Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (07 Oct 2020)
Sequence version 3 (16 Apr 2014)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

scny

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolase that deubiquitinates polyubiquitinated target proteins including imd (PubMed:19837371, PubMed:19039105). Required for preventing the constitutive activation of the imd/NF-kappa-B (Imd) signaling cascade under unchalleneged conditions (PubMed:19837371, PubMed:25027767). Deubiquitinates imd linked 'Lys-63' chains which leads its proteasomal degradation and consequently down-regulation of the Imd signaling cascade (PubMed:19837371). Removal of the activating 'Lys-63'-linked chains is likely to enable their replacement with 'Lys-48'-linked chains which act as 'tags' the for proteosomal degradation of imd (PubMed:19837371). Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells (PubMed:19039105). May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4me3) (PubMed:19039105). Controls selective autophagy activation by ubiquitinated proteins (PubMed:22622177).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei181NucleophilePROSITE-ProRule annotation2 Publications1
Active sitei439Proton acceptorPROSITE-ProRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5689880, Ub-specific processing proteases

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.097

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:scny
Synonyms:Usp36
ORF Names:CG5505
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0260936, scny

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants are lethal at larval stages (PubMed:19837371, PubMed:22622177). They are significantly smaller without gross morphological defects and die 5 days after egg laying (PubMed:22622177). Cells show accumulation of ubiquitinated proteins in both the nucleus and the cytoplasm, forming dense dots (PubMed:22622177). Double mutants for ref2P and scny die 96 hours after egg laying (PubMed:22622177). RNAi-mediated knockdown is also larval lethal (PubMed:19837371). RNAi-mediated knockdown in the fat body or gut of uninfected adults, results in a significant increase in the expression of the antimicrobial peptide genes Dpt, AttA and puc (PubMed:19837371). Adults raised under axenic conditions do not display any increase in Dpt, AttA and puc expression (PubMed:19837371). No significant increase in the expression of the antifungal peptide gene Drs (PubMed:19837371). Double knockdown with imd in the adult fat body, prevents the enhanced expression of Dpt in uninfected flies (PubMed:19837371).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi181C → S: Loss of H2B deubiquitination. Loss of 'K-48'- and 'K-63'-linked polyubiquitin chain hydrolysis; when associated with N-369. 2 Publications1
Mutagenesisi439H → N: Loss of 'K-48'- and 'K-63'-linked polyubiquitin chain hydrolysis; when associated with S-181. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003784981 – 1038Ubiquitin carboxyl-terminal hydrolase 36Add BLAST1038

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei513Phosphoserine1 Publication1
Modified residuei515Phosphoserine1 Publication1
Modified residuei658Phosphothreonine1 Publication1
Modified residuei662Phosphothreonine1 Publication1
Modified residuei672Phosphoserine1 Publication1
Modified residuei674Phosphoserine1 Publication1
Modified residuei747Phosphoserine1 Publication1
Modified residuei779Phosphoserine1 Publication1
Modified residuei782Phosphothreonine1 Publication1
Modified residuei785Phosphoserine1 Publication1
Modified residuei819Phosphoserine1 Publication1
Modified residuei825Phosphothreonine1 Publication1
Modified residuei843Phosphoserine1 Publication1
Modified residuei846Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VRP5

PRoteomics IDEntifications database

More...
PRIDEi
Q9VRP5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VRP5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0260936, Expressed in saliva-secreting gland and 38 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VRP5, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with atms/PAF1, but not with CycT (PubMed:19039105).

Interacts (via C-terminus) with imd (via N-terminus) (PubMed:19837371).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
64109, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VRP5, 96 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0076806

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VRP5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini172 – 480USPPROSITE-ProRule annotationAdd BLAST309

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1865, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170426

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006208_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VRP5

KEGG Orthology (KO)

More...
KOi
K11855

Identification of Orthologs from Complete Genome Data

More...
OMAi
KQSHRGY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443, UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform D (identifier: Q9VRP5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVSMAVCET ANVVNAALRE SLGGNSSAGS STDQAKSGED TNGSLQNHIV
60 70 80 90 100
ANAKRILMAK IEYEEVPNYH ESVLENLKSK YIVIKPGNPG AINGFSGKNN
110 120 130 140 150
TGKLVGANGH DNNGARKQAE HPNNQSHHIN HHNHQHPTSN PNELPKPKRV
160 170 180 190 200
LYPRENIRIG WKQSERKWQV GTGMINVGNT CYLNSTLQAL LHIPALANWL
210 220 230 240 250
VSEQAHLADC NVAEPGSGCI ICAMTKTLLA TQSNQSAVRP FLIYSKLKQI
260 270 280 290 300
CKHMVVGRQE DAHEFLRFLV EAMERAYLMR FRNYKELDQL VKETTPLGQI
310 320 330 340 350
FGGYLRSEVR CLSCNHVSIT FQHFQDLLLD IRKADSLEDA FEGHFSRERL
360 370 380 390 400
EDMGYKCEGC KKKVSATKQF SLERAPITLC IQLKRFSMIG NKLTKQISFK
410 420 430 440 450
SRIDLSKYAA RSQAAQAQPL TYRLVSMVTH LGASQHCGHY TAIGSTDTGS
460 470 480 490 500
FYNFDDSYVR PIAMHSVCNT NAYIMFFELD LSQAASPAAN RPNGVRLTNG
510 520 530 540 550
HSTTPVPAAT VSSPSPTRFI GPQLPAGGAN GYTNGNAQKT AIQFKQQNQQ
560 570 580 590 600
SPQNGLQLGT GKFQDTAKPP LVGAHAKGEA TSAPTANGNK SSSPSSNSSS
610 620 630 640 650
NHKSINQQQY LPISSDDEDI EDEMKPRPTT AQLPSMPNMT ENHTEPKAKS
660 670 680 690 700
PVKIQVKTPV KTPLKSLVPY ESASEEEEAP LPNPRKRPSG EDSSESDQES
710 720 730 740 750
GQTNGHSKTN GSHTNGSASS SVHVNNSKQK TDAIDEIFKS LKKSADSDED
760 770 780 790 800
DDEEEPSIQL TNGWHPQKQS QSQSKAPPSP KTPPSPAVIK SKTGIWKVTR
810 820 830 840 850
NDEVDAIEDD VDVVVVEGSP VKIPTPNKNH RNPFSSSKPS TDSPATPGAK
860 870 880 890 900
RQKLLNGSAL KSHQQPRVGN GYQSNATSNG STINELLKQS YRGYGSPVLS
910 920 930 940 950
WNGKPAELEK ELLVDAREQR QRDIDDDEEN EMDRGRQRKV KSGSAKGNNA
960 970 980 990 1000
SNSTPGYNPF QEYEGQKRWN KNGGGGGFPR FYNQNYRQNF QQRNKFKFNR
1010 1020 1030
FGGPGSAKFQ QQRALQRHLS AGGGFSRRQP SAQQQQQT
Length:1,038
Mass (Da):114,088
Last modified:April 16, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98CECD6993333E22
GO
Isoform B (identifier: Q9VRP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-110: ESVLENLKSK...TGKLVGANGH → MTVIMVDGFA...KLSTVLFTFA

Show »
Length:968
Mass (Da):107,252
Checksum:i941F6973D4435C8A
GO
Isoform C (identifier: Q9VRP5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     91-110: AINGFSGKNNTGKLVGANGH → MLHSPVPRYNKCVPFPTLRT

Show »
Length:948
Mass (Da):104,961
Checksum:i29E5A05BB8761243
GO
Isoform G (identifier: Q9VRP5-7) [UniParc]FASTAAdd to basket
Also known as: H

The sequence of this isoform differs from the canonical sequence as follows:
     911-1038: ELLVDAREQR...QPSAQQQQQT → ETFELVCAKR...PDPDRLTDGR

Show »
Length:976
Mass (Da):105,957
Checksum:i89E02FAC5B5FCC82
GO
Isoform I (identifier: Q9VRP5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     91-110: AINGFSGKNNTGKLVGANGH → MLHSPVPRYNKCVPFPTLRT
     911-1038: ELLVDAREQR...QPSAQQQQQT → ETFELVCAKR...PDPDRLTDGR

Show »
Length:886
Mass (Da):96,830
Checksum:i572BE9A8370C7615
GO
Isoform J (identifier: Q9VRP5-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-110: ESVLENLKSK...TGKLVGANGH → MTVIMVDGFA...KLSTVLFTFA
     911-1038: ELLVDAREQR...QPSAQQQQQT → ETFELVCAKR...PDPDRLTDGR

Show »
Length:906
Mass (Da):99,121
Checksum:i74BBC44F1AB468F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti115A → T in AAQ22589 (Ref. 4) Curated1
Sequence conflicti642N → D in AAQ22589 (Ref. 4) Curated1
Sequence conflicti642N → D in AAO42671 (Ref. 4) Curated1
Sequence conflicti766P → T in AAQ22589 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0375901 – 90Missing in isoform C and isoform I. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_0375911 – 70Missing in isoform B and isoform J. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_03759271 – 110ESVLE…GANGH → MTVIMVDGFALWLLYKLFLS PCCLLLWHVLKLSTVLFTFA in isoform B and isoform J. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_03759391 – 110AINGF…GANGH → MLHSPVPRYNKCVPFPTLRT in isoform C and isoform I. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_054032911 – 1038ELLVD…QQQQT → ETFELVCAKRIAGHGSVEGS DIVEGSVAVDAAVTSGSDSK DVVVIAVAVTDTTADAPDPD RLTDGR in isoform G, isoform I and isoform J. CuratedAdd BLAST128

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAN12107.1
AE014296 Genomic DNA Translation: AAN12108.2
AE014296 Genomic DNA Translation: AAN12109.1
AE014296 Genomic DNA Translation: AAN12110.2
AE014296 Genomic DNA Translation: AAN12111.1
AE014296 Genomic DNA Translation: AFH04310.1
AE014296 Genomic DNA Translation: AFH04311.1
AY051916 mRNA Translation: AAK93340.1
BT004507 mRNA Translation: AAO42671.1
BT010120 mRNA Translation: AAQ22589.1
BT046169 mRNA Translation: ACI47091.1

NCBI Reference Sequences

More...
RefSeqi
NP_001246639.1, NM_001259710.2 [Q9VRP5-7]
NP_001246640.1, NM_001259711.2 [Q9VRP5-7]
NP_647986.3, NM_139729.3 [Q9VRP5-9]
NP_729092.1, NM_168132.3 [Q9VRP5-3]
NP_729093.2, NM_168133.2 [Q9VRP5-8]
NP_729094.1, NM_168134.2 [Q9VRP5-6]
NP_729095.1, NM_168135.2 [Q9VRP5-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077100; FBpp0076806; FBgn0260936 [Q9VRP5-3]
FBtr0077101; FBpp0076807; FBgn0260936 [Q9VRP5-2]
FBtr0077103; FBpp0076809; FBgn0260936 [Q9VRP5-6]
FBtr0307975; FBpp0300344; FBgn0260936 [Q9VRP5-7]
FBtr0307976; FBpp0300345; FBgn0260936 [Q9VRP5-7]
FBtr0330127; FBpp0303160; FBgn0260936 [Q9VRP5-8]
FBtr0330128; FBpp0303161; FBgn0260936 [Q9VRP5-9]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38648

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5505

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAN12107.1
AE014296 Genomic DNA Translation: AAN12108.2
AE014296 Genomic DNA Translation: AAN12109.1
AE014296 Genomic DNA Translation: AAN12110.2
AE014296 Genomic DNA Translation: AAN12111.1
AE014296 Genomic DNA Translation: AFH04310.1
AE014296 Genomic DNA Translation: AFH04311.1
AY051916 mRNA Translation: AAK93340.1
BT004507 mRNA Translation: AAO42671.1
BT010120 mRNA Translation: AAQ22589.1
BT046169 mRNA Translation: ACI47091.1
RefSeqiNP_001246639.1, NM_001259710.2 [Q9VRP5-7]
NP_001246640.1, NM_001259711.2 [Q9VRP5-7]
NP_647986.3, NM_139729.3 [Q9VRP5-9]
NP_729092.1, NM_168132.3 [Q9VRP5-3]
NP_729093.2, NM_168133.2 [Q9VRP5-8]
NP_729094.1, NM_168134.2 [Q9VRP5-6]
NP_729095.1, NM_168135.2 [Q9VRP5-2]

3D structure databases

SMRiQ9VRP5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi64109, 9 interactors
IntActiQ9VRP5, 96 interactors
STRINGi7227.FBpp0076806

Protein family/group databases

MEROPSiC19.097

PTM databases

iPTMnetiQ9VRP5

Proteomic databases

PaxDbiQ9VRP5
PRIDEiQ9VRP5

Genome annotation databases

EnsemblMetazoaiFBtr0077100; FBpp0076806; FBgn0260936 [Q9VRP5-3]
FBtr0077101; FBpp0076807; FBgn0260936 [Q9VRP5-2]
FBtr0077103; FBpp0076809; FBgn0260936 [Q9VRP5-6]
FBtr0307975; FBpp0300344; FBgn0260936 [Q9VRP5-7]
FBtr0307976; FBpp0300345; FBgn0260936 [Q9VRP5-7]
FBtr0330127; FBpp0303160; FBgn0260936 [Q9VRP5-8]
FBtr0330128; FBpp0303161; FBgn0260936 [Q9VRP5-9]
GeneIDi38648
KEGGidme:Dmel_CG5505

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38648
FlyBaseiFBgn0260936, scny

Phylogenomic databases

eggNOGiKOG1865, Eukaryota
GeneTreeiENSGT00940000170426
HOGENOMiCLU_006208_0_0_1
InParanoidiQ9VRP5
KOiK11855
OMAiKQSHRGY

Enzyme and pathway databases

ReactomeiR-DME-5689880, Ub-specific processing proteases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
38648, 2 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
scny, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38648

Protein Ontology

More...
PROi
PR:Q9VRP5

Gene expression databases

BgeeiFBgn0260936, Expressed in saliva-secreting gland and 38 other tissues
GenevisibleiQ9VRP5, DM

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom
PfamiView protein in Pfam
PF00443, UCH, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP36_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VRP5
Secondary accession number(s): M9NE30
, Q7YTX7, Q86NM9, Q8IQ57, Q8IQ58, Q8IQ59, Q8IQ60, Q960Q4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: April 16, 2014
Last modified: October 7, 2020
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again