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Entry version 165 (07 Apr 2021)
Sequence version 1 (01 May 2000)
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Protein

3-oxoacyl-[acyl-carrier-protein] reductase

Gene

FASN1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferaseImported, HydrolaseImported, LyaseARBA annotation, Multifunctional enzymeARBA annotation, OxidoreductaseImported, Transferase
Biological processFatty acid biosynthesisARBA annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADPARBA annotation, Pyridoxal phosphateARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00094

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
drome-CG3523, Thioesterase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductaseARBA annotation (EC:1.1.1.100ARBA annotation, EC:1.3.1.39ARBA annotation, EC:2.3.1.41ARBA annotation, EC:3.1.2.14ARBA annotation)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthaseARBA annotation
Acyl-[acyl-carrier-protein] hydrolaseARBA annotation
Enoyl-[acyl-carrier-protein] reductaseARBA annotation
[Acyl-carrier-protein] S-acetyltransferaseARBA annotation
[Acyl-carrier-protein] S-malonyltransferaseARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FASN1Imported
Synonyms:anon-EST:Posey235Imported, anon-EST:Posey43Imported, anon-WO0138581.1Imported, BcDNA:GH07626Imported, BcDNA:gh07626Imported, dFASImported, dFASNImported, dFASN1Imported, DM_7295848Imported, Dmel\CG3523Imported, FASImported, FasImported, fasImported, FAS[CG3523]Imported, FASNImported, FasnImported, Fasn1Imported, FASN[CG3523]Imported, Fatty acid synthaseImported
ORF Names:CG3523Imported, Dmel_CG3523Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0283427, FASN1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2081O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation, S-nitrosylationARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VQL7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0027571, Expressed in arthropod fat body and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VQL7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VQL7, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VQL7, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VQL7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2046 – 2123CarrierInterPro annotationAdd BLAST78

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157276

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_31_7_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKVYYAS

Database of Orthologous Groups

More...
OrthoDBi
19161at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
1.10.1470.20, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR013149, ADH_C
IPR023102, Fatty_acid_synthase_dom_2
IPR011032, GroES-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR020843, PKS_ER
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR001031, Thioesterase
IPR016039, Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF00107, ADH_zinc_N, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit
PF00975, Thioesterase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827, PKS_AT, 1 hit
SM00826, PKS_DH, 1 hit
SM00829, PKS_ER, 1 hit
SM00825, PKS_KS, 1 hit
SM00823, PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 1 hit
SSF50129, SSF50129, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53474, SSF53474, 1 hit
SSF53901, SSF53901, 1 hit
SSF55048, SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VQL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPARFAEEVI TAEPAQRAAP QLDLGGGHYV PRQQHLNDEI AITGFSGRLP
60 70 80 90 100
ESSTIEEFKQ NLFDGVDMVN DDPRRWERGL YGLPDRIGKL KDSDLENFDQ
110 120 130 140 150
QFFGVHQKQA ECMDPLLRML LELTHEAIID AGLNPSDLRG SRTGVYIGVS
160 170 180 190 200
NSETEQHWCS DADRVNGYGL TGCARAMFAN RISFTFDFKG PSYSIDTACS
210 220 230 240 250
SSLYALEQAF SDMREGKVDN ALVAGAGLIL KPTMSLQFKR LNMLSPDGSC
260 270 280 290 300
KAFDESGNGY VRSDGCVVLL LQRTSAARRV YASILNVRTN TDGFKEQGIT
310 320 330 340 350
YPIGKMQNRL IRETYEEIGL NPADVVYVEA HGTGTKVGDP QEVNSITDFF
360 370 380 390 400
CKDRTTPLLI GSVKSNMGHS EPASGVCSVA KILIAMEEGV IPGNLHYNKP
410 420 430 440 450
NPDLYGLVDG RLKVVDRNLP WNGGIIGLNS FGFGGANAHV ILKSNPKPKA
460 470 480 490 500
LTPKDGALKV VLASGRTFEA VEQLLESAST NADDDEYLQL INEIHSKAIP
510 520 530 540 550
NHFFRGYGVV SSKGTHQREV IESNDDKRPI WYIYSGMGSQ WASMAKDLMK
560 570 580 590 600
IEAFAKTIQR CADVLKPEGV DLIDVLTRST DKSFENILNS FISIAAMQVA
610 620 630 640 650
LTDLLSSLGI HPDGIVGHSV GELGCAYADG CFTPEQTVLA AYWRGKSILD
660 670 680 690 700
TQLAKGKMAA VGLSWEDAHS RVPSDCFPVC HNSEDNCTIS GPEASIEALV
710 720 730 740 750
AKLNAEGVFA KAVNSSGYAF HSKYIAEAGP KLRKSLEKII PNAKNRTARW
760 770 780 790 800
ISTSIPESAW NTPVAKQSSA AYHVNNLLSP VLFHEALQHV PKNAISVEIA
810 820 830 840 850
PHGLLQAILK RALGPDATNL SLVKRGHENN VEFFLTNVGK LFAAGAQPQV
860 870 880 890 900
LTLVRPISYP VGRGTPMLNS KVGWDHTQKW LVAKFGKETS SGETIVEVDL
910 920 930 940 950
SKEDDAFLAG HTIDGRILFP ATGYMTLAWQ TFAKMQGSEF HKTPVVMENL
960 970 980 990 1000
VFHRATILNK NAVVKFGINF FDGTGAFEIC ESGSLAVSGK ITIPESIDNE
1010 1020 1030 1040 1050
ELPLEEQTPS AVAKELGTND VYKELRLRGY DYGGIFRGIV RSDTVASTGK
1060 1070 1080 1090 1100
LQWVDNWISF MDTMLQFSIL SKNLRELYLP TRIERAVINP AKHFELLSAL
1110 1120 1130 1140 1150
TKEEQVETGL PVQWYSDINV IKSAGVELRG LKANLAQRRP GTQAPPTLER
1160 1170 1180 1190 1200
YQFVPNINTT DLNENSEKAR LHALDVAIQV IIENSSGAVK LKGVELANGR
1210 1220 1230 1240 1250
NPDVLVANRL LQIIEGEPVL TGDVAVVTSN NNEETITAAL GDSGVRVVSK
1260 1270 1280 1290 1300
DVLKEPVEQN CHFVFGIDVL SRPDTKTLEN SIASIRENGF LILEETLPTY
1310 1320 1330 1340 1350
TKTGRALLTK FGFVAVQEQS LGATRVLVLA RKAVDLKTRK SVVVVATEQN
1360 1370 1380 1390 1400
FNWVDDLKAA LATAATEEQY VYVVCQGEEL FGAVGLMTCI KNENGGKLAR
1410 1420 1430 1440 1450
LVFVQDAKAE KFSLTSTLYR QQLEKDLISN VLKNGAWGTF RHLKLETQQA
1460 1470 1480 1490 1500
TLQVEHAYVN ALVKGDLASL KWIEAAQADT AATVDKNLET CTVYYAPINF
1510 1520 1530 1540 1550
RDVMLTSGKL AADALPGDLA EQDCVLGLEF AGRDTQGRRV MAMVPAKSLA
1560 1570 1580 1590 1600
TTCVASKRMM WQIPEKWTME EASTVPCVYS TVYYALVVRG QMKKGEKILI
1610 1620 1630 1640 1650
HAGSGGVGQA AISVALAHGL TVFTTVGSKE KREFLLKRFP KLQERNIGNS
1660 1670 1680 1690 1700
RDTSFEQLVL RETKGRGVDL VLNSLSEEKL QASIRCLGLN GRFLEIGKFD
1710 1720 1730 1740 1750
LSNNSPLGMS VFLKNTSFHG ILLDSVMEGE EEMQNQVVSL VAEGIKTGAV
1760 1770 1780 1790 1800
VPLPTSVFND QQVEQAFRFM ASGKHIGKVV IKVRDEEAGK KALQPKPRLI
1810 1820 1830 1840 1850
NAIPRTYMHP EKSYILVGGL GGFGLELTNW LVTRGARYIV LTSRSGVKTG
1860 1870 1880 1890 1900
YQGLMIRRWQ ERGVKVVIDT SDVTTAAGAK KLLENSNKLA LVGGIFNLAA
1910 1920 1930 1940 1950
VLRDALIEDQ TAKDFKTVAD PKVTATKYLD QFSRDICTEL DYFICFSSVS
1960 1970 1980 1990 2000
CGRGNIGQTN YGLANSAMER ICEQRQVSGF PGTAIQWGAI GDTGLVLENL
2010 2020 2030 2040 2050
GDNDTVIGGT LPQRMPSCLQ TIDLFLQQPH PVVASMVVAE KRKSDQSAGV
2060 2070 2080 2090 2100
SLIATIANIL GLRDTKNIQD GASLADLGMD SLMSAEIKQT LERNFDIVLS
2110 2120 2130 2140 2150
AQEIRQLTFG ALKAMDGGAD VKPAAAAPAA AAGVPEANIT SGGSSRTASP
2160 2170 2180 2190 2200
MGDGTQVVFT TSLIPTEAIV QLDTKAPANS KQSPIFFISP IEGFASALEP
2210 2220 2230 2240 2250
LAKRLEVPAY GLQYTEAVPS DSLESAAKFF IKQLRTVQPK GPYKLAGYSF
2260 2270 2280 2290 2300
GCLLTYVMAG ILEETNEVAN VIMLDGAPSY VNWYTSSFKQ RYTDGTNADN
2310 2320 2330 2340 2350
DNQSYGLAYF GIVLANIDYK ALVRLLIVIP TWEEKLERFA ELMSNEITQP
2360 2370 2380 2390 2400
VETIKKSATL FYKKLELADG YQPTLKLKTN VTLVKPTDNS AKLDEDYRLK
2410 2420 2430
EVCTKPVEVH TVEGNHRTFL IEDQSLKTIQ SILKRLFN
Length:2,438
Mass (Da):266,444
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD336104713119865
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z001B7Z001_DROME
3-oxoacyl-[acyl-carrier-protein] re...
FASN1 anon-EST:Posey235, anon-EST:Posey43, anon-WO0138581.1, BcDNA:GH07626, BcDNA:gh07626
2,540Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51148.1

NCBI Reference Sequences

More...
RefSeqi
NP_608748.1, NM_134904.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077659; FBpp0077343; FBgn0283427

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33524

UCSC genome browser

More...
UCSCi
CG3523-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51148.1
RefSeqiNP_608748.1, NM_134904.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6FN6X-ray2.70A/B889-2036[»]
SMRiQ9VQL7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ9VQL7, 3 interactors

Protein family/group databases

ESTHERidrome-CG3523, Thioesterase

Proteomic databases

PRIDEiQ9VQL7

Genome annotation databases

EnsemblMetazoaiFBtr0077659; FBpp0077343; FBgn0283427
GeneIDi33524
UCSCiCG3523-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33524
FlyBaseiFBgn0283427, FASN1

Phylogenomic databases

GeneTreeiENSGT00940000157276
HOGENOMiCLU_000022_31_7_1
OMAiCKVYYAS
OrthoDBi19161at2759

Enzyme and pathway databases

UniPathwayiUPA00094

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
33524, 1 hit in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FASN1, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33524

Gene expression databases

BgeeiFBgn0027571, Expressed in arthropod fat body and 39 other tissues
ExpressionAtlasiQ9VQL7, baseline and differential
GenevisibleiQ9VQL7, DM

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
1.10.1470.20, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR013149, ADH_C
IPR023102, Fatty_acid_synthase_dom_2
IPR011032, GroES-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR020843, PKS_ER
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR001031, Thioesterase
IPR016039, Thiolase-like
PfamiView protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF00107, ADH_zinc_N, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit
PF00975, Thioesterase, 1 hit
SMARTiView protein in SMART
SM00827, PKS_AT, 1 hit
SM00826, PKS_DH, 1 hit
SM00829, PKS_ER, 1 hit
SM00825, PKS_KS, 1 hit
SM00823, PKS_PP, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
SSF50129, SSF50129, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53474, SSF53474, 1 hit
SSF53901, SSF53901, 1 hit
SSF55048, SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VQL7_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VQL7
Secondary accession number(s): Q9Y129
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Proteomics identificationCombined sources, Reference proteomeImported
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