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Entry version 173 (02 Jun 2021)
Sequence version 3 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein, isoform B

Gene

Dmel\CG1494

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi575 – 582ATPPROSITE-ProRule annotation8
Nucleotide bindingi1394 – 1401ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1369062, ABC transporters in lipid homeostasis
R-DME-5683826, Surfactant metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized protein, isoform BImported
Submitted name:
Uncharacterized protein, isoform CImported (EC:3.6.1.3Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dmel\CG1494Imported
ORF Names:CG1494Imported, Dmel_CG1494Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0031169, CG1494

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 49HelicalSequence analysisAdd BLAST24
Transmembranei272 – 294HelicalSequence analysisAdd BLAST23
Transmembranei324 – 342HelicalSequence analysisAdd BLAST19
Transmembranei354 – 379HelicalSequence analysisAdd BLAST26
Transmembranei385 – 404HelicalSequence analysisAdd BLAST20
Transmembranei465 – 484HelicalSequence analysisAdd BLAST20
Transmembranei911 – 935HelicalSequence analysisAdd BLAST25
Transmembranei1084 – 1104HelicalSequence analysisAdd BLAST21
Transmembranei1125 – 1148HelicalSequence analysisAdd BLAST24
Transmembranei1160 – 1181HelicalSequence analysisAdd BLAST22
Transmembranei1193 – 1211HelicalSequence analysisAdd BLAST19
Transmembranei1223 – 1241HelicalSequence analysisAdd BLAST19
Transmembranei1281 – 1302HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VRG3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031169, Expressed in head and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VRG3, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VRG3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini541 – 773ABC transporterInterPro annotationAdd BLAST233
Domaini1352 – 1592ABC transporterInterPro annotationAdd BLAST241

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni490 – 511DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili863 – 883Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167230

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_19_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LLYWYDA

Database of Orthologous Groups

More...
OrthoDBi
131191at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR026082, ABCA
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229, PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VRG3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVRSYIRKF LLMNWKNHKL QLANPLELLV ILLVPPLFTL VAVLMRFFIP
60 70 80 90 100
VNHRSDTVYD PIDLDRSWMQ MVEKLEKARQ VADTYNVKGN PFTPHLVIGW
110 120 130 140 150
APKRYGIFQA MMRRVQKQIE PMTSVGFEDC EEMRESVIEN GLFAGLCFDG
160 170 180 190 200
SPFVEDQVFE EDTLESYSNI QPMLNYTILL PSELRMLDGD FRMANWMTLY
210 220 230 240 250
NDDPNTFVLT RLNQPYEGGF VGYVREGFIR LQKSVSESFL VLTSHKSLPT
260 270 280 290 300
IQIRRFPITG REQDPLMGNL NYGMPFIIII GFLFPAQLFV WQVVSEKQSQ
310 320 330 340 350
VRQFLINMNI GNLIHFVSWY LKGLIYEMIS SLIIAALLKI RWDQDHGVLT
360 370 380 390 400
QTPWYILILV LFCYNCAAVA FAIMVAAFFR NALNAVRVLT ILWIMSYVPT
410 420 430 440 450
FILSNNLEGN IHALRYVSYA LPNVVATLVI EFLIERESIV HITWEDSGYR
460 470 480 490 500
LNYDGGHITV TASSWIFMLN ALVYCAIGLY VDMWRGGDRS GKKMKKPNTN
510 520 530 540 550
ASVQEDPYHE RGDSFTHQGQ AIGVNSTKIY EVEPSHRRFK LKIKKLCKRF
560 570 580 590 600
ATNDRPALNL FSWNVYENEV TVLMGHNGCG KSTLLKILAG LVEPSRGTVM
610 620 630 640 650
ISSHNIQTER KAASMELGIA FGHDMLLTGF TVIDYLRFIC RVKGLHNNIE
660 670 680 690 700
IDGQSNYFLN VLQIGGLKTK RIRTLTDRDL CLVSICCAFV GNSPIILIDD
710 720 730 740 750
VHSDLDKRTQ SLVWNLINEE KSKRTIILVS NSPALAENIA DRMAIMSNGE
760 770 780 790 800
LKCTGTKPFL KNMYGHGYRL TCVKGKNYKR DELFGMMNSY MPNMSIERDI
810 820 830 840 850
GYKVTFVLEN KFEDQFPMLI DDLEENMQQL GVVSFRIRDT SMEEIFLRFG
860 870 880 890 900
CEDNDQSGAF QSHENAQVLL EEYYSTLAEA NEKGRRTGWK LFFLHGRAVI
910 920 930 940 950
YKRWIAAHRH WIVLIFEVLA MALVAVCTFS SIFIYGKNYE LEPLTFNLSQ
960 970 980 990 1000
LHTVDAFVEL FSEEEDVKDM HAYYTELLYW YDAHVATLTK NRHNAYALLT
1010 1020 1030 1040 1050
QNQFTAHVNS RYIFGATFDQ KIVTAWFNNI PLHSAPYALN VVHNAVARHL
1060 1070 1080 1090 1100
FDEEATIDVT LAPLPFRTAI NTFPPSSHTF GGCLAFGICF VLTFIWPAFA
1110 1120 1130 1140 1150
IYMITERGSL LKKQQFLAGV RVCSYWTFTV LYDLLFLLIF CACVVVMVAL
1160 1170 1180 1190 1200
YENPNHDVML YGYISVTLML GGFWVILLAY LMASLCRNPC YGFLWLCGIN
1210 1220 1230 1240 1250
SIGLVCFSQF YRTHPESMLL EPTFMAMYTV ATVICKLFMI YEFKLICMDP
1260 1270 1280 1290 1300
VVNFTSVEVF KCNSIPNCCI KSNYGTFTAG IYHDLVILTL LDIILLACLF
1310 1320 1330 1340 1350
VSEYHSILGF ADCRLDTRTN ESPDSNQESR AFPGILSNDT AALVDKEHTS
1360 1370 1380 1390 1400
RLNEEERSKY AAVGIGIVSK YRRNRVLRDL DFTLAKSECL SITGANNSGK
1410 1420 1430 1440 1450
TTLLKVVVNE TKMNAGQLWI HDYSVNTHRV QCYRMVGYCP QKDSLPSEFT
1460 1470 1480 1490 1500
PRELLYIHAM LQGHRHRIGR ELSEALLRLV GLTPCWNRSV RMCTTGQIRR
1510 1520 1530 1540 1550
LYFAYAVLGS PDLICVDGVP AGLDPTGKRI ILMMTSTMQA MGSSFLYTML
1560 1570 1580 1590 1600
TGLDAERLSL RTPLLLEGQL WMIRPMDTET ENYKSGYQLE VRFKRKVNPN
1610 1620 1630 1640 1650
VSMSRATWNL INHFPMSPNK KFSAFMEIKF PDAVLTIERD DSMVFVLPLG
1660 1670 1680 1690
TTTFSEIFLT LRKDAFEMNI EDYFITRNML VGFQIFTYDQ HQDNP
Length:1,695
Mass (Da):194,190
Last modified:June 26, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71CDD8385142EB3F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF50838.3
AE014298 Genomic DNA Translation: AGB95601.1

NCBI Reference Sequences

More...
RefSeqi
NP_001259763.1, NM_001272834.1
NP_608444.2, NM_134600.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0332306; FBpp0304585; FBgn0031169
FBtr0332307; FBpp0304586; FBgn0031169

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33102

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1494

UCSC genome browser

More...
UCSCi
CG1494-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF50838.3
AE014298 Genomic DNA Translation: AGB95601.1
RefSeqiNP_001259763.1, NM_001272834.1
NP_608444.2, NM_134600.2

3D structure databases

SMRiQ9VRG3
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9VRG3, 1 interactor

Proteomic databases

PRIDEiQ9VRG3

Genome annotation databases

EnsemblMetazoaiFBtr0332306; FBpp0304585; FBgn0031169
FBtr0332307; FBpp0304586; FBgn0031169
GeneIDi33102
KEGGidme:Dmel_CG1494
UCSCiCG1494-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0031169, CG1494

Phylogenomic databases

eggNOGiKOG0059, Eukaryota
GeneTreeiENSGT00940000167230
HOGENOMiCLU_000604_19_1_1
OMAiLLYWYDA
OrthoDBi131191at2759

Enzyme and pathway databases

ReactomeiR-DME-1369062, ABC transporters in lipid homeostasis
R-DME-5683826, Surfactant metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
33102, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33102

Gene expression databases

BgeeiFBgn0031169, Expressed in head and 15 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR026082, ABCA
IPR027417, P-loop_NTPase
PANTHERiPTHR19229, PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VRG3_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VRG3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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