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Entry version 138 (26 Feb 2020)
Sequence version 2 (16 Jun 2009)
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Protein

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

Gene

l(1)G0196

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.By similarity

Caution

Although related to histidine acid phosphatases, it lacks the conserved active sites, suggesting that it has no phosphatase activity.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei157ATPBy similarity1
Binding sitei210ATPBy similarity1
Binding sitei217ATPBy similarity1
Binding sitei236ATPBy similarity1
Binding sitei271SubstrateBy similarity1
Binding sitei285SubstrateBy similarity1
Binding sitei287ATPBy similarity1
Binding sitei332ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi260 – 263ATPBy similarity4
Nucleotide bindingi269 – 271ATPBy similarity3
Nucleotide bindingi344 – 346ATPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1855167 Synthesis of pyrophosphates in the cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC:2.7.4.21, EC:2.7.4.24)
Alternative name(s):
InsP6 and PP-IP5 kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CG14616
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0027279 l(1)G0196

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003156971 – 1696Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinaseAdd BLAST1696

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei974Phosphoserine1 Publication1
Modified residuei1001Phosphoserine1 Publication1
Modified residuei1060Phosphoserine1 Publication1
Modified residuei1255Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VR59

PRoteomics IDEntifications database

More...
PRIDEi
Q9VR59

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VR59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0027279 Expressed in adult Malpighian tubule (Drosophila) and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VR59 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VR59 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
59411, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-21851N

Protein interaction database and analysis system

More...
IntActi
Q9VR59, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0288801

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VR59

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 77Substrate bindingBy similarity2
Regioni236 – 237Substrate bindingBy similarity2
Regioni349 – 352Substrate bindingBy similarity4
Regioni394 – 465Polyphosphoinositide-binding domainBy similarityAdd BLAST72

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal kinase domain produces inositol polyphosphates. The C-terminal acid phosphatase-like domain binds inositol polyphosphates and negatively regulates their accumulation. The C-terminal domain reduces the amount of inositol pyrophosphates in a dose-dependent manner in vitro.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1057 Eukaryota
ENOG410XNSN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009048

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VR59

KEGG Orthology (KO)

More...
KOi
K13024

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VR59

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07061 HP_HAP_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR037446 His_Pase_VIP1
IPR029033 His_PPase_superfam
IPR040557 VIP1_N

The PANTHER Classification System

More...
PANTHERi
PTHR12750 PTHR12750, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00328 His_Phos_2, 1 hit
PF18086 PPIP5K2_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53254 SSF53254, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform I (identifier: Q9VR59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYTELESGY QDISQQHQQQ NPHQSQPQQR VGFYLGLQDG NGDTDFGDSN
60 70 80 90 100
DGMDSDTSTS SSNSKQVVVG ICAMAKKTQS KPMKEILTRL GEFEFIKLVT
110 120 130 140 150
FEENVILREP VQNWPTCDCL VSFHSKGFPL EKAIEYAQLR NPFVLNNLHM
160 170 180 190 200
QYDIQDRRRV YAILEKEGIE IPRYAVLDRD SPDPKHHELI ESEDHVEVNG
210 220 230 240 250
ITFNKPFVEK PVSAEDHNIY IYYPTSAGGG SQRLFRKIGS RSSVYSPESR
260 270 280 290 300
VRKTGSFIYE DFMPTDGTDV KVYTVGPDYA HAEARKSPAL DGKVERDSEG
310 320 330 340 350
KEIRYPVILN HSEKLISRKV CLAFKQTVCG FDLLRANGKS YVCDVNGFSF
360 370 380 390 400
VKNSNKYYDD CAKILGNMIL RELTPTLHIP WSVPFQLDDP PIVPTTFGKM
410 420 430 440 450
MELRCVVAVI RHGDRTPKQK MKVEVRHPKF FEIFEKYDGY KLGHVKLKRP
460 470 480 490 500
KQLQEILDIA RFLLSEIHTK AHAEIEEKES KLEQLKNVLE MYGHFSGINR
510 520 530 540 550
KVQMKYQPKG RPRGSSSDDT NLAADQPVEP SLVLILKWGG ELTPAGRIQA
560 570 580 590 600
EELGRIFRCM YPGGQGRSDY SGTQGLGLLR LHSTFRHDLK IYASDEGRVQ
610 620 630 640 650
MTAAAFAKGL LALEGELTPI LVQMVKSANT NGLLDNDCDS SKYQNLAKGR
660 670 680 690 700
LHELMQNDRE FSKEDRELIN PCNSKSITQA LDFVKNPVDC CHHVHLLIRE
710 720 730 740 750
LLHIISIKKD DPKTKDAILY HGETWDLMRC RWEKIEKDFS TKSKLFDISK
760 770 780 790 800
IPDIYDCIKY DLQHNQHTLQ YDQAEELYIY AKNLADIVIP QEYGLTPQEK
810 820 830 840 850
LAIGQGICSP LLRKIKGDLQ RNIDEVEDEF MNRLNPHYSH GVASPQRHVR
860 870 880 890 900
TRLYFTSESH VHSLLTVLRY GGLLNVVTDE QWRRAMDYIS MVSELNYMSQ
910 920 930 940 950
IVIMLYEDPT KDPTSEERFH VELHFSPGVN CCVQKNLPPG PGFRPHSHGD
960 970 980 990 1000
NACNVSLQSS DESNPARIEE ENDSNSGEER EGKKRGTSGQ RSTDRSAERI
1010 1020 1030 1040 1050
SPAFGFNRLE LRSKQFKSKP IPIGAHHTVS GHEAMDLAKR LNEELASHQQ
1060 1070 1080 1090 1100
QQNQQLRPIS PDIRAVTPDC EPRSRSFEQR PTSGVCAKEP DSQVSVSVSA
1110 1120 1130 1140 1150
SVSSANASTS SRRQRHSIAG QMSYMKMLGF GGFSKKMATS ANSLFSTAVI
1160 1170 1180 1190 1200
SGSSSAPNLR DMITVSSSGF GDVPPIRPLE TLHNALSLRK LDSFLQDMIL
1210 1220 1230 1240 1250
AQIFKTPTGS PPRGFSKNTL PAVSSMTLTA SNQTEVVEHE PISTTVTPTF
1260 1270 1280 1290 1300
DRRGSESGST ADAHLRLLSE SQCPNLDDSN TELRESLAGK MELWPQDIVK
1310 1320 1330 1340 1350
AAEDEELNLS ELETKPSLDL TMEIMERGVA GIASIQPMNR DSDETMGGGV
1360 1370 1380 1390 1400
FLSVCEEQGS GSTCLTPVSF GMDLDLSMVA NKGSITLSME GFDDDEDATL
1410 1420 1430 1440 1450
SAATTPSLLA DCEPRLESCY CCPSHAEAPP EVPSDDPRFG FALPVRVTQA
1460 1470 1480 1490 1500
SPEHARPVRR AHDPVSPRIQ KQISLFEGNA AMATGQEKTE SSGSVGGGAI
1510 1520 1530 1540 1550
LHASINLPAA GPHHLRQDAR LRKFENLTQS TSNSNFPFES NTLKRVPMQT
1560 1570 1580 1590 1600
TKDYDNVSHT QSCINLKSGS SGVLGGSPQR QRGSDGGGVG ASGVPAESRE
1610 1620 1630 1640 1650
PTRVHYGRMN STCCSASASP SPSPGALIVK ERFIEPPKRG VVRGYHGKTQ
1660 1670 1680 1690
SMDADFLFNE FLLLPAMAPA KISFDSSDID QASDDDSPSS SKQRHA
Length:1,696
Mass (Da):188,677
Last modified:June 16, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB013ECB582C96D3
GO
Isoform G (identifier: Q9VR59-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1293-1300: LWPQDIVK → QYPTEPSI
     1301-1696: Missing.

Show »
Length:1,300
Mass (Da):146,528
Checksum:i644A2123503DB726
GO
Isoform H (identifier: Q9VR59-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-40: SYTELESGYQ...VGFYLGLQDG → EWTWFKDWWR...DDFCYCEVCM
     266-266: D → DVYFS
     1293-1305: LWPQDIVKAAEDE → RKCRKKSVVEWQC
     1306-1696: Missing.

Show »
Length:1,416
Mass (Da):159,831
Checksum:i95E98D85E6F735A6
GO
Isoform J (identifier: Q9VR59-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1090: P → PATETAEDTS...PSCCTKTIAT
     1293-1300: LWPQDIVK → QYPTEPSI
     1301-1696: Missing.

Show »
Length:1,447
Mass (Da):162,288
Checksum:i33909E1FE36F5731
GO
Isoform K (identifier: Q9VR59-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1090: P → PVSSPDFGDN...PSCCTKTIAT
     1293-1300: LWPQDIVK → QYPTEPSI
     1301-1696: Missing.

Show »
Length:1,846
Mass (Da):204,458
Checksum:i803BD74B91DAC0EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JCY0X2JCY0_DROME
Inositol hexakisphosphate and dipho...
l(1)G0196 CG32502, Dmel\CG14616, CG14616, Dmel_CG14616
1,700Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JGE9X2JGE9_DROME
Inositol hexakisphosphate and dipho...
l(1)G0196 CG32502, Dmel\CG14616, CG14616, Dmel_CG14616
1,146Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JEN2X2JEN2_DROME
Inositol hexakisphosphate and dipho...
l(1)G0196 CG32502, Dmel\CG14616, CG14616, Dmel_CG14616
1,687Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JG41X2JG41_DROME
Inositol hexakisphosphate and dipho...
l(1)G0196 CG32502, Dmel\CG14616, CG14616, Dmel_CG14616
1,413Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JLN4X2JLN4_DROME
Inositol hexakisphosphate and dipho...
l(1)G0196 CG32502, Dmel\CG14616, CG14616, Dmel_CG14616
1,334Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABN49448 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti329C → F in ABN49448 (Ref. 3) Curated1
Sequence conflicti734K → KN in ABN49448 (Ref. 3) Curated1
Sequence conflicti906Y → H in ABN49448 (Ref. 3) Curated1
Sequence conflicti1092S → G in AAT94524 (Ref. 3) Curated1
Sequence conflicti1116H → R in AAT94524 (Ref. 3) Curated1
Sequence conflicti1124Y → C in AAT94524 (Ref. 3) Curated1
Sequence conflicti1124Y → C in ABN49448 (Ref. 3) Curated1

<p>This subsection of the 'Sequence' section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at positions 1093, 1117 and 1121.1 Publication
Partially edited. Target of Adar.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti1093Q → R in RNA edited version. 1
Natural varianti1117S → G in RNA edited version. 1
Natural varianti1121Q → R in RNA edited version. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0306402 – 40SYTEL…GLQDG → EWTWFKDWWRLKKLRSRHQR HKKKLQATAASAEAAVTASA FLAGSGCAESGGSQDPQTNR LHSLDAVPSDGTLARRRHGS RDSLRRNRLLQRQRRSQSAA VRSHRSHDDDDDGEYGPFNV SDYEDYGPNHGSDEESDDFC YCEVCM in isoform H. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_030641266D → DVYFS in isoform H. 1 Publication1
Alternative sequenceiVSP_0306431090P → PATETAEDTSMDIQPKICIG KCAPGLLTPTVTTTDILKGI RDIAPTATQTSPPTFTPSTT TTTGAAAALFDNTATMSSNR PFTNQFQSIDPTSNDAPHQH HVHQHQYQHHRKTTTTIINN TLNENHTTATITNNTTTTPS CCTKTIAT in isoform J. Curated1
Alternative sequenceiVSP_0335931090P → PVSSPDFGDNSRTRSSEFGE TCHARVGTASNSDGGGSHPR ADHRTAFQIRVTNSLSFFKI DSSTNELPLSDIDFSLHPPT PQCGPLSHKRFHILTMRRME SCDDGAELEQVRHLPQISPM ATNERPLSSCNCSSSAAQAH SHSKSLMDLAQAVVMTSPQE TGPNSEQGCDPTTAADVSVS SFDDDFQLSSSAPAILMSAH FGNRPVVASLSSMVHVTTSP SASTLQLCRDKDKALASGTS SAHSKATSNSCGQLSMAGSA PVVTENPFRFTVSSLGSAAT NTACFVGSFEPIEEQITSIV EVDSKPLQPEPQVVYNLPTV LITGTASSSELSTKLNSNIL PTVTNAFSAIDTEINDEIGI SKEVGIGTIRITNTHTPCNK ATVTRPDTKIAITTDPQTVT ATETAEDTSMDIQPKICIGK CAPGLLTPTVTTTDILKGIR DIAPTATQTSPPTFTPSTTT TTGAAAALFDNTATMSSNRP FTNQFQSIDPTSNDAPHQHH VHQHQYQHHRKTTTTIINNT LNENHTTATITNNTTTTPSC CTKTIAT in isoform K. Curated1
Alternative sequenceiVSP_0306481293 – 1305LWPQD…AAEDE → RKCRKKSVVEWQC in isoform H. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0306491293 – 1300LWPQDIVK → QYPTEPSI in isoform G, isoform J and isoform K. 1 Publication8
Alternative sequenceiVSP_0306501301 – 1696Missing in isoform G, isoform J and isoform K. 1 PublicationAdd BLAST396
Alternative sequenceiVSP_0306511306 – 1696Missing in isoform H. 1 PublicationAdd BLAST391

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAN09569.2
AE014298 Genomic DNA Translation: AAN09570.3
AE014298 Genomic DNA Translation: AAN09571.2
AE014298 Genomic DNA Translation: AAN09573.2
AE014298 Genomic DNA Translation: ABW09458.2
BT015295 mRNA Translation: AAT94524.1
BT030309 mRNA Translation: ABN49448.1 Frameshift.

NCBI Reference Sequences

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RefSeqi
NP_001097041.2, NM_001103571.2 [Q9VR59-7]
NP_788950.2, NM_176777.2 [Q9VR59-1]
NP_788951.2, NM_176778.2 [Q9VR59-3]
NP_788952.2, NM_176779.3 [Q9VR59-6]
NP_788953.2, NM_176780.2 [Q9VR59-5]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0299522; FBpp0288797; FBgn0027279 [Q9VR59-3]
FBtr0299523; FBpp0288798; FBgn0027279 [Q9VR59-6]
FBtr0299524; FBpp0288799; FBgn0027279 [Q9VR59-1]
FBtr0299525; FBpp0288800; FBgn0027279 [Q9VR59-5]
FBtr0299526; FBpp0288801; FBgn0027279 [Q9VR59-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
33137

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG14616

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAN09569.2
AE014298 Genomic DNA Translation: AAN09570.3
AE014298 Genomic DNA Translation: AAN09571.2
AE014298 Genomic DNA Translation: AAN09573.2
AE014298 Genomic DNA Translation: ABW09458.2
BT015295 mRNA Translation: AAT94524.1
BT030309 mRNA Translation: ABN49448.1 Frameshift.
RefSeqiNP_001097041.2, NM_001103571.2 [Q9VR59-7]
NP_788950.2, NM_176777.2 [Q9VR59-1]
NP_788951.2, NM_176778.2 [Q9VR59-3]
NP_788952.2, NM_176779.3 [Q9VR59-6]
NP_788953.2, NM_176780.2 [Q9VR59-5]

3D structure databases

SMRiQ9VR59
ModBaseiSearch...

Protein-protein interaction databases

BioGridi59411, 4 interactors
DIPiDIP-21851N
IntActiQ9VR59, 7 interactors
STRINGi7227.FBpp0288801

PTM databases

iPTMnetiQ9VR59

Proteomic databases

PaxDbiQ9VR59
PRIDEiQ9VR59

Genome annotation databases

EnsemblMetazoaiFBtr0299522; FBpp0288797; FBgn0027279 [Q9VR59-3]
FBtr0299523; FBpp0288798; FBgn0027279 [Q9VR59-6]
FBtr0299524; FBpp0288799; FBgn0027279 [Q9VR59-1]
FBtr0299525; FBpp0288800; FBgn0027279 [Q9VR59-5]
FBtr0299526; FBpp0288801; FBgn0027279 [Q9VR59-7]
GeneIDi33137
KEGGidme:Dmel_CG14616

Organism-specific databases

FlyBaseiFBgn0027279 l(1)G0196

Phylogenomic databases

eggNOGiKOG1057 Eukaryota
ENOG410XNSN LUCA
GeneTreeiENSGT00390000009048
InParanoidiQ9VR59
KOiK13024
PhylomeDBiQ9VR59

Enzyme and pathway databases

ReactomeiR-DME-1855167 Synthesis of pyrophosphates in the cytosol

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33137

Protein Ontology

More...
PROi
PR:Q9VR59

Gene expression databases

BgeeiFBgn0027279 Expressed in adult Malpighian tubule (Drosophila) and 39 other tissues
ExpressionAtlasiQ9VR59 baseline and differential
GenevisibleiQ9VR59 DM

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR037446 His_Pase_VIP1
IPR029033 His_PPase_superfam
IPR040557 VIP1_N
PANTHERiPTHR12750 PTHR12750, 1 hit
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
PF18086 PPIP5K2_N, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVIP1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VR59
Secondary accession number(s): A2VEZ0
, A8JUU5, Q6AWF3, Q8IQ22, Q8IQ23, Q8IQ24
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 16, 2009
Last modified: February 26, 2020
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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