Extra-extra

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB-UniRule
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro

GO - Biological processⁱ

• axon target recognition Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Drosophila HB9 is expressed in a subset of motoneurons and interneurons, where it regulates gene expression and axon pathfinding."
    Odden J.P., Holbrook S., Doe C.Q.
    J Neurosci 22:9143-9149(2002) [PubMed] [Europe PMC] [Abstract]
• central nervous system development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila homeodomain protein dHb9 directs neuronal fate via crossrepressive and cell-nonautonomous mechanisms."
    Broihier H.T., Skeath J.B.
    Neuron 35:39-50(2002) [PubMed] [Europe PMC] [Abstract]
• nervous system development Source: FlyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Genetic control of Drosophila nerve cord development."
    Skeath J.B., Thor S., Skeath J.B.
    Curr Opin Neurobiol 13:8-15(2003) [PubMed] [Europe PMC] [Abstract]
• neuroendocrine cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Postmitotic specification of Drosophila insulinergic neurons from pioneer neurons."
    Miguel-Aliaga I., Thor S., Gould A.P.
    PLoS Biol 6:e58-e58(2008) [PubMed] [Europe PMC] [Abstract]
• neuron projection morphogenesis Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• spinal cord motor neuron cell fate specification Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSSAQVSQQP PPPPLTASSS TSMPSQLLLS HIQHHSSSLH HQRSHQRSSP 
        60         70         80         90        100
PAQDYDQGSN QSTLSPRSQI TPSPPAASPT HSAATTGSPV STYTPALSPG 
       110        120        130        140        150
GAQDSSQTES GQSSQMPLLV APMPVGTGPP HSHPPPPHPR LYVEGFPPPH 
       160        170        180        190        200
HVPHPHPALG TYPLPRLPLM LPANPPGVPS GAAAPPPVSP QPAANHLSHS 
       210        220        230        240        250
GATMATTTLL PPAQSQPKKS FCIDALLAKS QHQSGEPQPI IVDDRLAALH 
       260        270        280        290        300
YARDQAELNH AFVTASNAAA AAQAAASAAG GISEQEALQR IRDSREYDSP 
       310        320        330        340        350
SPDGMSRSES PTSSHRSSPP ISPGCEDQQQ PHGALHPQHL SMRMSDFHDE 
       360        370        380        390        400
FKKPIPPHSP IRPQDFPLYA GGHPYQLLAQ GGSAFHRPLD PSGKPIPIPM 
       410        420        430        440        450
GHNFMPSQLQ FEFLARAGML HHRIPELAAY PHHAILGKTR RPRTAFTSQQ 
       460        470        480        490        500
LLELEKQFKQ NKYLSRPKRF EVASGLMLSE TQVKIWFQNR RMKWKRSKKA 
       510        520 
QQEAKERAKA NQQQQQQQQT PSAAS                            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ