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Entry version 159 (03 Jul 2019)
Sequence version 2 (01 Oct 2002)
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Protein

Zinc finger protein ush

Gene

ush

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription regulator that modulates expression mediated by transcription factors of the GATA family such as pnr and srp. Represses transcription of proneural achaete-scute complex (AS-C), which is usually activated by pnr. Involved in cardiogenesis, blood, and eye development. During hematopoiesis, it is required to restrict the number of crystal cells, probably via its interaction with the isoform SrpNC of srp. Negatively regulates expression of sr. Probably acts by interacting with the GATA-type zinc finger of proteins such as pnr and srp, possibly antagonizing the interaction between the GATA-type zinc finger and some cofactor.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri202 – 235CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri279 – 301C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 368CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri720 – 753CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri791 – 824CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri882 – 907C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri910 – 932C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri983 – 1006C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1113 – 1146CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein ush
Alternative name(s):
Protein U-shaped
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ush
ORF Names:CG2762
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003963 ush

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi231C → A: Abolishes interaction with GATA-type zinc fingers. 1 Publication1
Mutagenesisi1142C → H: Transforms the C2HC-type zinc finger into a C2H2-type, leading to abolish interaction with pnr. 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002210471 – 1191Zinc finger protein ushAdd BLAST1191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei116Phosphoserine1 Publication1
Modified residuei118Phosphoserine1 Publication1
Modified residuei1013Phosphoserine1 Publication1
Modified residuei1015Phosphoserine1 Publication1
Modified residuei1017Phosphoserine1 Publication1
Modified residuei1156Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VPQ6

PRoteomics IDEntifications database

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PRIDEi
Q9VPQ6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VPQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

First expressed in stage 5 at high levels in the primordium of the amnioserosa. Also expressed in germ band extending embryos in cells of the developing anterior and posterior midgut and in hemocyte precursors present in the cephalic mesoderm. In embryonic stage 8, it is expressed in blood cell precursors. By stage 10, it is expressed in hemocyte precursors that have spread throughout the lateral and ventral head mesoderm. By stage 11, it is expressed in the dorsal ectoderm and in precursor cells of the hemocytes and fat body. As embryogenesis proceeds, it is also expressed in stage 13 plasmatocytes migrating throughout the head mesoderm and down the ventral midline. By late embryogenesis, expression strongly decreases but remains in the dorsal ectoderm during dorsal closure, in cells within, or associated with, the central nervous system, and in plasmatocytes circulating throughout the embryonic hemolymph. During larval development, it is expressed in primary and secondary lobes of lymph glands. Expressed in the dorsal part of the thoracic imaginal disk.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003963 Expressed in 53 organ(s), highest expression level in spermathecum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9VPQ6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VPQ6 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with pnr, although weak this interaction is essential.

Interacts with the isoform SrpNC of srp.

Interacts with CtBP corepressor.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
59481, 13 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305228

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VPQ6

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9VPQ6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CCHC FOG-type zinc fingers 1, 4 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FOG (Friend of GATA) family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri202 – 235CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri279 – 301C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 368CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri720 – 753CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri791 – 824CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri882 – 907C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri910 – 932C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri983 – 1006C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1113 – 1146CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063823

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VPQ6

KEGG Orthology (KO)

More...
KOi
K17441

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VPQ6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR12958 PTHR12958, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9VPQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSSNTRGDC SDTAEEMTVD SRDSKDLSAQ DIGEQKQQQM EDQLEDQLND
60 70 80 90 100
SRDPQNNNNN IDDDADEDAE FEEPEKANPQ QDQDLGETEM EQEHDLQQED
110 120 130 140 150
LQQELPANSP STPPRSPSSP QLIPKLEQPA TPPSEPEASP CPSPSPCPTP
160 170 180 190 200
KYPKVRLNAL LASDPALKPD AKELTLPDSR LLAPPPLVKP DTQAQPEVAE
210 220 230 240 250
PLLKPARFMC LPCGIAFSSP STLEAHQAYY CSHRIKDTDE AGSDKSGAGG
260 270 280 290 300
SGATAGDAAG LTGGSTEPPA KMARTGKQYG CTQCSYSADK KVSLNRHMRM
310 320 330 340 350
HQTSPAAPTL AGLPSLLQNG IAPPGVTPNP MEDSSSQQTD RYCSHCDIRF
360 370 380 390 400
NNIKTYRAHK QHYCSSRRPE GQLTPKPDAS PGAGSGPGSA GGSIGVSAQA
410 420 430 440 450
ATPGKLSPQA RNKTPTPAMV AVAAAAAAAA ASLQATPHSH PPFLALPTHP
460 470 480 490 500
IIIVPCSLIR AASFIPGPLP TPNSGIVNPE TTCFTVDNGT IKPLATALVG
510 520 530 540 550
ATLEPERPSA PSSAAEATEA KSSPPEPKRK EAGLTRESAP LDLSLRRSPI
560 570 580 590 600
TLNSLSLRQR QLRNALLDVE EVLLAGVGTG KENVETPRGG GSVTPEQIVC
610 620 630 640 650
APSLPSSPSM SPSPKRRAIS PRSSGAGSAS SMSPPGLNVA VPHLLDMRSM
660 670 680 690 700
LPADFGLSES LLAKTNPELA LKLAAAAAAA AVAGSSGAAA FPPASLPAQT
710 720 730 740 750
SSGNPGSGGS AGGAQQPQIY VKKGVSKCME CNIVFCKYEN YLAHKQHYCS
760 770 780 790 800
ARSQEGASEV DVKSAVSPSI AGAGGLGAGA AEAASSVETT PVAYQQLICA
810 820 830 840 850
ACGIKYTSLD NLRAHQNYYC PKGGAVAAPA ATPTDPGQLG MPKEKCGKCK
860 870 880 890 900
TLHEIGLPCP PPVANPLAAP TVNPQPATNS LNKCPVCGVV SPTAALAKKH
910 920 930 940 950
MEMHGTVKAY RCSICQYKGN TLRGMRTHIR THFDKKTSDV NEELYMTCIF
960 970 980 990 1000
EEDASALSQE LVTPTGASTT TGHDSMDHPS QMFNCDYCNY VSTYKGNVLR
1010 1020 1030 1040 1050
HMKLMHPHVA INSPSISPDT RDQDVTSNPT TNQHSNSDVS NGEAPSFHIK
1060 1070 1080 1090 1100
SEPLDPPPTV NLVHENNNSP IATPHIKAEP IEVGADAAPG GLVPPMTSPL
1110 1120 1130 1140 1150
GNSSSVAAAA AAAAEVMKKY CSTCDISFNY VKTYLAHKQF YCKNKPIRPE
1160 1170 1180 1190
ASDSPSPNHL GGGVAVGLGI GGLVGGHGQQ KNKENLQEAA I
Length:1,191
Mass (Da):124,533
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77A9D990767FE6ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PDU3M9PDU3_DROME
U-shaped, isoform D
ush CG2762, dFOG, Dmel\CG2762, FOG, l(2)19
1,175Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBN1M9PBN1_DROME
U-shaped, isoform C
ush CG2762, dFOG, Dmel\CG2762, FOG, l(2)19
1,212Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PC12M9PC12_DROME
U-shaped, isoform B
ush dFOG, Dmel\CG2762, FOG, l(2)19, u-sh
1,198Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti524P → H in CAA72991 (PubMed:9367989).Curated1
Sequence conflicti532A → S in CAA72991 (PubMed:9367989).Curated1
Sequence conflicti1045P → A in CAA72991 (PubMed:9367989).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y12322 mRNA Translation: CAA72991.1
AE014134 Genomic DNA Translation: AAF51488.2
BT015278 mRNA Translation: AAT94507.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T13850

NCBI Reference Sequences

More...
RefSeqi
NP_476780.1, NM_057432.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0078063; FBpp0077723; FBgn0003963

Database of genes from NCBI RefSeq genomes

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GeneIDi
33225

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2762

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12322 mRNA Translation: CAA72991.1
AE014134 Genomic DNA Translation: AAF51488.2
BT015278 mRNA Translation: AAT94507.1
PIRiT13850
RefSeqiNP_476780.1, NM_057432.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FU9NMR-A1113-1146[»]
1FV5NMR-A202-235[»]
1JN7NMR-A1113-1146[»]
1Y0JNMR-B202-235[»]
2L6ZNMR-B202-235[»]
SMRiQ9VPQ6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi59481, 13 interactors
STRINGi7227.FBpp0305228

PTM databases

iPTMnetiQ9VPQ6

Proteomic databases

PaxDbiQ9VPQ6
PRIDEiQ9VPQ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078063; FBpp0077723; FBgn0003963
GeneIDi33225
KEGGidme:Dmel_CG2762

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33225
FlyBaseiFBgn0003963 ush

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063823
InParanoidiQ9VPQ6
KOiK17441
PhylomeDBiQ9VPQ6

Enzyme and pathway databases

ReactomeiR-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ush fly
EvolutionaryTraceiQ9VPQ6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
33225

Protein Ontology

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PROi
PR:Q9VPQ6

Gene expression databases

BgeeiFBgn0003963 Expressed in 53 organ(s), highest expression level in spermathecum
ExpressionAtlasiQ9VPQ6 baseline and differential
GenevisibleiQ9VPQ6 DM

Family and domain databases

InterProiView protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR12958 PTHR12958, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUSH_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VPQ6
Secondary accession number(s): O18414, Q6AWH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2002
Last modified: July 3, 2019
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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