Cleavage and polyadenylation specificity factor subunit 6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• mRNA binding Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming."
    Tang H.W., Hu Y., Chen C.L., Xia B., Zirin J., Yuan M., Asara J.M., Rabinow L., Perrimon N.
    Cell Metab 27:1040-1054.e8(2018) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• mRNA processing Source: UniProtKB-KW
• positive regulation of autophagy Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming."
    Tang H.W., Hu Y., Chen C.L., Xia B., Zirin J., Yuan M., Asara J.M., Rabinow L., Perrimon N.
    Cell Metab 27:1040-1054.e8(2018) [PubMed] [Europe PMC] [Abstract]
• regulation of alternative mRNA splicing, via spliceosome Source: FlyBaseInferred from high throughput mutant phenotypeⁱ
  • "Identification of alternative splicing regulators by RNA interference in Drosophila."
    Park J.W., Parisky K., Celotto A.M., Reenan R.A., Graveley B.R.
    Proc. Natl. Acad. Sci. U.S.A. 101:15974-15979(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of RNA splicing Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming."
    Tang H.W., Hu Y., Chen C.L., Xia B., Zirin J., Yuan M., Asara J.M., Rabinow L., Perrimon N.
    Cell Metab 27:1040-1054.e8(2018) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MADVVLDLYA EDLDKDFAGQ AQDEFGGDGV DLYDDIGGPT ESAASGGGGG 
        60         70         80         90        100
GTPSADGAAG PGSGEPGERN SGGPNGVYHQ SSGSLTPTMN RRYQLYVGNL 
       110        120        130        140        150
TWWTTDQDIA NSLRDIGVSD LQEVKFFENR ANGQSKGFSV ISLGSESSLR 
       160        170        180        190        200
AVLDQLPKKE MHGQAPVVTY PSKQALTQFE SLQKTRPVPP PQQNGPPRGP 
       210        220        230        240        250
APPSMGGGPM PTGHPGGPQG GGPPGHPPRG MNSIMQPGQY RPQHMSQVPQ 
       260        270        280        290        300
VGGPNSGPPR MQPPMHPQGG LMGNQQPPPR YPSAQGQWPG QRPGGPRPGP 
       310        320        330        340        350
PNGPPQRPMF QGGPMGMPVR GPAGPDWRRP PMHGGFPPQG PPRGLPPAPG 
       360        370        380        390        400
PGGPHGAPAP HVNPAFFNQP GGPAQHPGMG GPPHGAPGPQ PGMNMPPQQG 
       410        420        430        440        450
MNMTPQHGPP PQFAQHGPRG PWPPPQGKPP GPFPDPQQMG PQLTEVEFEE 
       460        470        480        490        500
VMSRNRTVSS SAIARAVSDA AAGEYSSAIE TLVTAISLIK QSKVAHDERC 
       510        520        530        540        550
KILISSLQDT LHGIEAKSYN RRERSRSRER SHRSRQRRER STSRYRERSR 
       560        570        580        590        600
ERERDRDRER ERDGGSYRER SRSRERERQA PDHYRDDSRS VRPRKSPEPV 
       610        620        630        640        650
VAEAAEAPSS KRYYEDRERY RSSDRERRDR DRDRDRERER DRDRREEHRS 

RH                                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. SIMILARITY comments
   Index of protein domains and families