Zinc finger protein ush

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB-KW
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II activating transcription factor binding Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.5

    "Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila."
    Haenlin M., Cubadda Y., Blondeau F., Heitzler P., Lutz Y., Simpson P., Ramain P.
    Genes Dev. 11:3096-3108(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH PNR.
• RNA polymerase II transcription factor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "U-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila."
    Cubadda Y., Heitzler P., Ray R.P., Bourouis M., Ramain P., Gelbart W., Simpson P., Haenlin M.
    Genes Dev. 11:3083-3095(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

GO - Biological processⁱ

• amnioserosa maintenance Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A group of genes required for maintenance of the amnioserosa tissue in Drosophila."
    Frank L.H., Rushlow C.
    Development 122:1343-1352(1996) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chaeta development Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "CtBP is required for proper development of peripheral nervous system in Drosophila."
    Stern M.D., Aihara H., Roccaro G.A., Cheung L., Zhang H., Negeri D., Nibu Y.
    Mech Dev 126:68-79(2009) [PubMed] [Europe PMC] [Abstract]
• compound eye development Source: FlyBaseInferred from mutant phenotypeⁱ
  • Ref.8

    "The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila."
    Fossett N., Tevosian S.G., Gajewski K., Zhang Q., Orkin S.H., Schulz R.A.
    Proc. Natl. Acad. Sci. U.S.A. 98:7342-7347(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• germ-band shortening Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A group of genes required for maintenance of the amnioserosa tissue in Drosophila."
    Frank L.H., Rushlow C.
    Development 122:1343-1352(1996) [PubMed] [Europe PMC] [Abstract]
  • "Cellular pathways acting along the germband and in the amnioserosa may participate in germband retraction of the Drosophila melanogaster embryo."
    Goldman-Levi R., Miller C., Greenberg G., Gabai E., Zak N.B.
    Int J Dev Biol 40:1043-1051(1996) [PubMed] [Europe PMC] [Abstract]
• heart development Source: FlyBaseInferred from mutant phenotypeⁱ
  • Ref.8

    "The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila."
    Fossett N., Tevosian S.G., Gajewski K., Zhang Q., Orkin S.H., Schulz R.A.
    Proc. Natl. Acad. Sci. U.S.A. 98:7342-7347(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• larval lymph gland hemopoiesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila."
    Sorrentino R.P., Tokusumi T., Schulz R.A.
    Dev Biol 311:311-323(2007) [PubMed] [Europe PMC] [Abstract]
  • "Upregulation of the Drosophila Friend of GATA gene U-shaped by JAK/STAT signaling maintains lymph gland prohemocyte potency."
    Gao H., Wu X., Fossett N.
    Mol Cell Biol 29:6086-6096(2009) [PubMed] [Europe PMC] [Abstract]
• lymph gland crystal cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Extracellular matrix-modulated Heartless signaling in Drosophila blood progenitors regulates their differentiation via a Ras/ETS/FOG pathway and target of rapamycin function."
    Dragojlovic-Munther M., Martinez-Agosto J.A.
    Dev Biol 384:313-330(2013) [PubMed] [Europe PMC] [Abstract]
• lymph gland development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Regulation of Drosophila friend of GATA gene, u-shaped, during hematopoiesis: a direct role for serpent and lozenge."
    Muratoglu S., Garratt B., Hyman K., Gajewski K., Schulz R.A., Fossett N.
    Dev Biol 296:561-579(2006) [PubMed] [Europe PMC] [Abstract]
• lymph gland plasmatocyte differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Extracellular matrix-modulated Heartless signaling in Drosophila blood progenitors regulates their differentiation via a Ras/ETS/FOG pathway and target of rapamycin function."
    Dragojlovic-Munther M., Martinez-Agosto J.A.
    Dev Biol 384:313-330(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.5

    "Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila."
    Haenlin M., Cubadda Y., Blondeau F., Heitzler P., Lutz Y., Simpson P., Ramain P.
    Genes Dev. 11:3096-3108(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH PNR.
• negative regulation of hemocyte differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Friend of GATA Transcriptional Co-Regulator, U-Shaped, Is a Downstream Antagonist of Dorsal-Driven Prohemocyte Differentiation in Drosophila."
    Gao H., Baldeosingh R., Wu X., Fossett N.
    PLoS One 11:e0155372-e0155372(2016) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: FlyBaseInferred from direct assayⁱ
  • Ref.1

    "U-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila."
    Cubadda Y., Heitzler P., Ray R.P., Bourouis M., Ramain P., Gelbart W., Simpson P., Haenlin M.
    Genes Dev. 11:3083-3095(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• positive regulation of antibacterial peptide biosynthetic process Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling."
    Valanne S., Myllymaki H., Kallio J., Schmid M.R., Kleino A., Murumagi A., Airaksinen L., Kotipelto T., Kaustio M., Ulvila J., Esfahani S.S., Engstrom Y., Silvennoinen O., Hultmark D., Parikka M., Ramet M.
    J Immunol 184:6188-6198(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: FlyBaseInferred from direct assayⁱ
  • Ref.1

    "U-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila."
    Cubadda Y., Heitzler P., Ray R.P., Bourouis M., Ramain P., Gelbart W., Simpson P., Haenlin M.
    Genes Dev. 11:3083-3095(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• RNA polymerase II activating transcription factor binding Source: FlyBaseInferred from physical interactionⁱ
  • Ref.5

    "Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila."
    Haenlin M., Cubadda Y., Blondeau F., Heitzler P., Lutz Y., Simpson P., Ramain P.
    Genes Dev. 11:3096-3108(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH PNR.
• RNA polymerase II transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.1

    "U-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila."
    Cubadda Y., Heitzler P., Ray R.P., Bourouis M., Ramain P., Gelbart W., Simpson P., Haenlin M.
    Genes Dev. 11:3083-3095(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MLSSNTRGDC SDTAEEMTVD SRDSKDLSAQ DIGEQKQQQM EDQLEDQLND 
        60         70         80         90        100
SRDPQNNNNN IDDDADEDAE FEEPEKANPQ QDQDLGETEM EQEHDLQQED 
       110        120        130        140        150
LQQELPANSP STPPRSPSSP QLIPKLEQPA TPPSEPEASP CPSPSPCPTP 
       160        170        180        190        200
KYPKVRLNAL LASDPALKPD AKELTLPDSR LLAPPPLVKP DTQAQPEVAE 
       210        220        230        240        250
PLLKPARFMC LPCGIAFSSP STLEAHQAYY CSHRIKDTDE AGSDKSGAGG 
       260        270        280        290        300
SGATAGDAAG LTGGSTEPPA KMARTGKQYG CTQCSYSADK KVSLNRHMRM 
       310        320        330        340        350
HQTSPAAPTL AGLPSLLQNG IAPPGVTPNP MEDSSSQQTD RYCSHCDIRF 
       360        370        380        390        400
NNIKTYRAHK QHYCSSRRPE GQLTPKPDAS PGAGSGPGSA GGSIGVSAQA 
       410        420        430        440        450
ATPGKLSPQA RNKTPTPAMV AVAAAAAAAA ASLQATPHSH PPFLALPTHP 
       460        470        480        490        500
IIIVPCSLIR AASFIPGPLP TPNSGIVNPE TTCFTVDNGT IKPLATALVG 
       510        520        530        540        550
ATLEPERPSA PSSAAEATEA KSSPPEPKRK EAGLTRESAP LDLSLRRSPI 
       560        570        580        590        600
TLNSLSLRQR QLRNALLDVE EVLLAGVGTG KENVETPRGG GSVTPEQIVC 
       610        620        630        640        650
APSLPSSPSM SPSPKRRAIS PRSSGAGSAS SMSPPGLNVA VPHLLDMRSM 
       660        670        680        690        700
LPADFGLSES LLAKTNPELA LKLAAAAAAA AVAGSSGAAA FPPASLPAQT 
       710        720        730        740        750
SSGNPGSGGS AGGAQQPQIY VKKGVSKCME CNIVFCKYEN YLAHKQHYCS 
       760        770        780        790        800
ARSQEGASEV DVKSAVSPSI AGAGGLGAGA AEAASSVETT PVAYQQLICA 
       810        820        830        840        850
ACGIKYTSLD NLRAHQNYYC PKGGAVAAPA ATPTDPGQLG MPKEKCGKCK 
       860        870        880        890        900
TLHEIGLPCP PPVANPLAAP TVNPQPATNS LNKCPVCGVV SPTAALAKKH 
       910        920        930        940        950
MEMHGTVKAY RCSICQYKGN TLRGMRTHIR THFDKKTSDV NEELYMTCIF 
       960        970        980        990       1000
EEDASALSQE LVTPTGASTT TGHDSMDHPS QMFNCDYCNY VSTYKGNVLR 
      1010       1020       1030       1040       1050
HMKLMHPHVA INSPSISPDT RDQDVTSNPT TNQHSNSDVS NGEAPSFHIK 
      1060       1070       1080       1090       1100
SEPLDPPPTV NLVHENNNSP IATPHIKAEP IEVGADAAPG GLVPPMTSPL 
      1110       1120       1130       1140       1150
GNSSSVAAAA AAAAEVMKKY CSTCDISFNY VKTYLAHKQF YCKNKPIRPE 
      1160       1170       1180       1190 
ASDSPSPNHL GGGVAVGLGI GGLVGGHGQQ KNKENLQEAA I          

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families