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Protein

Eukaryotic peptide chain release factor subunit 1

Gene

eRF1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.By similarity

GO - Molecular functioni

  • translation release factor activity Source: InterPro
  • translation termination factor activity Source: FlyBase

GO - Biological processi

  • smoothened signaling pathway Source: FlyBase
  • translational termination Source: FlyBase

Keywordsi

Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-DME-72764 Eukaryotic Translation Termination
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic peptide chain release factor subunit 1
Short name:
Eukaryotic release factor 1
Short name:
eRF1
Gene namesi
Name:eRF1
ORF Names:CG5605
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036974 eRF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431531 – 438Eukaryotic peptide chain release factor subunit 1Add BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei341Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VPH7
PRIDEiQ9VPH7

PTM databases

iPTMnetiQ9VPH7

Expressioni

Gene expression databases

BgeeiFBgn0036974
ExpressionAtlasiQ9VPH7 baseline and differential
GenevisibleiQ9VPH7 DM

Interactioni

Subunit structurei

Heterodimer of two subunits, one of which binds GTP.

Protein-protein interaction databases

BioGridi65501, 10 interactors
DIPiDIP-18487N
IntActiQ9VPH7, 3 interactors
STRINGi7227.FBpp0304202

Structurei

3D structure databases

ProteinModelPortaliQ9VPH7
SMRiQ9VPH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic release factor 1 family.Curated

Phylogenomic databases

eggNOGiKOG0688 Eukaryota
COG1503 LUCA
GeneTreeiENSGT00390000009004
InParanoidiQ9VPH7
KOiK03265
OMAiGPGTEKM
OrthoDBiEOG091G0MEJ
PhylomeDBiQ9VPH7

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
3.30.960.10, 1 hit
InterProiView protein in InterPro
IPR005140 eRF1_1_Pelota
IPR005141 eRF1_2
IPR005142 eRF1_3
IPR029064 L30e-like
IPR004403 Peptide_chain-rel_eRF1/aRF1
IPR024049 Release_factor_eRF1/aRF1_N
PANTHERiPTHR10113 PTHR10113, 1 hit
PfamiView protein in Pfam
PF03463 eRF1_1, 1 hit
PF03464 eRF1_2, 1 hit
PF03465 eRF1_3, 1 hit
SMARTiView protein in SMART
SM01194 eRF1_1, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
SSF55481 SSF55481, 1 hit
TIGRFAMsiTIGR03676 aRF1/eRF1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VPH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEETSADR NVEIWKIKKL IKSLEMARGN GTSMISLIIP PKDQISRVSK
60 70 80 90 100
MLADEFGTAS NIKSRVNRLS VLGAITSVQH RLKLYTKVPP NGLVIYCGTI
110 120 130 140 150
VTEEGKEKKV NIDFEPFKPI NTSLYLCDNK FHTEALTALL ADDNKFGFIV
160 170 180 190 200
MDGNGALFGT LQGNTREVLH KFTVDLPKKH GRGGQSALRF ARLRMEKRHN
210 220 230 240 250
YVRKVAEVAT QLFITNDKPN IAGLILAGSA DFKTELSQSD MFDPRLQSKV
260 270 280 290 300
IKLVDVSYGG ENGFNQAIEL AAESLQNVKF IQEKKLIGRY FDEISQDTGK
310 320 330 340 350
YCFGVEDTLR ALELGSVETL ICWENLDIQR YVLKNHANST STTVLHLTPE
360 370 380 390 400
QEKDKSHFTD KESGVEMELI ESQPLLEWLA NNYKMFGATL EIITDKSQEG
410 420 430
SQFVRGFGGI GGILRYKVDF QSMQLDELDN DGFDLDDY
Length:438
Mass (Da):49,160
Last modified:August 15, 2003 - v2
Checksum:iE16B3C08FBA1C485
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF51574.2
AE014296 Genomic DNA Translation: AAN12121.1
AE014296 Genomic DNA Translation: AAN12122.1
AE014296 Genomic DNA Translation: AAN12123.1
AE014296 Genomic DNA Translation: AAO41278.1
AY069511 mRNA Translation: AAL39656.1
RefSeqiNP_649210.1, NM_140953.3
NP_730517.1, NM_168845.2
NP_730518.1, NM_168846.2
NP_730519.1, NM_168847.2
NP_730520.1, NM_168848.2
NP_788547.1, NM_176369.3
UniGeneiDm.2095

Genome annotation databases

EnsemblMetazoaiFBtr0078173; FBpp0077831; FBgn0036974
FBtr0078174; FBpp0077832; FBgn0036974
FBtr0078175; FBpp0077833; FBgn0036974
FBtr0078176; FBpp0077834; FBgn0036974
FBtr0078177; FBpp0077835; FBgn0036974
FBtr0078178; FBpp0077836; FBgn0036974
GeneIDi40240
KEGGidme:Dmel_CG5605

Similar proteinsi

Entry informationi

Entry nameiERF1_DROME
AccessioniPrimary (citable) accession number: Q9VPH7
Secondary accession number(s): A4V259, Q0E8C7, Q8T071
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 15, 2003
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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