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Entry version 180 (07 Oct 2020)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Rhea, isoform B

Gene

rhea

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-114608, Platelet degranulation
R-DME-354192, Integrin signaling
R-DME-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rhea, isoform BImported
Submitted name:
Rhea, isoform EImported
Submitted name:
Rhea, isoform FImported
Submitted name:
TalinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rheaImported
Synonyms:CT21159Imported, Dmel\CG6831Imported, RheaImported, TalinImported, talinImported, tendrilsImported, TlnImported
ORF Names:CG6831Imported, Dmel_CG6831Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0260442, rhea

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation, MembraneARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0260442, Expressed in capitellum (Drosophila) and 43 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0293740

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VSL8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini88 – 412FERMInterPro annotationAdd BLAST325
Domaini2297 – 2538I/LWEQInterPro annotationAdd BLAST242

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2563 – 2708DisorderedSequence analysisAdd BLAST146
Regioni2810 – 2836DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1068 – 1088Sequence analysisAdd BLAST21
Coiled coili1806 – 1826Sequence analysisAdd BLAST21
Coiled coili1834 – 1854Sequence analysisAdd BLAST21
Coiled coili2504 – 2533Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2563 – 2592PolarSequence analysisAdd BLAST30
Compositional biasi2601 – 2631Pro-richSequence analysisAdd BLAST31
Compositional biasi2632 – 2648PolarSequence analysisAdd BLAST17
Compositional biasi2668 – 2706PolarSequence analysisAdd BLAST39
Compositional biasi2816 – 2836PolyampholyteSequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4261, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168860

KEGG Orthology (KO)

More...
KOi
K06271

Identification of Orthologs from Complete Genome Data

More...
OMAi
VDMTQHY

Database of Orthologous Groups

More...
OrthoDBi
9839at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit
cd12150, talin-RS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR032425, FERM_f0
IPR035964, I/LWEQ_dom_sf
IPR002558, ILWEQ_dom
IPR002404, IRS_PTB
IPR011993, PH-like_dom_sf
IPR037438, Talin1/2-RS
IPR015224, Talin_cent
IPR036476, Talin_cent_sf
IPR015009, Vinculin-bd_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16511, FERM_f0, 1 hit
PF00373, FERM_M, 1 hit
PF01608, I_LWEQ, 1 hit
PF02174, IRS, 1 hit
PF09141, Talin_middle, 1 hit
PF08913, VBS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM00307, ILWEQ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109880, SSF109880, 1 hit
SSF109885, SSF109885, 4 hits
SSF47031, SSF47031, 1 hit
SSF47220, SSF47220, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00660, FERM_1, 1 hit
PS50057, FERM_3, 1 hit
PS50945, I_LWEQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9VSL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTLSLRIQL EGGRVTKTIQ FQPNTTVFDA CKVIRDKFAE AVQGQPSEYG
60 70 80 90 100
LFISDEQNQQ GVWLEPGRTL GYYILHNQDT LEYRRKTRTL RVRMLDGAVK
110 120 130 140 150
TILVDDSQPV SQLMVVICTK IGITNHEEYG LVREDNEAQN ENLPDNKFGT
160 170 180 190 200
LTLKRKIMEK DRDAKMESLR KKLKTDDEMN WVDVSRTLRE QGIDEAETVL
210 220 230 240 250
LRRRFFFSDQ NIDSRDPVQL NLLYVQARDA ILDGTHPVTQ DKACEFAGIQ
260 270 280 290 300
VHIQFGPHNE AKHKTGFLDL KDFLPQSYVR TKGIEKKIFS EHRKHVDLSE
310 320 330 340 350
IDAKVLYTKT ARELPTYGVT FFLVKEKMNG KNKLVPRLLG VTKDSVLRLD
360 370 380 390 400
EHTKEILISW PLTTVRRWGA SPNTFTLDFG DYANQYYSVQ TTEAEQIVQL
410 420 430 440 450
IAGYIDIILK KKQTKDHFGI EGDEGSTMVE ESVAPSKATF LQHETNRMEQ
460 470 480 490 500
LNVESLAHPG IMRPYDGERS YMENEVQTVQ YGAFVGQVNH AHQPPTTKEV
510 520 530 540 550
RISSVNLTEP QRALLGYISA GQDVLIRADE ELRTKAPIQE LGSDLRSIEW
560 570 580 590 600
RENTLDTSKQ AVSSHVATMS AATAQIITAS HPDEVDTEAI SASVSQIAQT
610 620 630 640 650
IPEVTKEVRL IAALMENDTS GDQLLEAARN LCSAFSDLLK AAEPESKEPP
660 670 680 690 700
QHLINAASRV GEATTHVLST IAEEEVPENR DLHDMLLALA KAVANTTAAL
710 720 730 740 750
VLRAKNIAAS CDDEQARNRV IGAASQCALA TSQLVACAKV VAPTLHNAAC
760 770 780 790 800
REQLEAAAKN VARAVNSLCE VCNEASNDPK LKADLLAAAR DVSKSLTDML
810 820 830 840 850
EHVKLSSREH ANRTSTELSP VENVIIGTDI LVSTHDPQEM VRHARTLGQT
860 870 880 890 900
TAQLIQSIKG EADQQQDADM KRHLLSAAKQ LADATAKLVE AARLCSSNPH
910 920 930 940 950
DSDNQNALRK AAEELREITT TAANTPAMKR GLIQRLEFCS KQAASAATQC
960 970 980 990 1000
ISAAQNAVQH SQDHQTKETL LQDCKRVADT IPRLVTSLKT TRAQPDDPNA
1010 1020 1030 1040 1050
QLNLIEAAEQ FIEPALQVSK SSRALQPTVT DIPSATQLSK GALHLGQCVS
1060 1070 1080 1090 1100
ELHSVAQRAR DACGGQELES ALEEVRKLHD VLDDTRQAAI AGQLRPLPGQ
1110 1120 1130 1140 1150
TVENTADELR KSAKNVGIAL SQLLSSVLHN QRSYAGAAGR DTALALGDFT
1160 1170 1180 1190 1200
RSVHGVAATT QNPAIIDCAD DVVTSSARLI EQAQRTLQGA SNPEALTQAG
1210 1220 1230 1240 1250
REVTGALSAT VDCIPGQREV DVALRNVSEL SEILSMSEFP PSSRPYATLQ
1260 1270 1280 1290 1300
SELKQVAEQL SSAGGEIVVS YSSPALLAES SQNFAANYRD LLSVSMEMAG
1310 1320 1330 1340 1350
QTQEEEVRSH MIESLRHVST QSCSLLSTAK SIAADPGQPN AKNLLHAAAR
1360 1370 1380 1390 1400
GVTESINQLV DASIQSAPGQ KECDNAMRNI EALRLMLDYP HEPINELGYF
1410 1420 1430 1440 1450
DCVEQATGKS RNLGYAISEM INNAKQSQHV EFSQSVNNVN DSIQGLIESS
1460 1470 1480 1490 1500
SQAAYLIGVS HPSSVAGRPG IIDQAQLTWA YQGIRQHCDI VSSQQSTKPQ
1510 1520 1530 1540 1550
MISALTVIAK HTSYLCSICR QASMNTSNPV AKNEFIVLAK QVATATSDLV
1560 1570 1580 1590 1600
QDIKAIEEQS AGGSRERLVD PLLEAVKAVR QYASSSEFSS VPAKISAEGR
1610 1620 1630 1640 1650
KAQEPVIQAG RGVIDGVVEM VKAAKSLALT PDNPPVWQQL SMHSTPVSES
1660 1670 1680 1690 1700
VKRLVDNIRD KAPGQAQCEQ VLHTLGTCTR ELDSCALAVN AQGLSQRRDN
1710 1720 1730 1740 1750
NLHGFSGQTM NSASELIDKL EPIRMAGKNN AEQLGHAVGE ISRYVVPMVN
1760 1770 1780 1790 1800
GAIGACTHIV HSQQQMSLIQ QTRSVVESAI TLVQSAKESA GNPRATHAHP
1810 1820 1830 1840 1850
RLDDAIDGTR EAIQELQQTV EKINAETGIV TGLMEQVNRS ITRLTDKRQS
1860 1870 1880 1890 1900
LLNASYSDTF VDYQTRMVAR AKEIASLANE MNAKSSVEPS ALPQLAVDMT
1910 1920 1930 1940 1950
QNYQQLTQDS VGASTTTSSP DVAMRIRTTV IDLGRSVSSM IQSSAGGARP
1960 1970 1980 1990 2000
NDAGAQKEIA RSAREVSEKV AQVLAALQAG SRGTQACINA AHTVSGIIGD
2010 2020 2030 2040 2050
LDTTIMFATA GTLHSDGDGS FADHREHILQ TAKALVEDTK VLVTGAAGTQ
2060 2070 2080 2090 2100
DQLANAAQNA VSTITQLAEA VKRGACSLGS TQPDSQVMVI NAVKDVASAL
2110 2120 2130 2140 2150
GDLINCTKLA SGKSINDPSM QDLKESARVM VLNVSSLLKT VKAVEDEHTR
2160 2170 2180 2190 2200
GTRAMEATVE AISQEIRAMH SPPPVGNTQV GPEDLIRVTM NVTAATAKAV
2210 2220 2230 2240 2250
AAGTSNLQAD IVSAANLGRR AISEMLIVCR SVAWNCAETE ELRSRTLEAG
2260 2270 2280 2290 2300
TAVGESYRDL LSGILHNCSA DDRMHLSRRV AKCVTDLVAM ARLLKGSDWI
2310 2320 2330 2340 2350
DPEDPTVIAE NELLGAAASI DAAAKKLASL RPRRQADVKI ELDENMKFDE
2360 2370 2380 2390 2400
MILEAAKGIM GASAALVRAA NAAQRELIDT GKVARRPLTS SDDGQWSEGL
2410 2420 2430 2440 2450
ISAARLVAAA THSLVEAAQN LVRGVGTEEM LISTAKQVAA STAQLLIACK
2460 2470 2480 2490 2500
VKSNPNSEAG RRLQAAGNAV IKSTDNLVHS AQQGLEAEEE HSLKINTSMV
2510 2520 2530 2540 2550
DGMAQEINAR SAVLRKEKEL EEARQLLKNV RHAQRYAKNA QGFTTDESDT
2560 2570 2580 2590 2600
EYAYRSQNNT LGRSGYYGSS EMPSSPSYLS GGQQQKHHYN HASPQPQHFH
2610 2620 2630 2640 2650
HPGAVSPPPS NYPPMDDPNG DFPPPPPPLS TTISNMQTAT SGHSFRPNPK
2660 2670 2680 2690 2700
LTANAVPRPY PGSPGGSNGL ISAPTTTGTP TNTNYQQSYE SSSIKTLNSS
2710 2720 2730 2740 2750
PPAVPKKPTV NRNLAACVQD LHDKTFGQGG VVQLTGGNGY PGQNYEGYTS
2760 2770 2780 2790 2800
RYETRNFDKS ANNTTSSSSE LGAVKPLESS FSQMTLNTDG GKISIVDQGS
2810 2820 2830
ERLTSMTQRV MERKSFTTTT ESRSETKTEK HSFRLD
Length:2,836
Mass (Da):306,994
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11A52A01CD3683E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PEJ8M9PEJ8_DROME
Rhea, isoform H
rhea CT21159, Dmel\CG6831, Rhea, Talin, talin
2,689Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBW9M9PBW9_DROME
Rhea, isoform G
rhea CT21159, Dmel\CG6831, Rhea, Talin, talin
2,815Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NDM3M9NDM3_DROME
Rhea, isoform C
rhea CT21159, Dmel\CG6831, Rhea, Talin, talin
2,169Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PF06M9PF06_DROME
Rhea, isoform I
rhea CT21159, Dmel\CG6831, Rhea, Talin, talin
513Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50399.1
AF299248 mRNA Translation: AAG22814.1
AE014296 Genomic DNA Translation: AFH04345.1
AE014296 Genomic DNA Translation: AGB94281.1

NCBI Reference Sequences

More...
RefSeqi
NP_001246674.1, NM_001259745.2
NP_001261586.1, NM_001274657.1
NP_648238.1, NM_139981.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0305210; FBpp0293740; FBgn0260442
FBtr0333105; FBpp0305317; FBgn0260442
FBtr0333106; FBpp0305318; FBgn0260442

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6831

UCSC genome browser

More...
UCSCi
CG6831-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50399.1
AF299248 mRNA Translation: AAG22814.1
AE014296 Genomic DNA Translation: AFH04345.1
AE014296 Genomic DNA Translation: AGB94281.1
RefSeqiNP_001246674.1, NM_001259745.2
NP_001261586.1, NM_001274657.1
NP_648238.1, NM_139981.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FYQX-ray1.95A1981-2168[»]
SMRiQ9VSL8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0293740

Genome annotation databases

EnsemblMetazoaiFBtr0305210; FBpp0293740; FBgn0260442
FBtr0333105; FBpp0305317; FBgn0260442
FBtr0333106; FBpp0305318; FBgn0260442
GeneIDi38978
KEGGidme:Dmel_CG6831
UCSCiCG6831-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38978
FlyBaseiFBgn0260442, rhea

Phylogenomic databases

eggNOGiKOG4261, Eukaryota
GeneTreeiENSGT00940000168860
KOiK06271
OMAiVDMTQHY
OrthoDBi9839at2759

Enzyme and pathway databases

ReactomeiR-DME-114608, Platelet degranulation
R-DME-354192, Integrin signaling
R-DME-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
38978, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
38978

Gene expression databases

BgeeiFBgn0260442, Expressed in capitellum (Drosophila) and 43 other tissues

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
cd12150, talin-RS, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR032425, FERM_f0
IPR035964, I/LWEQ_dom_sf
IPR002558, ILWEQ_dom
IPR002404, IRS_PTB
IPR011993, PH-like_dom_sf
IPR037438, Talin1/2-RS
IPR015224, Talin_cent
IPR036476, Talin_cent_sf
IPR015009, Vinculin-bd_dom
PfamiView protein in Pfam
PF16511, FERM_f0, 1 hit
PF00373, FERM_M, 1 hit
PF01608, I_LWEQ, 1 hit
PF02174, IRS, 1 hit
PF09141, Talin_middle, 1 hit
PF08913, VBS, 1 hit
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM00307, ILWEQ, 1 hit
SUPFAMiSSF109880, SSF109880, 1 hit
SSF109885, SSF109885, 4 hits
SSF47031, SSF47031, 1 hit
SSF47220, SSF47220, 4 hits
PROSITEiView protein in PROSITE
PS00660, FERM_1, 1 hit
PS50057, FERM_3, 1 hit
PS50945, I_LWEQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VSL8_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VSL8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 7, 2020
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Proteomics identificationCombined sources, Reference proteomeImported
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