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UniProtKB - Q9VS33 (Q9VS33_DROME)
Protein
Folliculin
Gene
BHD
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- guanyl-nucleotide exchange factor activity Source: InterPro
GO - Biological processi
- germ-line stem cell population maintenance Source: FlyBase
- negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding Source: FlyBase
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- negative regulation of transcription of nucleolar large rRNA by RNA polymerase I Source: FlyBase
- positive regulation of GTPase activity Source: GO_Central
- positive regulation of TORC1 signaling Source: GO_Central
- positive regulation of transforming growth factor beta receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | GTPase activationARBA annotation |
Enzyme and pathway databases
Reactomei | R-DME-9639288, Amino acids regulate mTORC1 |
Names & Taxonomyi
Protein namesi | Recommended name: FolliculinARBA annotation |
Gene namesi | Name:BHDImported Synonyms:CG8616-RAImported, CT25610Imported, DBHDImported, dFLCNImported, Dmel\CG8616Imported ORF Names:CG8616Imported, Dmel_CG8616Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0261111, BHD |
VEuPathDBi | VectorBase:FBgn0261111 |
Subcellular locationi
Lysosome
- Lysosome membrane ARBA annotation
Nucleus
- Nucleus ARBA annotation
Cytoskeleton
- centrosome ARBA annotation
- spindle ARBA annotation
Cytoplasm and Cytosol
- cytosol ARBA annotation
Other locations
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
- spindle Source: UniProtKB-SubCell
Cytosol
- cytosol Source: GO_Central
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Nucleus
- nucleolus Source: FlyBase
Other locations
Keywords - Cellular componenti
Cell projectionARBA annotation, Cytoplasm, CytoskeletonARBA annotation, LysosomeARBA annotation, MembraneARBA annotation, NucleusARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 460 | UDENN FLCN/SMCR8-typeInterPro annotationAdd BLAST | 408 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 156 – 176 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the folliculin family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG3715, Eukaryota |
GeneTreei | ENSGT00390000009864 |
HOGENOMi | CLU_035854_3_0_1 |
OMAi | WKNKVTC |
OrthoDBi | 998434at2759 |
Family and domain databases
Gene3Di | 1.10.10.1730, 1 hit |
InterProi | View protein in InterPro IPR037521, FLCN/SMCR8_DENN IPR044886, FLCN_DENN_C_sf IPR021713, Folliculin IPR037520, Folliculin/SMCR8_longin IPR032035, Folliculin_DENN |
PANTHERi | PTHR31441, PTHR31441, 1 hit |
Pfami | View protein in Pfam PF11704, Folliculin, 1 hit PF16692, Folliculin_C, 1 hit |
PROSITEi | View protein in PROSITE PS51834, DENN_FLCN_SMCR8, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VS33-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNAVIALCHF CEAHGPCAIF CTQTLRDTKL EDLSLEQQTQ KTCSACNYSM
60 70 80 90 100
GKNNNAIYSR DTESGATFVS TKVAVLPEVA SLVKQAAVLS LSNGTDASKD
110 120 130 140 150
GEFVFFGDSS RGHILSHTFR VSDLQARGYS QLFSIIVLMK DKYFLLNIKP
160 170 180 190 200
FLAEHLKKVS SELQAAAKKT KETEEQTYSE RQRRLSGAQF LMPTSRALLE
210 220 230 240 250
LTGEEHIFAQ LHSHFSWLLL AGSRFLTEHV TFGNLPWLPP QSSGRPPAQR
260 270 280 290 300
LTYNSSTLPM IESIDDPDLE EFFSLRHLKS VVRKEEFATV CYCALTGVKI
310 320 330 340 350
VVRGDPRKTF RFMVCLKKLL PEPMHNLMRI DAQHQHSISS EYKIISVSND
360 370 380 390 400
IAVPMASSSV YRIDFLDKHV NGHEVSVKWP GELPRKLPDL MVKLLKAVEE
410 420 430 440 450
KNFTELVLNK QTKVLIEEWK NKVTCLNHAK STSVQGKLKK VLGVQPHDQP
460
IINYWSTHLH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF50597.1 AY119656 mRNA Translation: AAM50310.1 BT088971 mRNA Translation: ACT82953.1 |
RefSeqi | NP_648090.1, NM_139833.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0076834; FBpp0076545; FBgn0261111 |
GeneIDi | 38793 |
KEGGi | dme:Dmel_CG8616 |
UCSCi | CG8616-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF50597.1 AY119656 mRNA Translation: AAM50310.1 BT088971 mRNA Translation: ACT82953.1 |
RefSeqi | NP_648090.1, NM_139833.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7227.FBpp0076545 |
Protocols and materials databases
DNASUi | 38793 |
Genome annotation databases
EnsemblMetazoai | FBtr0076834; FBpp0076545; FBgn0261111 |
GeneIDi | 38793 |
KEGGi | dme:Dmel_CG8616 |
UCSCi | CG8616-RA, d. melanogaster |
Organism-specific databases
CTDi | 50947 |
FlyBasei | FBgn0261111, BHD |
VEuPathDBi | VectorBase:FBgn0261111 |
Phylogenomic databases
eggNOGi | KOG3715, Eukaryota |
GeneTreei | ENSGT00390000009864 |
HOGENOMi | CLU_035854_3_0_1 |
OMAi | WKNKVTC |
OrthoDBi | 998434at2759 |
Enzyme and pathway databases
Reactomei | R-DME-9639288, Amino acids regulate mTORC1 |
Miscellaneous databases
BioGRID-ORCSi | 38793, 0 hits in 1 CRISPR screen |
GenomeRNAii | 38793 |
Gene expression databases
Bgeei | FBgn0261111, Expressed in embryo and 24 other tissues |
Family and domain databases
Gene3Di | 1.10.10.1730, 1 hit |
InterProi | View protein in InterPro IPR037521, FLCN/SMCR8_DENN IPR044886, FLCN_DENN_C_sf IPR021713, Folliculin IPR037520, Folliculin/SMCR8_longin IPR032035, Folliculin_DENN |
PANTHERi | PTHR31441, PTHR31441, 1 hit |
Pfami | View protein in Pfam PF11704, Folliculin, 1 hit PF16692, Folliculin_C, 1 hit |
PROSITEi | View protein in PROSITE PS51834, DENN_FLCN_SMCR8, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VS33_DROME | |
Accessioni | Q9VS33Primary (citable) accession number: Q9VS33 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |