I → M in AAL40005 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0523721624 – 1629EDDKVG → GMRFSY in isoform D. 1 Publication6
Alternative sequenceiVSP_0523731630 – 3479Missing in isoform D. 1 PublicationAdd BLAST1850

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF310159 mRNA Translation: AAG41424.1
AF351187 mRNA Translation: AAK37558.1
AE014296 Genomic DNA Translation: AAF50228.2
AE014296 Genomic DNA Translation: ABI31247.1
AY069860 mRNA Translation: AAL40005.1 Different initiation.
RefSeqiNP_729520.1, NM_168357.3 [Q9VT28-1]
UniGeneiDm.1919

Genome annotation databases

EnsemblMetazoaiFBtr0076417; FBpp0076146; FBgn0016081 [Q9VT28-1]
GeneIDi39122
KEGGidme:Dmel_CG32045

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFRY_DROME
AccessioniPrimary (citable) accession number: Q9VT28
Secondary accession number(s): Q0E8G4
, Q8T9A1, Q9BIR5, Q9GPT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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