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Entry version 167 (02 Jun 2021)
Sequence version 2 (21 Mar 2012)
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Protein

Dual oxidase

Gene

Duox

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in innate immunity limiting microbial proliferation in the gut (PubMed:16272120, PubMed:25639794).

Acts downstream of a hh-signaling pathway to induce the production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).

May generate antimicrobial oxidative burst through its peroxidase-like domain (PubMed:16272120).

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Peroxidase activity is inhibited by aminotriazole and azide.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi868 – 8791PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi904 – 9152PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, FAD, Flavoprotein, Metal-binding, NADP

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual oxidase (EC:1.11.1.-, EC:1.6.3.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Duox
ORF Names:CG3131
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0283531, Duox

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 626ExtracellularSequence analysisAdd BLAST626
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 1029CytoplasmicSequence analysisAdd BLAST382
Transmembranei1030 – 1050HelicalSequence analysisAdd BLAST21
Topological domaini1051 – 1065ExtracellularSequence analysisAdd BLAST15
Transmembranei1066 – 1086HelicalSequence analysisAdd BLAST21
Topological domaini1087 – 1116CytoplasmicSequence analysisAdd BLAST30
Transmembranei1117 – 1137HelicalSequence analysisAdd BLAST21
Topological domaini1138 – 1171ExtracellularSequence analysisAdd BLAST34
Transmembranei1172 – 1192HelicalSequence analysisAdd BLAST21
Topological domaini1193 – 1202CytoplasmicSequence analysis10
Transmembranei1203 – 1223HelicalSequence analysisAdd BLAST21
Topological domaini1224 – 1230ExtracellularSequence analysis7
Transmembranei1231 – 1251HelicalSequence analysisAdd BLAST21
Topological domaini1252 – 1537CytoplasmicSequence analysisAdd BLAST286

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown severely reduces adult survival following the ingestion of E.carotovora.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002233521 – 1537Dual oxidaseAdd BLAST1537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi577N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi606N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei826PhosphoserineBy similarity1
Modified residuei1105PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VQH2

PRoteomics IDEntifications database

More...
PRIDEi
Q9VQH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031464, Expressed in capitellum (Drosophila) and 31 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VQH2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VQH2, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
59700, 9 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0289611

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VQH2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini855 – 890EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini891 – 926EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini936 – 971EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini1078 – 1218Ferric oxidoreductaseAdd BLAST141
Domaini1253 – 1358FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni63 – 628Peroxidase-like; mediates peroxidase activityBy similarityAdd BLAST566

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the peroxidase family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0039, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163963

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004482_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VQH2

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVFMWRT

Database of Orthologous Groups

More...
OrthoDBi
27424at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VQH2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09820, dual_peroxidase_like, 1 hit
cd00051, EFh, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.640.10, 1 hit
3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029595, DUOX1/Duox
IPR034821, DUOX_peroxidase
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR017938, Riboflavin_synthase-like_b-brl

The PANTHER Classification System

More...
PANTHERi
PTHR11972:SF175, PTHR11972:SF175, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03098, An_peroxidase, 1 hit
PF00036, EF-hand_1, 1 hit
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00457, ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF48113, SSF48113, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS51384, FAD_FR, 1 hit
PS50292, PEROXIDASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VQH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVPSAPHQR AESKNRVPRP GQKNRKLPKL RLHWPGATYG GALLLLLISY
60 70 80 90 100
GLELGSVHCY EKMYSQTEKQ RYDGWYNNLA HPDWGSVDSH LVRKAPPSYS
110 120 130 140 150
DGVYAMAGAN RPSTRRLSRL FMRGKDGLGS KFNRTALLAF FGQLVANEIV
160 170 180 190 200
MASESGCPIE MHRIEIEKCD EMYDRECRGD KYIPFHRAAY DRDTGQSPNA
210 220 230 240 250
PREQINQMTA WIDGSFIYST SEAWLNAMRS FHNGTLLTEK DGKLPVRNTM
260 270 280 290 300
RVPLFNNPVP SVMKMLSPER LFLLGDPRTN QNPAILSFAI LFLRWHNTLA
310 320 330 340 350
QRIKRVHPDW SDEDIYQRAR HTVIASLQNV IVYEYLPAFL GTSLPPYEGY
360 370 380 390 400
KQDIHPGIGH IFQAAAFRFG HTMIPPGIYR RDGQCNFKET PMGYPAVRLC
410 420 430 440 450
STWWDSSGFF ADTSVEEVLM GLASQISERE DPVLCSDVRD KLFGPMEFTR
460 470 480 490 500
RDLGALNIMR GRDNGLPDYN TARESYGLKR HKTWTDINPP LFETQPELLD
510 520 530 540 550
MLKEAYDNKL DDVDVYVGGM LESYGQPGEF FTAVIKEQFQ RLRDADRFWF
560 570 580 590 600
ENERNGIFTP EEIAELRKIT LWDIIVNSTD VKEEEIQKDV FMWRTGDPCP
610 620 630 640 650
QPMQLNATEL EPCTYLEGYD YFSGSELMFI YVCVFLGFVP ILCAGAGYCV
660 670 680 690 700
VKLQNSKRRR LKIRQEALRA PQHKGSVDKM LAREWLHANH KRLVTVKFGP
710 720 730 740 750
EAAIYTVDRK GEKLRTFSLK HIDVVSVEES ATNHIKKKPY ILLRVPSDHD
760 770 780 790 800
LVLELESYGA RRKFVKKLED FLLLHKKEMT LMEVNRDIML ARAETRERRQ
810 820 830 840 850
KRLEYFFREA YALTFGLRPG ERRRRSDASS DGEVMTVMRT SLSKAEFAAA
860 870 880 890 900
LGMKPNDMFV RKMFNIVDKD QDGRISFQEF LETVVLFSRG KTDDKLRIIF
910 920 930 940 950
DMCDNDRNGV IDKGELSEMM RSLVEIARTT SLGDDQVTEL IDGMFQDVGL
960 970 980 990 1000
EHKNHLTYQD FKLMMKEYKG DFVAIGLDCK GAKQNFLDTS TNVARMTSFN
1010 1020 1030 1040 1050
IEPMQDKPRH WLLAKWDAYI TFLEENRQNI FYLFLFYVVT IVLFVERFIH
1060 1070 1080 1090 1100
YSFMAEHTDL RHIMGVGIAI TRGSAASLSF CYSLLLLTMS RNLITKLKEF
1110 1120 1130 1140 1150
PIQQYIPLDS HIQFHKIAAC TALFFSVLHT VGHIVNFYHV STQSHENLRC
1160 1170 1180 1190 1200
LTREVHFASD YKPDITFWLF QTVTGTTGVM LFIIMCIIFV FAHPTIRKKA
1210 1220 1230 1240 1250
YNFFWNMHTL YIGLYLLSLI HGLARLTGPP RFWMFFLGPG IVYTLDKIVS
1260 1270 1280 1290 1300
LRTKYMALDV IDTDLLPSDV IKIKFYRPPN LKYLSGQWVR LSCTAFRPHE
1310 1320 1330 1340 1350
MHSFTLTSAP HENFLSCHIK AQGPWTWKLR NYFDPCNYNP EDQPKIRIEG
1360 1370 1380 1390 1400
PFGGGNQDWY KFEVAVMVGG GIGVTPYASI LNDLVFGTST NRYSGVACKK
1410 1420 1430 1440 1450
VYFLWICPSH KHFEWFIDVL RDVEKKDVTN VLEIHIFITQ FFHKFDLRTT
1460 1470 1480 1490 1500
MLYICENHFQ RLSKTSIFTG LKAVNHFGRP DMSSFLKFVQ KKHSYVSKIG
1510 1520 1530
VFSCGPRPLT KSVMSACDEV NKTRKLPYFI HHFENFG
Length:1,537
Mass (Da):177,690
Last modified:March 21, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE26329E7BFBAB34C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PCF1M9PCF1_DROME
NAD(P)H oxidase (H(2)O(2)-forming)
Duox Cy, dDuox, dduox, Dmel\CG3131, DUOX
1,537Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAT94476 differs from that shown. Reason: Frameshift.Curated
The sequence AAT94476 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51201.2
BT015247 mRNA Translation: AAT94476.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_001259968.1, NM_001273039.1
NP_608715.2, NM_134871.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0300382; FBpp0289611; FBgn0283531
FBtr0335133; FBpp0307132; FBgn0283531

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33477

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3131

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51201.2
BT015247 mRNA Translation: AAT94476.1 Sequence problems.
RefSeqiNP_001259968.1, NM_001273039.1
NP_608715.2, NM_134871.3

3D structure databases

SMRiQ9VQH2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi59700, 9 interactors
STRINGi7227.FBpp0289611

Proteomic databases

PaxDbiQ9VQH2
PRIDEiQ9VQH2

Genome annotation databases

EnsemblMetazoaiFBtr0300382; FBpp0289611; FBgn0283531
FBtr0335133; FBpp0307132; FBgn0283531
GeneIDi33477
KEGGidme:Dmel_CG3131

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
565097
FlyBaseiFBgn0283531, Duox

Phylogenomic databases

eggNOGiKOG0039, Eukaryota
GeneTreeiENSGT00940000163963
HOGENOMiCLU_004482_1_0_1
InParanoidiQ9VQH2
OMAiDVFMWRT
OrthoDBi27424at2759
PhylomeDBiQ9VQH2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
33477, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
33477

Protein Ontology

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PROi
PR:Q9VQH2

Gene expression databases

BgeeiFBgn0031464, Expressed in capitellum (Drosophila) and 31 other tissues
ExpressionAtlasiQ9VQH2, baseline and differential
GenevisibleiQ9VQH2, DM

Family and domain databases

CDDicd09820, dual_peroxidase_like, 1 hit
cd00051, EFh, 3 hits
Gene3Di1.10.640.10, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR029595, DUOX1/Duox
IPR034821, DUOX_peroxidase
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR017938, Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF175, PTHR11972:SF175, 1 hit
PfamiView protein in Pfam
PF03098, An_peroxidase, 1 hit
PF00036, EF-hand_1, 1 hit
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit
PRINTSiPR00457, ANPEROXIDASE
SMARTiView protein in SMART
SM00054, EFh, 3 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF48113, SSF48113, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS51384, FAD_FR, 1 hit
PS50292, PEROXIDASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDUOX_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VQH2
Secondary accession number(s): Q6AWK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 21, 2012
Last modified: June 2, 2021
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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