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Entry version 167 (12 Aug 2020)
Sequence version 3 (30 Nov 2010)
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Protein

Adenylyl cyclase 78C

Gene

Ac78C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the formation of the signaling molecule cAMP in response to G-protein coupled receptor signaling (PubMed:10603085, PubMed:23929551). Probably downstream of gustatory receptors, involved in taste perception of sucrose, trehalose and caffeine (PubMed:19046378). Has no role in bitter perception (PubMed:19046378). In the circadian brain neuron evening cells (E-cells), involved in circadian pacemaker synchronization by playing a role in signaling downstream of the G protein-coupled receptor Pdfr, probably in conjunction with other, as yet unidentified, adenylate cyclases (PubMed:23929551).3 Publications
Does not have adenylyl cyclase activity and it is not involved in taste perception.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi580Magnesium 1PROSITE-ProRule annotation1
Metal bindingi580Magnesium 2PROSITE-ProRule annotation1
Metal bindingi581Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi624Magnesium 1PROSITE-ProRule annotation1
Metal bindingi624Magnesium 2PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei672ATPBy similarity1
Binding sitei1440ATPBy similarity1
Binding sitei1564ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi580 – 585ATPBy similarity6
Nucleotide bindingi622 – 624ATPBy similarity3
Nucleotide bindingi1517 – 1519ATPBy similarity3
Nucleotide bindingi1524 – 1528ATPBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adenylate cyclase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processcAMP biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenylyl cyclase 78C1 PublicationImported (EC:4.6.1.11 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ac78C1 PublicationImported
ORF Names:CG10564Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0024150, Ac78C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 327CytoplasmicCuratedAdd BLAST327
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 366ExtracellularCuratedAdd BLAST18
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 397CytoplasmicCurated10
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 422ExtracellularCurated4
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 445CytoplasmicCurated2
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467 – 476ExtracellularCurated10
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21
Topological domaini498 – 1023CytoplasmicCuratedAdd BLAST526
Transmembranei1024 – 1044HelicalSequence analysisAdd BLAST21
Topological domaini1045 – 1048ExtracellularCurated4
Transmembranei1049 – 1069HelicalSequence analysisAdd BLAST21
Topological domaini1070 – 1094CytoplasmicCuratedAdd BLAST25
Transmembranei1095 – 1115HelicalSequence analysisAdd BLAST21
Topological domaini1116 – 1241ExtracellularCuratedAdd BLAST126
Transmembranei1242 – 1262HelicalSequence analysisAdd BLAST21
Topological domaini1263CytoplasmicCurated1
Transmembranei1264 – 1284HelicalSequence analysisAdd BLAST21
Topological domaini1285 – 1301ExtracellularCuratedAdd BLAST17
Transmembranei1302 – 1322HelicalSequence analysisAdd BLAST21
Topological domaini1323 – 1718CytoplasmicCuratedAdd BLAST396

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown in sugar gustatory neurons results in reduced sucrose response and no alteration in response to water (PubMed:19046378). RNAi-mediated knockdown in the pacemaker dorsal lateral neurons (LNDs) results in reduced Pigment-dispersing factor (Pdf) response in the circadian brain neurons evening cells (E-cells) (PubMed:23929551). Isoform B: Results in reduced sucrose and trehalose substances response and no alteration of water response or bitter perception (PubMed:19046378).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004457971 – 1718Adenylyl cyclase 78CCuratedAdd BLAST1718

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VP76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in labella, particularly in sugar-sensitive gustatory receptor neurons (GRNs).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform B: Ubiquitously expressed in embryos, larvae and adult (PubMed:10603085). Isoform C: Temporally restricted to the earliest hours of embryogenesis before cellularization (PubMed:10603085). As germ band extension commences, expression decreases along the entire ventral surface of the embryo and is restricted to the cephalic furrow (CF) and anterior and posterior dorsal transverse folds (DTFs) (PubMed:10603085). By state 7, restricted expression in the CF and DTFs on the dorsal and lateral surfaces of the embryo (PubMed:10603085).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0024150, Expressed in embryo and 38 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VP76, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VP76, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VP76, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VP76

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001072_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VP76

KEGG Orthology (KO)

More...
KOi
K08048

Identification of Orthologs from Complete Genome Data

More...
OMAi
AYQRYSH

Database of Orthologous Groups

More...
OrthoDBi
107368at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VP76

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1230, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR032628, AC_N
IPR009398, Adcy_conserved_dom
IPR029787, Nucleotide_cyclase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16214, AC_N, 1 hit
PF06327, DUF1053, 1 hit
PF00211, Guanylate_cyc, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044, CYCc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55073, SSF55073, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform BImported (identifier: Q9VP76-1) [UniParc]FASTAAdd to basket
Also known as: L1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVELEEEEE RICLRTAEEG QLANMDDDKL VSDEVHLRQL SATPSSAFSL
60 70 80 90 100
QHSRGSDTKE EAPPEGGTMG GKSAAPREEG EPDERVVLRR AVDKGAIALA
110 120 130 140 150
QIDDLKLEGD DDDEAVVNGE EVDGLGLSNP AAQTTDDEQI TVNGTGAAAT
160 170 180 190 200
SSVAADAASS EQDAASTAMA TPDMSKIPRL PGDGAQMEDN GSGDLPPSLR
210 220 230 240 250
ASTTSILSNL RKKQQGGPLR GGVAKQTPLR VQSVRIVEAK RAYGPKRRTE
260 270 280 290 300
SCSIFGNSNF EHDLESGNSL ASIPGQSQRP LNNEMYSAFK SGNVVKGILC
310 320 330 340 350
PSLTNSFKQS SLERSYLTYT HRQRQKSLII VNVVDFVLKI VLAFVWIMRR
360 370 380 390 400
SELGPIESDD GTSMATAITW SVCCGIANMA ICFLGYWRCF ANNYLHWAAV
410 420 430 440 450
CTWVLFNIQG FVGQGVGFAD REYLVWYILF VIFVPYAMLP LPLKWCVVGG
460 470 480 490 500
TITASCHLAV ITIIKLQHGE ATINPECVLF QIFANFILYT AINVAGMYTK
510 520 530 540 550
YLTDRGQRLA FIETHKAMEH KKESEKELQR TQKLLDSILP NIVNNQIRSE
560 570 580 590 600
MYKGTDPTVE TQFNKLYVYP MDNVSILFAD IKGFTELASK TSAQQLVKIL
610 620 630 640 650
NDLFARFDRI AEDNHCLRVK LLGDCYYCVS QFESDNWKTR PDHAVCSVET
660 670 680 690 700
GLHMIKAIKD VRLHTHVDLN MRIGIHSGSV MCGVLGNKKW HFDVWSNDVI
710 720 730 740 750
IANHMESGGI PGRVHISEAT LKCLNDAYEV EPGNGGCRDN HLKMLNVKTY
760 770 780 790 800
LIKRTEPLRP KRRFGTRSSA HLAGSVATAA PPCATPTALP KSISASGSGS
810 820 830 840 850
IGGVTATGND GASIDGRSLE YAATIAVPAQ QPTQLLQQQQ KKNISLNSLP
860 870 880 890 900
NVVEGVAMDS RRIRNGCGVM GGAGGTGGGG TGPCGMSTVS SPTAMMSAPL
910 920 930 940 950
EVQLRPRNGA CSIQNLAEAI DGKGLIIEDE STTDWIPEIP FKNLNSPEDG
960 970 980 990 1000
LNRADSILVD TKEDHRVSVA VLDEEIDEFI EQNIQINSNK EIRREYLNPW
1010 1020 1030 1040 1050
TLKFKDKSQE QKFCQLREDM FRSNMLCVFV IWIFMVLCQV IIIPRCTRLI
1060 1070 1080 1090 1100
ICLSVGTVIL TFCCVLVMAE EFPGLPRCLK TNSAKLVHQR QRRTLFICGV
1110 1120 1130 1140 1150
IVSMCMLSAI GLVLCPSSTY IGTADEHSRF LRMVSPYSNI SMTEKEFKLN
1160 1170 1180 1190 1200
VYLSATIHHN ITISTPASGG PTPLVDITSS GPSDEFVRST LNALTLNLTP
1210 1220 1230 1240 1250
PLPQSHRPYT LTTNGHSVSL SNLSYSDASV MQSSSDVEGQ CAHPEYLVFT
1260 1270 1280 1290 1300
WVLCLVSLAT ALKLYYLVKA LMALAMVAFY TTLIMMKFGS GDSFSLVELS
1310 1320 1330 1340 1350
RLGMPLGVQM LILLISFLVM VCYHARLVEV TSRLDFIWKE QAERELTNMK
1360 1370 1380 1390 1400
SNRALNDTLI KNILPDHVAT YYLSDEHTDE LYSKMHNLCG VMFASIPNFQ
1410 1420 1430 1440 1450
DFYSEDIDNG KACIRILNEI ICDFDELLEE PRFASVEKIK TVGATYMAAA
1460 1470 1480 1490 1500
GLNHEHLRLR GETSEDSVCD LVEFAFAMKQ KLEEINGDAF NNFQLRVGIC
1510 1520 1530 1540 1550
SGPLVSGVIG ARKPVYDIWG NTVNVASRMD STGENWRVQV PENTAELLCS
1560 1570 1580 1590 1600
RGYTCVKRGE IAVKGKGMMT TFYVHPKGIS ESQLISPVRM PAGIPLAQTP
1610 1620 1630 1640 1650
NLQRQTSHHG SFSAVVFGML QASKRSTAIA GTPTGTPSPQ IRRGHRGSTF
1660 1670 1680 1690 1700
SSVRLSQKST TVNPVRRNTT RVRGRSYRQK KSSSNNSIVT QASSSYMPSF
1710
RRIDQIETTI SKSHNDAL
Length:1,718
Mass (Da):189,013
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CED55D0AF4FF87D
GO
Isoform CImported (identifier: Q9VP76-2) [UniParc]FASTAAdd to basket
Also known as: S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-496: Missing.

Note: Catalytically inactive.1 Publication
Show »
Length:1,222
Mass (Da):135,280
Checksum:iE9693B9EBB2FDAA1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PID8M9PID8_DROME
Adenylate cyclase
Ac78C AC 78C, AC78C, CG10554, DAC78C, DAC78C-s
1,727Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PD54M9PD54_DROME
Adenylate cyclase
Ac78C AC 78C, AC78C, CG10554, DAC78C, DAC78C-s
1,717Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PG27M9PG27_DROME
Adenylate cyclase
Ac78C AC 78C, AC78C, CG10554, DAC78C, DAC78C-s
1,694Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0599681 – 496Missing in isoform C. Add BLAST496

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF51680.3
AE014296 Genomic DNA Translation: AFH04528.1

NCBI Reference Sequences

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RefSeqi
NP_001246857.1, NM_001259928.2 [Q9VP76-2]
NP_524194.3, NM_079470.5 [Q9VP76-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0301701; FBpp0290915; FBgn0024150 [Q9VP76-1]
FBtr0305501; FBpp0293953; FBgn0024150 [Q9VP76-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
40333

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG10564

UCSC genome browser

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UCSCi
CG10564-RA, d. melanogaster [Q9VP76-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF51680.3
AE014296 Genomic DNA Translation: AFH04528.1
RefSeqiNP_001246857.1, NM_001259928.2 [Q9VP76-2]
NP_524194.3, NM_079470.5 [Q9VP76-1]

3D structure databases

SMRiQ9VP76
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9VP76, 3 interactors

Proteomic databases

PRIDEiQ9VP76

Genome annotation databases

EnsemblMetazoaiFBtr0301701; FBpp0290915; FBgn0024150 [Q9VP76-1]
FBtr0305501; FBpp0293953; FBgn0024150 [Q9VP76-2]
GeneIDi40333
KEGGidme:Dmel_CG10564
UCSCiCG10564-RA, d. melanogaster [Q9VP76-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
40333
FlyBaseiFBgn0024150, Ac78C

Phylogenomic databases

HOGENOMiCLU_001072_3_1_1
InParanoidiQ9VP76
KOiK08048
OMAiAYQRYSH
OrthoDBi107368at2759
PhylomeDBiQ9VP76

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
40333, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
40333

Protein Ontology

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PROi
PR:Q9VP76

Gene expression databases

BgeeiFBgn0024150, Expressed in embryo and 38 other tissues
ExpressionAtlasiQ9VP76, baseline and differential
GenevisibleiQ9VP76, DM

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR032628, AC_N
IPR009398, Adcy_conserved_dom
IPR029787, Nucleotide_cyclase
PfamiView protein in Pfam
PF16214, AC_N, 1 hit
PF06327, DUF1053, 1 hit
PF00211, Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044, CYCc, 2 hits
SUPFAMiSSF55073, SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAC78C_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VP76
Secondary accession number(s): M9NG95, Q9VP75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2018
Last sequence update: November 30, 2010
Last modified: August 12, 2020
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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