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Entry version 178 (10 Feb 2021)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Uncharacterized protein, isoform A

Gene

Dmel\CG7376

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized protein, isoform AImported
Submitted name:
Uncharacterized protein, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dmel\CG7376Imported
Synonyms:SHPRHImported
ORF Names:CG7376Imported, Dmel_CG7376Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0035689, CG7376

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0035689, Expressed in embryo and 31 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0304173

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini213 – 482Helicase ATP-bindingInterPro annotationAdd BLAST270
Domaini636 – 669TPR_REGIONInterPro annotationAdd BLAST34
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati636 – 669TPRPROSITE-ProRule annotationAdd BLAST34
Domaini1037 – 1081RING-typeInterPro annotationAdd BLAST45
Domaini1109 – 1262Helicase C-terminalInterPro annotationAdd BLAST154

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili728 – 748Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, TPR repeatPROSITE-ProRule annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0298, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170579

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001726_1_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRTCKSK

Database of Orthologous Groups

More...
OrthoDBi
357670at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
3.30.40.10, 2 hits
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR011011, Znf_FYVE_PHD
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00184, RING, 1 hit
SM00028, TPR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50005, TPR, 1 hit
PS50293, TPR_REGION, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VRV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGVVLCEIA DEVPPESPED PTEFRYGKKR WVFKDNLVEH KEEILICIEK
60 70 80 90 100
CQNARTRKLK FRSIRQESGS CILVLSHEQT HVRAREIEME VGEQVLPLFF
110 120 130 140 150
KDFRGSLEFE VAQQEKEHKR PLKTYVTTKL YDALYEKHRQ TVHVEQERSL
160 170 180 190 200
DLPKRFQSQL RKYQQRTVSW MLGREQQITQ VPANFIVLHA IDGITRVFKH
210 220 230 240 250
KYCLQFYPFE EEIPKISLPP GGILADEMGL GKTVEFLAML LMNPRPQDSY
260 270 280 290 300
RNDYWHQRLE EFSDEVPLKR SRISKKDEVF CICTKKHGKR VQCTKCRRWQ
310 320 330 340 350
HEMCMTISEK SDLPHLCPSC WSELVKSGER LVESGATIIV SPNAIKMQWF
360 370 380 390 400
EEIHKHISPS LKVLLYFGLH STFWVSPFDL AQYDVVLTDY TILRNEIYHT
410 420 430 440 450
TDFKSDRQMR HQQRYMRPNS PLLMVNWWRV CLDEAQMVES STSAAAEMVR
460 470 480 490 500
MLPAINRWAV TGTIDELPPL LEFVGRPEVC RPPDAWQTVD KAFQLNYKCE
510 520 530 540 550
PLLELLEHSL WRTCKSKVEH ELGIPPQTEV VHRLELSNVE SLYYREEHLK
560 570 580 590 600
CHEQFLAAVA KHTRHNADNS SCLASISPQL LRIILKPFLR IRQTCSVPVV
610 620 630 640 650
FNSNVSSTDY LHPQDLLARL KSNNENECKT ELRTWASSYN GLAAIYFIKN
660 670 680 690 700
DFPQAIKYYN LLLKLANEYN EQNISVDSVL QIHAIYNLLQ ASSLAPAEHK
710 720 730 740 750
LTELEHKKYQ AQMSRLEWKY LEDNTRVLES ALSSYNENLE KVSELEKRFE
760 770 780 790 800
GSTLDLLATM VNHKTSLHDA IWNKVRDDFF RQNISVERLE NVNSMAGMLY
810 820 830 840 850
FMDIWHNKLQ NLKSTLIAEF EFLKGVMQQA CEAIKTGVLL SMEIINFIEN
860 870 880 890 900
VTVCHLTDIL DANKDKPVKP KKHRYCRLCL IRDSLNQFEC LLFAKKLDEK
910 920 930 940 950
ATVTEGLENP SMEISFIKSI FAFLRSKQDF SEWKEECQSK LELLSCLQDL
960 970 980 990 1000
VKFQIKYWIE VEYMVKAFDE LEMCKMRILL TDDPEEQSNY RILACQLDEQ
1010 1020 1030 1040 1050
LQFNQYNLQT SQLNFTRLCG RLKYLKHLKE DSADKPCPIC QTQDDVRYVM
1060 1070 1080 1090 1100
MVCGHFVCQH CLDSMRRKNG RAGVTKCPLC RQDSPQLYYS VRPGAHKSII
1110 1120 1130 1140 1150
GDFSTKISSV VELVLKIKGE NEQEKIIVFS QWQAILIEIA RALSLNGIQF
1160 1170 1180 1190 1200
RNKCTNKDFD DFKNPLSNVT CLLMPLSKGS KGLNLIEATH VFLVEPILNP
1210 1220 1230 1240 1250
GDERQAIGRI HRFGQKRPTK VHRFIVNETI EENILSLITS ADDTTTLSTH
1260 1270
WDLENMTLDS LKKLFILKEE
Length:1,270
Mass (Da):148,059
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAA6EC8B082699E4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50680.1
AE014296 Genomic DNA Translation: AGB94166.1

NCBI Reference Sequences

More...
RefSeqi
NP_001261471.1, NM_001274542.1
NP_648034.1, NM_139777.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0076998; FBpp0076706; FBgn0035689
FBtr0331788; FBpp0304173; FBgn0035689

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38715

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7376

UCSC genome browser

More...
UCSCi
CG7376-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50680.1
AE014296 Genomic DNA Translation: AGB94166.1
RefSeqiNP_001261471.1, NM_001274542.1
NP_648034.1, NM_139777.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0304173

Genome annotation databases

EnsemblMetazoaiFBtr0076998; FBpp0076706; FBgn0035689
FBtr0331788; FBpp0304173; FBgn0035689
GeneIDi38715
KEGGidme:Dmel_CG7376
UCSCiCG7376-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0035689, CG7376

Phylogenomic databases

eggNOGiKOG0298, Eukaryota
GeneTreeiENSGT00940000170579
HOGENOMiCLU_001726_1_1_1
OMAiWRTCKSK
OrthoDBi357670at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
38715, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38715

Gene expression databases

BgeeiFBgn0035689, Expressed in embryo and 31 other tissues

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.30.40.10, 2 hits
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR011011, Znf_FYVE_PHD
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00184, RING, 1 hit
SM00028, TPR, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50005, TPR, 1 hit
PS50293, TPR_REGION, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VRV2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VRV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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