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Protein

60 kDa heat shock protein homolog 1, mitochondrial

Gene

Hsp60B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa heat shock protein homolog 1, mitochondrial
Alternative name(s):
60 kDa chaperonin
CPN60
Heat shock protein 60
Short name:
HSP-60
Hsp60
Gene namesi
Name:Hsp60B
ORF Names:CG2830
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0011244 Hsp60B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionBy similarityAdd BLAST55
ChainiPRO_000000503256 – 64860 kDa heat shock protein homolog 1, mitochondrialAdd BLAST593

Proteomic databases

PaxDbiQ9VPS5
PRIDEiQ9VPS5

Expressioni

Gene expression databases

BgeeiFBgn0011244
GenevisibleiQ9VPS5 DM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi71509, 39 interactors
DIPiDIP-17907N
IntActiQ9VPS5, 41 interactors
STRINGi7227.FBpp0077665

Structurei

3D structure databases

ProteinModelPortaliQ9VPS5
SMRiQ9VPS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00390000005727
HOGENOMiHOG000291639
InParanoidiQ9VPS5
KOiK04077
OMAiWTSPKIT
OrthoDBiEOG091G04JM
PhylomeDBiQ9VPS5

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VPS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRSCVPKAI TSSRCFARMY SKDVRFGSGV RAMMIRGVDI LADAVAVTMG
60 70 80 90 100
PKGRSVIVER PWTSPKITKD GFTVARSIAL KDQHMNLGAK LVQDVADNTN
110 120 130 140 150
ESAGDGTTTA TVLARAIAKE GFNQITMGAN PVEIRRGVML AVDVVKDKLK
160 170 180 190 200
EMSKAVETRE EIQQVATLSA NGDTEIGRLI GEATDKVGPR GTITVKDGKR
210 220 230 240 250
LKDELNIIQG LRFDNGYVSP FFVNSSKGSK VEFANALVMI SLKKITGLSQ
260 270 280 290 300
IVKGLEQSLR QRRPLIIIAE DISGEALNAL VLNKLRLGLQ VCAVKSPSYG
310 320 330 340 350
HHRKELIGDI SAATGATIFG DDINYSKMEE AKLEDLGQVG EAVISKDSTM
360 370 380 390 400
LLQGKPKTGL LEMRIQQIQD ELAEKQIKPE QRDRLRQRLS ALTKGVAVLH
410 420 430 440 450
IGGGSEVEVN EKKDRVVDAL NATRAAIEEG IVPGGGTAFL RCIPYLQELK
460 470 480 490 500
TESADLQKGV DIVCNALRMP CQTIAQNAGV DGPMVVAKVL NGSEDYGYDA
510 520 530 540 550
MGDEYCRLVE KGIIDPTKVL RTAITDAAGV ASLLSTTEVV ITDSRNDDLL
560 570 580 590 600
SKLSGAGGGM DDGLDMNMGG LEELAALSGL GGMGGMGGMG GMGGMGGMGG
610 620 630 640
GFGGMGAGGG MSASASNDGP TAEEMNEMVK AIPGMEQVEV RDIDSGMM
Length:648
Mass (Da):68,637
Last modified:May 1, 2000 - v1
Checksum:iE45D44A166C78455
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199K → N in AAK77276 (PubMed:12537569).Curated1
Sequence conflicti581 – 589Missing in AAK77276 (PubMed:12537569).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51467.1
AY047544 mRNA Translation: AAK77276.1
BT001426 mRNA Translation: AAN71181.1
RefSeqiNP_524925.1, NM_080186.4
UniGeneiDm.21712

Genome annotation databases

EnsemblMetazoaiFBtr0078000; FBpp0077665; FBgn0011244
GeneIDi48572
KEGGidme:Dmel_CG2830

Similar proteinsi

Entry informationi

Entry nameiCH60B_DROME
AccessioniPrimary (citable) accession number: Q9VPS5
Secondary accession number(s): Q53YH7, Q961V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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