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Entry version 126 (29 Sep 2021)
Sequence version 1 (01 May 2000)
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Protein

FHIP family protein CG3558

Gene

CG3558

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FHIP family protein CG3558
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CG3558
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0025681, CG3558

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0025681

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003195801 – 1041FHIP family protein CG3558Add BLAST1041

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei490Phosphoserine1 Publication1
Modified residuei797Phosphoserine1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VQK0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VQK0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0025681, Expressed in digestive system element and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VQK0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VQK0, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
71376, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VQK0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0271738

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni619 – 648DisorderedSequence analysisAdd BLAST30
Regioni792 – 818DisorderedSequence analysisAdd BLAST27
Regioni858 – 879DisorderedSequence analysisAdd BLAST22
Regioni903 – 947DisorderedSequence analysisAdd BLAST45
Regioni959 – 986DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi627 – 648Polar residuesSequence analysisAdd BLAST22
Compositional biasi796 – 818Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FHIP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3695, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182936

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VQK0

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLDWDSG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VQK0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019384, RetinoicA-induced_16-like

The PANTHER Classification System

More...
PANTHERi
PTHR21705, PTHR21705, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10257, RAI16-like, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: Q9VQK0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWLRQSSGGG VASVGHVGPL RQRPIDAATD CDPRACYDSF CKHWQQAFEI
60 70 80 90 100
IQHSAPPSHD DVLGVVSHLD YMVTLLLVEL HHCNKVSLPA AEASGPPAAP
110 120 130 140 150
CLEFLLSENL LDKLYEWACT TGRYANAVRL EQLKLYELLV SHSRHQLLCH
160 170 180 190 200
EPFLRPLLKI LASSQGEIFP PDLEKRLVIL LNQLCVVLMQ NVHLLDLFFF
210 220 230 240 250
SAQTQVQEQI LNGNVAPPKS GTTTNFIIFS LLIPYVHREG SLGHQARDAL
260 270 280 290 300
LLCMALSQKN SNIGTYIAQY SSICPLLVTG LGGLYSRLPN SIEISSIDWH
310 320 330 340 350
RITPDDVTEI PELTLFMNAL EFCNAVVQVA HEMIKQQLLD FMYQGFIVPV
360 370 380 390 400
LGPAILQTNI DSQISAMSYL DLILRSITEP GLLRAFVRFL LDTEKFDGER
410 420 430 440 450
ILDALVERLN SPDANLCMVT MALFDTLLGL HCEDLMLELL LKFMLPGKHV
460 470 480 490 500
PISHRHKINK IDPYLNSSEF FLELSPDVMK RARDLARPKS VHEPVVSELT
510 520 530 540 550
PLPSLPSPVM SKTIGANWNY YGVHTGDSLY ANIQAYLFEA HWRIAQCQKD
560 570 580 590 600
CLKWANSYRY QKWPRHGQGR VHAHALELAR QFFSEFGGGP IAANETGEKQ
610 620 630 640 650
LDSLQSIGES SGYESFKWRP ADEESEATDT TVATTASEAD MDHNSSSLSS
660 670 680 690 700
VLGASGKRES WRTSNSNRNE LILTDLDFSE DLFAQGTVSL GPFLNAIWGK
710 720 730 740 750
LQTFTSNSLY VNLHLTGLIT RLAWYPLPLI HSLLLRSDIA ITSDTPSFHQ
760 770 780 790 800
VLRILKQQID AELPVTEDSL EIIDVARSSL IDREFRLANA RKGNEGSPMH
810 820 830 840 850
HSQQQQMVTN SGQQQGQLRS AYATLSAATP VQATPTSAYD PFKRSDNKRR
860 870 880 890 900
SISKSITSMF SRKSASTSTA PPNGSSASSG LSQIYAFFTG AASNLVGNNA
910 920 930 940 950
SNDGRGISQA QTSAGTCETS LSTQPPAGAS RTGANATSTA ASGSNSSIAG
960 970 980 990 1000
STLTLSAQSN TTTHSASTLH GLDGGPSTGG FNSEPASLDS VASMGIIAST
1010 1020 1030 1040
SGTERSRDLA LCAVLMDEWL KELAAIAQEQ SVVLVTEQGS L
Length:1,041
Mass (Da):113,845
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6A55D655AA854EC
GO
Isoform C (identifier: Q9VQK0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-356: L → LQTLKGKHF

Show »
Length:1,049
Mass (Da):114,785
Checksum:iF44543564C16F84A
GO
Isoform B (identifier: Q9VQK0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     877-889: Missing.

Show »
Length:1,028
Mass (Da):112,471
Checksum:i7B7EAF568149DFB4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PB19M9PB19_DROME
Uncharacterized protein, isoform D
Dmel\CG3558 BEST:LD23852, c4.3, LD23852, CG3558, Dmel_CG3558
1,036Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL28233 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037630356L → LQTLKGKHF in isoform C. Curated1
Alternative sequenceiVSP_031496877 – 889Missing in isoform B. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51167.1
AE014134 Genomic DNA Translation: AAN10405.1
AE014134 Genomic DNA Translation: ACL82984.1
BT021330 mRNA Translation: AAX33478.1
AY060685 mRNA Translation: AAL28233.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001137777.1, NM_001144305.2 [Q9VQK0-3]
NP_652064.2, NM_143807.3 [Q9VQK0-1]
NP_722866.1, NM_164519.2 [Q9VQK0-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077644; FBpp0077329; FBgn0025681 [Q9VQK0-1]
FBtr0077645; FBpp0077330; FBgn0025681 [Q9VQK0-2]
FBtr0273230; FBpp0271738; FBgn0025681 [Q9VQK0-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
48421

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3558

UCSC genome browser

More...
UCSCi
CG3558-RA, d. melanogaster [Q9VQK0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51167.1
AE014134 Genomic DNA Translation: AAN10405.1
AE014134 Genomic DNA Translation: ACL82984.1
BT021330 mRNA Translation: AAX33478.1
AY060685 mRNA Translation: AAL28233.1 Different initiation.
RefSeqiNP_001137777.1, NM_001144305.2 [Q9VQK0-3]
NP_652064.2, NM_143807.3 [Q9VQK0-1]
NP_722866.1, NM_164519.2 [Q9VQK0-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi71376, 4 interactors
IntActiQ9VQK0, 2 interactors
STRINGi7227.FBpp0271738

PTM databases

iPTMnetiQ9VQK0

Proteomic databases

PaxDbiQ9VQK0

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
48421

Genome annotation databases

EnsemblMetazoaiFBtr0077644; FBpp0077329; FBgn0025681 [Q9VQK0-1]
FBtr0077645; FBpp0077330; FBgn0025681 [Q9VQK0-2]
FBtr0273230; FBpp0271738; FBgn0025681 [Q9VQK0-3]
GeneIDi48421
KEGGidme:Dmel_CG3558
UCSCiCG3558-RA, d. melanogaster [Q9VQK0-1]

Organism-specific databases

FlyBaseiFBgn0025681, CG3558
VEuPathDBiVectorBase:FBgn0025681

Phylogenomic databases

eggNOGiKOG3695, Eukaryota
GeneTreeiENSGT00950000182936
InParanoidiQ9VQK0
OMAiCLDWDSG
PhylomeDBiQ9VQK0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
48421, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
48421

Protein Ontology

More...
PROi
PR:Q9VQK0

Gene expression databases

BgeeiFBgn0025681, Expressed in digestive system element and 37 other tissues
ExpressionAtlasiQ9VQK0, baseline and differential
GenevisibleiQ9VQK0, DM

Family and domain databases

InterProiView protein in InterPro
IPR019384, RetinoicA-induced_16-like
PANTHERiPTHR21705, PTHR21705, 1 hit
PfamiView protein in Pfam
PF10257, RAI16-like, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiU518_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VQK0
Secondary accession number(s): B7Z000, Q8IPZ4, Q95SN7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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