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Protein
Submitted name:

FI23903p1

Gene

robo2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein homodimerization activity Source: FlyBase

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-376176 Signaling by ROBO receptors
R-DME-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-DME-428890 Role of ABL in ROBO-SLIT signaling
R-DME-9010553 Regulation of expression of SLITs and ROBOs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FI23903p1Imported
Submitted name:
Roundabout 2, isoform AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:robo2Imported
Synonyms:anon-EST:Liang-1.75Imported, CG14347Imported, CG14348Imported, CG5574Imported, clone 1.75Imported, CT17326Imported, D-Robo2Imported, D-robo2Imported, Dmel\CG5481Imported, dRobo-2Imported, fus4Imported, leaImported, lea-RAImported, Robo 2Imported, Robo-2Imported, robo-2Imported, ROBO2Imported, Robo2Imported, Robo2 (Lea)Imported
ORF Names:CG5481Imported, Dmel_CG5481Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002543 robo2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei990 – 1012HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002543 Expressed in 4 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VQ08, 5 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini91 – 183Ig-likeInterPro annotationAdd BLAST93
Domaini189 – 278Ig-likeInterPro annotationAdd BLAST90
Domaini283 – 369Ig-likeInterPro annotationAdd BLAST87
Domaini374 – 469Ig-likeInterPro annotationAdd BLAST96
Domaini478 – 567Ig-likeInterPro annotationAdd BLAST90
Domaini590 – 687Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini748 – 859Fibronectin type-IIIInterPro annotationAdd BLAST112
Domaini864 – 963Fibronectin type-IIIInterPro annotationAdd BLAST100

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4222 Eukaryota
ENOG410XPQS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167162

Identification of Orthologs from Complete Genome Data

More...
OMAi
GILLNYH

Database of Orthologous Groups

More...
OrthoDBi
173520at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VQ08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLCEMRGMP LRLQPQCLTN ESEIQIKIKS KIKNKTASEI KRRHRNNRDF
60 70 80 90 100
HGERLKIMPV DRSRRAVFPL LLLLAGLNGL TQVGALKGEN PRIIEHPMDT
110 120 130 140 150
TVPKNDPFTF NCQAEGNPTP TIQWFKDGRE LKTDTGSHRI MLPAGGLFFL
160 170 180 190 200
KVIHSRRESD AGTYWCEAKN EFGVARSRNA TLQVAFLRDE FRLEPANTRV
210 220 230 240 250
AQGEVALMEC GAPRGSPEPQ ISWRKNGQTL NLVGNKRIRI VDGGNLAIQE
260 270 280 290 300
ARQSDDGRYQ CVVKNVVGTR ESATAFLKVH VRPFLIRGPQ NQTAVVGSSV
310 320 330 340 350
VFQCRIGGDP LPDVLWRRTA SGGNMPLRRV HVLEDRSLKL DDVTLEDMGE
360 370 380 390 400
YTCEADNAVG GITATGILTV HAPPKFVIRP KNQLVEIGDE VLFECQANGH
410 420 430 440 450
PRPTLYWSVE GNSSLLLPGY RDGRMEVTLT PEGRSVLSIA RFAREDSGKV
460 470 480 490 500
VTCNALNAVG SVSSRTVVSV DTQFELPPPI IEQGPVNQTL PVKSIVVLPC
510 520 530 540 550
RTLGTPVPQV SWYLDGIPID VQEHERRNLS DAGALTISDL QRHEDEGLYT
560 570 580 590 600
CVASNRNGKS SWSGYLRLDT PTNPNIKFFR APELSTYPGP PGKPQMVEKG
610 620 630 640 650
ENSVTLSWTR SNKVGGSSLV GYVIEMFGKN ETDGWVAVGT RVQNTTFTQT
660 670 680 690 700
GLLPGVNYFF LIRAENSHGL SLPSPMSEPI TVGTRYFNSG LDLSEARASL
710 720 730 740 750
LSGDVVELSN ASVVDSTSMK LTWQIINGKY VEGFYVYARQ LPNPIVNNPA
760 770 780 790 800
PVTSNTNPLL GSTSTSASAS ASASALISTK PNIAAAGKRD GETNQSGGGA
810 820 830 840 850
PTPLNTKYRM LTILNGGGAS SCTITGLVQY TLYEFFIVPF YKSVEGKPSN
860 870 880 890 900
SRIARTLEDV PSEAPYGMEA LLLNSSAVFL KWKAPELKDR HGVLLNYHVI
910 920 930 940 950
VRGIDTAHNF SRILTNVTID AASPTLVLAN LTEGVMYTVG VAAGNNAGVG
960 970 980 990 1000
PYCVPATLRL DPITKRLDPF INQRYPINQD HVNDVLTQPW FIILLGAILA
1010 1020 1030 1040 1050
VLMLSFGAMV FVKRKHMMMK QSALNTMRGN HTSDVLKMPS LSARNGNGYW
1060 1070 1080 1090 1100
LDSSTGGMVW RPSPGGDSLE MQKDHIADYA PVCGAPGSPA GGGTSSGGSG
1110 1120 1130 1140 1150
GAGSGASGGD DIHGGHGSER NQQRYVGEYS NIPTDYAEVS SFGKAPSEYG
1160 1170 1180 1190 1200
RHGNASPAPY ATSSILSPHQ QQQQQQPRYQ QRPVPGYGLQ RPMHPHYQQQ
1210 1220 1230 1240 1250
QHQQQQAQQT HQQHQALQQH QQLPPSNIYQ QMSTTSEIYP TNTGPSRSVY
1260 1270 1280 1290 1300
SEQYYYPKDK QRHIHITENK LSNCHTYEAA PGAKQSSPIS SQFASVRRQQ
1310 1320 1330 1340 1350
LPPNCSIGRE SARFKVLNTD QGKNQQNLLD LDGSSMCYNG LADSGCGGSP
1360 1370 1380 1390 1400
SPMAMLMSHE DEHALYHTAD GDLDDMERLY VKVDEQQPPQ QQQQLIPLVP
1410 1420 1430 1440 1450
QHPAEGHLQS WRNQSTRSSR KNGQECIKEP SELIYAPGSV ASERSLLSNS
1460
GSGTSSQPAG HNV
Length:1,463
Mass (Da):159,977
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i177A21647E6BD5A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PC46M9PC46_DROME
Roundabout 2, isoform B
robo2 anon-EST:Liang-1.75, CG14347, CG14348, CG5574, clone 1.75
1,519Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51375.2
BT150394 mRNA Translation: AHA59284.1

NCBI Reference Sequences

More...
RefSeqi
NP_536792.2, NM_080531.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077941; FBpp0077606; FBgn0002543

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
44522

UCSC genome browser

More...
UCSCi
CG5481-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51375.2
BT150394 mRNA Translation: AHA59284.1
RefSeqiNP_536792.2, NM_080531.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

IntActiQ9VQ08, 5 interactors

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077941; FBpp0077606; FBgn0002543
GeneIDi44522
UCSCiCG5481-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6092
FlyBaseiFBgn0002543 robo2

Phylogenomic databases

eggNOGiKOG4222 Eukaryota
ENOG410XPQS LUCA
GeneTreeiENSGT00940000167162
OMAiGILLNYH
OrthoDBi173520at2759

Enzyme and pathway databases

ReactomeiR-DME-376176 Signaling by ROBO receptors
R-DME-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-DME-428890 Role of ABL in ROBO-SLIT signaling
R-DME-9010553 Regulation of expression of SLITs and ROBOs

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
44522

Gene expression databases

BgeeiFBgn0002543 Expressed in 4 organ(s), highest expression level in embryo

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VQ08_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VQ08
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: January 16, 2019
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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