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UniProtKB - Q9VRP4 (Q9VRP4_DROME)

Entry version 160 (25 May 2022)
Sequence version 2 (01 Mar 2001)
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Protein
Submitted name:

Bifunctional phosphopantetheine adenylyltransferase - Dephospho-CoA kinase

Gene

Ppat-Dpck

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, NucleotidyltransferaseImported, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-196783, Coenzyme A biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Bifunctional phosphopantetheine adenylyltransferase - Dephospho-CoA kinaseImported (EC:2.7.1.24Imported, EC:2.7.7.3Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ppat-DpckImported
Synonyms:dCOASYImported, Dmel\CG10575Imported, DPCKImported, dPPAT-DPCKImported, PPATImported, PPAT-DPCKImported
ORF Names:CG10575Imported, Dmel_CG10575Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0035632, Ppat-Dpck

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0035632

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9VRP4

PRoteomics IDEntifications database

More...PRIDEi		Q9VRP4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0035632, Expressed in arthropod fat body and 18 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9VRP4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9VRP4, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7227.FBpp0076826

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9VRP4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VRP4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini149 – 288CTP_transf_likeInterPro annotationAdd BLAST140

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3220, Eukaryota
KOG3351, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000075078

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027827_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9VRP4

Identification of Orthologs from Complete Genome Data

More...OMAi		VIDCDKV

Database of Orthologous Groups

More...OrthoDBi		1543581at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9VRP4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 1 hit
3.40.50.620, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00376, Dephospho_CoA_kinase, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004821, Cyt_trans-like
IPR001977, Depp_CoAkinase
IPR027417, P-loop_NTPase
IPR014729, Rossmann-like_a/b/a_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01121, CoaE, 1 hit
PF01467, CTP_transf_like, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00125, cyt_tran_rel, 1 hit
TIGR00152, TIGR00152, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51219, DPCK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VRP4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSTGLLVV SNIKHLGKSL RAIEKYVNSL YIHLNVAGST STTSPVPPPP 
        60         70         80         90        100
VWGRLISQLY ANSSSYVGKQ LDLRVLVSPL RPGANGSLKL RQPVDLIFSD 
       110        120        130        140        150
AHHPELCDRL RADLNISKPT IFLDDSVISD LSAQQDDTQP PKVYPSVVLG 
       160        170        180        190        200
GTFDRIHLGH KIFLTQAVLR TCKRLVVGVT TSAMTKGKTL PDLILPVEER 
       210        220        230        240        250
IARLREFLVD IDDTLQYEIV PIDDPFGPTQ VDPDLDMIVV SAETLRGGQK 
       260        270        280        290        300
VNEVRSAKQL RELEIFVIDI VESNVHDGIH ETKVSSSNTR IDLLGTRWRR 
       310        320        330        340        350
PEPRPQLPPR PYIIGLTGGI ASGKSKMGER LANMGAHVID CDKVAHDVYE 
       360        370        380        390        400
PGQLCYTRIV QHFGQGIVSD DGRIDRSKLG PLVFADPKQL QALNGIVWPE 
       410        420        430        440        450
LIAEVNRRLD ALRSQADVPR VVVLEAAVLL RAGWETNCHE VWSMIVPPDE 
       460        470        480        490        500
AVRRIIERNK LSEVEAQKRL ASQVPNSEIV AKSHVIFSSQ WDHEFTQKQA 
       510 
ERAWKMLTKE LDSYQSSL
Length:518
Mass (Da):57,641
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i368B21DCBE34076A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50749.2

NCBI Reference Sequences

More...RefSeqi		NP_647985.1, NM_139728.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0077120; FBpp0076826; FBgn0035632

Database of genes from NCBI RefSeq genomes

More...GeneIDi		38647

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG10575

UCSC genome browser

More...UCSCi		CG10575-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50749.2
RefSeqiNP_647985.1, NM_139728.2

3D structure databases

AlphaFoldDBiQ9VRP4
SMRiQ9VRP4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0076826

Proteomic databases

PaxDbiQ9VRP4
PRIDEiQ9VRP4

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		38647

Genome annotation databases

EnsemblMetazoaiFBtr0077120; FBpp0076826; FBgn0035632
GeneIDi38647
KEGGidme:Dmel_CG10575
UCSCiCG10575-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		38647
FlyBaseiFBgn0035632, Ppat-Dpck
VEuPathDBiVectorBase:FBgn0035632

Phylogenomic databases

eggNOGiKOG3220, Eukaryota
KOG3351, Eukaryota
GeneTreeiENSGT00550000075078
HOGENOMiCLU_027827_2_1_1
InParanoidiQ9VRP4
OMAiVIDCDKV
OrthoDBi1543581at2759
PhylomeDBiQ9VRP4

Enzyme and pathway databases

ReactomeiR-DME-196783, Coenzyme A biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		38647, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Pka-C3, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		38647

Gene expression databases

BgeeiFBgn0035632, Expressed in arthropod fat body and 18 other tissues
ExpressionAtlasiQ9VRP4, baseline and differential
GenevisibleiQ9VRP4, DM

Family and domain databases

Gene3Di3.40.50.300, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00376, Dephospho_CoA_kinase, 1 hit
InterProiView protein in InterPro
IPR004821, Cyt_trans-like
IPR001977, Depp_CoAkinase
IPR027417, P-loop_NTPase
IPR014729, Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01121, CoaE, 1 hit
PF01467, CTP_transf_like, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00125, cyt_tran_rel, 1 hit
TIGR00152, TIGR00152, 1 hit
PROSITEiView protein in PROSITE
PS51219, DPCK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VRP4_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VRP4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: May 25, 2022
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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