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UniProtKB - Q9VSU7 (USE1_DROME)
Protein
Vesicle transport protein USE1
Gene
Use1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (By similarity).
Required for protein secretion.
By similarity1 PublicationGO - Molecular functioni
- SNAP receptor activity Source: UniProtKB
GO - Biological processi
- Golgi organization Source: FlyBase
- protein secretion Source: FlyBase
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: UniProtKB
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-DME-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Vesicle transport protein USE1Alternative name(s): USE1-like protein |
Gene namesi | Name:Use1 ORF Names:CG14181 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0035965, Use1 |
VEuPathDBi | VectorBase:FBgn0035965 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type IV membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: FlyBase
- integral component of cytoplasmic side of endoplasmic reticulum membrane Source: FlyBase
Other locations
- endomembrane system Source: FlyBase
- SNARE complex Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 221 | CytoplasmicSequence analysisAdd BLAST | 221 | |
Transmembranei | 222 – 242 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 243 – 250 | LumenalSequence analysis | 8 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215582 | 1 – 250 | Vesicle transport protein USE1Add BLAST | 250 |
Proteomic databases
PaxDbi | Q9VSU7 |
PRIDEi | Q9VSU7 |
PTM databases
SwissPalmi | Q9VSU7 |
Expressioni
Gene expression databases
Bgeei | FBgn0035965, Expressed in saliva-secreting gland and 33 other tissues |
Genevisiblei | Q9VSU7, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 64451, 24 interactors |
STRINGi | 7227.FBpp0076264 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 72 – 92 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 117 – 147 | DisorderedSequence analysisAdd BLAST | 31 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 197 – 221 | Sequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 131 – 147 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the USE1 family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2678, Eukaryota |
GeneTreei | ENSGT00390000014361 |
HOGENOMi | CLU_087320_0_0_1 |
InParanoidi | Q9VSU7 |
OMAi | CWLWLMI |
PhylomeDBi | Q9VSU7 |
Family and domain databases
InterProi | View protein in InterPro IPR019150, Vesicle_transport_protein_Use1 |
PANTHERi | PTHR13050, PTHR13050, 1 hit |
Pfami | View protein in Pfam PF09753, Use1, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9VSU7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATKLNVNIR TLLANCEELA KSEQNFWRLQ KFIKSLDTML AELEAMGDPQ
60 70 80 90 100
SVKRIPGYLE RLQALKISTG YADVPGSTTK TPSQSSAVSE TGENALKEIR
110 120 130 140 150
QLQNSKYHNE LRKELLQDSD ALRRRRGADE SSSSSGSANV QETSGENMNQ
160 170 180 190 200
AAKYYTNAQE KITEHMLSLT RNLKEQTETA NRIIRRDTEV VSRSAGMADR
210 220 230 240 250
NINSLGKEAE KLEQHSKKAY KCWLWLMIAF VIATFIGMVL FMKIMKKKKS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 52 | V → A in AAR96209 (Ref. 3) Curated | 1 | |
Sequence conflicti | 99 | I → M in AAR96209 (Ref. 3) Curated | 1 | |
Sequence conflicti | 117 | Q → H in AAR96209 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012668 | 1 – 38 | Missing in isoform 2. 1 PublicationAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF50314.3 BT011417 mRNA Translation: AAR96209.1 |
RefSeqi | NP_648289.2, NM_140032.3 [Q9VSU7-1] |
Genome annotation databases
EnsemblMetazoai | FBtr0076537; FBpp0076264; FBgn0035965 [Q9VSU7-1] |
GeneIDi | 39051 |
KEGGi | dme:Dmel_CG14181 |
UCSCi | CG14181-RA, d. melanogaster [Q9VSU7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF50314.3 BT011417 mRNA Translation: AAR96209.1 |
RefSeqi | NP_648289.2, NM_140032.3 [Q9VSU7-1] |
3D structure databases
AlphaFoldDBi | Q9VSU7 |
SMRi | Q9VSU7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 64451, 24 interactors |
STRINGi | 7227.FBpp0076264 |
PTM databases
SwissPalmi | Q9VSU7 |
Proteomic databases
PaxDbi | Q9VSU7 |
PRIDEi | Q9VSU7 |
Genome annotation databases
EnsemblMetazoai | FBtr0076537; FBpp0076264; FBgn0035965 [Q9VSU7-1] |
GeneIDi | 39051 |
KEGGi | dme:Dmel_CG14181 |
UCSCi | CG14181-RA, d. melanogaster [Q9VSU7-1] |
Organism-specific databases
CTDi | 55850 |
FlyBasei | FBgn0035965, Use1 |
VEuPathDBi | VectorBase:FBgn0035965 |
Phylogenomic databases
eggNOGi | KOG2678, Eukaryota |
GeneTreei | ENSGT00390000014361 |
HOGENOMi | CLU_087320_0_0_1 |
InParanoidi | Q9VSU7 |
OMAi | CWLWLMI |
PhylomeDBi | Q9VSU7 |
Enzyme and pathway databases
Reactomei | R-DME-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 39051, 0 hits in 1 CRISPR screen |
ChiTaRSi | Use1, fly |
GenomeRNAii | 39051 |
PROi | PR:Q9VSU7 |
Gene expression databases
Bgeei | FBgn0035965, Expressed in saliva-secreting gland and 33 other tissues |
Genevisiblei | Q9VSU7, DM |
Family and domain databases
InterProi | View protein in InterPro IPR019150, Vesicle_transport_protein_Use1 |
PANTHERi | PTHR13050, PTHR13050, 1 hit |
Pfami | View protein in Pfam PF09753, Use1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | USE1_DROME | |
Accessioni | Q9VSU7Primary (citable) accession number: Q9VSU7 Secondary accession number(s): Q6NN76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | February 1, 2005 | |
Last modified: | May 25, 2022 | |
This is version 123 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families